CN101868533A - 来自间充质饲养细胞的旁分泌信号以及使用该旁分泌信号调节肝祖细胞的扩增和分化 - Google Patents

来自间充质饲养细胞的旁分泌信号以及使用该旁分泌信号调节肝祖细胞的扩增和分化 Download PDF

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CN101868533A
CN101868533A CN200880102251.3A CN200880102251A CN101868533A CN 101868533 A CN101868533 A CN 101868533A CN 200880102251 A CN200880102251 A CN 200880102251A CN 101868533 A CN101868533 A CN 101868533A
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cell
liver
collagen
stem cells
matrix components
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洛拉·M·里德
兰德尔·E·麦克莱兰
乔舒亚·乌罗尼斯
姚兴磊
埃利亚内·沃蒂耶
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University of North Carolina at Chapel Hill
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University of North Carolina at Chapel Hill
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • C12N5/0672—Stem cells; Progenitor cells; Precursor cells; Oval cells
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    • C12N2502/00—Coculture with; Conditioned medium produced by
    • C12N2502/13—Coculture with; Conditioned medium produced by connective tissue cells; generic mesenchyme cells, e.g. so-called "embryonic fibroblasts"
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
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    • C12N2533/54—Collagen; Gelatin
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/70—Polysaccharides
    • C12N2533/80—Hyaluronan

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  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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CN200880102251.3A 2007-06-15 2008-06-13 来自间充质饲养细胞的旁分泌信号以及使用该旁分泌信号调节肝祖细胞的扩增和分化 Pending CN101868533A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94443507P 2007-06-15 2007-06-15
US60/944,435 2007-06-15
PCT/US2008/007397 WO2008156667A1 (en) 2007-06-15 2008-06-13 Paracrine signals from mesenchymal feeder cells and regulating expansion and differentiation of hepatic progenitors using same

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CN101868533A true CN101868533A (zh) 2010-10-20

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CN200880102251.3A Pending CN101868533A (zh) 2007-06-15 2008-06-13 来自间充质饲养细胞的旁分泌信号以及使用该旁分泌信号调节肝祖细胞的扩增和分化

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US (2) US20080318316A1 (https=)
EP (1) EP2171040A4 (https=)
JP (1) JP2010529855A (https=)
KR (1) KR20100094970A (https=)
CN (1) CN101868533A (https=)
AU (1) AU2008266992A1 (https=)
BR (1) BRPI0813353A2 (https=)
CA (1) CA2727535A1 (https=)
IL (1) IL202738A0 (https=)
IN (1) IN2010KN00157A (https=)
MX (1) MX2009013819A (https=)
TW (1) TW200916581A (https=)
WO (1) WO2008156667A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104321064A (zh) * 2012-05-23 2015-01-28 阿尔特刚股份有限公司 软骨素用于医学
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
CN110381968A (zh) * 2017-02-01 2019-10-25 菲尼克松生物制品公司 包含肝细胞的共培养物的组合物和方法

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070269412A1 (en) * 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
US20100209399A1 (en) * 2009-02-13 2010-08-19 Celavie Biosciences, Llc Brain-derived stem cells for repair of musculoskeletal system in vertebrate subjects
CN105456292B (zh) * 2009-10-30 2019-03-26 北卡罗来纳大学教堂山分校 来自肝外胆管树的专能干细胞及其分离方法
AU2011247984B2 (en) * 2010-05-07 2015-04-30 University Of North Carolina At Chapel Hill Method of engrafting cells from solid tissues
JP6435267B2 (ja) * 2012-11-08 2018-12-05 インジェネロン インコーポレイテッド 再生細胞の培養、保存、及び投与のための培地
US9533013B2 (en) 2013-03-13 2017-01-03 University Of North Carolina At Chapel Hill Method of treating pancreatic and liver conditions by endoscopic-mediated (or laparoscopic-mediated) transplantation of stem cells into/onto bile duct walls of particular regions of the biliary tree
US11066649B2 (en) 2014-03-19 2021-07-20 Institut National De La Sante Et De La Recherche Medicale (Inserm) Method for inducing human cholangiocyte differentiation
CN106559994A (zh) * 2014-07-16 2017-04-05 国立大学法人大阪大学 层粘连蛋白片段的细胞培养基质活性增强方法
US20170369849A1 (en) * 2016-05-11 2017-12-28 The University Of North Carolina At Chapel Hill Compositions and methods for bioengineered tissues
EP3684386A4 (en) * 2017-09-22 2021-06-30 Lifenet Health PLATE HEPATOCYTES AND THE PREPARATION AND USES OF THEM
EP3865572B1 (en) * 2018-10-11 2025-01-01 Ichimaru Pharcos Co., Ltd. Medium for growth of neuronal stem cells

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6069005A (en) * 1991-08-07 2000-05-30 Albert Einstein College Of Medicine Of Yeshwa University Hapatoblasts and method of isolating same
WO1993003142A1 (en) * 1991-08-07 1993-02-18 Albert Einstein College Of Medicine Proliferation of hepatocyte precursors
AU779706B2 (en) * 1999-01-19 2005-02-10 University Of North Carolina At Chapel Hill, The Human liver progenitors
US7456017B2 (en) * 1999-10-01 2008-11-25 University Of North Carolina At Chapel Hill Processes for clonal growth of hepatic progenitor cells
HUE032238T2 (en) * 2002-03-15 2017-09-28 Univ North Carolina Chapel Hill Primitive and proximal liver stem cells
AU2006315163A1 (en) * 2005-11-16 2007-05-24 University Of North Carolina At Chapel Hill Extracellular matrix components for expansion or differentiation of hepatic progenitors
CA2689241A1 (en) * 2006-06-28 2008-01-03 Vesta Therapeutics, Inc. Matrix and method for isolation of hepatic progenitor cells
WO2008109659A2 (en) * 2007-03-06 2008-09-12 University Of North Carolina At Chapel Hill Complexes of hyaluronans, other matrix components, hormones and growth factors for maintenance, expansion and/or differentiation of cells

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104321064A (zh) * 2012-05-23 2015-01-28 阿尔特刚股份有限公司 软骨素用于医学
CN108431209A (zh) * 2015-06-12 2018-08-21 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
CN108431209B (zh) * 2015-06-12 2023-02-10 新加坡科技研究局 肝脏干细胞的衍生和成熟肝细胞类型及其用途
US11795436B2 (en) 2015-06-12 2023-10-24 Agency For Science, Technology And Research Derivation of hepatic stem cells and mature liver cell types and uses thereof
CN110381968A (zh) * 2017-02-01 2019-10-25 菲尼克松生物制品公司 包含肝细胞的共培养物的组合物和方法

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MX2009013819A (es) 2010-05-17
EP2171040A1 (en) 2010-04-07
US20080318316A1 (en) 2008-12-25
KR20100094970A (ko) 2010-08-27
TW200916581A (en) 2009-04-16
JP2010529855A (ja) 2010-09-02
US8404483B2 (en) 2013-03-26
IL202738A0 (en) 2011-08-01
BRPI0813353A2 (pt) 2014-10-14
AU2008266992A1 (en) 2008-12-24
IN2010KN00157A (https=) 2015-08-28
WO2008156667A1 (en) 2008-12-24
EP2171040A4 (en) 2010-08-04
US20110065188A1 (en) 2011-03-17
CA2727535A1 (en) 2008-12-24

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