CN101855541B - 等温滴定微测热计装置和使用方法 - Google Patents
等温滴定微测热计装置和使用方法 Download PDFInfo
- Publication number
- CN101855541B CN101855541B CN2008801148263A CN200880114826A CN101855541B CN 101855541 B CN101855541 B CN 101855541B CN 2008801148263 A CN2008801148263 A CN 2008801148263A CN 200880114826 A CN200880114826 A CN 200880114826A CN 101855541 B CN101855541 B CN 101855541B
- Authority
- CN
- China
- Prior art keywords
- pipette
- pipette assembly
- titration
- syringe
- needle
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01K—MEASURING TEMPERATURE; MEASURING QUANTITY OF HEAT; THERMALLY-SENSITIVE ELEMENTS NOT OTHERWISE PROVIDED FOR
- G01K17/00—Measuring quantity of heat
- G01K17/006—Microcalorimeters, e.g. using silicon microstructures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N25/00—Investigating or analyzing materials by the use of thermal means
- G01N25/20—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity
- G01N25/48—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation
- G01N25/4846—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample
- G01N25/4866—Investigating or analyzing materials by the use of thermal means by investigating the development of heat, i.e. calorimetry, e.g. by measuring specific heat, by measuring thermal conductivity on solution, sorption, or a chemical reaction not involving combustion or catalytic oxidation for a motionless, e.g. solid sample by using a differential method
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/02—Devices for withdrawing samples
- G01N1/10—Devices for withdrawing samples in the liquid or fluent state
- G01N1/14—Suction devices, e.g. pumps; Ejector devices
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N35/1081—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane
- G01N35/109—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices characterised by the means for relatively moving the transfer device and the containers in an horizontal plane with two horizontal degrees of freedom
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
- G01N2035/1027—General features of the devices
- G01N2035/1048—General features of the devices using the transfer device for another function
- G01N2035/1058—General features of the devices using the transfer device for another function for mixing
Landscapes
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- Combustion & Propulsion (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hydrology & Water Resources (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating Or Analyzing Materials Using Thermal Means (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98443207P | 2007-11-01 | 2007-11-01 | |
| US60/984432 | 2007-11-01 | ||
| US60/984,432 | 2007-11-01 | ||
| PCT/US2008/081961 WO2009059110A1 (en) | 2007-11-01 | 2008-10-31 | Isothermal titration microcalorimeter apparatus and method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101855541A CN101855541A (zh) | 2010-10-06 |
| CN101855541B true CN101855541B (zh) | 2013-12-11 |
Family
ID=40591475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801148263A Active CN101855541B (zh) | 2007-11-01 | 2008-10-31 | 等温滴定微测热计装置和使用方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US8449175B2 (https=) |
| EP (1) | EP2208057B1 (https=) |
| JP (1) | JP5542678B2 (https=) |
| CN (1) | CN101855541B (https=) |
| WO (1) | WO2009059110A1 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9103782B2 (en) | 2008-12-02 | 2015-08-11 | Malvern Instruments Incorporated | Automatic isothermal titration microcalorimeter apparatus and method of use |
| US9513240B2 (en) | 2011-02-22 | 2016-12-06 | The Trustees Of Columbia University In The City Of New York | MEMS-based calorimeter, fabrication, and use thereof |
| EP2678651B1 (en) * | 2011-02-22 | 2017-08-23 | The Trustees of Columbia University in the City of New York | Mems-based calorimeter |
| JP6066498B2 (ja) * | 2011-07-01 | 2017-01-25 | ベックマン コールター, インコーポレイテッド | 自動化された分析器のための低飛沫同伴液体取扱プローブ |
| US9075021B2 (en) | 2012-02-17 | 2015-07-07 | Toyota Motor Engineering & Manufacturing North America, Inc. | Methods and systems for monitoring content of coating solutions using automated titration devices |
| JP2015526720A (ja) | 2012-07-24 | 2015-09-10 | ザ トラスティーズ オブ コロンビア ユニバーシティ イン ザ シティオブ ニューヨーク | Memsベースの等温滴定熱量測定 |
| US9702793B2 (en) | 2015-03-16 | 2017-07-11 | Todd A Balisky | Variable volume sample capture device |
| US10337933B2 (en) | 2015-04-17 | 2019-07-02 | Waters Technologies Corporation | Stirring paddle for isothermal titration calorimetry |
| AU2017206687B2 (en) * | 2016-01-14 | 2021-12-23 | Jamlet MONASELIDZE | Differential scanning microcalorimeter device for detecting disease and monitoring therapeutic efficacy |
| RU2610853C1 (ru) * | 2016-01-26 | 2017-02-16 | Федеральное государственное бюджетное учреждение науки Институт биологического приборостроения с опытным производством Российской Академии наук (ИБП РАН) | Капиллярный титрационный калориметр для исследования митохондрий |
| RU2618670C1 (ru) * | 2016-03-21 | 2017-05-05 | Федеральное государственное бюджетное учреждение науки Институт биологического приборостроения с опытным производством Российской Академии наук (ИБП РАН) | Капиллярный титрационный нанокалориметр для исследования митохондрий |
| US10225628B2 (en) | 2016-09-14 | 2019-03-05 | Fiber Mountain, Inc. | Intelligent fiber port management |
| EP4726345A2 (en) | 2017-08-31 | 2026-04-15 | Waters Technologies Corporation | Hybrid calorimeter cell |
| CN107643317B (zh) * | 2017-09-19 | 2019-08-06 | 北京科技大学 | 内热式同步热跟踪法测定溶液解吸热的装置及测定方法 |
| GB2567694A (en) * | 2017-10-23 | 2019-04-24 | Malvern Instruments Ltd | Stirrer |
| CN110354338B (zh) * | 2018-09-03 | 2024-04-26 | 上海北昂医药科技股份有限公司 | 具有旋转分配及注射功能的泵阀一体装置 |
| RU2713808C1 (ru) * | 2018-09-04 | 2020-02-07 | Федеральное государственное бюджетное учреждение науки "Федеральный исследовательский центр "Пущинский научный центр биологических исследований Российской академии наук" (ФИЦ ПНЦБИ РАН) | Способ охлаждения и нагрева с постоянной скоростью протяженных калориметрических камер изотермического капиллярного дифференциального титрационного нанокалориметра, предназначенного для работы с короткоживущими объектами |
| CN112649555A (zh) * | 2019-10-10 | 2021-04-13 | 句容康泰膨润土有限公司 | 一种膨润土蒙脱石含量自动检测设备及检测方法 |
| US11047748B1 (en) * | 2020-08-14 | 2021-06-29 | Frank L. Wu | Adiabatic power compensation differential scanning calorimeter |
| CN114307788A (zh) * | 2021-12-31 | 2022-04-12 | 南京岚煜生物科技有限公司 | 一种抗原乳化装置及其使用方法 |
| GB2643440A (en) * | 2024-08-15 | 2026-02-18 | Platform Kinetics Ltd | Environmental sampling apparatus |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987000086A1 (en) * | 1985-07-01 | 1987-01-15 | American Hospital Supply Corporation | Reagent dispenser for analyzing system |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259843A (en) * | 1979-10-09 | 1981-04-07 | Cromemco Inc. | Isolation chamber for electronic devices |
| US4681741A (en) * | 1985-07-01 | 1987-07-21 | American Hospital Supply Corporation | Reagent dispenser for an analyzing system |
| US4643879A (en) * | 1985-07-01 | 1987-02-17 | American Hospital Supply Corporation | Tower for analyzing system |
| CA1302979C (en) * | 1986-10-24 | 1992-06-09 | Richard W. Hanaway | Multiple pipette sampler |
| US5000921A (en) * | 1986-10-24 | 1991-03-19 | Hanaway Richard W | Multiple pipette samples |
| GR871619B (en) * | 1986-10-31 | 1988-03-03 | Genetic Systems Corp | Automated patient sample analysis instrument |
| US5813763A (en) * | 1996-10-11 | 1998-09-29 | Microcal Incorporated | Ultrasensitive differential microcalorimeter |
| DE19746455C1 (de) * | 1997-10-21 | 1999-05-27 | Jenoptik Jena Gmbh | Pipettier- und Handlingsautomat für Mikrotitrationsplatten mit permeablen Böden |
| US6573088B2 (en) | 2001-08-08 | 2003-06-03 | Dade Microscan Inc. | Automated random access microbiological analyzer |
| JP3990944B2 (ja) | 2002-06-28 | 2007-10-17 | 株式会社日立ハイテクノロジーズ | 自動分析装置 |
| JP4327760B2 (ja) * | 2005-03-29 | 2009-09-09 | シチズンホールディングス株式会社 | 熱量計およびそれを用いた分析方法 |
-
2008
- 2008-10-31 WO PCT/US2008/081961 patent/WO2009059110A1/en not_active Ceased
- 2008-10-31 EP EP08843953.4A patent/EP2208057B1/en active Active
- 2008-10-31 JP JP2010532272A patent/JP5542678B2/ja active Active
- 2008-10-31 CN CN2008801148263A patent/CN101855541B/zh active Active
- 2008-10-31 US US12/740,380 patent/US8449175B2/en active Active
-
2013
- 2013-02-28 US US13/780,536 patent/US8827549B2/en active Active
-
2014
- 2014-04-15 US US14/253,168 patent/US20140219311A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1987000086A1 (en) * | 1985-07-01 | 1987-01-15 | American Hospital Supply Corporation | Reagent dispenser for analyzing system |
Non-Patent Citations (1)
| Title |
|---|
| Alan Cooper and Christopher M.Johnson.Isothermal Titration Microcalorimetry.《Methods in Molecular Biology》.1994,第22卷137-150. * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009059110A1 (en) | 2009-05-07 |
| EP2208057A4 (en) | 2016-06-22 |
| CN101855541A (zh) | 2010-10-06 |
| EP2208057B1 (en) | 2024-10-09 |
| US20130171042A1 (en) | 2013-07-04 |
| US20100238968A1 (en) | 2010-09-23 |
| EP2208057A1 (en) | 2010-07-21 |
| US8827549B2 (en) | 2014-09-09 |
| US8449175B2 (en) | 2013-05-28 |
| JP2011503546A (ja) | 2011-01-27 |
| JP5542678B2 (ja) | 2014-07-09 |
| US20140219311A1 (en) | 2014-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: MALVERN INSTRUMENT INC. Free format text: FORMER OWNER: AMERSHAM BIOSCIENCES CORP. Effective date: 20140806 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20140806 Address after: Massachusetts, USA Patentee after: Malvern Instr Inc. Address before: new jersey Patentee before: Amersham Biosciences Corp. |