CN101822702A - Oral preparation for easing fatigue and preparation method thereof - Google Patents
Oral preparation for easing fatigue and preparation method thereof Download PDFInfo
- Publication number
- CN101822702A CN101822702A CN200910113079A CN200910113079A CN101822702A CN 101822702 A CN101822702 A CN 101822702A CN 200910113079 A CN200910113079 A CN 200910113079A CN 200910113079 A CN200910113079 A CN 200910113079A CN 101822702 A CN101822702 A CN 101822702A
- Authority
- CN
- China
- Prior art keywords
- water
- parts
- oral formulations
- panacis quinquefolii
- add
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses an oral preparation for easing fatigue and a preparation method thereof. The oral preparation consists of an effective quantity of active ingredient for easing fatigue and/or a pharmaceutically acceptable carrier, wherein the active ingredient is prepared with the following raw materials according to the weight ratio: 20-30 parts of American ginseng liquid extract with the relative density being 1.15-1.20, 1-5 part(s) of pseudo-ginseng and 3-8 parts of honey. Since the American ginseng is mixed with the pseudo-ginseng and the honey compatibility for use, the invention has excellent anti-fatigue health care effect, and the anti-fatigue effect of the invention is obviously superior to that of similar products on the market which simply adopt the American ginseng as the main raw material.
Description
Technical field
The present invention relates to a kind of oral formulations and preparation method thereof, relate to a kind of oral formulations that is used for fatigue alleviating and preparation method thereof particularly.
Background technology
The modern lives a fast and stressful life, owing to can not get sufficient rest for a long time, health is in the fatigue state of overwork, and fatigue is the unbalance relatively performances of energy and blood of human body negative and positive, need take good care of oneself by food, many-sides such as time balanced nutritious, that arrange work and have a rest with striking a proper balance between work and rest come comprehensive adjustment.If human body is in fatigue state for a long time, not only reduce work efficiency, and can cause body immunity to descend, cause various diseases.At present the oral liquid or the medicine of the fatigue alleviating of using comprise biology, chemistry and Chinese medicine preparation, this wherein, the use with Chinese medicine preparation is the most extensive again.Yet, mix in numerous oral liquid good and the bads, there is the irrational problem of prescription in part oral liquid, as add the medicine of a large amount of blood-enriching qi-invigoratings, and get angry easily after taking, cause aphtha of the mouth and tongue, and cause symptoms such as constipation, or add such as nervous stimulants such as caffeine, tea polyphenols, make health be in excitatory state, do not play the effect of alleviation, allaying tiredness veritably.
Summary of the invention
The objective of the invention is to a kind of oral formulations that is used for fatigue alleviating.
Another object of the present invention provides a kind of preparation method of oral formulations.
In order to reach above-mentioned purpose, solution of the present invention is:
A kind of oral formulations that is used for fatigue alleviating, it is made up of fatigue alleviating effective amount of actives and/or pharmaceutically acceptable carrier, it is characterized in that, described active component is prepared by following materials of weight proportions: relative density is 20～30 parts of 1.15～1.20 Radix Panacis Quinquefolii fluid extracts (60 ℃), 3～8 parts of 1～5 part of Radix Notoginseng and Mel.
The preferred weight proportioning of preparation active component of the present invention is: relative density is 6 parts of 1.15～1.20 25 parts of Radix Panacis Quinquefolii fluid extracts (60 ℃), 3 parts of Radix Notoginseng and Mel.
Described carrier includes but not limited to solvent and sweeting agent for oral liquid, and described solvent can be water, organic solvent such as glycerol or glycols such as Polyethylene Glycol, or the mixture of the different proportion of these organic solvents in water; Described sweeting agent can be at least a in sucrose, glucose or the aspartame etc.
Preferably, described solvent is a water, and described sweeting agent is a glucose.
Described carrier is for tablet, buccal tablet, effervescent tablet or granule, include but not limited to filler, disintegrating agent, binding agent, wetting agent, lubricant, described filler is starch, dextrin, lactose, sucrose, Icing Sugar, microcrystalline Cellulose, glucose, meglumine, glucosamine, mannitol, calcium sulfate or calcium bisulfate; Disintegrating agent is hyprolose, carboxymethyl starch sodium, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose or crosslinked hydroxypropyl methylcellulose; Binding agent is hydroxypropyl methylcellulose sodium or polyvidone; Wetting agent is water or ethanol; Lubricant is magnesium stearate or Pulvis Talci.
In the further embodiment of the present invention, the step that obtains the Radix Panacis Quinquefolii fluid extract is as follows: Radix Panacis Quinquefolii is tentatively broken, soaked into 1～2 day with 50%～80% ethanol, in the diafiltration jar of then packing into 50%～80% alcohol dipping 3～5 days, the first filtrate of collection; Add 50%～80% ethanol again and soak into after 1～2 day in filtering residue, collect filtrate, merge filtrate twice, filter and be placed in the concentrating under reduced pressure jar, at 0.06～0.09Mpa, being concentrated into the solution relative density under 75～90 ℃ is 1.15～1.20 (60 ℃).Among the present invention, soak into or flood employed ethanol dosage and be not advisable to have Radix Panacis Quinquefolii.
The preparation method of above-mentioned oral liquid comprises following step:
1) getting relative density by weight ratio is 3～8 parts of 1.15～1.20 20～30 parts of Radix Panacis Quinquefolii fluid extracts (60 ℃), 1～5 part of Radix Notoginseng, 3～8 parts of Mel and glucoses;
2) Radix Notoginseng is tentatively broken, decoct with water secondary, add the water of 5～8 times of amounts for the first time, decoct 2～3 hours after-filtration, collect filtrate; Add for the second time the water of 4～7 times of amounts, decoct 1～2 hour after-filtration, collect the filtrate extracting solution; Merge filtrate twice, standby;
3) in jacketed pan, add 200～300 parts of purified water, Mel and glucose are added wherein heating for dissolving; Then add Radix Panacis Quinquefolii fluid extract, Radix Notoginseng extracting solution, continue heated and boiled 4～8min, to be cooled during to 75～85 ℃ by diatomite filter and/or plate and frame filter, filtrate is put storage tank, and is standby;
4) fill, Zha Gai, sterilization obtain product.
Need to prove that employed purified water obtains by following mode among the present invention: municipal Drinking Water is through activated carbon filtration, through 3 μ, 1 μ filter secondary filter, adopts the reverse osmosis purified water device to handle again, after ultraviolet sterilization obtain.Can remove water pollutants such as colloidal substance, antibacterial, virus, silicon dioxide and various neutral particles in the water body by above-mentioned means.
The application dosage of oral formulations is the fatigue alleviating effective dose, its can according to age of consumer, body weight, and condition etc. do accommodation, its daily dose can be 0.01～100mg/kg by Radix Panacis Quinquefolii saponin, is preferably 0.05～10mg/kg, and can use by one or many in one day.
Unless name especially, the implication of employed here all technology and scientific terminology is identical with the common implication of understanding of the technical field of the invention those skilled in the art.Equally, all publication, patent application, patent and other reference materials are all introduced the present invention as a reference referred in this.
According to record in " Records of Tradition Chinese and Western Medicine in Combination ", Radix Panacis Quinquefolii has " can subsidize edema caused by disorder of QI, and can tonification blood system "; And according to " Chinese Medicine voluminous dictionary " record, Radix Notoginseng " function is enriched blood, and blood stasis removing decreases, and the hemostasis nosebleed can be led to and can be mended, and effect is the best, the most precious person in the side's of being medicine "; According to another Compendium of Material Medica record, Mel " merit of being used as medicine has five, heat clearing away also, invigorating middle warmer also, detoxifcation is also moisturized also, pain relieving also.Living then cool in nature, Gu the energy heat clearing away; Ripe then warm in nature, so the energy invigorating middle warmer; Sweet and gentle, so can detoxify; Soften and Ru Ze, so can moisturize; Delay and to go urgency, so can end pain of trusted subordinate's muscle skin infection; In can causing, thus can be in harmonious proportion hundred medicines, and with the same merit of Radix Glycyrrhizae ".The present invention uses Radix Panacis Quinquefolii and Radix Notoginseng and Mel compatibility, makes it have splendid anti-fatigue health-caring effect, its anti-fatigue effect obviously be better than on the market some be merely the like product of primary raw material with the Radix Panacis Quinquefolii.
The specific embodiment
Embodiment 1
1) gets municipal Drinking Water,, adopt the reverse osmosis purified water device to handle again, after ultraviolet sterilization obtains purified water successively through active carbon, 3 μ, 1 μ filter secondary filter;
2) Radix Panacis Quinquefolii is tentatively broken, soak into 1 day (soaking into or flood employed ethanol dosage was not advisable to have Radix Panacis Quinquefolii) with 50% ethanol, in the diafiltration jar of then packing into 50% alcohol dipping 5 days, filtrate at the beginning of the collection; In filtering residue, add 50% ethanol again and soak into after 1 day, collect filtrate, merge filtrate twice, filter and be placed in the concentrating under reduced pressure jar,, be concentrated into the solution relative density under 75 ℃ and be 1.15 Radix Panacis Quinquefolii fluid extract (60 ℃) at 0.06Mpa;
3) get Radix Panacis Quinquefolii fluid extract 3000g, Radix Notoginseng 100g, Mel 500g and glucose 500g;
4) Radix Notoginseng is tentatively broken, decoct with water secondary, add the water of 5 times of amounts for the first time, decoct 3 hours after-filtration, collect filtrate; Add for the second time the water of 4 times of amounts, decoct 1 hour after-filtration, collect the filtrate extracting solution; Merge filtrate twice, standby;
5) purified water of adding 20Kg in jacketed pan adds wherein heating for dissolving with Mel and glucose; Then add Radix Panacis Quinquefolii fluid extract, Radix Notoginseng extracting solution, continue heated and boiled 4min, to be cooled during to 75 ℃ by diatomite filter and/or plate and frame filter, filtrate is put storage tank, obtains light yellow liquid, and is standby;
6) fill, Zha Gai, sterilization: in the GMP workshop of 300,000 grades of cleanliness factors, get cleaning, the oven dry after medicinal glass bottle, in every bottle of 30mL fill of automatic filling machine, Zha Gai; The vehicle of sterilization of then packing into advances cabinet; High temperature sterilize is 20 minutes in 115～120 ℃, the steam of pressure 0.06Mpa, offer for sale after the blood pressure lowering cooling, and water rinsing bottle wall, lamp inspection, outer package obtains product.
Embodiment 2
1) gets municipal Drinking Water,, adopt the reverse osmosis purified water device to handle again, after ultraviolet sterilization obtains purified water successively through active carbon, 3 μ, 1 μ filter secondary filter;
2) Radix Panacis Quinquefolii is tentatively broken, soak into 2 days (soaking into or flood employed ethanol dosage was not advisable to have Radix Panacis Quinquefolii) with 80% ethanol, in the diafiltration jar of then packing into 80% alcohol dipping 3 days, filtrate at the beginning of the collection; In filtering residue, add 80% ethanol again and soak into after 2 days, collect filtrate, merge filtrate twice, filter and be placed in the concentrating under reduced pressure jar,, be concentrated into the Radix Panacis Quinquefolii fluid extract that the solution relative density is 1.20 (60 ℃) under 90 ℃ at 0.09Mpa;
3) get Radix Panacis Quinquefolii fluid extract 2000g, Radix Notoginseng 500g, Mel 300g and glucose 300g;
4) Radix Notoginseng is tentatively broken, decoct with water secondary, add the water of 8 times of amounts for the first time, decoct 2 hours after-filtration, collect filtrate; Add for the second time the water of 7 times of amounts, decoct 2 hours after-filtration, collect the filtrate extracting solution; Merge filtrate twice, standby;
5) purified water of adding 30Kg in jacketed pan adds wherein heating for dissolving with Mel and glucose; Then add Radix Panacis Quinquefolii fluid extract, Radix Notoginseng extracting solution, continue heated and boiled 8min, to be cooled during to 85 ℃ by diatomite filter and/or plate and frame filter, filtrate is put storage tank, obtains light yellow liquid, and is standby;
6) fill, Zha Gai, sterilization: in the GMP workshop of 300,000 grades of cleanliness factors, get cleaning, the oven dry after medicinal glass bottle, in every bottle of 30mL fill of automatic filling machine, Zha Gai; The vehicle of sterilization of then packing into advances cabinet; High temperature sterilize is 20 minutes in 115～120 ℃, the steam of pressure 0.06Mpa, offer for sale after the blood pressure lowering cooling, and water rinsing bottle wall, lamp inspection, outer package obtains product.
Embodiment 3
1) gets municipal Drinking Water,, adopt the reverse osmosis purified water device to handle again, after ultraviolet sterilization obtains purified water successively through active carbon, 3 μ, 1 μ filter secondary filter;
2) Radix Panacis Quinquefolii is tentatively broken, soak into 1 day (soaking into or flood employed ethanol dosage was not advisable to have Radix Panacis Quinquefolii) with 70% ethanol, in the diafiltration jar of then packing into 70% alcohol dipping 3 days, filtrate at the beginning of the collection; In filtering residue, add 70% ethanol again and soak into after 1 day, collect filtrate, merge filtrate twice, filter and be placed in the concentrating under reduced pressure jar,, be concentrated into the Radix Panacis Quinquefolii fluid extract that the solution relative density is 1.20 (60 ℃) under 85 ℃ at 0.08Mpa;
3) get Radix Panacis Quinquefolii fluid extract 2500g, Radix Notoginseng 300g, Mel 600g and glucose 600g;
4) Radix Notoginseng is tentatively broken, decoct with water secondary, add the water of 6 times of amounts for the first time, decoct 2 hours after-filtration, collect filtrate; Add for the second time the water of 5 times of amounts, decoct 1 hour after-filtration, collect the filtrate extracting solution; Merge filtrate twice, standby;
5) purified water of adding 25Kg in jacketed pan adds wherein heating for dissolving with Mel and glucose; Then add Radix Panacis Quinquefolii fluid extract, Radix Notoginseng extracting solution, continue heated and boiled 5min, to be cooled during to 80 ℃ by diatomite filter and/or plate and frame filter, filtrate is put storage tank, obtains light yellow liquid, and is standby;
6) fill, Zha Gai, sterilization: in the GMP workshop of 300,000 grades of cleanliness factors, get cleaning, the oven dry after medicinal glass bottle, in every bottle of 30mL fill of automatic filling machine, Zha Gai; The vehicle of sterilization of then packing into advances cabinet; High temperature sterilize is 20 minutes in 115～120 ℃, the steam of pressure 0.06Mpa, offer for sale after the blood pressure lowering cooling, and water rinsing bottle wall, lamp inspection, outer package obtains product.
The test example
The oral liquid that makes among 1.1 sample: embodiment 1, embodiment 2 and the embodiment 3.
1.2 laboratory animal: the healthy male white mouse of the ICR that Chinese Academy of Sciences's Shanghai Experimental Animal Center provides, the quality certification: No. the 003rd, the moving pipe of the Chinese Academy of Sciences, body weight 18～21g.This experiment is divided into four groups with animal and (uses embodiment 1 oral liquid for 1 group, carry out the swimming with a load attached to the body test; Use embodiment 3 oral liquids for 2 groups, carry out the serum urea nitrogen test; Use embodiment 2 oral liquids for 3 groups, carry out the hepatic glycogen test; Use embodiment 3 oral liquids for 4 groups, carry out the test of blood lactic acid), every group of each 50 animal.
1.3 dosage is selected: this sample human body day recommended amounts is 60ml, be equivalent to the 1.0mL/kg body weight, (human body is with the 60kg weighing machine) establishes three dosage groups by 5 times, 10 times, 20 times of recommended amounts, be respectively the 5.0mL/kg body weight, 10.0mL/kg body weight and 20.0mL/kg body weight.Other establishes the negative matched group of distilled water and is equivalent to the sugared matched group of middle dosage group glucose, Mel content.
1.4 route of administration: animal is weighed every day, and per os is irritated stomach, continuous 30 days, the dosage group of 5.0mL/kg and 10.0mL/kg body weight is assigned to desired concn with distilled water, and press 20mL/kg body weight per os filling stomach.
1.5 instrument and reagent: swimming case (50*50*40cm), electronic balance (food is defended section No. 008), sheet lead, 722 grating spectrophotometers (food is defended section No. 021), Hitachi's 7060 type automatic clinical chemistry analyzers (food is defended section No. 257), YS1500 lactate analyzer (food is defended section No. 189).Blood lactic acid reagent is available from U.S. YSI Inc., and blood urea nitrogen reagent is available from Shen, Shanghai energy-DESAY company limited; Concentrated sulphuric acid; 5% trichloroacetic acid (TCA), glucose titer 0.1g/dL, anthrone reagent.
1.6 experimental data statistical method: experimental data is carried out one factor analysis of variance with SPSS software.Through the variance test of homogeneity, the neat experimental data of variance adopts the LSD method to carry out statistical analysis, heterogeneity of variance or nonnormal experimental data is carried out the variable conversion add up.
1.7 test method:
1.7.1 swimming with a load attached to the body test:
After last was tried thing 30min, the load sheet lead of 5% body weight of mouse tail was put into depth of water 30cm, in the swimming case that water temperature is 25 ± 1.0 ℃.The record mice is from the extremely dead time of swimming beginning, as the mice swimming time.
1.7.2 serum urea nitrogen determination:
After last is tried thing 30min,, pull out eyeball behind the rest 60min and adopt the about 0.5mL of whole blood at not swimming with a load attached to the body of the water tank 90min of 30 ℃ of temperature.Put 4 ℃ of about 3h of refrigerator, the centrifugal 15min of 2000rpm gets upper serum and measures with full automatic biochemical apparatus behind the hemopexis.
1.7.3 hepatic glycogen is measured:
After last is tried thing 30min, put to death animal, get liver after the normal saline rinsing, blot with filter paper, accurately take by weighing liver 100mg, add 8mLTCA liquid, every pipe homogenate 1min, pour homogenate into centrifuge tube, with the centrifugal 15min of 3000rpm, supernatant is transferred to another in vitro, get the 1mL supernatant and put into the 10mL centrifuge tube, every pipe adds 95% ethanol 4mL, does not fully leave the interface between mixing to two liquid.Stopper back setting under room temperature is beyond the Great Wall placed and is spent the night.After precipitation was complete, the centrifugal 15min of 3000rpm went to be inverted 10min behind the supernatant, with 2mL dissolved in distilled water glycogen, used anthrone method at 620nm wavelength colorimetric determination hepatic glycogen.
1.7.4 blood lactic acid is measured:
After last was tried thing 30min, the vena ophthalmica 20 μ l that take a blood sample put into 30 ℃ of water of water temperature immediately and swim, and put into 1 every 1min, took out immediately behind the swimming 10min, dried moisture, each 20 μ l that take a blood sample, behind the quiet 20min at blood sampling 20 μ l.The rupture of membranes liquid of each blood of adopting being put into 40 μ l vibrates, and after the vibration evenly, measures blood lactic acid in YSI-1500 type blood lactic acid analyzer.
The result:
One, this sample is to the influence of mice body weight:
Table one embodiment 1 oral liquid to the influence of 1 group of mice body weight (x ± S, g)
P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table 1, this sample is respectively organized the weight increase value of mice does not have significance (P＞0.05) through variance analysis difference.Promptly this sample does not have influence to the body weight gain of mice.
Table two embodiment 2 oral liquids to the influence of 2 groups of mice body weight (x ± S, g)
P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table 2, this sample is respectively organized the weight increase value of mice does not have significance (P＞0.05) through variance analysis difference.Promptly this sample does not have influence to the body weight gain of mice.
Table three embodiment 3 oral liquids to the influence of 3 groups of mice body weight (x ± S, g)
P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table 3, this sample is respectively organized the weight increase value of mice does not have significance (P＞0.05) through variance analysis difference.Promptly this sample does not have influence to the body weight gain of mice.
Two, to the influence of mice swimming with a load attached to the body time
Table four embodiment 1 oral liquid is to the influence of mice swimming heavy burden time (x ± S)
*Compare P＜0.01 with the water matched group;
#Compare P＜0.05 with sugared matched group; P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table four, this sample can prolong the middle and high dosage mice swimming with a load attached to the body time, compares with the water matched group, and difference is highly significant (P＜0.01); Compare with sugared matched group, difference is significance (P＜0.05).
The influence of serum urea nitrogen during three, to mouse movement
The influence of table five embodiment 3 oral liquids serum urea nitrogen during to mouse movement (x ± S)
*Compare P＜0.01 with the water matched group;
*Compare P＜0.01 with the water matched group;
#Compare P＜0.05 with sugared matched group;
##Compare P＜0.01 with sugared matched group; P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table five, the content of the serum urea nitrogen that produces during the low dose group mouse movement during this sample makes reduces, and low dose group is compared with water, sugared matched group, and difference is highly significant (P＜0.01); Middle dosage group is compared with water, sugared matched group, and difference is significance (P＜0.05).
Four, to the influence of Mouse Liver glycogen content
Table six embodiment 2 oral liquids are to the influence of Mouse Liver glycogen content (x ± S)
P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table six, the hepatic glycogen content of each dosage group mice of this sample is compared with water, sugared matched group, and difference does not have significance (P＞0.05).
Five, to the influence of three time point blood of mice lactic acid area under curve
Table seven embodiment 3 oral liquids are to the influence of three time point blood of mice lactic acid area under curve (x ± S)
*Compare P＜0.01 with the water matched group;
*Compare P＜0.01 with the water matched group;
##Compare P＜0.01 with sugared matched group; P
Water: with the P value of water matched group after relatively; P
Sugar: with the P value of sugared matched group after relatively
As shown in table 7, this sample reduces the blood lactic acid area under curve of high dose group mice, compares with water, sugared matched group, and difference is highly significant (P＜0.01).
To sum up, the oral liquid that per os filling stomach gives to make among the embodiment 1,2 or 3 of mice various dose carried out the swimming with a load attached to the body test after 30 days, and the result can prolong the mice swimming with a load attached to the body time; The content of the serum urea nitrogen that produces when making mouse movement reduces; Mice blood lactic acid area under curve is reduced; Weight of mice there is not influence.Illustrate that this sample has effect of relieving physical fatigue.
The foregoing description is a preferred implementation of the present invention; but embodiments of the present invention are not restricted to the described embodiments; other any do not deviate from change, the modification done under spirit of the present invention and the principle, substitutes, combination, simplify; all should be the substitute mode of equivalence, be included within protection scope of the present invention.
Claims (7)
1. oral formulations that is used for fatigue alleviating, it is made up of fatigue alleviating effective amount of actives and/or pharmaceutically acceptable carrier, it is characterized in that, described active component is prepared by following materials of weight proportions: relative density is 20～30 parts of 1.15～1.20 Radix Panacis Quinquefolii fluid extracts, 3～8 parts of 1～5 part of Radix Notoginseng and Mel.
2. according to the oral formulations that is used for fatigue alleviating described in the claim 1, it is characterized in that described active component is preferably by the preparation of following materials of weight proportions: relative density is 6 parts of 1.15～1.20 3 parts of 25 parts of Radix Panacis Quinquefolii fluid extracts, Radix Notoginseng and Mel.
3. according to the oral formulations that is used for fatigue alleviating described in claim 1 or 2, it is characterized in that: described oral formulations is an oral liquid, it includes but not limited to solvent and sweeting agent described carrier, described solvent is water, organic solvent such as glycerol or glycols such as Polyethylene Glycol, or the mixture of the different proportion of these organic solvents in water; Described sweeting agent is at least a in sucrose, glucose or the aspartame.
4. according to the oral formulations that is used for fatigue alleviating described in the claim 3, it is characterized in that: described solvent is a water, and described sweeting agent is a glucose.
5. according to the oral formulations that is used for fatigue alleviating described in claim 1 or 2, it is characterized in that: described oral formulations is tablet, buccal tablet, effervescent tablet or granule, described carrier includes but not limited to filler, disintegrating agent, binding agent, wetting agent, lubricant, and described filler is starch, dextrin, lactose, sucrose, Icing Sugar, microcrystalline Cellulose, glucose, meglumine, glucosamine, mannitol, calcium sulfate or calcium bisulfate; Disintegrating agent is hyprolose, carboxymethyl starch sodium, polyvinylpolypyrrolidone, cross-linking sodium carboxymethyl cellulose or crosslinked hydroxypropyl methylcellulose; Binding agent is hydroxypropyl methylcellulose sodium or polyvidone; Wetting agent is water or ethanol; Lubricant is magnesium stearate or Pulvis Talci.
6. according to the oral formulations that is used for fatigue alleviating described in claim 1 or 2, it is characterized in that: the step that obtains described Radix Panacis Quinquefolii fluid extract is as follows: Radix Panacis Quinquefolii is tentatively broken, soaked into 1～2 day with 50%～80% ethanol, then pack in the diafiltration jar with 50%～80% alcohol dipping 3～5 days, collect filtrate just; Add 50%～80% ethanol again and soak into after 1～2 day in filtering residue, collect filtrate, merge filtrate twice, filter and be placed in the concentrating under reduced pressure jar, at 0.06～0.09Mpa, being concentrated into the solution relative density under 75～90 ℃ is 1.15～1.20.
7. the preparation method of the oral formulations that is used for fatigue alleviating of claim 4 comprises following step:
1) getting relative density by weight ratio is 1.15～1.20 3～8 parts of 1～5 part of 20～30 parts of Radix Panacis Quinquefolii fluid extracts, Radix Notoginseng, Mel, 3～8 parts of glucoses;
2) Radix Notoginseng is tentatively broken, decoct with water secondary, add the water of 5～8 times of amounts for the first time, decoct 2～3 hours after-filtration, collect filtrate; Add for the second time the water of 4～7 times of amounts, decoct 1～2 hour after-filtration, collect the filtrate extracting solution; Merge filtrate twice, standby;
3) in jacketed pan, add 200～300 parts purified water, Mel and sweeting agent are added wherein heating for dissolving; Then add Radix Panacis Quinquefolii fluid extract, Radix Notoginseng extracting solution, continue heated and boiled 4～8min, to be cooled during to 75～85 ℃ by diatomite filter and/or plate and frame filter, filtrate is put storage tank, and is standby;
4) fill, Zha Gai, sterilization obtain product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101130798A CN101822702B (en) | 2009-12-17 | 2009-12-17 | Oral preparation for easing fatigue and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2009101130798A CN101822702B (en) | 2009-12-17 | 2009-12-17 | Oral preparation for easing fatigue and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101822702A true CN101822702A (en) | 2010-09-08 |
| CN101822702B CN101822702B (en) | 2013-03-06 |
Family
ID=42687005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2009101130798A Expired - Fee Related CN101822702B (en) | 2009-12-17 | 2009-12-17 | Oral preparation for easing fatigue and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101822702B (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475730A (en) * | 2010-11-25 | 2012-05-30 | 福建省泉州亚泰制药有限公司 | Medicine for treating male infertility and preparation method for medicine |
| CN104970369A (en) * | 2015-08-05 | 2015-10-14 | 海南正康药业有限公司 | Health food capable of enhancing immunity and preparation method of health food |
| CN105147751A (en) * | 2015-08-31 | 2015-12-16 | 孙太辉 | Skin nutrition drug with skin care, radiation resistance, cold resistance and temperature resistance functions and preparation method of skin nutrition drug |
| CN111480843A (en) * | 2020-04-29 | 2020-08-04 | 斯必利药业(厦门)有限公司 | American ginseng and pseudo-ginseng oral liquid and preparation process thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101142976A (en) * | 2007-10-29 | 2008-03-19 | 刘胜群 | American ginseng and honey composition and preparation method thereof |
-
2009
- 2009-12-17 CN CN2009101130798A patent/CN101822702B/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101142976A (en) * | 2007-10-29 | 2008-03-19 | 刘胜群 | American ginseng and honey composition and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 梁坚,李彬,何为涛,等: "《中国临床保健杂志》", 《三七口服液调脂作用的研究》 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102475730A (en) * | 2010-11-25 | 2012-05-30 | 福建省泉州亚泰制药有限公司 | Medicine for treating male infertility and preparation method for medicine |
| CN104970369A (en) * | 2015-08-05 | 2015-10-14 | 海南正康药业有限公司 | Health food capable of enhancing immunity and preparation method of health food |
| CN105147751A (en) * | 2015-08-31 | 2015-12-16 | 孙太辉 | Skin nutrition drug with skin care, radiation resistance, cold resistance and temperature resistance functions and preparation method of skin nutrition drug |
| CN111480843A (en) * | 2020-04-29 | 2020-08-04 | 斯必利药业(厦门)有限公司 | American ginseng and pseudo-ginseng oral liquid and preparation process thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN101822702B (en) | 2013-03-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101822702B (en) | Oral preparation for easing fatigue and preparation method thereof | |
| CN103194360A (en) | Medicinal liquor with healthcare function as well as preparation method and application thereof | |
| CN100546615C (en) | Be used for the treatment of Chinese medicine composition of cerebrovascular and preparation method thereof | |
| CN1720943A (en) | A kind of medicinal composition for the treatment of hyperuricemia and urate nephropathy | |
| CN103285218B (en) | Traditional Chinese medicine compound for treating spleen and kidney yang deficiency type constipation | |
| CN101468152A (en) | Chinese medicine foot-bathing agent for treating hypertension and technique for preparing the same | |
| CN103977390B (en) | A kind of preparation method and its usage of ginger onion medicated wine composition | |
| CN105434738A (en) | Traditional Chinese medicine composition for treating ADHD (Attention Deficit Hyperactivity Disorder) and preparation method thereof | |
| CN101732585A (en) | Medicinal composition for treating migraine, preparation method and application thereof | |
| CN108721431A (en) | A kind of Chinese medicine composition of re-scheduling metal and its application | |
| CN104623314A (en) | Medicine composition for treating dry mouth and bitter taste and preparation method thereof | |
| CN103860706A (en) | Health-care pure traditional Chinese medicinal preparation with alcoholic liver injury protecting function | |
| CN100453108C (en) | Chinese medicine composition with nourishing health function and its preparing method | |
| CN103585495B (en) | Capsule for treating diabetic kidney damage | |
| CN102861192B (en) | Medicine composition for chronic renal failure and peritoneal fibrosis | |
| CN102274428B (en) | Pharmaceutical composition with effect on treating irritable bowel syndrome and preparation method and application thereof | |
| CN102228596B (en) | Pharmaceutical composition and preparation and applications thereof in treating coronary heart disease and angina pectoris | |
| CN101926899B (en) | Health-care medicament for hyperlipemia and preparation method thereof | |
| CN112826901A (en) | Medicine for quickly relieving senile dementia symptoms | |
| CN100581566C (en) | Chinese medicine preparation for treating arrhythmia | |
| CN104606636B (en) | A kind of Chinese medicine composition for treating depression and preparation method thereof | |
| CN109363182A (en) | A kind of food and medicament dual-purpose composition of postpartum enriching yin qi-restoratives and preparation method thereof | |
| CN1695715A (en) | Medication for treating dementia in blood vessel type, and preparation method | |
| CN103877223B (en) | A kind of pharmaceutical composition and application thereof for the treatment of oral candidiasis | |
| CN113476542B (en) | Application of composition in preparation of medicines and kits |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130306 Termination date: 20151217 |
|
| EXPY | Termination of patent right or utility model |