CN101850095A - Brain-refreshing and channel obstruction-removing medicament used for treating ischemic cerebrovascular diseases - Google Patents
Brain-refreshing and channel obstruction-removing medicament used for treating ischemic cerebrovascular diseases Download PDFInfo
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- CN101850095A CN101850095A CN 201010224662 CN201010224662A CN101850095A CN 101850095 A CN101850095 A CN 101850095A CN 201010224662 CN201010224662 CN 201010224662 CN 201010224662 A CN201010224662 A CN 201010224662A CN 101850095 A CN101850095 A CN 101850095A
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Abstract
The invention relates to the field of medicament formula, in particular to a brain-refreshing and channel obstruction-removing medicament used for treating ischemic cerebrovascular diseases. The medicament is prepared by mixing the following raw materials of astragalus, grassleaf sweelflag rhizome, turmeric root-tuber, tabasheer, red paeony root and rhubarb, soaking the raw materials in water, boiling the raw materials and removing dregs to obtain a filtrate, pulverizing leeches in a superfine mode, sieving the pulverized leeches by using a 400-mesh sieve to obtain leech powder, and mixing the leech powder with the filtrate to obtain the medicament, wherein the raw materials comprises the following components in part by weight: 25 to 35 parts of fresh astragalus, 4 to 9 parts of leeches, 10 to 20 parts of grassleaf sweelflag rhizome, 9 to 18 parts of turmeric root-tuber, 9 to 18 parts of tabasheer, 13 to 17 parts of red paeony root and 4 to 9 parts of rhubar. The brain-refreshing and channel obstruction-removing medicament used for treating the ischemic cerebrovascular diseases has the advantages of low cost, high effect of curing cerebrovascular diseases and no toxic or side effects, has the effects of tonifying qi, activating blood circulation, refreshing brain and dissipating blood stasis, and plays a role in neuroprotection.
Description
Technical field
The present invention relates to a kind of Chinese patent medicine preparation, specifically a kind of brain-refreshing and channel obstruction-removing medicament that is used for the treatment of ischemic cerebrovascular.
Background technology
Cerebral infarction is one of very high commonly encountered diseases of sickness rate, disability rate and mortality rate.According to according to a preliminary estimate, the annual New Development apoplexy of China surpasses 2,000,000 people, deadly surpasses 1,500,000 people, and number of patients reaches 600～7,000,000.WHO is by present apoplexy anticipated mortality, to apoplexy year the year two thousand thirty death toll will increase by 4～5 times.The high incidence of apoplexy, high disability rate and high mortality have brought heavy economy and psychological burden for society and family, become the main cause that influences human health.Chinese medicine is one " a great treasure-house ", also is the important source of China's medical domain autonomous innovation.Enforcement is the national scientific and technological strategy to revitalize of core with the Chinese medicine, itself is exactly to implement at medical domain one of the concrete behave of the national strategy of autonomous innovation.From " interior warp ", doctor family to apoplexy due to illness machine opinions vary.Qing Dynasty's well-known doctor's Wang Qingren is thought ancient Chinese medicine doctor about " apoplexy is because the opinion of wind-fire phlegm-damp ", and very, the branch of apoplexy due to endogenous wind is not very reasonable, but approves of Zhang Jingyue " the non-wind of apoplexy by ", and is name of disease with " hemiplegia ".Wang Shi probes boldly apoplexy on the basis of summing up forefathers' achievement, has proposed the new theory of oneself.He solely advocates " blood stasis due to qi deficiency " opinion, proposes apoplexy " loss vigour is its origin ", the inrigorating qi and promoting blood circulation method of treatment of advocating.To apoplexy due to illness the full appreciation of machine be interpreted as the deficiency of vital energy, blood stasis, the deficiency of vital energy be this for because of, blood stasis is for being designated as really.The vigour loss is to cause hemiplegia (apoplexy), so abide by " deficiency syndrome should be treated by tonifying method " rule of treatment.Modern medicine thinks that the pathophysiology basis of cardiovascular and cerebrovascular disease is mainly determined by blood and blood vessel two big pathological changes, dysemia mainly is a platelet activation, disorders of lipid metabolism, inflammatory factor discharges, the factor relevant with blood coagulation is unusual, the increase of short bolt composition, hyperlipidemia etc. easily cause thrombosis.Vascular lesion is mainly vascular endothelium dysfunction, atherosclerosis, luminal stenosis, vascular inflammation, degeneration and damage etc., and these can cause cerebral infarction.Regrettably, cerebral infarction does not still have perfect Therapeutic Method so far.Although clinical trial both domestic and external shows that the super early stage application rt-PA of ischemic cerebral stroke patients is carried out thromboembolism treatment is effective, but because the thrombolytic time window is very of short duration, add the restriction of many thrombolytic conditions, so it is very low in fact can to accept patient's ratio of thromboembolism treatment.In addition, also exist reperfusion injury and problem such as hemorrhage behind the thromboembolism treatment.Therefore digging action shows important especially in the Chinese medicine preparation of many target spots, too many levels.The traditional Chinese medical science was continued to use " apoplexy is because the opinion of wind-fire phlegm-damp " about the cause of disease aspect of apoplexy always in the past, cause most of prescriptions not catch " at all " promptly to ignore " QI invigorating ", and stick to blood circulation promoting and blood stasis dispelling more, and pay attention to not enough for aspects such as antiinflammatory toxin-expulsion oxidation-resistances, cure the symptoms, not the disease, curative effect is often dissatisfied.
Summary of the invention
The objective of the invention is to overcome the deficiencies in the prior art, provide a kind of cost low, treatment cerebrovascular curative effect height has no side effect, and has QI invigorating, invigorates blood circulation, the function of refreshment, blood stasis dispelling, imitates to reach the good of treatment cerebrovascular.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of brain-refreshing and channel obstruction-removing medicament that is used for the treatment of ischemic cerebrovascular, adopt the Radix Astragali, Rhizoma Acori Graminei, Radix Curcumae, Concretio Silicea Bambusae, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei is a raw material, raw material is soaked in water after mixing, remove slag after decocting filtrate, the Hirudo micronizing is crossed 400 mesh sieves get Hirudo powder, with Hirudo powder mix with aforementioned filtrate medicinal liquid, it is characterized in that the weight portion of raw material is: 25～35 parts of Radix Astragali, 4～9 parts of Hirudos, 10～20 parts of Rhizoma Acori Graminei, 9～18 parts of Radix Curcumaes, 9～18 parts of Concretio Silicea Bambusaes, 13～17 parts of Radix Paeoniae Rubra, 4～9 parts of Radix Et Rhizoma Rhei.
The weight portion preferable range of raw material of the present invention is: 30 parts of Radix Astragali, 6 parts of Hirudos, 15 parts of Rhizoma Acori Graminei, 14 parts of Radix Curcumaes, 14 parts of Concretio Silicea Bambusaes, 15 parts of Radix Paeoniae Rubra, 6 parts of Radix Et Rhizoma Rhei, the Radix Astragali, Rhizoma Acori Graminei, Radix Curcumae, Concretio Silicea Bambusae, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei are soaked in water after mixing, remove slag after decocting filtrate, the Hirudo micronizing is crossed 400 mesh sieves gets Hirudo powder, with Hirudo powder mix with aforementioned filtrate medicinal liquid.
The invention has the beneficial effects as follows: cost is low, and treatment cerebrovascular curative effect height has no side effect, and has QI invigorating, invigorates blood circulation, the function of refreshment, blood stasis dispelling, the performance neuroprotective.
The specific embodiment
The invention will be further described below in conjunction with embodiment:
Embodiment 1:
Whenever the raw material weight of taking medicine is 100 grams, wherein Radix Astragali 30 restrains, Hirudo 6 grams, Rhizoma Acori Graminei 15 grams, Radix Curcumae 14 grams, Concretio Silicea Bambusae 14 grams, Radix Paeoniae Rubra 15 grams, Radix Et Rhizoma Rhei 6 grams, at room temperature with the Radix Astragali, Rhizoma Acori Graminei, Radix Curcumae, Concretio Silicea Bambusae, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei adds water to 400～600ml, soaked 4～6 hours, decoct about 60～90 minutes with slow fire then, remove slag about filtrate 150ml, medicinal residues add water 100～200ml again, decoct 30～40 minutes, remove slag filtrate 50～70ml, altogether 200～220ml left and right sides medicine juice, the Hirudo micronizing is crossed 400 mesh sieves get Hirudo powder, Hirudo powder is mixed promptly making the brain-refreshing and channel obstruction-removing medicament that is used for the treatment of ischemic cerebrovascular with aforementioned medicine juice.Pack in the aseptic vial, seal bottle cap is standby, and every day, 1 dose of branch 2 times was oral, and each (medicine) being taken before meal 100～110ml will shake when taking at every turn and prevent that all Hirudo powder from sinking to the bottom, takes to clinical symptoms and sign to disappear.
The principal agent Radix Astragali of the present invention is the panacea of QI invigorating, sweet in the mouth, and the feeble QI temperature, gas is thin and distinguish the flavor of densely, can rise and can fall, and the yang aspect of yang is also, and is nontoxic.Special QI invigorating.Modern study finds that the Radix Astragali has raise immunity, enhancing body anoxia enduring and stress ability, promotion organism metabolism, improves cardiac function, blood pressure lowering, protects the liver, blood sugar regulation, antibiotic and antiviral, the effect of parahormone sample etc.Reuse Radix Astragali treatment apoplexy and enjoy high praise in recent years, the void of strongly invigorating primordial QI, and the merit of playing the QI invigorating clots absorbing are " monarch drug " in fact.Hirudo has removing blood stasis, removing blood stasis, the effect of stimulating the menstrual flow.Modern study finds that Hirudo has multiple effects such as anticoagulation, thrombolytic, antiplatelet, blood fat reducing, termination of pregnancy, attenuating renal damage, experiment shows that Hirudo can promote the absorption of cephalophyma and ecchymosis, alleviate focus inflammatory reaction and edema on every side, alleviate intracranial pressure and raise, improve regional flow's circulation.Rhizoma Acori Graminei has suffering, and to open bitter dry temperature logical, and fragrance is walked to scurry, and the merit of the refreshment of having one's ideas straightened out is not only arranged, and has removing dampness concurrently, and eliminating phlegm is warded off dirty effect.Be good at that to control the mind that the foul heresy of phlegm-damp hoodwinks due to the key clearly dazed and confused.Control the apoplexy mental confusion due to phlegm, mind is dazed and confused, stiff tongue can not be spoken, and drying dampness to eliminate phlegm medicines such as the normal and Rhizoma Pinelliae, Rhizoma Arisaematis, dried tangerine peel share, as phlegm-removing decoction (recipes for Saving Lives); If control expectorant heat and hoodwink, hyperpyrexia, unconsciousness and delirium person, compatibilities such as normal and Radix Curcumae, the Rhizoma Pinelliae, Succus Bambusae are as Acorus calamus curcuma aromatica soup (" epidemic febrile disease pandect "); Control the hot epilepsy clonus of expectorant, can with compatibilities such as Fructus Aurantii Immaturus, Caulis Bambusae In Taenia, Rhizoma Coptidis, as the WEIDANTANG that clears away heart-fire (" doctor mirror ") at all times; Control demented expectorant Re Neisheng person, can with Radix Polygalae, Cinnabaris, the pig iron same usefulness that falls, as decoction of Iron Scale (" Medicine Comprehended "); Hoodwink with controlling turbid damp, dizziness, drowsiness, forgetful, tinnitus, diseases such as deafness, compatibilities such as normal again and Poria, Radix Polygalae, Os Draconis are as tranquilizing the mind ball (" Medicine Comprehended ").Modern pharmacological research finds that Rhizoma Acori Graminei has convulsion, the calmness of calming the nerves, improve multiple efficacies such as learning and memory and cognitive function, heat clearing away spasmolytic.Radix Curcumae acrid in the mouth, hardship, cool in nature.Have removing heat from blood and clear away heart-fire, stasis-dispelling and pain-killing, promoting QI circulation for relieving depression, effects such as promoting the function of the gallbladder to alleviate jaundice.Cure mainly the clear key of the evil illiteracy of epidemic febrile disease, obnubilation, breast gastral cavity painful abdominal mass is vexed; Infantile convulsion, demented; Uncomfortable in chest, chest pain; Hypochondriac pain, jaundice; Menoxenia, dysmenorrhea; Diseases such as haematemesis, epistaxis, hematuria.In the cow-bezoar bolus for resurrection that treatment epidemic febrile disease heating convulsion is fainted, use Radix Curcumae to assist removing heat from the heart to restore the consciousness; The treatment damp-warm diseases, numbness strongly fragrant and the sound of vomiting a surname's numbness soup in, with Radix Curcumae with the chest stuffiness relieving resolving depression.Radix Curcumae and Alumen are together in order to the treatment epilepsy in the platinum ball.Modern pharmacological research shows that Radix Curcumae has immunosuppressant and antiallergic action, raising phagocytic function, hepatic cholagogic, the inhibition atherosclerotic plaque forms and the deposition of lipid, increase fibrinolytic and antiplatelet aggregation, gastric acid inhibitory and antiulcer, spasmolytic, analgesia and hypnosis, multiple efficacies such as antibiotic.Concretio Silicea Bambusae is clinical Chinese medicine commonly used, and is sweet, cold.GUIXIN, Liver Channel.Can clear heat and eliminate phlegm, cool heart arresting convulsion.Clinically be usually used in controlling calentura coma delirium, middle wind-phlegm fan in silence, infantile convulsion is twitched, epilepsy or the like.Radix Paeoniae Rubra has effects such as blood stasis dispelling, pain relieving, removing heat from blood, detumescence.The effect of Radix Paeoniae Rubra in modern medicine comprises anti-thrombosis function, antiplatelet aggregative activity, blood fat reducing and arteriosclerosis effect, antitumor action, protects the liver, removes free radical etc.Big xanthorrhiza, rhizome mainly contain anthraquinone derivative.The anthraquinone class exists with two kinds of forms, and most of and glucose is combined into anthra-glucoside, and anthraquinone glycoside wherein and dianthrone glycosides are that Radix Et Rhizoma Rhei mainly rushes down composition down.Small part is aglycon such as chrysophanic acid, chrysophanol, emodin, aloe-emodin and the physcione of free form.The Radix Et Rhizoma Rhei bitter in the mouth, cold in nature.Return spleen, stomach, large intestine, liver, pericardium channel.Has heat and toxic materials clearing away, clearing away heat-fire, removing pathogenic heat from blood and toxic substance from the body, the effect of eliminating blood stasis and inducing menstruation.Radix Et Rhizoma Rhei can increase enterokinesia, suppresses the enteral moisture absorption, promotes defecation; Radix Et Rhizoma Rhei has anti-infectious function, and multiple Gram-positive and negative bacteria are all had inhibitory action, and wherein the most responsive is staphylococcus and streptococcus, is diphtheria corynebacterium, typhoid fever and Salmonella paratyphi, Diplococcus pneumoniae, dysentery bacterium etc. secondly; Influenza virus also there is inhibitory action; Because due to the tannin, so the constipation phenomenon is arranged again after rushing down; Function of gallbladder promoting and digestion promoting function are arranged; In addition, stop blooding in addition, protect the liver, multiple action such as blood pressure lowering, reduction serum cholesterol.
Full side's compatibility is rigorous, and all medicines cooperate, and QI and blood also turns round and look at, and QI invigorating is set upright to consolidate void, and treating both the principal and secondary aspects of a disease brings out the best in each other.
But each raw material of the present invention also blended embodiment of the listed ratio of according to the form below (weight portion) is realized.Its processing method is identical with embodiment 1.
| Embodiment | Radix Astragali | Hirudo | Rhizoma Acori Graminei | Radix Curcumae | Concretio Silicea Bambusae | Radix Paeoniae Rubra | Radix Et Rhizoma Rhei |
| Two | 25 | 9 | 10 | 18 | 9 | 17 | 4 |
| Three | 35 | 4 | 20 | 9 | 18 | 13 | 9 |
| Four | 28 | 7 | 16 | 14 | 16 | 14 | 8 |
Below in conjunction with my institute, i.e. the clinical trial carried out of Shandong Province Wendeng Central Hospital, Weihai City is done further, is described in detail the present invention:
(1) case is selected: on April 30,1 day～2010 March in 2008,243 examples are diagnosed as the ischemic cerebrovascular patient and include this observation in, 56～78 years old age, wherein male 123 examples, women 120 examples, the course of disease 15 minutes to 72 hours.All patients that participate in this research all have the symptom of one or more ischemic cerebral vascular, cross hyposexuality or unable as one of face or limbs, particularly in a side of health; One crosses the sex consciousness obstacle, speech or understanding difficulty; Simple eye or the eyes blurring of vision of one property crossed; One property crossed dysbasia, dizziness, balance and mutual aid obstacle; There is not the serious headache of a property crossed of bright reason etc.Except can cause that other situation of above-mentioned symptom is as flu, epilepsy etc.Ischemic cerebrovascular (comprising TIA) patient's diagnosis must have objective ischemic syndrome, or the above-mentioned foundation that causes ischemic cerebrovascular.
(2) therapeutic evaluation standard: clinical neurologic deficit degree scoring (CNIS) is adopted January in when the patient is admitted to hospital and treatment back, is divided into light-duty (0～15 minute), medium-sized (16～30 minutes) and heavy (31～45 minutes).Activity of daily living (ADL) scale is adopted in patient's survival condition and daily life active ability evaluation when treating back 3 months, and divides 5 grades: 1 grade for recovering activity of daily living fully, and 2 grades is independent living ability, and partly recovers the social life ability; 3 grades need others to help for activity of daily living slightly; 4 grades for keeping consciousness but be unable to leave the bed, and daily life needs others to help; 5 grades is the plant life state.
(3) Therapeutic Method: every day, 1 dose of branch 2 times was oral, and each (medicine) being taken before meal 100～110ml will shake when taking at every turn and prevent that all Hirudo powder from sinking to the bottom, and ten days is a course of treatment, totally six courses of treatment.Have Sx persons such as heating, cranium pressure height, severe infections, hypertension, diabetes and give respective handling.
(4) therapeutic effect:
Neurological functional recovery situation when 1, treating January
The treatment back is during January, patient's clinical neurologic deficit degree scoring (CNIS scale) shows, slight neurologic impairment person is significantly more than before the treatment (P＜0.01), and the damaged person of severe significantly is less than treatment preceding (P＜0.01), prompting brain-refreshing and channel obstruction-removing mixture can significantly improve patient's function of nervous system, sees Table 1.
2, back 3 months patient's neurological functional recovery situations of treatment
When treating back 3 months, patient's survival condition and daily life active ability evaluation (ADL scale) show, ADL
1 ~ 2Level person is significantly more than before the treatment (P＜0.01), and ADL
3 ~ 4Level, ADL
5Level person significantly is lower than treatment preceding (P＜0.01).Prompting brain-refreshing and channel obstruction-removing mixture can significantly improve patient's survival condition and daily life active ability, sees Table 2.
Claims (2)
1. brain-refreshing and channel obstruction-removing medicament that is used for the treatment of ischemic cerebrovascular, adopting the Radix Astragali, Rhizoma Acori Graminei, Radix Curcumae, Concretio Silicea Bambusae, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei is raw material, raw material is soaked in water after mixing, remove slag after decocting filtrate, the Hirudo micronizing is crossed 400 mesh sieves get Hirudo powder, with Hirudo powder mix with aforementioned filtrate medicinal liquid, it is characterized in that the weight portion of raw material is: 25～35 parts of Radix Astragali, 4～9 parts of Hirudos, 10～20 parts of Rhizoma Acori Graminei, 9～18 parts of Radix Curcumaes, 9～18 parts of Concretio Silicea Bambusaes, 13～17 parts of Radix Paeoniae Rubra, 4～9 parts of Radix Et Rhizoma Rhei.
2. according to the described a kind of brain-refreshing and channel obstruction-removing medicament that is used for the treatment of ischemic cerebrovascular of claim 1, the weight portion that it is characterized in that said raw material is, 30 parts of Radix Astragali, 6 parts of Hirudos, 15 parts of Rhizoma Acori Graminei, 14 parts of Radix Curcumaes, 14 parts of Concretio Silicea Bambusaes, 15 parts of Radix Paeoniae Rubra, 6 parts of Radix Et Rhizoma Rhei, the Radix Astragali, Rhizoma Acori Graminei, Radix Curcumae, Concretio Silicea Bambusae, Radix Paeoniae Rubra, Radix Et Rhizoma Rhei are soaked in water after mixing, remove slag after decocting filtrate, the Hirudo micronizing is crossed 400 mesh sieves gets Hirudo powder, with Hirudo powder mix with aforementioned filtrate medicinal liquid.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101194939A (en) * | 2007-12-07 | 2008-06-11 | 刘晓祥 | Chinese medicine prescription for treating early apoplexy and hemiplegia |
| CN100586458C (en) * | 2006-12-20 | 2010-02-03 | 丁金良 | Medicine for treating cerebral apoplexy |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100586458C (en) * | 2006-12-20 | 2010-02-03 | 丁金良 | Medicine for treating cerebral apoplexy |
| CN101194939A (en) * | 2007-12-07 | 2008-06-11 | 刘晓祥 | Chinese medicine prescription for treating early apoplexy and hemiplegia |
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