CN101848909A - 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶 - Google Patents

可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶 Download PDF

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Publication number
CN101848909A
CN101848909A CN200780012623A CN200780012623A CN101848909A CN 101848909 A CN101848909 A CN 101848909A CN 200780012623 A CN200780012623 A CN 200780012623A CN 200780012623 A CN200780012623 A CN 200780012623A CN 101848909 A CN101848909 A CN 101848909A
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aliphatic group
compound
disease
group
independently
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J-M·吉米内斯
P·克里尔
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Pulmonology (AREA)
  • Obesity (AREA)
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  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
CN200780012623A 2006-02-14 2007-02-12 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶 Pending CN101848909A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77314306P 2006-02-14 2006-02-14
US60/773,143 2006-02-14
PCT/US2007/003767 WO2007095223A2 (en) 2006-02-14 2007-02-12 Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
CN101848909A true CN101848909A (zh) 2010-09-29

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Application Number Title Priority Date Filing Date
CN200780012623A Pending CN101848909A (zh) 2006-02-14 2007-02-12 可用作蛋白激酶抑制剂的吡咯并[3,2-c]吡啶

Country Status (7)

Country Link
US (1) US7659283B2 (enExample)
EP (1) EP2004645A2 (enExample)
JP (1) JP2009528991A (enExample)
CN (1) CN101848909A (enExample)
AU (1) AU2007215161A1 (enExample)
CA (1) CA2641254A1 (enExample)
WO (1) WO2007095223A2 (enExample)

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CN109071455A (zh) * 2016-03-11 2018-12-21 科尔沃斯制药股份有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法

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EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
CN102532134A (zh) 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
KR20090017498A (ko) 2006-04-04 2009-02-18 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 Pi3 키나제 길항물질
EP2124951B1 (en) 2006-12-21 2014-05-21 Vertex Pharmaceuticals Inc. 5-cyan0-4- (pyrrolo[2, 3b]pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
EP2252293B1 (en) * 2008-03-14 2018-06-27 Intellikine, LLC Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
KR101903354B1 (ko) 2009-06-17 2018-10-04 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
KR101173678B1 (ko) 2010-10-20 2012-08-13 한국과학기술연구원 피롤로[3,2-c]피리딘 유도체 및 그의 제조 방법
EP2651940A1 (en) 2010-12-16 2013-10-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
KR20150061651A (ko) 2012-09-26 2015-06-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ire1의 조절
TW201536293A (zh) 2013-07-18 2015-10-01 Taiho Pharmaceutical Co Ltd 對fgfr抑制劑具耐受性之癌的治療藥
EP3023100B1 (en) 2013-07-18 2019-03-13 Taiho Pharmaceutical Co., Ltd. Antitumor drug for intermittent administration of fgfr inhibitor
DK3068776T3 (da) 2013-11-13 2019-07-29 Vertex Pharma Inhibitorer af replikation af influenzavira
ES2684755T3 (es) 2013-11-13 2018-10-04 Vertex Pharmaceuticals Incorporated Métodos para preparar inhibidores de la replicación de virus de la gripe
AU2015296210B2 (en) * 2014-07-31 2019-08-15 Merck Patent Gmbh Indolizine derivatives which are applicable to neurodegenerative diseases
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication

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CN109071455A (zh) * 2016-03-11 2018-12-21 科尔沃斯制药股份有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法
CN109071455B (zh) * 2016-03-11 2022-08-02 嘉兴和剂药业有限公司 用于调节布鲁顿酪氨酸激酶的化合物及方法

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