CN1087016A - The preparation method of medical ultrasonic coupling agent - Google Patents
The preparation method of medical ultrasonic coupling agent Download PDFInfo
- Publication number
- CN1087016A CN1087016A CN 92113430 CN92113430A CN1087016A CN 1087016 A CN1087016 A CN 1087016A CN 92113430 CN92113430 CN 92113430 CN 92113430 A CN92113430 A CN 92113430A CN 1087016 A CN1087016 A CN 1087016A
- Authority
- CN
- China
- Prior art keywords
- coupling agent
- ultrasonic
- couplant
- preparation
- medical ultrasonic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Landscapes
- Ultra Sonic Daignosis Equipment (AREA)
Abstract
A kind of manufacture method of medical ultrasonic coupling agent be get 5 the gram CBP-1 be that acrylate copolymer is that carbomer-1 type material was put into water 5～6 hours, after it is expanded, adding 20% sodium hydroxide solution makes its pH value between 6.8～7.2, add sodium benzoate and glycerol then, stirring adds water to 1000ml.This couplant is safe and reliable, and is functional, easy to use, and technology is simple, and material is cheap, is a kind of coupling agent for medical use that has wide application prospects.
Description
The invention belongs to the preparation technology of medical ultrasonic coupling agent.
Ultrasonics are emerge sciences that grow up the sixties.Along with the development of modern ultrasonic technique, ultrasonic diagnosis and ultrasonic therapeutic extensive use in medical treatment, also come out simultaneously with ultrasonic diagnosis and the closely-related medical ultrasonic coupling agent of ultrasonic therapeutic effect.Ultrasound wave is identical with sound wave, all need rely on medium to propagate, and produces reflection, phenomenons such as refraction on the interface that constitutes with different medium.What of ultrasonic reflections are decided according to the acoustic resistance difference of second medium, and the acoustic resistance difference of interface both sides material is bigger, reflection the more, the ultrasound wave that promptly enters second medium is fewer.Therefore, at the interface of body soft tissue and water formation, ultrasonic reflections seldom; But the interface that air and soft tissue constitute is then had children outside the state plan energy in a large number owing to reflection is lost.When diagnosis of using ultrasound ripple or ultrasonic therapy,, need with the space between medical ultrasonic coupling agent filling skin and the sound head in order to eliminate the loss that ultrasound wave causes because of reflection.The acoustic resistance of this couplant should be close with the acoustic resistance of human body soft tissue.The acoustic resistance (10 of several materials
5G/cm
2S) as follows: human body soft tissue: 1.59; Fatty tissue: 1.50; Muscular tissue: 1.49; Air: 0.000439; Water: 1.52.Medical ultrasonic coupling agent production is all arranged at present both at home and abroad.As recording and narrating the couplant that a kind of ultrasonic system uses in " ultrasonic system " patent of invention of EUROPEAN PATENT OFFICE's application on March 21st, 90 with the agent of improvement coupling, this couplant is the mixture of 1-butanols in glycerol, it can dilute by adding an amount of 2-hydroxyl ether, be mainly used in the probe of heavy caliber transducer mechanical scanning, be used in the implant between the acoustical generator and window in the ultrasonic scanner.The United States Patent (USP) that on February 4th, 1986 announced, application number is 4567895, name is called that to introduce medical ultrasonic coupling agent in " complete moistening mechanical ultrasound scanhead " be the implant that is used between ultrasound scanning head can and the rotor, and concrete composition and prescription be not introduction all.Domestic also have a succedaneum that uses couplant, as materials such as liquid paraffin, water, but since these materials second-rate influenced the effect of ultrasonic diagnosis and ultrasonic therapeutic significantly, and caused the grievous injury of ultrasonic instrument probe.
Purpose of the present invention just provides the preparation method of a kind of safety and reliability couplant good, easy to use.
The concrete grammar of preparation couplant of the present invention is, to get CBP-1 and be the acrylic acid polymer be carbomer-1 type material 5 grams, put into the container that fills 500～600ml water soaked into 4～5 hours, after it is fully expanded, drip 20% sodium hydroxide solution while stirring, transfer to pH value when 6.8～7.2 scope, add concentration again and be 1% sodium benzoate aqueous solution 100ml, glycerol 50～100ml and add water to 1000ml again stirs and promptly obtains this couplant.
This method prepares couplant, and the CBP-1 of adding is that acrylate copolymer is carbomer-I type, and its feature is its thickening efficiency height, and the homogenizing performance is good, and heatproof degree performance is good, is cosmetics residuite and medicine adjuvant.This product is by adjusting glycerol content, and promptly content can make the acoustic resistance of this couplant and human body soft tissue be close 5～10%, and promptly 1.571～1.623 * 10
5G/cm
2S meets the ultrasonic coupling agent standard that China is entrusted and worked out by national medical supersonic equipment branch skill, and its specific acoustic impedance should be 1.5～1.7 * 10
5G/cm
2The regulation of s.
The couplant of this method preparation has following characteristics and advantage:
1. safe and reliable: this product is non-stimulated to human body skin, does not have irritated and other untoward reaction, is applicable to the application of partes corporis humani position, to the no corrosiveness of ultrasonic instrument probe.
2. functional: this product can make probe and skin close-coupled, modest viscosity, and what neither flow and be easy to again pop one's head in moves, and makes ultrasonic image clear, the resolution height.
3. easy to use: this product fragrant odour is pleasant, color coordination, and pollution clothes is not easy to wiping.
4. this product acoustic resistance and human body soft tissue acoustic resistance are close, thus minimum to ultrasonic energy losses, be good ultrasonic media.
5. this product heatproof degree stability is high, and storage life is long.
6. this product production method is simple and easy to do, and supplementary material is cheap and easy to get.
Make ultrasonic coupling agent with the inventive method, successively carried out an over thousands of routine clinical trial from 90 years to 91 years in the Anshan Second Academy, Anshan iron and steel plant ferrum east hospital, Anshan iron and steel plant numerous mountains sanatorium etc., and compare with similar products at home and abroad, its performance safety, clear picture, the resolution height is to the no corrosiveness of probe, harmless, be a kind of good medical ultrasonic coupling agent of using.
Claims (1)
1, a kind of preparation method of medical ultrasonic couplant, it is characterized in that getting CBP-1 is that acrylate copolymer is carbomer-I type material 5 grams, putting into the container that fills 500～600ml water soaked into 4～5 hours, after it is fully expanded, drip 20% sodium hydroxide solution while stirring, transfer to pH value when 6.8～7.2 scope, add concentration again and be 1% sodium benzoate aqueous solution 100ml, glycerol 50～100ml reaches and adds water to 1000ml again, stirs and promptly obtains this couplant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92113430 CN1087016A (en) | 1992-11-14 | 1992-11-14 | The preparation method of medical ultrasonic coupling agent |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 92113430 CN1087016A (en) | 1992-11-14 | 1992-11-14 | The preparation method of medical ultrasonic coupling agent |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1087016A true CN1087016A (en) | 1994-05-25 |
Family
ID=4946398
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 92113430 Pending CN1087016A (en) | 1992-11-14 | 1992-11-14 | The preparation method of medical ultrasonic coupling agent |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1087016A (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101862460A (en) * | 2010-04-28 | 2010-10-20 | 重庆安碧捷生物科技有限公司 | Sterilizing medicinal ultrasonic coupling agent and preparation method thereof |
| CN1990048B (en) * | 2005-12-28 | 2010-11-10 | 重庆海扶(Hifu)技术有限公司 | Ultrasonic therapy couplant, its preparing process and packing apparatus |
| CN101658680B (en) * | 2009-10-09 | 2011-02-09 | 李晓鲁 | Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof |
| CN102107012B (en) * | 2009-12-28 | 2012-10-31 | 邵鹏飞 | Ultrasound coupling agent |
-
1992
- 1992-11-14 CN CN 92113430 patent/CN1087016A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1990048B (en) * | 2005-12-28 | 2010-11-10 | 重庆海扶(Hifu)技术有限公司 | Ultrasonic therapy couplant, its preparing process and packing apparatus |
| CN101658680B (en) * | 2009-10-09 | 2011-02-09 | 李晓鲁 | Medical environment-friendly sterilization ultrasound coupling agent and preparation method thereof |
| CN102107012B (en) * | 2009-12-28 | 2012-10-31 | 邵鹏飞 | Ultrasound coupling agent |
| CN101862460A (en) * | 2010-04-28 | 2010-10-20 | 重庆安碧捷生物科技有限公司 | Sterilizing medicinal ultrasonic coupling agent and preparation method thereof |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| NZ507730A (en) | Hematopoietic stimulation | |
| CN104189927B (en) | A kind of ultrasonic coupling agent | |
| CN108774330A (en) | The preparation method and products obtained therefrom of a kind of cross-linked hyaluronic acid gel and application | |
| CN106540281A (en) | B ultrasonic couplant and its preparation technology | |
| CN1087016A (en) | The preparation method of medical ultrasonic coupling agent | |
| CN102580122B (en) | Method for preparing medical disinfection couplant | |
| CN101612408A (en) | B ultrasonic couplant and preparation method | |
| CN101698107A (en) | Sterilizing medical ultrasonic coupling agent | |
| CN116999344A (en) | Biological enzyme composition, preparation method thereof and toothpaste prepared by biological enzyme composition | |
| CN104448038B (en) | Preparation process of calcium chondroitin sulfate salt | |
| JPS58213716A (en) | Carcisnostatic agent | |
| CN115590985B (en) | Sterile medical ultrasonic coupling agent and preparation method thereof | |
| CN107510851B (en) | Medical ultrasonic coupling pad and preparation method thereof | |
| CN211132285U (en) | A soak formula degassing unit for digestion scope | |
| CN220778836U (en) | Gel packaging container | |
| JP3721400B2 (en) | Tissue regeneration agent | |
| CN109620774A (en) | A kind of herbal mixture care toothpaste and preparation method thereof | |
| CN114668862A (en) | Preparation process of solid gel for detection probe | |
| SU797687A1 (en) | Agent for x-ray and microangiography examination | |
| WO1990004611A1 (en) | Copolymers of vinyl alcohol with vinyl acetate, cross-linked by glutaric dialdehyde, method of obtaining them and a pharmaceutical preparation based thereon | |
| CN220824407U (en) | Cervical treatment is with sticking structure | |
| CN117679537B (en) | Medical sterile ultrasonic coupling agent and preparation method thereof | |
| CN114588284A (en) | Transparent antibacterial medical ultrasonic coupling agent and preparation process thereof | |
| CN1374133A (en) | B-mode ultrasound coupling agent and its prepn | |
| FR2395006A1 (en) | Gel for ultrasonic diagnosis and therapy - contg. glycerine, water and a carboxy vinyl! polymer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |