CN101861300B - 盐酸替吉环素的晶型 - Google Patents

盐酸替吉环素的晶型 Download PDF

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Publication number
CN101861300B
CN101861300B CN200880116248.7A CN200880116248A CN101861300B CN 101861300 B CN101861300 B CN 101861300B CN 200880116248 A CN200880116248 A CN 200880116248A CN 101861300 B CN101861300 B CN 101861300B
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CN
China
Prior art keywords
crystal form
tigecycline
tigecycline hydrochloride
hydrochloride
scholar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN200880116248.7A
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English (en)
Chinese (zh)
Other versions
CN101861300A (zh
Inventor
J·威瑟尔
A·霍特
A·皮希勒
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Sandoz AG
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Sandoz AG
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Publication of CN101861300A publication Critical patent/CN101861300A/zh
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Publication of CN101861300B publication Critical patent/CN101861300B/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/02—Ortho- or ortho- and peri-condensed systems
    • C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
    • C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
    • C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
    • C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880116248.7A 2007-11-14 2008-11-12 盐酸替吉环素的晶型 Active CN101861300B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07120732 2007-11-14
EP07120732.8 2007-11-14
PCT/EP2008/065398 WO2009062963A1 (en) 2007-11-14 2008-11-12 Crystalline forms of tigecycline hydrochloride

Publications (2)

Publication Number Publication Date
CN101861300A CN101861300A (zh) 2010-10-13
CN101861300B true CN101861300B (zh) 2014-07-09

Family

ID=39186791

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880116248.7A Active CN101861300B (zh) 2007-11-14 2008-11-12 盐酸替吉环素的晶型

Country Status (9)

Country Link
US (2) US8252946B2 (cg-RX-API-DMAC10.html)
EP (1) EP2220033B1 (cg-RX-API-DMAC10.html)
JP (1) JP5574967B2 (cg-RX-API-DMAC10.html)
CN (1) CN101861300B (cg-RX-API-DMAC10.html)
CA (1) CA2704536C (cg-RX-API-DMAC10.html)
ES (1) ES2532880T3 (cg-RX-API-DMAC10.html)
IL (1) IL205451A0 (cg-RX-API-DMAC10.html)
SI (1) SI2220033T1 (cg-RX-API-DMAC10.html)
WO (1) WO2009062963A1 (cg-RX-API-DMAC10.html)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102285898A (zh) * 2011-06-29 2011-12-21 赵军旭 替加环素盐酸盐的晶型及其制备方法
CN106431963B (zh) * 2015-08-13 2019-03-05 江苏豪森药业集团有限公司 替加环素的新晶型及其制备方法
JP6883593B2 (ja) * 2016-06-22 2021-06-09 山東亨利醫藥科技有限責任公司 ９−アミノメチル基置換のテトラサイクリン系化合物の結晶型及びその製造方法
CN111060641B (zh) * 2019-12-27 2020-10-23 瀚晖制药有限公司 一种注射用替加环素中9-硝基米诺环素的检测方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
WO2005056538A1 (en) * 2003-12-08 2005-06-23 Wyeth Oxazole derivatives of tetracyclines
WO2006128150A2 (en) * 2005-05-27 2006-11-30 Wyeth Crystalline solid forms of tigecycline and methods of preparing same
WO2006130500A2 (en) * 2005-05-27 2006-12-07 Wyeth Tigecycline and methods of preparing 9-aminominocycline

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057034A1 (es) 2005-05-27 2007-11-14 Wyeth Corp Metodos para purificar tigeciclina
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
PT2016045E (pt) 2006-04-24 2015-02-05 Teva Pharma Forma cristalina de tigeciclina e processos para a sua preparação
EP2086926A2 (en) 2006-11-29 2009-08-12 Teva Pharmaceutical Industries Ltd. Crystalline forms of tigecycline and processes for preparation thereof
US20100160264A1 (en) 2007-06-21 2010-06-24 Josef Wieser Crystalline solid forms
CN101386582A (zh) * 2007-09-14 2009-03-18 上海来益生物药物研究开发中心有限责任公司 替加环素盐及其制备方法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5675030A (en) * 1994-11-16 1997-10-07 American Cyanamid Company Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound
WO2005056538A1 (en) * 2003-12-08 2005-06-23 Wyeth Oxazole derivatives of tetracyclines
WO2006128150A2 (en) * 2005-05-27 2006-11-30 Wyeth Crystalline solid forms of tigecycline and methods of preparing same
WO2006130500A2 (en) * 2005-05-27 2006-12-07 Wyeth Tigecycline and methods of preparing 9-aminominocycline

Also Published As

Publication number Publication date
SI2220033T1 (sl) 2015-07-31
US8252946B2 (en) 2012-08-28
JP2011503142A (ja) 2011-01-27
EP2220033B1 (en) 2014-12-17
JP5574967B2 (ja) 2014-08-20
IL205451A0 (en) 2010-12-30
CN101861300A (zh) 2010-10-13
US20110105772A1 (en) 2011-05-05
CA2704536A1 (en) 2009-05-22
CA2704536C (en) 2017-04-25
EP2220033A1 (en) 2010-08-25
WO2009062963A1 (en) 2009-05-22
US20130012481A1 (en) 2013-01-10
ES2532880T3 (es) 2015-04-01

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