CN105616169A - Water-soluble root canal lubricant and preparation method thereof - Google Patents
Water-soluble root canal lubricant and preparation method thereof Download PDFInfo
- Publication number
- CN105616169A CN105616169A CN201610095402.3A CN201610095402A CN105616169A CN 105616169 A CN105616169 A CN 105616169A CN 201610095402 A CN201610095402 A CN 201610095402A CN 105616169 A CN105616169 A CN 105616169A
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- China
- Prior art keywords
- lubricant
- water
- urea peroxide
- edta
- root pipe
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/50—Preparations specially adapted for dental root treatment
- A61K6/52—Cleaning; Disinfecting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/15—Compositions characterised by their physical properties
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/60—Preparations for dentistry comprising organic or organo-metallic additives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/005—Ingredients of undetermined constitution or reaction products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/10—Materials for lubricating medical devices
Abstract
The invention relates to a water-soluble root canal lubricant and a preparation method thereof.The lubricant is of a colloidal form and is prepared from EDTA or EDTA sodium, sodium citrate, polyethylene glycol and an excipient.The preparation method of the water-soluble root canal lubricant includes the following steps that 1, an appropriate amount of the EDTA and/or urea peroxide is taken and is finely grinded for standby application; 2, an appropriate amount of the sodium citrate is taken as an acid-base regulator, a formula dosage of water is added, and even stirring is performed; 3, the polyethylene glycol and the excipient are added, and even stirring is performed; 4, the main components EDTA and/or urea peroxide are added, and even stirring is performed to prepare colloid; 5, the colloid is encapsulated in a disposable syringe.The root canal lubricant prepared by means of the preparation method is good in root canal lubricating effect, can kill various germs while performing root canal lubrication and facilitates root canal treatment.A doctor can easily flush off the residual root canal lubricant after using the lubricant.
Description
Technical field
The invention belongs to medicine technical field of medical instruments, be specifically related to a kind of water solublity root pipe lubricant and preparation method thereof.
Background technology
Root canal therapy (RootCanalTherapy, RCT) is that treatment dental pulp disease, periapical disease be the most common, most efficient method, is the important means of teeth preservation. Root canal therapy improves and perfect through continuous for many years, establishes more complete system, including root canal preparation, root canal disinfection and the big step of root-canal filling three.
Root canal preparation can produce smear layer, smear layer covers and can affect root canal microscope on root canal wall and infiltrate through dentinal tubule, weaken its bactericidal action, also can affect the closely sealed of root canal filling material and root canal wall, cause the failure of root canal, therefore, remove smear layer and there is more important meaning in root canal. Adopting EDTA aqueous solution alternately to rinse root pipe with sodium hypochlorite clinically, EDTA can effectively remove the smear layer on root canal wall, and sodium hypochlorite can remove the organic principle in root pipe, it is suppressed that antibacterial.
Although it is effective that EDTA aqueous solution removes root pipe smear layer, but is easily caused the excessive demineralization of root canal wall. Gelatinous pipe lubricant coordinates aqueous flushing liquor, can reduce the obstruction of root pipe in the process of instrumentation.
EDTA is a kind of chelating agen, can form soluble complexes with the calcium ion in hydroxyapatite, make dentin soften, and effectively removes the inorganic constituents in root canal wall smear layer.
The root pipe lubricant of the present invention is the water-soluable gel body containing EDTA. When the instrument of use expands root inside pipe wall, effectively carrying out calcium combination, go out the calcium soft dentin in dentin for chelating from root pipe, it is also used as a kind of lubricant and fractures with the resistance prevention reducing file pin.
Being divided into two big classes in the product that root pipe lubricant is current, its total composition is EDTA(EDTA sodium), it is distinctive in that a class is containing disinfection composition (such as urea peroxide), a class has been free from disinfection composition.
Being antibacterial with methacryloxyalkyl pyridinium chloride, trichlorohydroxyl phenylate and biguanides in CN200910031514 patent, it acts on the effect adding urea peroxide in product sold in the market is same.
Urea peroxide is a kind of peroxide, and its bactericidal effect is clear and definite, and zest is little, and shortcoming is that stability is more weak.
The root pipe lubricant containing urea peroxide in the market is mostly made as the type of paste, in dentist's practical application, after root pipe lubrication, it is necessary to rinsed well by root pipe lubricant, the more difficult flushing of paste. Make paste and be conducive to stablizing of urea peroxide.
In view of the defect that above-mentioned prior art exists, therefore prepare a kind of safe and stable effective, quality controllable, urgent needs that the simple a kind of water solublity root pipe lubricant of preparation technology becomes those skilled in the art.
Summary of the invention
In order to solve above-mentioned technical problem, first purpose of the present invention is to provide a kind of water solublity root pipe lubricant, and second purpose of the present invention is to provide above-mentioned water solublity root pipe method for preparing lubricant. The water solublity root pipe lubricant of the present invention safe and stable effective, quality controllable, preparation technology is simple.
In order to realize above-mentioned first purpose, present invention employs following technical scheme:
A kind of water solublity root pipe lubricant, this lubricant is colloid form, the component included by weight percentage:
EDTA or EDETATE SODIUM 5%��25%
Sodium citrate 0.01%��1%
Polyethylene Glycol 20%��80%
Excipient 1%��40%.
As preferably, the component that this lubricant includes by weight percentage:
EDTA or EDETATE SODIUM 10%��20%
Sodium citrate 0.1%��0.5%
Polyethylene Glycol 35%��70%
Excipient 1%��20%.
As preferably, this lubricant also includes urea peroxide 3%��25%, it is preferred to urea peroxide 5%��20%.
As preferably, one or more mixing in carbomer, propylene glycol, hexadecanol and water selected by excipient.
As preferably, carbomer 1%��20%, it is preferred to 1.5%��15%.
As preferably, propylene glycol 0.1%��20%, it is preferred to 0.5%��15%.
As preferably, hexadecanol 0.1%��10%, it is preferred to 0.5%��8%.
As preferably, water 0.01%��8%, it is preferred to 0.1%��5%.
As preferably, this lubricant is made up of the component of following several formula by weight percentage:
One,
EDTA10 ~ 20% Polyethylene Glycol 40 ~ 60%
Sodium citrate 0.01 ~ 0.05% hexadecanol 0.01 ~ 0.1%
Urea peroxide 5 ~ 10% carbomer 1 ~ 5%
Propylene glycol 1 ~ 5% purified water 1 ~ 5%;
Two,
EDETATE SODIUM 15 ~ 25% Polyethylene Glycol 60 ~ 80%
Propylene glycol 1 ~ 5% hexadecanol 0.1 ~ 0.5%
Urea peroxide 5 ~ 20% purified water 2 ~ 5%;
Three,
EDETATE SODIUM 20 ~ 25% Polyethylene Glycol 50 ~ 70%
Propylene glycol 2 ~ 5% hexadecanol 0.1 ~ 0.5%
Carbomer 2 ~ 5% purified water 3 ~ 10%;
Four,
EDTA15 ~ 25% Polyethylene Glycol 70 ~ 80%
Urea peroxide 4 ~ 10% hexadecanol 0.01 ~ 0.05%
Propylene glycol 2 ~ 5%.
In order to realize above-mentioned second purpose, present invention employs following technical scheme:
A kind of method preparing described water solublity root pipe lubricant, the method comprises the following steps:
1) appropriate EDTA and/or urea peroxide are taken, fine ground standby;
2) weigh proper amount of sodium citrate, as acid-base modifier, add recipe quantity water, stir;
3) add Polyethylene Glycol and excipient, stir;
4) add main component EDTA and/or urea peroxide, stir, make colloid;
5) encapsulation is to disposable syringe.
According to the root pipe lubricant that the present invention prepares, root pipe lubricant effect is good, can kill various pathogenic bacteria, be conducive to the treatment of root pipe while root pipe lubrication. The root pipe lubricant of residual can be rinsed well after using by doctor easily. Simple according to the root pipe lubricant preparation technology that the present invention prepares, properties of product are stable.
Detailed description of the invention
Below by specific embodiment, the method for the present invention is illustrated, but the invention is not limited in this. Experimental technique described in following embodiment, if no special instructions, is conventional method; Described reagent and material, if no special instructions, all commercially obtain.
Embodiment 1
Prescription:
EDTA30g Polyethylene Glycol 90g
Sodium citrate 0.2g hexadecanol 0.4g
Urea peroxide 15g carbomer 3g
Propylene glycol 4g purified water 5g
Preparation method:
1. weigh above-mentioned amount EDTA and urea peroxide, fine ground standby;
2. weigh above-mentioned amount sodium citrate, add recipe quantity water, stir;
3. add recipe quantity Polyethylene Glycol, hexadecanol, propylene glycol, carbomer, stir;
4. add main component EDTA and urea peroxide, stir, make colloid;
5. encapsulation is to disposable syringe.
Embodiment 2
Prescription:
EDETATE SODIUM 30g Polyethylene Glycol 100g
Propylene glycol 4g hexadecanol 0.4g
Urea peroxide 15g purified water 5g
Preparation method:
1. weigh above-mentioned amount EDETATE SODIUM and urea peroxide, fine ground standby;
2. add recipe quantity water, Polyethylene Glycol, hexadecanol, propylene glycol, stir;
3. add main component EDETATE SODIUM and urea peroxide, stir, make colloid;
4. encapsulation is to disposable syringe.
Embodiment 3
Prescription:
EDTA30g Polyethylene Glycol 110g
Urea peroxide 11g hexadecanol 0.4g
Propylene glycol 7g purified water 5g
Preparation method:
1. weigh above-mentioned amount EDTA and urea peroxide, fine ground standby;
2. add recipe quantity water, Polyethylene Glycol, hexadecanol, propylene glycol, stir;
3. add main component EDTA and urea peroxide, stir, make colloid;
4. encapsulation is to disposable syringe.
Embodiment 4
Prescription:
EDETATE SODIUM 30g Polyethylene Glycol 80g
Propylene glycol 4g hexadecanol 0.4g
Carbomer 5g purified water 8g
Preparation method:
1. weigh above-mentioned amount EDETATE SODIUM, fine ground standby;
2. add recipe quantity water, Polyethylene Glycol, hexadecanol, propylene glycol, carbomer, stir;
3. add main component EDETATE SODIUM, stir, make colloid;
4. encapsulation is to disposable syringe.
Embodiment 5
Prescription:
EDTA30g Polyethylene Glycol 130g
Urea peroxide 10g hexadecanol 0.2g
Propylene glycol 5g
Preparation method:
1. weigh above-mentioned amount EDTA and urea peroxide, fine ground standby;
2. add recipe quantity water, Polyethylene Glycol, hexadecanol, propylene glycol, stir;
3. add main component EDTA and urea peroxide, stir, make colloid;
4. encapsulation is to disposable syringe.
The sample of Example 1 to 5, places 12 months under 15��25 DEG C of conditions
Claims (10)
1. a water solublity root pipe lubricant, it is characterised in that this lubricant is colloid form, the component included by weight percentage:
EDTA or EDETATE SODIUM 5%��25%
Sodium citrate 0.01%��1%
Polyethylene Glycol 20%��80%
Excipient 1%��40%.
2. a kind of water solublity root pipe lubricant according to claim 1, it is characterised in that the component that this lubricant includes by weight percentage:
EDTA or EDETATE SODIUM 10%��20%
Sodium citrate 0.1%��0.5%
Polyethylene Glycol 35%��70%
Excipient 1%��20%.
3. a kind of water solublity root pipe lubricant according to claim 1, it is characterised in that this lubricant also includes urea peroxide 3%��25%, it is preferred to urea peroxide 5%��20%.
4. a kind of water solublity root pipe lubricant according to claim 1 ~ 3 any one, it is characterised in that one or more mixing in carbomer, propylene glycol, hexadecanol and water selected by excipient.
5. a kind of water solublity root pipe lubricant according to claim 4, it is characterised in that carbomer 1%��20%, it is preferred to 1.5%��15%.
6. a kind of water solublity root pipe lubricant according to claim 4, it is characterised in that propylene glycol 0.1%��20%, it is preferred to 0.5%��15%.
7. a kind of water solublity root pipe lubricant according to claim 4, it is characterised in that hexadecanol 0.1%��10%, it is preferred to 0.5%��8%.
8. a kind of water solublity root pipe lubricant according to claim 4, it is characterised in that water 0.01%��8%, it is preferred to 0.1%��5%.
9. a kind of water solublity root pipe lubricant according to claim 1, it is characterised in that it is characterized in that this lubricant is made up of the component of following several formula by weight percentage:
One,
EDTA10 ~ 20% Polyethylene Glycol 40 ~ 60%
Sodium citrate 0.01 ~ 0.05% hexadecanol 0.01 ~ 0.1%
Urea peroxide 5 ~ 10% carbomer 1 ~ 5%
Propylene glycol 1 ~ 5% purified water 1 ~ 5%;
Two,
EDETATE SODIUM 15 ~ 25% Polyethylene Glycol 60 ~ 80%
Propylene glycol 1 ~ 5% hexadecanol 0.1 ~ 0.5%
Urea peroxide 5 ~ 20% purified water 2 ~ 5%;
Three,
EDETATE SODIUM 20 ~ 25% Polyethylene Glycol 50 ~ 70%
Propylene glycol 2 ~ 5% hexadecanol 0.1 ~ 0.5%
Carbomer 2 ~ 5% purified water 3 ~ 10%;
Four,
EDTA15 ~ 25% Polyethylene Glycol 70 ~ 80%
Urea peroxide 4 ~ 10% hexadecanol 0.01 ~ 0.05%
Propylene glycol 2 ~ 5%.
10. the method preparing water solublity root pipe lubricant described in claim 1 ~ 9 any one claim, the method comprises the following steps:
1) appropriate EDTA and/or urea peroxide are taken, fine ground standby;
2) weigh proper amount of sodium citrate, as acid-base modifier, add recipe quantity water, stir;
3) add Polyethylene Glycol and excipient, stir;
4) add main component EDTA and/or urea peroxide, stir, make colloid;
5) encapsulation is to disposable syringe.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610095402.3A CN105616169A (en) | 2016-02-22 | 2016-02-22 | Water-soluble root canal lubricant and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610095402.3A CN105616169A (en) | 2016-02-22 | 2016-02-22 | Water-soluble root canal lubricant and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN105616169A true CN105616169A (en) | 2016-06-01 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095402.3A Pending CN105616169A (en) | 2016-02-22 | 2016-02-22 | Water-soluble root canal lubricant and preparation method thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498876A (en) * | 2018-05-06 | 2018-09-07 | 李志军 | antibacterial lubricating gel |
| CN108721121A (en) * | 2018-05-31 | 2018-11-02 | 济南秦鲁药业科技有限公司 | A kind of lubricant for root canal therapy and preparation method thereof |
| CN111281809A (en) * | 2020-03-17 | 2020-06-16 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
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| CN101244012A (en) * | 2007-02-14 | 2008-08-20 | 张郁 | Lubricant agent for root canal treatment |
| CN101869534A (en) * | 2009-04-22 | 2010-10-27 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
| CN105213200A (en) * | 2015-10-14 | 2016-01-06 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
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2016
- 2016-02-22 CN CN201610095402.3A patent/CN105616169A/en active Pending
Patent Citations (3)
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| CN101244012A (en) * | 2007-02-14 | 2008-08-20 | 张郁 | Lubricant agent for root canal treatment |
| CN101869534A (en) * | 2009-04-22 | 2010-10-27 | 日进齿科材料(昆山)有限公司 | Lubricant for root canal therapy |
| CN105213200A (en) * | 2015-10-14 | 2016-01-06 | 陕西恒远生物科技有限公司 | A kind of lubricant for root canal |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108498876A (en) * | 2018-05-06 | 2018-09-07 | 李志军 | antibacterial lubricating gel |
| CN108721121A (en) * | 2018-05-31 | 2018-11-02 | 济南秦鲁药业科技有限公司 | A kind of lubricant for root canal therapy and preparation method thereof |
| CN111281809A (en) * | 2020-03-17 | 2020-06-16 | 四川涑爽医疗用品有限公司 | Lubricant for root canal therapy and preparation method thereof |
| CN112022725A (en) * | 2020-09-10 | 2020-12-04 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
| WO2022052631A1 (en) * | 2020-09-10 | 2022-03-17 | 昆明蓝橙口腔医院有限责任公司 | Application of citrate metal salt in endodontic treatment, and formulation obtained by preparation |
| CN112022725B (en) * | 2020-09-10 | 2022-09-20 | 昆明蓝橙口腔医院有限责任公司 | Application of metal citrate in root canal treatment and preparation prepared from metal citrate |
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Application publication date: 20160601 |