CN101822752A - Quick-acting paste for preventing and treating haemorrhoids and production process thereof - Google Patents
Quick-acting paste for preventing and treating haemorrhoids and production process thereof Download PDFInfo
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- CN101822752A CN101822752A CN201010164702A CN201010164702A CN101822752A CN 101822752 A CN101822752 A CN 101822752A CN 201010164702 A CN201010164702 A CN 201010164702A CN 201010164702 A CN201010164702 A CN 201010164702A CN 101822752 A CN101822752 A CN 101822752A
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Abstract
The invention discloses a quick-acting paste for preventing and treating haemorrhoids and a production process thereof. The product comprises the following components in percentage by weight: 5 to 8 percent of peach branch extract, 5 to 8 percent of clerodendrum bungei extract, 10 to 15 percent of perilla leaf extract, 30 to 40 percent of deioned water, 5 to 8 percent of ethanol, 8 to 10 percent of glycerol, 18 to 25 percent of vaseline and 1 to 2 percent of spice, wherein the peach branch extract is water-soluble dry powder, contains 1 to 1.6 percent of natural plant antibiotic with alkaloid nature, and also contains amyrin, naringenin, persicoside, persicogenin and salipurposide; the clerodendrum bungei contains effective compounds and is colorless wax; and the perilla leaf extract is dry powder and contains 12 organic active components such as alpha-bergamotene, laurolene and beta-sitosterol; therefore, the quick-acting paste has quick effect of eliminating focus and treating both principal and secondary aspect of disease on internal hemorrhoids, external hemorrhoids, rectocele, anal fissure, and anus rotting and dropping.
Description
Technical field the present invention relates to a kind of ZHICHUANG GAO and production technology thereof, particularly a kind of hemorrhoid instant effecting ointment and production technology thereof of preventing and treating.
The hemorrhoid medicine that background technology is sold in the market is more, the accurate word Z42021920 of traditional Chinese medicines number " MAYINGLONGZHICHUANGGAO " that wherein has Wuhan Ma Yinglong drugmaker to produce, and it has mainly adopted artificial Moschus, artificial Calculus Bovis, Borneolum Syntheticum is medicinal raw material.The ZHICHUAN SHUAN that other has France to produce, the treatment that is used for anal hemorrhoid and outer hemorrhoids all has certain alleviation pain due to hemorrhoid and hemorrhage effect.Hemorrhoid are fester feature performances of pertinacious disease of viral cyst (benign tumor), it is obstinate not only, allow the patient when morbidity uneasy in either sitting or lying, pain unbearably, particularly on patient's diet after the bad temper food stimulus, hemorrhoid promptly produce pain, symptom such as hemorrhage, and hemorrhoid to have a heritability gene performance (ancestors patient entails newborn patient of future generation) the most obvious.
Summary of the invention the objective of the invention is to be improved innovation at shortcoming that exists in the background technology and problem, and a kind of hemorrhoid instant effecting ointment and production technology thereof of preventing and treating is provided.
Technical scheme of the present invention: a kind of hemorrhoid instant effecting ointment of preventing and treating, it is characterized in that: it contains following raw materials by weight percent component: Ramulus Persicae extract 5%～8%, Caulis et folium clerodendri bungei extract 5%～8%, Folium perillae extract 10%～15%, deionized water 30%～40%, ethanol 5%～8%, glycerol 8%～10%, vaseline 18%～25%, spice 1%～2%, above raw material components percentage by weight sum is 100%, described Ramulus Persicae extract is a water-soluble dry powder shape thing, the natural plants antibiotic that wherein contains 1%～1.6% alkaloid character, also contain: amyrin, naringenin, the peach glycosides, peach skin element, it is colourless wax that purpurein, described Caulis et folium clerodendri bungei contain effective chemical compound; Contain in the described Folium Perillae: a-bergmot oil alkene, lauro lene, β-Flos Caryophylli alkene, cumfrey, dihydroperilla alcohol, isoegomaketone, ι-limonene, linalool, menthol-b, 1.2-methylene-dioxy-4-methoxyl group-5-pi-allyl-benzene-3-piece-β-D-pyranglucoside, Folium Perillae olefine aldehydr, cupreol are the dried shape thing of water solublity.
A kind of hemorrhoid instant effecting ointment and production technology thereof of preventing and treating, it is characterized in that: the component raw material of following proportioning is stirred, vacuum sterilization, the degassing, canned, contain in the cream: Ramulus Persicae extract 5%～8%, Caulis et folium clerodendri bungei extract 5%～8%, Folium perillae extract 10%～15%, deionized water 30%～40%, ethanol 5%～8%, glycerol 8%～10%, vaseline 18%～25%, spice 1%～2%, above raw material components percentage by weight sum is 100%, described Ramulus Persicae extract is a water-soluble dry powder shape thing, the natural plants antibiotic that wherein contains 1%～1.6% alkaloid character, also contain: amyrin, naringenin, the peach glycosides, peach skin element, it is colourless wax that purpurein, described Caulis et folium clerodendri bungei contain effective chemical compound; Described Folium perillae extract contains: a-bergmot oil alkene, lauro lene, β-Flos Caryophylli alkene, cumfrey, dihydroperilla alcohol, isoegomaketone, ι-limonene, linalool, menthol-b, 1.2-methylene-dioxy-4-methoxyl group-5-pi-allyl-benzene-3-piece-β-D-pyranglucoside, Folium Perillae olefine aldehydr, cupreol.
The present invention has following advantage: the Ramulus Persicae of mainly preparing burden, Caulis et folium clerodendri bungei and Folium Perillae be easy to get, inexpensive, and extraction process is simple, environmental protection; Anus internal hemorrhoid, anus external hemorrhoid, proctoptosis, anal fissure, the tenesmus of rotting there are the focus of eliminating, treating both the principal and secondary aspects of a disease, have immediate effect.
A kind of hemorrhoid instant effecting ointment and production technology thereof of preventing and treating of the specific embodiment, 1), comprises following production stage: with the Ramulus Persicae clean it up, pulverize 80～120 order powders through pulverizer, with the water of 1～10 times of powder weight heating cylinder internal heating 15～30 minutes, 80 ℃～100 ℃ of boiling points, medicinal residues are filtered removal in 15 minutes by centrifuge and promptly get liquid, again medicinal liquid suction spraying drying tower is promptly got the powdered thing; 2), with the Caulis et folium clerodendri bungei clean it up, pulverize 80～120 order powders through pulverizer, with the water of 1～10 times of powder weight heating cylinder internal heating 15～30 minutes, 80 ℃～100 ℃ of boiling points, medicinal residues are filtered removal in 15 minutes by centrifuge and promptly get liquid, again medicinal liquid suction spraying drying tower is promptly got the powdered thing; 3) with the Folium Perillae clean it up, pulverize 80～120 order powders through pulverizer, with the water of 1～10 times of powder weight heating cylinder internal heating 15～30 minutes, 80 ℃～100 ℃ of boiling points, medicinal residues are filtered removal in 15 minutes by centrifuge and promptly get liquid, again medicinal liquid suction spraying drying tower is promptly got the powdered thing; 4), Ramulus Persicae extract, Caulis et folium clerodendri bungei extract, Folium perillae extract, deionized water, ethanol, glycerol, all upward woodss, each component of spice are prepared by above-mentioned percentage by weight, pour them into blender then and stir, vacuum outgas, sterilize, be packaged into product.
Important component raw material Ramulus Persicae of the present invention, Caulis et folium clerodendri bungei and Folium Perillae pharmacological research data show:
1, contained chemical compound composition in the Ramulus Persicae: amyrin, have the antifungal medicinal effects, referring in the SO4 book the 71st page, the chemical compound code name is 737.
2, contain the chemical compound composition in the Ramulus Persicae: naringenin, have antitumor, antibiotic, antiviral, anti-liver poison, antiinflammatory, antioxidation, spasmolytic, function of gallbladder promoting, anticoagulant, 5-hydroxy tryptamine suppresses and histidine decarboxylase suppresses, the medicinal principle of expression of nodulation gene when inducing rhizobium leguminosarum and Semen Pisi sativi symbiosis, referring in the SO4 book the 652nd page, code name 7082.
3, contained bonded composition peach glycosides, purpurein in the Ramulus Persicae, have effects such as antibiotic, antiviral, anticancer, antifertility, blood sugar lowering, blood fat reducing and immunomodulating, cardiovascular system, interrenal system and enzymatic activity all there is tangible physiologically active, referring in the 116th page, SO4 book in the SO5 book the 711st page, code name 7734.
4, contained chemical compound composition in the Ramulus Persicae: peach skin element, referring in the SO4 book the 711st, code 7733.
5, contained chemical constituent in the Caulis et folium clerodendri bungei: colourless wax, have quick antiinflammatory, eliminate cyst, usefulness such as hemostasis, referring in the S04 book the 112nd page, code name: 1168, also contain wind-damp dispelling, blood pressure lowering, pain relieving, rheumatic arthralgia, the equivalence of hypertension pharmacology can, referring to: in the S02 book the 635th page; Contain medicinal principles such as treatment beriberi edema, rheumatic arthritis, carbuncle poison hemorrhoid in the Caulis et folium clerodendri bungei in addition, referring in the S03 book the 269th page.
6, contained chemical compound composition in the Folium Perillae: a-bergmot oil alkene, referring in the S04 book the 97th page, code name: 1004.
7, contained chemical compound composition in the Folium Perillae: lauro lene, have usefulness such as antihypertensive, hyperlipidemia, referring in the S04 book the 123rd page, code name 1295.
8, contained chemical compound composition: β-Flos Caryophylli alkene is natural perfume material in the Folium Perillae, has inhibitor effectiveness, referring in the S04 book the 134th page, and code name: 1415.
9, contained chemical compound composition in the Folium Perillae: cumfrey, referring in the S04 book the 191st page, code name: 2015.
10, contained chemical compound composition in the Folium Perillae: dihydroperilla alcohol, referring in the S04 book the 254th page.
11, contained chemical compound composition in the Folium Perillae: isoegomaketone, referring in the S04 book the 480th page.
12, contained chemical compound composition in the Folium Perillae: ι-limonene, referring in the S04 book the 536th page.
13, contained chemical compound composition in the Folium Perillae: linalool has antibiotic, antifungal, antiviral, calmness, usefulness such as anticorrosion.Referring in the S04 book the 536th page, code name: 5728.
14, contained chemical compound composition: menthol-b in the Folium Perillae is referring in the S04 book the 578th page.
15, contained chemical compound composition in the Folium Perillae: 1.2-methylene-dioxy-4-methoxyl group-5-pi-allyl-benzene-3-piece-B-D-pyranglucoside, have effects such as anticancer, antifertility, blood sugar lowering, blood fat reducing and immunomodulating, cardiovascular system, nervous system, interrenal system and enzymatic activity are all had tangible physiologically active.Referring in the S05 book the 116th page.
16, contained chemical compound composition in the Folium Perillae: the Folium Perillae olefine aldehydr has effects such as sweeting agent.Referring in the S04 book the 710th page, code name: 7722.
17, contained chemical compound composition in the Folium Perillae: cupreol has usefulness such as cough that antitumor, pulmonary carcinoma and adenocarcinoma, antiinflammatory, ammonia causes, resisting hypertension.Referring in the S04 book the 824th page, code name: 8903.
18, contained effective ingredient in the Folium Perillae, have that treatment trusted subordinate distension, expelling pathogenic factors from muscles are delivered, acute mastitis, swell and ache, relieving bowels, promoting the circulation of QI to alleviate the stagnation in middle-JIAO, the sharp lung of expectorant and blood warming middle-JIAO to relieve pain, solving toxin of fish and crab, kill all ichthyosacrotoxins, small piece of land surrounded by water pharmacology usefulness such as disease, incised wound is hemorrhage, trauma is hemorrhage of losing blood, referring among the S06 the 755th page, 756 pages.
The Folium Perillae research and utilization present situation at home and abroad that the present invention adopts:
1, entered since the eighties in 20th century, U.S. scientific circles discover, the a-linolenic acid of Perilla plant species in oils and fats, function of nervous system there is the important activity effect, and find that further this fatty acid has the effect that suppresses cancer and improve allergic constitution, American National ICR in May nineteen ninety (NCD) is focused on research and development utilization with the Folium Perillae herb as anti-cancer food in the health food project
2, in the various constant nutritional labelings of Folium Perillae blade, crude protein content is up to 28%, and the aminoacid kind reaches 18 kinds, belongs to complete protein.
3, the vitamin of Folium Perillae blade, mineral element contain the micro-mineral element of multiple needed by human body, these elements all play an important role at mediator's internal milieu, support and aspects such as participation human body chemical reaction, regulate body temperature and structure sclerous tissues, wherein beta-carotene has important physical and pharmacological function, it can stimulating immune system, improve body immunity, suppress cancer etc.
4, in the contained volatile oil of Folium Perillae the a-linolenic acid have antithrombotic and blood pressure lowering, keep that brain and function of nervous system are normal, prevention canceration and suppress tumor cell and shift, suppress effects such as metamorphosis, property disease, referring in the S07 book the 431st, 432,440 page.
Chemical reaction structural principle of the present invention:
1, contained alkaloid has alkalescence, optical activity and special and significant biological agent in the Ramulus Persicae.Contain 20% alkaloid in the Folium Perillae, alkaloid is the azacyclo-structure that is present in many tools of class complexity of biosphere, and have the alkalescence and a general name that contains organic compound of notable biological activity, alkaloid can combine salify with acid, has complicated circulus, nitrogen-atoms is included in the ring, has optical activity and special and significant biological agent.
2, alkaloidal alkalescence is because contain one or more nitrogen-atoms in their chemical constitution, nitrogen-atoms in the alkaloid is the same with nitrogen-atoms in the amine, has a pair of lone pair electron right, and proton is had certain captivation, so be alkalescence, can combine salify with acid.
3, alkaloidal biological activity is mainly reflected in: the activity of cardiovascular system aspect, anti-tumor activity, parasite killing and parasiticide activity, antibiotic, antiviral activity, and to the activity of digestion Excretory system, to neural effect and separate the spasm activity.
4, the bouvardin of contained alkaloid character is potent alkalescence in the Ramulus Persicae, has antibiotic, antitumor, antiviral, anti-algae, protozoacide, parasiticide and insecticidal action, referring to the 254th, 272,273,280,281,282,116 pages of SO5 books.
The antibiotic scientific basis of natural plants of the alkaloid character that is adopted among the present invention, principle, category:
1, alkaloid is the azacyclo-structure that is present in many tools of class complexity of biosphere, and have the alkalescence and a general name that contains organic compound of notable biological activity, alkaloid can combine salify with acid, has complicated circulus, nitrogen-atoms is included in the ring, has optical activity and special and significant biological agent.
2, the bouvardin of contained alkaloid character in the Ramulus Persicae has antibiotic, antitumor, antiviral, anti-algae, protozoacide, parasiticide and insecticidal action, reduces antibiotics, referring to the 523rd, 524 pages of SO1 books.
Advantage that compared with prior art the present invention had and effect
1, in material medicine Ramulus Persicae of the present invention, Caulis et folium clerodendri bungei and the Folium Perillae under the effective ingredient and alkaloid and mixed chemical pharmacological action of contained multiple antitumor and cancer, at bleeding hemorrhoids hemostasis rapidly, blood stasis dispelling, antiinflammatory, sterilization.
2, medicine of the present invention can be fast to hemorrhoid fester, hemorrhage shape repairs.
3, the present invention to hemorrhoid quick heat clearing away preserve moisture, to hemorrhoid internal hemorrhoid, external hemorrhoid and anal fissure have promoting blood circulation and detumescence, (cyst atrophy) cures to make the anus mixed hemorrhoids, bowel movement is unobstructed, no longer causes bleeding.
4, use the present invention's cyst on the 7th to disappear, sensation of pricking no longer takes place, permanent eliminating focus does not recur.
5, the present invention has quick antiinflammatory, promotes anus body no longer perianal hemorroids, anal fissure, proctoptosis perianal hemorroids, anal fissure, proctoptosis symptom, repairs and shrinks cyst, and restoring stagnates in anus body week tightens.
6, the present invention and blood detumescence, removing the necrotic tissue and promoting granulation are to hemorrhoid, anal fissure symptom that dampness and heat stasis caused and defecate hemorrhage or the pain tenesmus has immediate effect.
Using method of the present invention:
When 1, all generation hemorrhoid (internal hemorrhoid, external hemorrhoid) enlargement, hemorrhage, twinge, pain, notes are advanced device be enclosed within on the product mastic tube head of the present invention, extruding mastic pipe, mastic is got in the anus under pressure, each 0.5～1 gram, antiinflammatory fast, hemostasis, detumescence, sterilization.
2, all anus external hemorrhoids (cyst) embrocate mastic of the present invention in whole cyst, detumescence fast, antiinflammatory, analgesia.
3, all external hemorrhoid (hemorrhoid) is with the broken yellow liquid cyst blood stasis that flows out of acupuncture more than 5 years, and it is better that repaste is wiped product effect of the present invention.
4, all mixed hemorrhoidss are used outside the warm water cleaning anal at every turn greatly after an action of the bowels, use product mastic of the present invention to annotate into or embrocate and get final product.
5, used product of the present invention continuously 7, hemorrhage, pain, twinge, cyst Lock-out are festered, perianal hemorroids, anal fissure, proctoptosis, and the granulation promoting of rotting is repaired complete, and gets rid of focus.
The actual clinical test of product of the present invention:
In January, 2006, drug moiety of the present invention and chemical formulation are entrusted synthetic 50,000 of the Chinese of Yingde City, Guangdong bio tech ltd processing, respectively anus mixed hemorrhoids, perianal hemorroids, anal fissure, hemorrhage, proctoptosis patient are implemented to use, effective percentage reaches more than 98%, and observation in 4 years does not find that the patient has pathologic rebound phenomenon or malaise symptoms to take place.
Attached bibliography
S01: " biochemistry " Wang Jingyan chief editor, Higher Education Publishing House, in April, 1980 front page, in April, 2004 the third printing.
S02: " Chinese herbal medicine color atlas " Xu Guojun writes, Fujian science tech publishing house, in May, 2006 third edition the third printing.
S03: published in 1969 at " North Guangdong medical herbs book " Shaoguan, Guangdong Province prefecture revolutionary committee and sanitary work station, prefecture, Shaoguan.
S04: " the former plant chemical ingredient handbook of Chinese medicine Chemical Industry Press in JIUYUE, 2004 is published, the Zhou Jiaju chief editor.
S05: " plant chemical ingredient " Chemical Industry Press, in JIUYUE, 2004, Chen Yegao chief editor.
S06: Compendium of Material Medica Nanjing version, the People's Health Publisher publishes in November, 1999.
S07: " plant resource explorations research and application " Zhang Weimin etc. is write the first impression in 2005 of publishing house of Southeast China University.
Claims (2)
1. prevent and treat the hemorrhoid instant effecting ointment for one kind, it is characterized in that: it contains following raw materials by weight percent component: Ramulus Persicae extract 5%～8%, Caulis et folium clerodendri bungei extract 5%～8%, Folium perillae extract 10%～15%, deionized water 30%～40%, ethanol 5%～8%, glycerol 8%～10%, vaseline 18%～25%, spice 1%～2%, above raw material components percentage by weight sum is 100%, described Ramulus Persicae extract is a water-soluble dry powder shape thing, the natural plants antibiotic that wherein contains 1%～1.6% alkaloid character, also contain: amyrin, naringenin, the peach glycosides, peach skin element, it is colourless wax that purpurein, described Caulis et folium clerodendri bungei contain effective chemical compound; Contain in the described Folium Perillae extracted dry powder: a-bergmot oil alkene, lauro lene, β-Flos Caryophylli alkene, cumfrey, dihydroperilla alcohol, isoegomaketone, ι-limonene, linalool, menthol-b, 1.2-methylene-dioxy-4-methoxyl group-5-pi-allyl-benzene-3-piece-β-D-pyranglucoside, Folium Perillae olefine aldehydr, cupreol.
2. production technology of preventing and treating the hemorrhoid instant effecting ointment, it is characterized in that: the component raw material of following proportioning is stirred, vacuum sterilization, it is canned to outgas, contain in the cream: Ramulus Persicae extract 5%～8%, Caulis et folium clerodendri bungei extract 5%～8%, Folium perillae extract 10%～15%, deionized water 30%～40%, ethanol 5%～8%, glycerol 8%～10%, vaseline 18%～25%, spice 1%～2%, above raw material components percentage by weight sum is 100%, described Ramulus Persicae extract is a water-soluble dry powder shape thing, the natural plants antibiotic that wherein contains 1%～1.6% alkaloid character, also contain: amyrin, naringenin, the peach glycosides, peach skin element, it is colourless wax that purpurein, described Caulis et folium clerodendri bungei contain effective chemical compound; Described Folium Perillae extracted dry powder: a-bergmot oil alkene, lauro lene, β-Flos Caryophylli alkene, cumfrey, dihydroperilla alcohol, isoegomaketone, ι-limonene, linalool, menthol-b, 1.2-methylene-dioxy-4-methoxyl group-5-pi-allyl-benzene-3-piece-β-D-pyranglucoside, Folium Perillae olefine aldehydr, cupreol.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021531251A (en) * | 2018-07-05 | 2021-11-18 | クラリアント・インターナシヨナル・リミテツド | Antibacterial combination composition comprising a glycerol derivative and a reciprocal compound |
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2010
- 2010-04-28 CN CN201010164702A patent/CN101822752A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2021531251A (en) * | 2018-07-05 | 2021-11-18 | クラリアント・インターナシヨナル・リミテツド | Antibacterial combination composition comprising a glycerol derivative and a reciprocal compound |
| JP7404281B2 (en) | 2018-07-05 | 2023-12-25 | クラリアント・インターナシヨナル・リミテツド | Antimicrobial combination composition comprising a glycerol derivative and a dicyclic compound |
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Open date: 20100908 |