CN101862460A - Sterilizing medicinal ultrasonic coupling agent and preparation method thereof - Google Patents
Sterilizing medicinal ultrasonic coupling agent and preparation method thereof Download PDFInfo
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- CN101862460A CN101862460A CN 201010159213 CN201010159213A CN101862460A CN 101862460 A CN101862460 A CN 101862460A CN 201010159213 CN201010159213 CN 201010159213 CN 201010159213 A CN201010159213 A CN 201010159213A CN 101862460 A CN101862460 A CN 101862460A
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Abstract
The invention discloses a sterilizing medicinal ultrasonic coupling agent and a preparation method thereof. The sterilizing medicinal ultrasonic coupling agent contains 0.05 to 2 percent of 2,4,4'-trichloro-2'-hydroxydiphenyl ether, 0.1 to 2 percent of R-polysaccharide, 2 to 7 percent of propylene glycol, 2 to 7 percent of glycerol, 0.6 to 1.5 percent of cross-linking polyacrylic resin and 80.5 to 95.25 percent of distilled water; and in addition, triethanolamine which accounts for 0.8 to 1.2 percent of the total weight of the previous mixture is added into the mixture. The preparation method comprises the following steps of: preparing mixed solution of the propylene glycol and the glycerol; fully dissolving the 2,4,4'-trichloro-2'-hydroxydiphenyl ether and the R-polysaccharide into the prepared mixed solution; preparing cross-linking polyacrylic resin solution; adding the prepared mixed solution into the cross-linking polyacrylic resin solution to form a gelatinous macromolecular substance; and dripping triethanolamine solution into the gelatinous macromolecular substance to obtain neutral ultrasonic coupling agent. The sterilizing medicinal ultrasonic coupling agent thoroughly solves the problem that effective sterilization cannot be realized in short time, and is suitable for sterilizing the skin and the mucosa.
Description
Technical field
The present invention relates to the preparation of couplant between medical treatment instrument probe and the human body skin, be specifically related to a kind of disinfection sterilizing type medical supersonic couplant and preparation method thereof.
Background technology
The function of traditional medical ultrasonic coupling agent is the coupling of strengthening between ultrasonic probe and the human body skin, and isolated ultrasonic probe and be examined air between the skin of position makes the sound wave conduction not be subjected to air influence and decays, to reach good detection effect.CN1087016A disclosed " preparation method of medical ultrasonic coupling agent " be get earlier 5 the gram CPB-1 be that acrylate copolymer (being carbomer-1 type material) was put into water 5～6 hours, after it is expanded, adding 20% sodium hydroxide solution makes its pH value between 6.8～7.2, then, add sodium benzoate and glycerol, stirring adds water to 1000ml.Medical ultrasonic coupling agent with this method preparation is the same with traditional medical ultrasonic coupling agent, does not have the function of sterilization.The sterilization of ultrasonic probe is to perplex a great problem that medical supersonic detects always, and main cause has three:
(1) no suitable compound, the particularity of ultrasonic probe material, the disinfectant that has determined at present great majority on the market that these plastics and rubber are had corrosivity and a swellability can not be used for the sterilization of ultrasonic probe;
(2) no suitable medium, the particularity of structure of ultrasonic makes it can not use the most frequently used infusion method to carry out disinfection, to the requirement height of medium;
(3) disinfecting time, because of the operating frequency height, the blanking time between the tested patient is very short, usually about 1 minute, kill bacteria simultaneously in short time like this, the disinfectant of mycete and virus is not also gone public at present.
CN1108956A discloses " coupling agent for medical ultrasonic diagnostic probe and preparation method thereof ", coupling agent with this method preparation is made up of thickening agent NS-90, solubilizing agent tween 80, disinfectant 1522, antibacterial sorbic acid, inclusion compound α-CD, spice, pigment, can play the sterilizing effect, avoid cross infection, and harmless to the person, to the instrument probe not damaged.But preparation technology is comparatively complicated, need add the water stirring during use and leave standstill, and is not too convenient.
Facts have proved, contain 2,4,4 '-three excessive chloro-2 '-dihydroxy diphenyl ethers, mucosa is had the strong impulse effect at medical ultrasonic coupling agent.In order to strengthen safety management to the skin and mucous membrane disinfection agent, the notice that the part composition value of limiting the quantity of is stipulated on April 6th, 2006, Chinese Ministry of Public Health was about issue skin and mucous membrane disinfection agent is clearly stipulated: in skin antiseptic 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether concentration (W/V) of limiting the quantity of is 2.00%, in the mucosa disinfectant 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers concentration (W/V) of limiting the quantity of is 0.35%.Under such condition of limiting the quantity of, it is not enough only adopting 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers to come kill bacteria, mycete and virus, can not reach disinfection sterilizing type medical supersonic couplant and not only be fit to skin degerming, but also has been fit to the requirement of mucosa disinfectant.
Summary of the invention
The purpose of this invention is to provide a kind of disinfection sterilizing type medical supersonic couplant, it does not have any corrosivity and swellability to ultrasonic probe, and soaking-free can reach disinfective action, and is easy to use; Disinfection time is short, can carry out sterilizing to ultrasonic probe in whole testing process, both has been fit to the sterilization to skin, is fit to the sterilization to mucosa again, reduces the cross infection risk, and the person under inspection is healthy in protection.
Another object of the present invention provides a kind of preparation method of disinfection sterilizing type medical supersonic couplant, and this preparation method operation is simple, uses equipment investment few.
A kind of disinfection sterilizing type medical supersonic couplant of the present invention, the percentage by weight that contains active ingredient is:
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers (Triclosan, molecular formula: C
12H
7Cl
3O
2) 0.05-2%, its effect is kill bacteria, mycete and virus;
R-polysaccharide 0.1-2%, its effect is collaborative 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether kill bacteria, mycete and virus;
Propylene glycol (Dipropylene Glycol, molecular formula: C
3H
8O
2) 2-7%; Its effect is dissolving 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, collaborative 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers and R-polysaccharide kill bacteria, mycete and virus;
Glycerol (Glycerine; Glycerol, molecular formula: C
3H
8O
3) 2-7%, its effect is collaborative propylene glycol dissolving 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, lubricated skin;
Crosslinked polypropylene diluted acid resin (Carbomer, molecular formula: 0.6-1.5% [CH2-CH-] N-COOH), its effect is to form gelatinous polymer substance;
Distilled water 80.5-95.25%, its effect is dilution;
In addition, add the triethanolamine of above-mentioned gross weight 0.8-1.2%, its effect be in and crosslinked polypropylene diluted acid resin, make the couplant finished product be neutral.
The present invention has kept the character and the coupling function of conventional medical ultrasonic coupling agent, through up to a hundred tests, in numerous disinfectant, filter out two kinds internationally recognized, to environment and body harmless, to silastic product and the non-corrosive efficient germicide 2 of metallic article, 4,4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide, and by after propylene glycol and the glycerol dissolving, on the traditional product basis, the sterilization type medical ultrasonic coupling agent of new generation of the transparent gel-form of preparing.The present invention fill a prescription all raw materials all be through checking to human body and environmentally friendly Green Product, chemical reaction does not take place and produce new harmful substance each other.
The present invention can kill pathogenic microbes such as various bacteria, fungus, virus simultaneously, reaches the dual sterilization to ultrasonic probe and skin.
(1) efficient germicide 2,4, and 4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide do not have any corrosivity and swellability to ultrasonic probe, can be used for the sterilization of ultrasonic probe fully;
(2) with scientific methods biocide is dissolved, be molecularity and be distributed in the couplant that is transparent gel-form, become the gel disinfectant, itself is aseptic condition product, make the ultrasonic probe soaking-free can reach disinfective action simultaneously, solved ultrasonic probe sterilised medium problem;
(3) ultrasonic probe begins to detect the patient to detecting end Zi contacting couplant, and ultrasonic probe is under the disinfection all the time in whole testing process, has thoroughly solved and can not realize effective disinfectant problem in the short time.Both be fit to sterilization, be fit to sterilization again mucosa to skin.
The preparation method of described a kind of disinfection sterilizing type medical supersonic couplant, preparation process is as follows:
The first step takes by weighing the propylene glycol of 2-7% and the glycerol of 2-7% by weight percentage and is mixed with mixed solution;
Second step took by weighing 2,4,4 '-three the chloro-2 '-dihydroxy diphenyl ethers of 0.05-2% and the R-polysaccharide of 0.1-2% by weight percentage, dissolved in fully in the mixed solution that the first step makes, and kept somewhere;
The 3rd goes on foot, and takes by weighing the crosslinked polypropylene diluted acid resin of 0.6-1.5% by weight percentage, is dissolved in the distilled water of gross weight 25%-35%, obtains crosslinked polypropylene diluted acid resin solution;
The 4th step, second step was contained 2,4, the mixed solution of 4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide is under agitation added the crosslinked polypropylene diluted acid resin solution that the 3rd step obtained, form gelatinous polymer substance, be ultrasonic coupling agent, and 80.5-95.25% supplies distilled water by weight percentage, continue to stir;
The 5th step under stirring, slowly dripped the triethanolamine solution that accounts for above-mentioned gross weight 0.8-1.2% in addition, made the ultrasonic coupling agent that obtains be neutral;
The 6th step, fill.
Prepare a kind of disinfection sterilizing type medical supersonic couplant of the present invention, need not very complicated tip device.Required manufacturing equipment is common vessel, stirring and emulsifying device, auto-filling equipment, checkout equipment, easy being easy to get.
A kind of disinfection sterilizing type medical supersonic couplant according to above prescription and preparation method make detects its character, pH value, sanitary index and function, and testing result meets the requirements, and sees the following form:
| Test item | Examination criteria | Testing result | Judge |
| Character and appearance requirement pH value total number of bacteria staphylococcus aureus bacillus pyocyaneus enzyme bacterium and yeast count | The colorless transparent gel body does not have or only has a small amount of bubble, does not have or only contain superfine little particulate matter 6.5 ± 1.0 must not must not detect must not detect detect and detect following blank | Meet the requirements and 6.6 do not detect | Qualified qualified |
The present invention compares with prior art and has the following advantages: the present invention had both kept the acoustic characteristic of medical ultrasonic coupling agent, thoroughly solved and to have realized effective disinfectant problem in the short time, can kill pathogenic microbes such as various bacteria, fungus, virus simultaneously, reach dual sterilization ultrasonic probe and skin; Make the ultrasonic probe soaking-free can reach disinfective action, solved ultrasonic probe sterilised medium problem.Both be fit to sterilization, be fit to sterilization again mucosa to skin.Required manufacturing equipment is common vessel, stirring and emulsifying device, automatic filling machine, checkout equipment, easy being easy to get, and preparation technology is simple.
The specific embodiment
Embodiment 1: the preparation gross weight is the medical ultrasonic coupling agent with disinfection function of 1000kg.
The first step takes by weighing 2% propylene glycol, 20kg by weight percentage, takes by weighing 2% glycerol, 20kg by weight percentage, is mixed with mixed solution;
Second step took by weighing 0.05% 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, 1kg by weight percentage, took by weighing 0.1% R-polysaccharide, 1kg by weight percentage, dissolved in fully in the mixed solution that the first step makes, and kept somewhere;
The 3rd goes on foot, and takes by weighing 0.6% crosslinked polypropylene diluted acid resin, 6kg by weight percentage, is dissolved in the distilled water of 350kg, obtains crosslinked polypropylene diluted acid resin solution;
The 4th step, second step was contained 2,4, the mixed solution of 4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide is under agitation added the crosslinked polypropylene diluted acid resin solution that the 3rd step obtained, form gelatinous polymer substance, i.e. ultrasonic coupling agent, and 95.25% supply distilled water 602.5kg by weight percentage,, continue to stir;
The 5th step under stirring, slowly dripped the triethanolamine solution that accounts for above-mentioned gross weight 0.8-1.2% in addition, made the ultrasonic coupling agent that obtains be neutral, and pH value is adjusted between 6.5 ± 1.0;
The 6th step, fill.
Embodiment 2: the preparation gross weight is the medical ultrasonic coupling agent with disinfection function of 1000kg.
The first step takes by weighing 5% propylene glycol, 50kg by weight percentage, takes by weighing 5% glycerol, 50kg by weight percentage, is mixed with mixed solution;
Second step took by weighing 0.19% 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, 1.9kg by weight percentage, took by weighing 1.0% R-polysaccharide, 10kg by weight percentage, dissolved in fully in the mixed solution that the first step makes, and kept somewhere;
The 3rd goes on foot, and takes by weighing 1.0% crosslinked polypropylene diluted acid resin, 10kg by weight percentage, is dissolved in the distilled water of 300kg, obtains crosslinked polypropylene diluted acid resin solution;
The 4th step, second step was contained 2,4, the mixed solution of 4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide is under agitation added the crosslinked polypropylene diluted acid resin solution that the 3rd step obtained, form gelatinous polymer substance, be ultrasonic coupling agent, and 87.81% supply distilled water 578.1kg by weight percentage, continue to stir;
The 5th step under stirring, slowly dripped the triethanolamine solution that accounts for above-mentioned gross weight 0.8-1.2% in addition, made the ultrasonic coupling agent that obtains be neutral, and pH value is adjusted between 6.5 ± 1.0;
The 6th step, fill.
Embodiment 3: the preparation gross weight is the medical ultrasonic coupling agent with disinfection function of 1000kg.
The first step takes by weighing 7% propylene glycol, 70kg by weight percentage, takes by weighing 7% glycerol, 70kg by weight percentage, is mixed with mixed solution;
Second step took by weighing 0.35% 2,4,4 '-three chloro-2 '-dihydroxy diphenyl ethers, 3.5kg by weight percentage, took by weighing 2.0% R-polysaccharide, 20kg by weight percentage, dissolved in fully in the mixed solution that the first step makes, and kept somewhere;
The 3rd goes on foot, and takes by weighing 1.5% crosslinked polypropylene diluted acid resin, 15kg by weight percentage, is dissolved in the distilled water of 300kg, obtains crosslinked polypropylene diluted acid resin solution;
The 4th step, second step was contained 2,4, the mixed solution of 4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide is under agitation added the crosslinked polypropylene diluted acid resin solution that the 3rd step obtained, form gelatinous polymer substance, be ultrasonic coupling agent, and 82.15% supply distilled water 521.5kg by weight percentage, continue to stir;
The 5th step under stirring, slowly dripped the triethanolamine solution (weight concentration is 99%) that accounts for above-mentioned gross weight 0.8-1.2% in addition, made the ultrasonic coupling agent that obtains be neutral, and pH value is adjusted between 6.5 ± 1.0;
The 6th step, fill.
Claims (2)
1. disinfection sterilizing type medical supersonic couplant, the percentage by weight that contains active ingredient is:
2,4,4 '-three chloro-2 '-dihydroxy diphenyl ether 0.05-2%, R-polysaccharide 0.1-2%, propylene glycol 2-7%, glycerol 2-7%, crosslinked polypropylene diluted acid resin 0.6-1.5%, distilled water 80.5-95.25%; In addition, the triethanolamine that adds above-mentioned gross weight 0.8-1.2%.
2. the preparation method of a kind of disinfection sterilizing type medical supersonic couplant as claimed in claim 1, preparation process is as follows:
The first step takes by weighing the propylene glycol of 2-7% and the glycerol of 2-7% by weight percentage and is mixed with mixed solution;
Second step took by weighing 2,4,4 '-three the chloro-2 '-dihydroxy diphenyl ethers of 0.05-2% and the R-polysaccharide of 0.1-2% by weight percentage, dissolved in fully in the mixed solution that the first step makes, and kept somewhere;
The 3rd goes on foot, and takes by weighing the crosslinked polypropylene diluted acid resin of 0.6-1.5% by weight percentage, is dissolved in the distilled water of gross weight 25%-35%, obtains crosslinked polypropylene diluted acid resin solution;
The 4th step, second step was contained 2,4, the mixed solution of 4 '-three chloro-2 '-dihydroxy diphenyl ether and R-polysaccharide is under agitation added the crosslinked polypropylene diluted acid resin solution that the 3rd step obtained, form gelatinous polymer substance, be ultrasonic coupling agent, and 80.5-95.25% supplies distilled water by weight percentage, continue to stir;
The 5th step under stirring, dripped the triethanolamine solution that accounts for above-mentioned gross weight 0.8-1.2% in addition, made the ultrasonic coupling agent that obtains be neutral;
The 6th step, fill.
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|---|---|---|---|
| CN2010101592130A CN101862460B (en) | 2010-04-28 | 2010-04-28 | Sterilizing medicinal ultrasonic coupling agent and preparation method thereof |
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|---|---|---|---|
| CN2010101592130A CN101862460B (en) | 2010-04-28 | 2010-04-28 | Sterilizing medicinal ultrasonic coupling agent and preparation method thereof |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075890A (en) * | 1992-03-02 | 1993-09-08 | 马洪图 | A kind of ultrasonic coupling agent and preparation method |
| CN1087016A (en) * | 1992-11-14 | 1994-05-25 | 鞍山钢铁公司 | The preparation method of medical ultrasonic coupling agent |
| JPH0859513A (en) * | 1994-08-26 | 1996-03-05 | Lion Corp | Composition for dyeing bacterial plaque |
| CN101219223A (en) * | 2007-01-10 | 2008-07-16 | 重庆安碧捷生物科技有限公司 | Medical supersonic couplant with disinfection function and method for preparing the same |
-
2010
- 2010-04-28 CN CN2010101592130A patent/CN101862460B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1075890A (en) * | 1992-03-02 | 1993-09-08 | 马洪图 | A kind of ultrasonic coupling agent and preparation method |
| CN1087016A (en) * | 1992-11-14 | 1994-05-25 | 鞍山钢铁公司 | The preparation method of medical ultrasonic coupling agent |
| JPH0859513A (en) * | 1994-08-26 | 1996-03-05 | Lion Corp | Composition for dyeing bacterial plaque |
| CN101219223A (en) * | 2007-01-10 | 2008-07-16 | 重庆安碧捷生物科技有限公司 | Medical supersonic couplant with disinfection function and method for preparing the same |
Non-Patent Citations (1)
| Title |
|---|
| 《肉类工业》 2008 王心礼 天然食品防腐剂-R-多糖（克霉王）的抑菌效果评价 第39-41页 1-2 , 第7期 2 * |
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