CN105213200A - A kind of lubricant for root canal - Google Patents
A kind of lubricant for root canal Download PDFInfo
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- CN105213200A CN105213200A CN201510660921.5A CN201510660921A CN105213200A CN 105213200 A CN105213200 A CN 105213200A CN 201510660921 A CN201510660921 A CN 201510660921A CN 105213200 A CN105213200 A CN 105213200A
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- lubricant
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- 210000004262 dental pulp cavity Anatomy 0.000 title claims abstract description 56
- 239000000314 lubricant Substances 0.000 title claims abstract description 52
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract description 87
- LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 claims abstract description 26
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- IMQLKJBTEOYOSI-UHFFFAOYSA-N Phytic acid Natural products OP(O)(=O)OC1C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C(OP(O)(O)=O)C1OP(O)(O)=O IMQLKJBTEOYOSI-UHFFFAOYSA-N 0.000 description 3
- 239000005708 Sodium hypochlorite Substances 0.000 description 3
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- SGKRLCUYIXIAHR-AKNGSSGZSA-N (4s,4ar,5s,5ar,6r,12ar)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O SGKRLCUYIXIAHR-AKNGSSGZSA-N 0.000 description 1
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- XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 description 1
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Landscapes
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses a kind of lubricant for root canal, comprise sodium ethylene diamine tetracetate, citric acid, urea peroxide, cetyl trimethyl ammonium bromide, sodium carboxymethyl cellulose, G & W.Lubricant of the present invention can soften root canal wall, reduce preparation resistance and be particularly useful for the preparation of steep-taper NiTi instruments, use root pipe lubricant (experimental group) by contrast and do not use root pipe lubricant (matched group) two groups of samples, clinical test results is presented in root canal preparation and uses root pipe lubricant, in root pipe, bacterium picking out rate is starkly lower than and does not make with lubricator group, show to make in root canal preparation with lubricator to contribute to eliminating antibacterial in root pipe, create the condition being beneficial to the healing of clinical chronic periapical periodontitis.
Description
Technical field
The invention belongs to tooth root canal field, be specifically related to a kind of lubricant for root canal, its main purpose removes the smear layer and infectious agent that can not remove in root pipe mechanical means preliminary procedure.
Background technology
According to investigation, the Adult Onset of Chinese oral disease leads and accounts for 60% ~ 80% of Chinese population, and wherein pulpitis, pulp necrosis, periapical periodontitis sickness rate are higher, and the most effectively curing means for this type of disease is exactly root canal.Especially for decoronated teeth tooth, reparation section needs to carry out post crown restoration, and root canal therapy is the Therapeutic Method uniquely can selected.
Root canal thoroughly removes the source of infection in root pipe by debridement, machinery and chemical method, because root canal system is very complicated, comprises collateral pulp canal, Accessory canals etc., and the simple mechanical preparation that relies on cannot thoroughly clear up antibacterial in root pipe.Flushing liquor composition main clinically is at present sodium hypochlorite, sodium hypochlorite can dissolve the organic organization in root pipe in smear layer, smear layer can be made thinning, loose and be more easily rinsed liquid to wash away, but due to smear layer composition mainly inorganic substances, therefore be used alone sodium hypochlorite and can not remove smear layer completely, must remove with the use of the root pipe lubricant containing special chemical composition.
The main component of root pipe lubricant has MTAD (mixture such as tetracycline, surfactant) and EDTA, the doxycycline content of MTAD middle and high concentration may produce drug resistance strain, strengthen the risk of tetracycline pigmentation teeth, therefore the clinical effect of MTAD still can not obtain consistent affirmative.The irrigation effectively removing smear layer is acid and metal-chelator, and EDTA, as metal-chelator, can soften root canal wall, removes smear layer and have the effect of lubrication, emulsifying chip, be conducive to the clean of root pipe and be shaped.
Root pipe lubricant main component common is in the market EDTA, or add the auxiliary substances such as urea peroxide, water-soluble base, phytic acid, its principle is with EDTA complexation of metal ions, utilize the strong sequestering power of phytic acid to strengthen the combination of calcium ion further, urea peroxide plays the effect of removing antibacterial.Research display, root canal system infects the mixed infection mainly based on anaerobe, and wherein obligate anaerobe accounts for more than 70%, and bacteroides melanogenicus is the main pathogenic fungi that pulp necrosis related symptoms occurs, and bacteroides melanogenicus is gram negative bacteria.Phytic acid is botanical extract, itself there is certain bacteriostasis, but the cell membrane of gram negative bacteria can stop the permeability of its antimicrobial component cell membrane, gram negative bacteria is provided with patience to plants antimicrobial material, cause cannot showing antibacterial effect to gram negative bacteria, it then has poor antibacterial effect for gram negative bacteria, the object of thorough bacteria removal cannot be played in root pipe is antibacterial, and itself permeability of existing lubricant is bad, needs the EDTA of higher concentration just can complete corresponding effect.
Summary of the invention
For defect of the prior art and deficiency, thoroughly remove to make smear layer in root pipe and can effectively remove pathogen in root pipe again outward, the invention provides a kind of lubricant for root canal, the while that object being and can removing root pipe smear layer, there is good antibacterial action.
The present invention is achieved through the following technical solutions:
For a lubricant for root canal, comprise sodium ethylene diamine tetracetate, citric acid, urea peroxide, cetyl trimethyl ammonium bromide, sodium carboxymethyl cellulose, G & W.
Concrete, by mass percentage, described sodium ethylene diamine tetracetate is 10% ~ 20%, citric acid is 5% ~ 14%, and urea peroxide is 10% ~ 18%, and cetyl trimethyl ammonium bromide is 0.02% ~ 0.1%, sodium carboxymethyl cellulose is 0.5% ~ 5%, glycerol is 10% ~ 25%, and all the other are water, and the total amount of said components is 100%.
Concrete again, by mass percentage, described sodium ethylene diamine tetracetate is 10%, and citric acid is 5%, urea peroxide is 18%, and cetyl trimethyl ammonium bromide is 0.1%, and sodium carboxymethyl cellulose is 3%, glycerol is 10%, and all the other are water, and the total amount of said components is 100%.
More specifically, by mass percentage, described sodium ethylene diamine tetracetate is 15%, and citric acid is 10%, urea peroxide is 10%, and cetyl trimethyl ammonium bromide is 0.02%, and sodium carboxymethyl cellulose is 2%, glycerol is 15%, and all the other are water, and the total amount of said components is 100%.
Further, by mass percentage, described sodium ethylene diamine tetracetate is 17%, and citric acid is 12%, urea peroxide is 15%, and cetyl trimethyl ammonium bromide is 0.03%, and sodium carboxymethyl cellulose is 0.5%, glycerol is 25%, and all the other are water, and the total amount of said components is 100%.
Or by mass percentage, described sodium ethylene diamine tetracetate is 20%, and citric acid is 14%, urea peroxide is 12%, and cetyl trimethyl ammonium bromide is 0.04%, and sodium carboxymethyl cellulose is 5%, glycerol is 20%, and all the other are water, and the total amount of said components is 100%.
Advantage of the present invention is:
(1) lubricant for root canal of the present invention can soften root canal wall, reduce preparation resistance and be particularly useful for the preparation of steep-taper NiTi instruments, lubricant for root canal of the present invention is carried out root canal to the patient that 100 routine clinical diagnosises are chronic periapical periodontitis by Stomatological Hospital, Military Surgeon Univ. No. 4, clinical test results is presented in root canal preparation and uses lubricant of the present invention, in root pipe, bacterium picking out rate is starkly lower than and does not make with lubricator group, show in root canal preparation, to use lubricant of the present invention to contribute to eliminating antibacterial in root pipe, create the condition being beneficial to the healing of clinical chronic periapical periodontitis,
(2) the present invention has good killing action to gram negative bacteria after found through experiments and citric acid being added root pipe lubricant, to gram positive bacteria, there is good killing action after cetyl trimethyl ammonium bromide being added root pipe lubricant, root pipe smear layer can not only be removed after two kinds of materials are joined root pipe lubricant simultaneously, good killing action can also be had to gram positive bacteria and gram negative bacteria, expand the sterilizing scope of existing pipe lubricant greatly.
Detailed description of the invention
EDTA, as a kind of metal ion chelation agent, forms soluble complexes with the calcium ion in hydroxyapatite, thus makes dentin demineralization, open tubules, and residual dental pulp is decomposed in emulsifying, effectively removes smear layer.Consider that EDTA antibacterial action is more weak, effectively can not sterilize to root pipe, in composition, add urea peroxide, urea peroxide combines rear Hydrogen Peroxide with organic, produce bubble, be conducive to the diffus-sion and permeation of effective ingredient, play the effect of sterilization and deodorization.
Because EDTA has very strong Demineralization, as excessive concentration, action time is long, can cause excessive demineralization that is collagen fibril denaturing and root canal wall.In order to address this problem, this product adds carboxymethyl cellulose as excipient in formula, makes lubricant have certain solid shape.Carboxymethyl cellulose aqueous solution, in glutinous thick liquid, plays lubrication in endodontic procedure.Glycerol can reduce solution surface tension, the penetration of increasing action partial lubrication agent, makes the EDTA of low concentration also can play good cleaning effect.
In addition, inventor studies by experiment and finds that citric acid is a kind of excellent chelating agen, have multiple excellent performance, be widely used, citric acid has good osmosis to trouble root of the tooth, its hydrogen ion concentration is high, make to be positioned at bacterial cell surface or sensitive composition degeneration around and infiltrate antibacterial inside, thus playing antibacterial effect, comparatively gram positive bacteria is more responsive to gram negative bacteria for citric acid, during application citric acid effect root canal, can effectively remove gram negative pathogenic bacteria in root pipe;
Cetyl trimethyl ammonium bromide solubilized cell membrane, is a kind of cationic detergent, stablizes in an acidic solution, has the performances such as excellent infiltration, emulsifying, biological degradability and sterilization, especially has good bactericidal effect to gram positive bacteria.With untreated pipe unlike, in the root canal system of root canal failure, bacterial species is less, in the majority with gram-positive bacterium, and these antibacterials mainly comprise: excrement chain bacterium, enterococcus faecalis etc.Therefore, no matter be gram negative bacteria, positive bacteria, the composition of cetyl trimethyl ammonium bromide and citric acid can be worked in coordination with and be played biocidal efficacies, removes pathogen in root pipe.
Root pipe smear layer can not only be removed after citric acid and cetyl trimethyl ammonium bromide are joined root pipe lubricant simultaneously, good killing action can also be had to gram positive bacteria and gram negative bacteria, expand the sterilizing scope of existing pipe lubricant greatly.
Below in conjunction with specific embodiment and application of clinic experimentation, the present invention is illustrated.
Embodiment 1: the lubricant for root canal of the present embodiment, each component by mass percentage proportioning is as follows, sodium ethylene diamine tetracetate: 10%, citric acid: 5%, urea peroxide: 18%, cetyl trimethyl ammonium bromide: 0.1%, sodium carboxymethyl cellulose: 3%, glycerol: 10%, its surplus is water.
Embodiment 2: the lubricant for root canal of the present embodiment, each component by mass percentage proportioning is as follows, sodium ethylene diamine tetracetate: 15%, citric acid: 10%, urea peroxide: 10%, cetyl trimethyl ammonium bromide: 0.02%, sodium carboxymethyl cellulose: 2%, glycerol: 15%, its surplus is water.
Embodiment 3: the lubricant for root canal of the present embodiment, each component by mass percentage proportioning is as follows, sodium ethylene diamine tetracetate: 17%, citric acid: 12%, urea peroxide: 15%, cetyl trimethyl ammonium bromide: 0.03%, sodium carboxymethyl cellulose: 0.5%, glycerol: 25%, its surplus is water.
Embodiment 4: the lubricant for root canal of the present embodiment, each component by mass percentage proportioning is as follows, sodium ethylene diamine tetracetate: 20%, citric acid: 14%, urea peroxide: 12%, cetyl trimethyl ammonium bromide: 0.04%, sodium carboxymethyl cellulose: 5%, glycerol: 20%, its surplus is water.
Comparative example 1:(does not add citric acid)
The lubricant for root canal of the present embodiment, proportioning is as follows by mass percentage for each component, sodium ethylene diamine tetracetate: 15%, urea peroxide: 10%, cetyl trimethyl ammonium bromide: 0.02%, sodium carboxymethyl cellulose: 2%, glycerol: 15%, its surplus is water.
Comparative example 2:(does not add cetyl trimethyl ammonium bromide)
The lubricant for root canal of the present embodiment, proportioning is as follows by mass percentage for each component, sodium ethylene diamine tetracetate: 15%, citric acid: 10%, urea peroxide: 10%, sodium carboxymethyl cellulose: 2%, glycerol: 15%, and its surplus is water.
Clinical experiment:
In order to verify the effect of the lubricant for root canal of the present invention in root canal irrigation, lubricant for root canal of the present invention has been carried out clinical laboratory data statistics to the impact of antibacterial Scavenging activity in root pipe, to clinical diagnosis be chronic periodontitis, the patient of periapical periodontitis carries out root canal, be divided into confirmatory experiment and contrast experiment, wherein:
Matched group (not using the lubricant for root canal) and processed group 1 (using the lubricant for root canal of embodiment 2) is divided in confirmatory experiment;
Contrast groups (using the lubricant for root canal of embodiment 2), processed group 2 (using the lubricant for root canal in comparative example 1) and processed group 3 (using the lubricant for root canal in comparative example 2) is divided in contrast experiment;
Experimentation and experimental result record as follows:
At labial teeth chronic periapical periodontitis patient 100 example totally 100 teeth that Xi-an No.4 Military Medical Univ. stomatological hospital Endodontics goes to a doctor, wherein male 45 example, women 55 example, 18 ~ 63 years old age.Informed choice is divided into matched group, processed group 1, contrast groups, processed group 2 and processed group 3 after agreeing at random, often organizes 20 teeth.
1, experimental technique (root canal preparation):
Experimental group: rubber dam isolate, after removing the abundant exposed roots mouth of pipe in marrow top completely, adopt hat to purgation, hands with ProTaper instrumentation to F3.For first detecting root pipe → #15K file with traditional #10K file, detailed step determines that active length → pulp chamber and root pipe built-in pipe lubricant → ProTaperSx preparation → 30mL/L hydrogen peroxide liquid, each 2mL of normal saline rinse root pipe 1min → ProTaperS1 → Pro-TaperS2 → ProTaperF1 → ProTaperF2 → ProTaperF3.The preparation of every root file completes rinses root pipe with rear said method, places lubricant, again rinse, finally use 5mL normal saline flushing root pipe 1min, dry root pipe, Ca (OH) after preparation before changing a file in root pipe
2the further consultation row root-canal filling after 1 week of envelope medicine.
Protaper apparatus comprises six roots of sensation apparatus: Sx, S1, S2, F1, F2, F3; Represent the apparatus of different size respectively.
Matched group is the same experimental group of all the other steps except not using the lubricant for root canal in root canal preparation.
2, bacterial sampling and cultivation
Each pipe puts 30s sampling in root pipe with aseptic spill respectively before root canal preparation, after preparation, is inoculated in blood agar plate, Anaerobic Blood Agar plate and bacteroides melanogenicus, actinomycetes, Fusobacterium 3 kinds of selective medium plates.Put in anaerobic culture box by anaerobic culture base after inoculation and cultivate 7d, aerobe cultivates 2d in aerobic environment, observation unit's volume clump count.
3, date processing
SPSS16.0 is adopted to carry out statistical analysis.Before and after preparation, the comparison of bacterium picking out rate adopts paired t-test, inspection level a=0.05.
4, experimental result statistics
(1) confirmatory experiment result:
A table one pipe bacterium picking out rate (CFU/mL,
)
* with organize prepare before compared with P < 0.05; △ is P < 0.05 compared with after matched group preparation
Experimental result in table 1 shows that in processed group 1, in root pipe, bacterium picking out rate is starkly lower than matched group, show in root canal preparation, to use the lubricant for root canal to contribute to eliminating antibacterial in root pipe, create the condition being beneficial to the healings such as clinical periodontitis, periapical periodontitis, root pipe lubricant is while removal smear layer, open dentinal tubule, do not cause obvious demineralization, and the lubricant for root canal in embodiment 2 all has good killing action for gram positive bacteria and gram negative bacteria.
(2) contrast and experiment:
A table two pipe bacterium picking out rate (CFU/mL,
)
* with organize prepare before compared with P < 0.05; △ is P < 0.05 compared with after contrast groups preparation
A table three pipe bacterium picking out rate (CFU/mL,
)
* with organize prepare before compared with P < 0.05; △ is P < 0.05 compared with after contrast groups preparation
Experimental result in table two and table three shows, contrast groups and processed group 2 and the forward and backward bacterium picking out rate of processed group 3 preparation, and difference has statistical significance (P ﹤ 0.05); In table two processed group 2 experimental group preparation after bacterium picking out rate apparently higher than contrast groups, but the inhibition of gram positive bacteria and contrast groups difference not obvious; In table three processed group 3 experimental group preparation after bacterium picking out rate apparently higher than contrast groups, but the inhibition of gram negative bacteria and matched group difference not obvious; And prepare the inhibition of front and back to gram positive bacteria in processed group 2 significantly better than processed group 3, prepare the inhibition of front and back to gram negative bacteria in processed group 3 significantly better than processed group 2, but all there is no the good antimicrobial effect in contrast groups;
Adding of above-mentioned the results show cetyl trimethyl ammonium bromide can have inhibition to antibacterial most in oral cavity, particularly obvious for gram positive bacteria inhibition; Adding of citric acid can have inhibition to the most antibacterials in oral cavity, particularly obvious to the killing effect of gram negative bacteria; And when citric acid and cetyl trimethyl ammonium bromide add after in lubricant more obvious to the inhibition of two kinds of antibacterials simultaneously, illustrate that citric acid and the suppression of cetyl trimethyl ammonium bromide to oral cavity bacterium have synergism.
Claims (6)
1. for a lubricant for root canal, it is characterized in that, comprise sodium ethylene diamine tetracetate, citric acid, urea peroxide, cetyl trimethyl ammonium bromide, sodium carboxymethyl cellulose, G & W.
2. as claimed in claim 1 for the lubricant of root canal, it is characterized in that, by mass percentage, described sodium ethylene diamine tetracetate is 10% ~ 20%, and citric acid is 5% ~ 14%, urea peroxide is 10% ~ 18%, cetyl trimethyl ammonium bromide is 0.02% ~ 0.1%, and sodium carboxymethyl cellulose is 0.5% ~ 5%, and glycerol is 10% ~ 25%, all the other are water, and the total amount of said components is 100%.
3. as claimed in claim 1 for the lubricant of root canal, it is characterized in that, by mass percentage, described sodium ethylene diamine tetracetate is 10%, and citric acid is 5%, urea peroxide is 18%, cetyl trimethyl ammonium bromide is 0.1%, and sodium carboxymethyl cellulose is 3%, and glycerol is 10%, all the other are water, and the total amount of said components is 100%.
4. as claimed in claim 1 for the lubricant of root canal, it is characterized in that, by mass percentage, described sodium ethylene diamine tetracetate is 15%, and citric acid is 10%, urea peroxide is 10%, cetyl trimethyl ammonium bromide is 0.02%, and sodium carboxymethyl cellulose is 2%, and glycerol is 15%, all the other are water, and the total amount of said components is 100%.
5. as claimed in claim 1 for the lubricant of root canal, it is characterized in that, by mass percentage, described sodium ethylene diamine tetracetate is 17%, and citric acid is 12%, urea peroxide is 15%, cetyl trimethyl ammonium bromide is 0.03%, and sodium carboxymethyl cellulose is 0.5%, and glycerol is 25%, all the other are water, and the total amount of said components is 100%.
6. as claimed in claim 1 for the lubricant of root canal, it is characterized in that, by mass percentage, described sodium ethylene diamine tetracetate is 20%, and citric acid is 14%, urea peroxide is 12%, cetyl trimethyl ammonium bromide is 0.04%, and sodium carboxymethyl cellulose is 5%, and glycerol is 20%, all the other are water, and the total amount of said components is 100%.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616169A (en) * | 2016-02-22 | 2016-06-01 | 浙江浙北药业有限公司 | Water-soluble root canal lubricant and preparation method thereof |
| CN108721121A (en) * | 2018-05-31 | 2018-11-02 | 济南秦鲁药业科技有限公司 | A kind of lubricant for root canal therapy and preparation method thereof |
| CN111281809A (en) * | 2020-03-17 | 2020-06-16 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
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| CN101259082A (en) * | 2008-04-16 | 2008-09-10 | 厦门大学 | Root canal anti-inflammation developing agent and preparation thereof |
| CN101869534A (en) * | 2009-04-22 | 2010-10-27 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
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| CN101259082A (en) * | 2008-04-16 | 2008-09-10 | 厦门大学 | Root canal anti-inflammation developing agent and preparation thereof |
| CN101869534A (en) * | 2009-04-22 | 2010-10-27 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105616169A (en) * | 2016-02-22 | 2016-06-01 | 浙江浙北药业有限公司 | Water-soluble root canal lubricant and preparation method thereof |
| CN108721121A (en) * | 2018-05-31 | 2018-11-02 | 济南秦鲁药业科技有限公司 | A kind of lubricant for root canal therapy and preparation method thereof |
| CN111281809A (en) * | 2020-03-17 | 2020-06-16 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
| CN112022725B (en) * | 2020-09-10 | 2022-09-20 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
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| CN105213200B (en) | 2018-04-03 |
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