CN108721121A - A kind of lubricant for root canal therapy and preparation method thereof - Google Patents
A kind of lubricant for root canal therapy and preparation method thereof Download PDFInfo
- Publication number
- CN108721121A CN108721121A CN201810546992.6A CN201810546992A CN108721121A CN 108721121 A CN108721121 A CN 108721121A CN 201810546992 A CN201810546992 A CN 201810546992A CN 108721121 A CN108721121 A CN 108721121A
- Authority
- CN
- China
- Prior art keywords
- lubricant
- root canal
- edta
- surfactant
- solvent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/52—Cleaning; Disinfecting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
- A61K6/69—Medicaments
Landscapes
- Health & Medical Sciences (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dental Preparations (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a kind of lubricant for root canal therapy and preparation method thereof, lubricant includes the component of following mass percent：EDTA, EDTA-2Na or EDTA-4Na：15-25%；PH value adjustment agent：4-14%；Surfactant：1.5-2.5%；Excipients：3-8%；Solvent：Surplus.PH conditioning agents are citric acid, sodium citrate, one kind in phytic acid or arbitrary combination；Surfactant is polyethylene glycols nonionic surface active agent or ammonium salt class organic cation type surfactant；Excipients are Carmomer or silica；Solvent is deionized water and glycerine.Lubricant of the present invention for root canal can soften root canal wall, effectively remove smear layer, and have good antibiotic and sterilizing effect.
Description
Technical field
The present invention relates to a kind of lubricant for root canal therapy and preparation method thereof.
Background technology
Pulpitis, pulp necrosis, periapical inflammation are the higher mouth diseases of incidence, are controlled for such illness is most effective
More means are exactly root canal.Particularly with decoronated teeth tooth, reparation section needs to carry out post crown restoration, and root canal therapy is only
One therapy that can be selected.Root canal is that the method by debridement, mechanically and chemically is thoroughly removed and infected in root pipe
Source, since root canal system is sufficiently complex, including collateral pulp canal, Accessory canals etc., it merely can not thorough cleaning root by mechanical preparation
Bacterium in pipe.Flushing liquor ingredient clinically mainly is sodium hypochlorite at present, and sodium hypochlorite can dissolve in root pipe in smear layer
Organic organization, smear layer can be made thinning, loose and be more easy to be rinsed liquid and wash away, but be mainly inorganic matter due to staining composition of layer
Matter, therefore exclusive use sodium hypochlorite cannot completely remove smear layer, it is necessary to it is used cooperatively the root pipe containing special chemical ingredient
Lubricant is removed.
Invention content
The present invention is intended to provide a kind of lubricant for root canal therapy and preparation method thereof.
Technical scheme is as follows：
A kind of lubricant for root canal therapy, which is characterized in that include the component of following mass percent：
EDTA, EDTA-2Na or EDTA-4Na：15-25%；
PH value adjustment agent：4-14%；
Surfactant：1.5-2.5%；
Excipients：3-8%；
Solvent：Surplus.
Above-mentioned PH conditioning agents are citric acid, sodium citrate, one kind in phytic acid or arbitrary combination；Surfactant is poly- second
Glycols nonionic surface active agent or ammonium salt class organic cation type surfactant；Excipients are Carmomer or oxidation
Silicon；Solvent is deionized water and glycerine, and the mass ratio of the two is 1:1.3 to 4.5:1.
The present invention also provides a kind of preparation method of above-mentioned lubricant for root canal therapy is as follows：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA, EDTA-2Na or EDTA-4Na are added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Beneficial effects of the present invention：Lubricant of the present invention for root canal can soften root canal wall, effectively remove flaw
There is anti-corrosion, bacteriostasis, citric acid root pipe lubricant is added and makees with good killing to Gram-negative bacteria for pollution layer, phytic acid
There is good osmosis to suffering from root of the tooth with, citric acid, hydrogen ion concentration is high, makes to be located at bacterial cell surface or surrounding
Sensitive composition is denaturalized and penetrates into inside bacterium, to play the role of antibacterial effect, when using citric acid root canal, in root pipe
Gram negative pathogenic bacteria can be removed effectively.
Specific implementation mode
The present invention is further described with reference to specific embodiment.
Embodiment 1
This embodiment offers a kind of lubricant for root canal therapy, include the component of following mass percent：
EDTA：15%；
PH value adjustment agent：4%；
Surfactant：1.5%；
Excipients：3%；
Solvent：Surplus.
Above-mentioned PH conditioning agents are citric acid；Surfactant is polyethylene glycols nonionic surface active agent；Excipients
For Carmomer；Solvent is deionized water and glycerine, and the mass ratio of the two is 1:1.3.
The embodiment additionally provides a kind of preparation method for above-mentioned lubricant for root canal therapy, and its step are as follows：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA is added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Embodiment 2
This embodiment offers a kind of lubricant for root canal therapy, include the component of following mass percent：
EDTA-2Na：25%；
PH value adjustment agent：14%；
Surfactant：2.5%；
Excipients：8%；
Solvent：Surplus.
Above-mentioned PH conditioning agents are sodium citrate；Surfactant is ammonium salt class organic cation type surfactant；Excipient
Agent is silica；Solvent is deionized water and glycerine, and the mass ratio of the two is 4.5:1.
The embodiment additionally provides a kind of preparation method for above-mentioned lubricant for root canal therapy, and its step are as follows：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA-2Na is added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Embodiment 3
This embodiment offers a kind of lubricant for root canal therapy, include the component of following mass percent：
EDTA-4Na：20%；
PH value adjustment agent：10%；
Surfactant：2%；
Excipients：5%；
Solvent：Surplus.
Above-mentioned PH conditioning agents are phytic acid；Surfactant is polyethylene glycols nonionic surface active agent；Excipients are
Carmomer；Solvent is deionized water and glycerine, and the mass ratio of the two is 1:1.
The embodiment additionally provides a kind of preparation method for above-mentioned lubricant for root canal therapy, and its step are as follows：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA-4Na is added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Embodiment 4
This embodiment offers a kind of lubricant for root canal therapy, include the component of following mass percent：
EDTA：15%；
PH value adjustment agent：14%；
Surfactant：2.5%；
Excipients：3%；
Solvent：Surplus.
Above-mentioned PH conditioning agents are citric acid and phytic acid；Surfactant be polyethylene glycols nonionic surface active agent and
Ammonium salt class organic cation type surfactant；Excipients are Carmomer；Solvent is deionized water and glycerine, the quality of the two
Than being 4.5:1.
The present invention also provides a kind of preparation method of above-mentioned lubricant for root canal therapy is as follows：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA is added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Embodiment 5
This embodiment offers a kind of lubricant for root canal therapy, include the component of following mass percent：
EDTA-4Na：25%；
PH value adjustment agent：4%；
Surfactant：2.5%；
Excipients：3%；
Solvent：Surplus.
Above-mentioned PH conditioning agents are citric acid, sodium citrate and phytic acid；Surfactant is polyethylene glycols nonionic table
Face activating agent and ammonium salt class organic cation type surfactant；Excipients are Carmomer and silica；Solvent is deionized water
And glycerine, the mass ratio of the two is 1:1.3 to 4.5:1.
The present invention also provides a kind of preparation method of above-mentioned lubricant for root canal therapy is as follows：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA, EDTA-2Na or EDTA-4Na are added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Above-described is only the preferred embodiments of the present invention.It should be pointed out that for the ordinary skill of this field
It for personnel, without departing from the principles of the present invention, can also make several improvements and modification, this is also considered as the present invention's
Protection domain.
Claims (7)
1. a kind of lubricant for root canal therapy, which is characterized in that include the component of following mass percent：
EDTA, EDTA-2Na or EDTA-4Na：15-25%；
PH value adjustment agent：4-14%；
Surfactant：1.5-2.5%；
Excipients：3-8%；
Solvent：Surplus.
2. lubricant for root canal therapy according to claim 1, it is characterised in that：The PH conditioning agents are citric acid, lemon
One kind in sour sodium, phytic acid or arbitrary combination.
3. lubricant for root canal therapy according to claim 1, it is characterised in that：The surfactant is polyethylene glycols
Nonionic surface active agent or ammonium salt class organic cation type surfactant.
4. lubricant for root canal therapy according to claim 1, it is characterised in that：The excipients are Carmomer or oxidation
Silicon.
5. lubricant for root canal therapy according to claim 1, it is characterised in that：The solvent is deionized water and the third three
Alcohol.
6. lubricant for root canal therapy according to claim 5, it is characterised in that：The quality of the deionized water and glycerine
Than being 1:1.3 to 4.5:1.
7. the preparation method of lubricant for root canal therapy is as follows as described in any one of claim 1-6：
Step 1: preparing solvent in proportion, it is added to 50 ± 5 DEG C；
Step 2: EDTA, EDTA-2Na or EDTA-4Na are added in above-mentioned solvent, it is uniformly mixed；
Step 3: pH value adjustment agent, surfactant, excipients are added, stir evenly；
Step 4: stirring or emulsifying are prepared into colloid；
Step 5: being filled in disposable injection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810546992.6A CN108721121A (en) | 2018-05-31 | 2018-05-31 | A kind of lubricant for root canal therapy and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810546992.6A CN108721121A (en) | 2018-05-31 | 2018-05-31 | A kind of lubricant for root canal therapy and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108721121A true CN108721121A (en) | 2018-11-02 |
Family
ID=63931292
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810546992.6A Pending CN108721121A (en) | 2018-05-31 | 2018-05-31 | A kind of lubricant for root canal therapy and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108721121A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244012A (en) * | 2007-02-14 | 2008-08-20 | 张郁 | Lubricant agent for root canal treatment |
| CN101869534A (en) * | 2009-04-22 | 2010-10-27 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
| CN105213200A (en) * | 2015-10-14 | 2016-01-06 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
| CN105616169A (en) * | 2016-02-22 | 2016-06-01 | 浙江浙北药业有限公司 | Water-soluble root canal lubricant and preparation method thereof |
-
2018
- 2018-05-31 CN CN201810546992.6A patent/CN108721121A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101244012A (en) * | 2007-02-14 | 2008-08-20 | 张郁 | Lubricant agent for root canal treatment |
| CN101869534A (en) * | 2009-04-22 | 2010-10-27 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
| CN105213200A (en) * | 2015-10-14 | 2016-01-06 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
| CN105616169A (en) * | 2016-02-22 | 2016-06-01 | 浙江浙北药业有限公司 | Water-soluble root canal lubricant and preparation method thereof |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
| WO2022052631A1 (en) * | 2020-09-10 | 2022-03-17 | 昆明蓝橙口腔医院有限责任公司 | Application of citrate metal salt in endodontic treatment, and formulation obtained by preparation |
| CN112022725B (en) * | 2020-09-10 | 2022-09-20 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Safavi et al. | Root canal dentinal tubule disinfection | |
| Ulusoy et al. | Effects of different irrigation solutions on root dentine microhardness, smear layer removal and erosion | |
| Lottanti et al. | Effects of ethylenediaminetetraacetic, etidronic and peracetic acid irrigation on human root dentine and the smear layer | |
| JP7138633B2 (en) | Root canal patch composition | |
| Nikhil et al. | Effect of addition of 2% chlorhexidine or 10% doxycycline on antimicrobial activity of biodentine | |
| ES2557354T3 (en) | Composition and method for irrigation of a prepared dental root canal | |
| Yadav et al. | Efficacy of etidronic acid, BioPure MTAD and SmearClear in removing calcium ions from the root canal: An in vitro study | |
| KR20170098956A (en) | Enzyme solutions, enzyme-containing nonwoven fabrics, and methods for making and using the same | |
| Karunakaran et al. | The effects of various irrigating solutions on intra-radicular dentinal surface: An SEM analysis | |
| Cruz et al. | Debris remaining in the apical third of root canals after chemomechanical preparation by using sodium hypochlorite and glyde: an in vivo study | |
| DK160033B (en) | Agent for cleaning dentine surfaces | |
| Srikumar et al. | Coronal microleakage with five different temporary restorative materials following walking bleach technique: An: ex-vivo: study | |
| NO863208L (en) | MUNNRENSINGSOPPLOESNING. | |
| CN108721121A (en) | A kind of lubricant for root canal therapy and preparation method thereof | |
| US20110159462A1 (en) | Therapeutic agent for periodontal diseases and method of treating periodontal diseases | |
| López et al. | Effect of different irrigating solutions and photo-activated therapy for in vivo root canal treatment | |
| CN105616169A (en) | Water-soluble root canal lubricant and preparation method thereof | |
| CN105213200A (en) | A kind of lubricant for root canal | |
| Hwang et al. | Efficacy of different carriers for the triple antibiotic powder during regenerative endodontic procedures | |
| Maru et al. | Assessment of bacterial load using 3.8% SDF as an irrigant in pulpectomized primary molars: a randomized controlled trial | |
| JP2566676B2 (en) | Dental composition | |
| Hegde et al. | Comparison of removal of endodontic smear layer using ethylene glycol bis (beta-amino ethyl ether)-N, N, N', N'-tetraacetic acid and citric acid in primary teeth: A scanning electron microscopic study | |
| WO2014079938A1 (en) | Method for eliminating biofilms for cleaning medical instruments, in particular for combating nosocomial infections | |
| Koga et al. | EDTA as final irrigating gold standard in endodontics | |
| Atom et al. | Antimicrobial efficacy of different pulp-capping materials against Enterococcus faecalis: An In vitro study |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20181102 |