AU2007215161A1 - Pyrrolo(3,2-C) pyridines useful as inhibitors of protein kinases - Google Patents

Pyrrolo(3,2-C) pyridines useful as inhibitors of protein kinases Download PDF

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Publication number
AU2007215161A1
AU2007215161A1 AU2007215161A AU2007215161A AU2007215161A1 AU 2007215161 A1 AU2007215161 A1 AU 2007215161A1 AU 2007215161 A AU2007215161 A AU 2007215161A AU 2007215161 A AU2007215161 A AU 2007215161A AU 2007215161 A1 AU2007215161 A1 AU 2007215161A1
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Australia
Prior art keywords
aliphatic
disease
ring
compound according
compound
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Abandoned
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AU2007215161A
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English (en)
Inventor
Philip Collier
Juan-Miguel Jimenez
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Filing date
Publication date
Application filed by Vertex Pharmaceuticals Inc filed Critical Vertex Pharmaceuticals Inc
Publication of AU2007215161A1 publication Critical patent/AU2007215161A1/en
Abandoned legal-status Critical Current

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    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
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    • A61P9/14Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Immunology (AREA)
  • Diabetes (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Pain & Pain Management (AREA)
AU2007215161A 2006-02-14 2007-02-12 Pyrrolo(3,2-C) pyridines useful as inhibitors of protein kinases Abandoned AU2007215161A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US77314306P 2006-02-14 2006-02-14
US60/773,143 2006-02-14
PCT/US2007/003767 WO2007095223A2 (en) 2006-02-14 2007-02-12 Pyrrolo(3,2-c) pyridines useful as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
AU2007215161A1 true AU2007215161A1 (en) 2007-08-23

Family

ID=38180574

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2007215161A Abandoned AU2007215161A1 (en) 2006-02-14 2007-02-12 Pyrrolo(3,2-C) pyridines useful as inhibitors of protein kinases

Country Status (7)

Country Link
US (1) US7659283B2 (enExample)
EP (1) EP2004645A2 (enExample)
JP (1) JP2009528991A (enExample)
CN (1) CN101848909A (enExample)
AU (1) AU2007215161A1 (enExample)
CA (1) CA2641254A1 (enExample)
WO (1) WO2007095223A2 (enExample)

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Publication number Priority date Publication date Assignee Title
EP1831225A2 (en) 2004-11-19 2007-09-12 The Regents of the University of California Anti-inflammatory pyrazolopyrimidines
CN102532134A (zh) 2006-01-17 2012-07-04 沃泰克斯药物股份有限公司 适用作詹纳斯激酶抑制剂的吖吲哚类
KR20090017498A (ko) 2006-04-04 2009-02-18 더 리젠트스 오브 더 유니이버시티 오브 캘리포니아 Pi3 키나제 길항물질
EP2124951B1 (en) 2006-12-21 2014-05-21 Vertex Pharmaceuticals Inc. 5-cyan0-4- (pyrrolo[2, 3b]pyridine-3-yl) -pyrimidine derivatives useful as protein kinase inhibitors
WO2009046448A1 (en) 2007-10-04 2009-04-09 Intellikine, Inc. Chemical entities and therapeutic uses thereof
WO2009145814A2 (en) * 2008-03-10 2009-12-03 Vertex Pharmaceuticals Incorporated Pyrimidines and pyridines useful as inhibitors of protein kinases
EP2252293B1 (en) * 2008-03-14 2018-06-27 Intellikine, LLC Kinase inhibitors and methods of use
US8993580B2 (en) 2008-03-14 2015-03-31 Intellikine Llc Benzothiazole kinase inhibitors and methods of use
US20110224223A1 (en) 2008-07-08 2011-09-15 The Regents Of The University Of California, A California Corporation MTOR Modulators and Uses Thereof
BRPI0915231A2 (pt) 2008-07-08 2018-06-12 Intellikine Inc compostos inibidores de quinase e métodos de uso
KR101903354B1 (ko) 2009-06-17 2018-10-04 버텍스 파마슈티칼스 인코포레이티드 인플루엔자 바이러스 복제의 억제제
WO2011047384A2 (en) 2009-10-16 2011-04-21 The Regents Of The University Of California Methods of inhibiting ire1
KR101173678B1 (ko) 2010-10-20 2012-08-13 한국과학기술연구원 피롤로[3,2-c]피리딘 유도체 및 그의 제조 방법
EP2651940A1 (en) 2010-12-16 2013-10-23 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
UA118010C2 (uk) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед Інгібітори реплікації вірусів грипу
WO2013077921A2 (en) 2011-09-02 2013-05-30 The Regents Of The University Of California Substituted pyrazolo[3,4-d]pyrimidines and uses thereof
KR20150061651A (ko) 2012-09-26 2015-06-04 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 Ire1의 조절
TW201536293A (zh) 2013-07-18 2015-10-01 Taiho Pharmaceutical Co Ltd 對fgfr抑制劑具耐受性之癌的治療藥
EP3023100B1 (en) 2013-07-18 2019-03-13 Taiho Pharmaceutical Co., Ltd. Antitumor drug for intermittent administration of fgfr inhibitor
DK3068776T3 (da) 2013-11-13 2019-07-29 Vertex Pharma Inhibitorer af replikation af influenzavira
ES2684755T3 (es) 2013-11-13 2018-10-04 Vertex Pharmaceuticals Incorporated Métodos para preparar inhibidores de la replicación de virus de la gripe
AU2015296210B2 (en) * 2014-07-31 2019-08-15 Merck Patent Gmbh Indolizine derivatives which are applicable to neurodegenerative diseases
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
MX388026B (es) 2016-03-11 2025-03-19 Angel Pharmaceutical Co Ltd Compuestos y métodos para modular la tirosina cinasa de bruton.

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JP4326024B2 (ja) * 1996-03-15 2009-09-02 ノバルティス アクチエンゲゼルシャフト 新規なN―7―ヘテロサイクリル―ピロロ[2,3―d]ピリミジンおよびこれらの使用
EP1025102B1 (en) * 1997-10-20 2004-05-19 F. Hoffmann-La Roche Ag Bicyclic kinase inhibitors
DE69928414T2 (de) * 1998-09-18 2006-08-03 Abbott Gmbh & Co. Kg 4-aminopyrrolopyrimidine als kinaseinhibitoren
TR200101186T2 (tr) * 1998-09-18 2001-10-22 Basf Aktiengesellschaft Protein kinaz engelleyiciler olarak pyrrolopyrimidin'ler
CA2320730A1 (en) 1998-12-23 2000-07-06 Renhua Li Thrombin or factor xa inhibitors
US20040235867A1 (en) * 2001-07-24 2004-11-25 Bilodeau Mark T. Tyrosine kinase inhibitors
US20050026944A1 (en) * 2003-07-24 2005-02-03 Patrick Betschmann Thienopyridine and furopyridine kinase inhibitors
TW200538453A (en) * 2004-04-26 2005-12-01 Bristol Myers Squibb Co Bicyclic heterocycles as kinase inhibitors
WO2006004984A1 (en) * 2004-06-30 2006-01-12 Vertex Pharmaceuticals Incorporated Azaindoles useful as inhibitors of protein kinases
ATE524467T1 (de) * 2005-04-25 2011-09-15 Merck Patent Gmbh Neuartige aza-heterozyklen als kinase-inhibitoren

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Publication number Publication date
US7659283B2 (en) 2010-02-09
JP2009528991A (ja) 2009-08-13
WO2007095223A3 (en) 2010-06-24
CN101848909A (zh) 2010-09-29
WO2007095223A2 (en) 2007-08-23
CA2641254A1 (en) 2007-08-23
EP2004645A2 (en) 2008-12-24
US20070213327A1 (en) 2007-09-13

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