CN101856361A - Progesterone composite preparation for regulating and controlling estrus of cow - Google Patents
Progesterone composite preparation for regulating and controlling estrus of cow Download PDFInfo
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- CN101856361A CN101856361A CN 201010199544 CN201010199544A CN101856361A CN 101856361 A CN101856361 A CN 101856361A CN 201010199544 CN201010199544 CN 201010199544 CN 201010199544 A CN201010199544 A CN 201010199544A CN 101856361 A CN101856361 A CN 101856361A
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Abstract
The invention discloses a progesterone composite preparation for regulating and controlling estrus of a cow. The progesterone composite preparation is prepared by the following steps of: dissolving progesterone with edible vegetable oil to prepare solution, every milliliter of which contains 20mg of progesterone; dissolving estradiol with sterilized edible vegetable oil to prepare the solution, every milliliter of which contains 10mg of estradiol; and preparing the progesterone composite preparation from 75.00 to 87.50 weight percent of the solution of the progesterone, 8.75 to 10.00 weight percent of the solution of the estradiol and 2.50 to 6.25 weight percent of the edible vegetable oil. The progesterone composite preparation comprises estrogen and progesterone, is injected for regulating and controlling the estrus of the cow, and can obviously improve the estrus synchronization rate and the estrus conception rate of the cow. When used for pre-processing, the progesterone composite preparation can improve the activity of the ovary of the processed cow and the sensitivity to gonadotropic hormone so as to stimulate estrogen secretion and promote follicular development and can prevent insufficient secretion of the progesterone of the processed cow so as not to affect the sexual desire and the estrus of the cow.
Description
Technical field
A kind of hormone preparation of injection contains estrogen and progesterone when the present invention relates to the regulating and controlling estrus of cow processing, is a kind of progesterone composite preparation that is used for regulating and controlling estrus of cow specifically.
Background technology
The estrus of cow control technology starts from phase late 1940s.Christain (1948) gives colony's cow injection progesterone, makes it estrus cycleization, in the hope of improving test-tube efficient, and implements the domestic animal breed improvement simultaneously.Since half a century, people have had very big raising to the understanding that mother educates reproductive process.The foundation of putting immune technology makes people to reproductive hormone regulation and control reproduction deep understanding arranged, and hormone preparation continues to bring out.Along with animal husbandry to the popularizing of intensification, the development of scale direction and technology of artificial insemination, 1970's the control technology of oestrusing make significant progress and enter the practical stage.The purpose of the control technology of oestrusing is fully to control the breeding potential of cow, obtains high economic benefit to raise less cow.The control technology of oestrusing at present proceeded to comprise estrus synchronization, bring out oestrus, aspects such as same period ovulation and superovulation.The purpose that estrus synchronization is handled is cow to be concentrated oestrus and ovulate, so that large-scale artificial insemination, embryo transfer and intensification production.In a lot of animal husbandry developed country, bring out childbirth and also generally be used.Hormonal regulation principle according to the estrus of cow cycle, handle cow estrus synchronization method and mainly contain two kinds: (1) shortens luteal phase: promptly by inducing luteolytic effect that shortened the luteal phase in estrus cycle, thereby occur new follicular phase, as prostaglandin (PC) method; (2) prolong luteal phase: promptly prolong the luteal phase in estrus cycle, as progesterone and analog facture by implantation progestogens material.Prostaglandin (PC) facture: it is the cattle estrus synchronization method of using always that prostaglandin and analog thereof are handled, and prostaglandin is handled the luteolysis that will make in the ovary.The prostaglandin facture is divided into prostaglandin processing once or twice.Prostaglandin has 70% cattle to oestrus in theory when handling.In fact 70% cattle does not oestrus.Normally twice prostaglandin of 11d handled at interval.But experiment showed, cow pregnancy rate height when twice prostaglandin estrus synchronization of 14d handled at interval.The progestogen facture is used for the various progestin preparations of having of cow estrus synchronization.Progestogen are handled the purpose that 14d can reach estrus synchronization, thereby but influence rate of fertilization owing to weakened sperm transportation in the cow reproductive tract, ovum fertilization and the spilting of an egg.
For guaranteeing that progesterone taking-up or prostaglandin have the dominant follicle that is growing to exist when handling, be necessary to make the follicle ripple synchronization in the ovary, the follicle synchronization has two kinds of methods: 1. remove large follicle; 2. HORMONE TREATMENT, its method is as follows: follicle synchronization method: progestogen are handled and are surpassed 14d and just the cow rate of fertilization is impacted.Correspondingly, the short-term progestogen are handled and before the progestogen processing finishes or inject prostaglandin simultaneously and can improve pregnancy rate.Yet this method estrus synchronization and the ovulation same period are poor.In addition, long-term progestogen are handled or when handling beginning, and cow is in the pmgravid later stage all can reduce pregnancy rate because of dominant follicle exists for a long time and arranges aged ovum.Remove large follicle:, just have the follicle ripple of new synchronization to occur handling and to ovulate the same period through 2 prostaglandins behind the 4d of a specified duration behind the 1.5d with the puncture large follicle of diameter＞5mm of ultrasonic leading.
Summary of the invention
In order to overcome the above-mentioned problems in the prior art, the invention provides a kind of estrogen and progesterone of containing, can significantly improve a kind of progesterone composite preparation that is used for regulating and controlling estrus of cow of estrus synchronization rate and the non-return rate of cow after the injection treatment.
The present invention adopts following technical proposals to solve its technical problem:
A kind of progesterone composite preparation that is used for regulating and controlling estrus of cow is characterized in that: Progesterone is made into the solution that every ml contains 20mg with the edible vegetable oil dissolving; Estradiol is made into after every ml contains the solution of 10mg with sterilization edible vegetable oil dissolving, formulated by following percentage by weight:
Progesterone solution 75.00%-87.50%, estradiol solution 8.75%-10.00%, edible vegetable oil 2.50%-6.25%;
Press following process production:
A. take by weighing Progesterone and estradiol respectively by proportional quantity, pulverize respectively;
B. edible vegetable oil is heated in glass dish to 250 ℃ of maintenance 20min, is cooled to 50 ℃ thereafter, adds Progesterone, estradiol; Stir, dissolve; For the first time dissolved medicinal liquid pour out → undissolved medicinal liquid continues to heat to 70-80 ℃, places 30min; Dissolved medicinal liquid and dissolved medicinal liquid two parts mix homogeneously for the second time for the first time.
C. admixing medical solutions is sealed respectively in the 50ml that packs into, 100ml, the 200ml vial, labelled.
For heifer, described raw material and percentage by weight are:
Progesterone solution 87.50%, estradiol solution 10.00%, edible vegetable oil 2.50%.
The clothes method of giving of preparation of the present invention is:
Select the compound progesterone preparation of cow → intramuscular injection → vagina heeling-in progesterone vagina releasing device → 8～10 days recession bolts, remove bolt intramuscular injection simultaneously pregnant mare serum gonadotrop(h)in (PMSG) → pregnant mare serum gonadotrop(h)in (PMSG) and handle the back breeding of artificial insemination for the first time in 48～56 hours → insemination breeding first quiet notes hCG (HCG) or No. 3 (LRH-A of induced ovulation simultaneously
)The breeding of artificial insemination was for the second time observed and is returned feelings → occur oestrusing composite in → the 20-21 days behind) → 6 hour.
Progesterone composite preparation of the present invention is a kind of hormone preparation of injection when regulating and controlling estrus of cow is handled, and contains estrogen and progesterone, can significantly improve estrus synchronization rate and the non-return rate of cow after the processing.Adopt the progesterone composite preparation pretreatment, can improve the processed cow ovarian activity and, and then stimulate estrogen secretion, promote follicular development the sensitivity of promoting sexual gland hormone.With the progesterone composite preparation pretreatment, can prevent that the processed cow progesterone secretion is not enough and influence cow performance libido and oestrus, because under normal circumstances cow oestruses to show and need a spot of progestogen sexual centre is played a role.When progesterone is not enough, just can not bring into play this effect.Therefore, although progesterone does not have facilitation to follicular development, can reach the effect that improves the estrus induction effect with promoting sexual gland hormone.
The method that the present invention proposes, be based on when putting progesterone vagina releasing device the compound progesterone preparation that injection estradiol benzoate and progesterone are made, its purpose is intended to make the follicle ripple of cow more stable, follicle ripple synchronism is higher, the cow ovulation is more concentrated, synchronism is more concentrated, conception rate is higher.Use this method cow synchronization and fertilization effect all higher.Breeding time generally in 3d, can be saved the time of observing estrus of cow.
The specific embodiment
The present invention is described in detail below in conjunction with the specific embodiment.
Embodiment 1
To the cow that grows up, according to 4 milliliters of administrations of every part total amount, the compound formulation preparation:
1. medicine weighing
Analytical balance weighing Progesterone 60mg, estradiol 3.25mg pulverize respectively.
2, get sterilization edible vegetable oil 0.25ml and in glass dish, heat to 250 ℃ and keep 20min down, be cooled to 50 ℃ thereafter, add respectively that the Progesterone, the estradiol powder that pulverize stir, dissolving; Pour dissolved medicinal liquid into another container, undissolved medicinal liquid is continued to heat to 80 ℃, place 30min; With twice dissolved medicinal liquid mix homogeneously.
3. admixing medical solutions is sealed respectively in the 50ml that packs into, 100ml, the 200ml vial, labelled, in order to using.
Embodiment 2
To heifer, according to 4 milliliters of administrations of every part total amount, the preparation of compound formulation:
1. medicine weighing
Analytical balance weighing Progesterone 70mg, estradiol 4mg pulverize respectively.
2, get sterilization edible vegetable oil 0.25ml and in glass dish, heat to 250 ℃ and keep 20min down, be cooled to 50 ℃ thereafter, add respectively that the Progesterone, the estradiol powder that pulverize stir, dissolving; Pour dissolved medicinal liquid into another container, undissolved medicinal liquid is continued to heat to 70 ℃, place 30min; With twice dissolved medicinal liquid mix homogeneously.
C. admixing medical solutions is sealed respectively in the 50ml that packs into, 100ml, the 200ml vial, labelled, in order to using.
Claims (2)
1. a progesterone composite preparation that is used for regulating and controlling estrus of cow is characterized in that: Progesterone is made into the solution that every ml contains 20mg with the dissolving of sterilization edible vegetable oil; Estradiol is made into after every ml contains the solution of 10mg with sterilization edible vegetable oil dissolving, formulated by following percentage by weight:
Progesterone solution 75.00%～87.50%, estradiol solution 8.75%～10.00%, edible vegetable oil 2.50%～6.25%;
Press following process production:
A. take by weighing Progesterone and estradiol respectively by proportional quantity, pulverize respectively;
B, get sterilization edible vegetable oil 0.25ml and in glass dish, heat to 250 ℃ and keep 20min down, be cooled to 50 ℃ thereafter, add that the Progesterone that pulverizes stirs, dissolving; Pour dissolved medicinal liquid into another container, undissolved medicinal liquid is continued to heat to 70 ℃～80 ℃, place 30min; With twice dissolved medicinal liquid mix homogeneously.
C. admixing medical solutions is sealed respectively in the 50ml that packs into, 100ml, the 200ml vial, labelled.
2. a kind of progesterone composite preparation that is used for regulating and controlling estrus of cow according to claim 1 is characterized in that for heifer described raw material and percentage by weight are:
Progesterone solution 87.50%, estradiol solution 10.00%, edible vegetable oil 2.50%.
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| CN 201010199544 CN101856361A (en) | 2010-06-08 | 2010-06-08 | Progesterone composite preparation for regulating and controlling estrus of cow |
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| CN 201010199544 CN101856361A (en) | 2010-06-08 | 2010-06-08 | Progesterone composite preparation for regulating and controlling estrus of cow |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105248368A (en) * | 2015-10-15 | 2016-01-20 | 内蒙古自治区农牧业科学院 | Method for promoting dual-calf production of beef cattle |
| CN106137448A (en) * | 2015-03-19 | 2016-11-23 | 河北工程大学 | A kind of method inducing high yield cow timing to ovulate and improve conception rate |
| CN107306881A (en) * | 2017-06-22 | 2017-11-03 | 赖永雄 | A kind of cross breeding method of the sharp ox in high-quality high-grade beef cattle new varieties building |
| CN109419565A (en) * | 2017-08-30 | 2019-03-05 | 周建标 | A kind of cow artificial insemination method |
| US10898432B2 (en) | 2015-12-18 | 2021-01-26 | Proinvet Innovations S.A. | Formulations and methods for controlling the reproductive cycle and ovulation |
| CN112870337A (en) * | 2021-01-26 | 2021-06-01 | 浙江科瑞特生物科技有限公司 | Freeze-dried powder of composite hormone of somatotropin and chorionic gonadotropin and preparation method thereof |
| CN115868447A (en) * | 2023-02-15 | 2023-03-31 | 新疆天澳牧业有限公司 | Breeding management method for synchronous estrus returning and timed semen deposition of young cattle |
-
2010
- 2010-06-08 CN CN 201010199544 patent/CN101856361A/en active Pending
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| 《上海畜牧兽医通讯》 20100220 吕善潮 等 母牛发情控制技术研究进展 75页4.3节 1-2 , 第1期 2 * |
| 《新疆农业科学》 20011231 张居农 等 非繁殖季节诱导母羊发情优选方案的研究 98-99页 1-2 , 第S1期 2 * |
| 《生产技术》 19921231 周虚 我国家畜同期发情技术进展 31页 1-2 第22卷, 第6期 2 * |
| 《黑龙江畜牧兽医》 19991231 张居农 等 非繁殖季节诱导母羊发情优选方案的研究 12-13页 1-2 , 第4期 2 * |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106137448A (en) * | 2015-03-19 | 2016-11-23 | 河北工程大学 | A kind of method inducing high yield cow timing to ovulate and improve conception rate |
| CN105248368A (en) * | 2015-10-15 | 2016-01-20 | 内蒙古自治区农牧业科学院 | Method for promoting dual-calf production of beef cattle |
| US10898432B2 (en) | 2015-12-18 | 2021-01-26 | Proinvet Innovations S.A. | Formulations and methods for controlling the reproductive cycle and ovulation |
| CN107306881A (en) * | 2017-06-22 | 2017-11-03 | 赖永雄 | A kind of cross breeding method of the sharp ox in high-quality high-grade beef cattle new varieties building |
| CN109419565A (en) * | 2017-08-30 | 2019-03-05 | 周建标 | A kind of cow artificial insemination method |
| CN112870337A (en) * | 2021-01-26 | 2021-06-01 | 浙江科瑞特生物科技有限公司 | Freeze-dried powder of composite hormone of somatotropin and chorionic gonadotropin and preparation method thereof |
| CN115868447A (en) * | 2023-02-15 | 2023-03-31 | 新疆天澳牧业有限公司 | Breeding management method for synchronous estrus returning and timed semen deposition of young cattle |
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Open date: 20101013 |