CN101810797B - Chinese medicinal preparation for curing psoriasis and preparation method thereof - Google Patents
Chinese medicinal preparation for curing psoriasis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal preparation for curing psoriasis and a preparation method thereof. The Chinese medicinal preparation is prepared by exploring folk secret prescription according to the theory and treatment principles of traditional Chinese medicine for regimen and principles of formulating prescription of traditional Chinese medicine, consists of the following Chinese medicament raw materials: pine bark, honeysuckle flower, hypericum japonicum thunb and sugar-cane, can be taken orally and applied externally simultaneously to make the medicament directly reach a focus, effectively changes the epidermis symptoms of the psoriasis, unblocks pores, improves the cell viability, adjusts internal secretion and promotes regeneration function of the skin cells and blood circulation of the skin. The Chinese medicinal preparation for curing the psoriasis has quick response, high curative effect, high cure rate and low relapse rate, cures both the symptoms and root causes, is safe and reliable, effectively strengthens the immunity of a human body, particularly has high curative effect on psoriasis vulgaris and psoriasis pustulosa and has better curative effects on arthropathic psoriasis, erythrodermic psoriasis, neurodermatitis, eczema and acne.
Description
Technical field:
The invention belongs to the Chinese medicine preparation technical field, relate to a kind of treatment psoriasis Chinese medicine preparation and preparation method thereof.
Background technology:
Psoriasis is that a kind of common chronic recurrent inflammatory skin is sick.Basic skin lesion is erythema, pimple, or is covered with the silvery white squama of multilamellar on the speckle.Belong to " spending in vain ", " chronic eczema ", " psoriasis " category of Chinese medicine, also claim psoriasis.This disease sickness rate is high, and is especially between twenty and fifty, good sending out in winter-spring season, and groups of people have family's heredity history.According to World Health Organization's statistics, there are every year 800～1,000 ten thousand people to suffer from psoriasis approximately.Because have industrial pollution and Ecological environment worsening in the environment, psoriatic sickness rate has the trend of rising.Though psoriasis is threat to life not, having a strong impact on people's body and mind Jiankang.The psoriatic course of disease is long, and sustainable several years or many decades are difficult to radical cure, the Chang Fanfu outbreak, and convulsion is itched unbearably during outbreak, also influences attractive in appearance.Psoriasis generally is divided into homeliness type, abscess type, arthrosis type and erythrodermic:
1. homeliness type: homeliness type is clinically to see the psoriasis type more, and acute onset expands and prolongs whole body, and former dermexanthesis is the inflammatory pimple of hatpin head to Seem Lablab Album size; Be distinctive pale red, boundary is obvious, and the silvery white squama of surface-coated multilamellar has slight blush on every side; Divest squama and can expose semitransparent thin film, divest this film and little petechia then occurs, flat itching in various degree arranged; Send out in the whole body many places, especially extremity and elbow, knee position are symmetry.
2. abscess type: the abscess type is divided into general whole body and limitation amphitypy.Clinical more rare.Morbidity sharply often accompanies by hyperpyrexia and leukocytosis, and pustule can enlarge and is fused into " pus paste " shape; Often because of erosion appears in the contact friction, moistening back knot is silly, refers to can take place under (toe) first keratinization and squama and heaps; Nail matrix also little abscess can occur, and symptom takes a turn for the better or is converted into erythroderma.
3. arthrosis type: the arthrosis type is claimed psoriasis arthropathica again, is mainly the asymmetry polyarthritis, sees with little joints such as wrist, foots more.Joint congestion and swelling pain mostly damages with fingernail.
4. erythrodermic: erythrodermic is mostly because malpractice, uses the strong medicine of zest to use due to the hormones with a large amount of.Flushing appears in the primary disease initial stage, expands rapidly and prolongs sheet, and last whole body is the diffusivity flushing and soaks into, and lamellar normal " red island " is arranged in the infiltration.A large amount of squamas come off, and scalp has thick long-pending squama silly.The later stage brothers are large stretch of skin exfoliation.Refer to (toe) onychauxis, be out of shape, come off and merge heating, fear of cold, headache and general malaise.
At present, to curing psoriasis, be mostly that local topical medicine such as keratoplastics, cortex class are because of pure cream etc.; And, immunosuppressant, retinoic acid, antibiotic, cortex class are then arranged because of alcohol etc. to the systemic administration thing.These medicinal applications are proper, are that short-term curative effects is preferably arranged to psoriasis.But the life-time service side effect is big, and price is high, and relapse rate is higher.The traditional Chinese medical science is to control through dialectical opinion, and the treatment psoriasis has certain advantage, but still can't popularize.Some treat psoriatic Chinese medicine tablet or pill or ointment, like the blue or green ball etc. of putting in order of YUJIN YINXIE PIAN, Radix Salviae Miltiorrhizae Tabellae, Radix Tripterygii Wilfordii tablet and compound recipe, the treatment psoriasis are all had certain therapeutic effect.But, often the course of treatment longer, cure rate is lower.At present, Chinese and western medicine is to treating the still definite medicine of inefficacy of psoriasis.
Summary of the invention:
The object of the invention: be to provide a kind of and have that heat-clearing and toxic substances removing, invigorating blood circulation are tired, mediation microcirculation, enhancing human body immunity function, cure rate is high, relapse rate is low treatment psoriasis Chinese medicine preparation and preparation method thereof.
Technical scheme of the present invention is such:
Accumulate in deficiency of both QI and blood, the heat in blood because psoriasis is, living air slaking are dry, failure of skin and muscle to be nourished forms.Because blood system has heat, or damp and hotly accumulate long-pendingly from the beginning of being mostly, feel exopathogen again, disorder of QI and blood strongly fragrantly forms in the flesh table; Sick for a long time or because of fire formation from evil accumulation, consumption impairment of YIN blood, qi-blood disharmony, it is dry to give birth to air slaking, failure of skin and muscle to be nourished; Or blockage of the vessel, QI and blood condenses; Eating and drinking without temperance, deficiency of both the liver and kidney or Chong and Ren channel disorder or cause deficiency of qi and blood.Identify and correct according to Chinese medicine and to execute the principle of controlling; The tame chief of the many doctors of collection; Adopt among the people and national strange medicine wonderful recipe; In conjunction with modern medicine to psoriatic pathogenetic understanding and Therapeutic Principle, select for use to psoriasis specific analgesic, dispel the wind, dehumidify, invigorate blood circulation, stop blooding, hold back the former medicine of skin ulcer, granulation promoting, antibiotic, antiviral, antioxidation, adjusting immunologic function, prepare convenient treatment, the higher psoriasis Chinese medicine preparation of therapeutic effect.
The present invention is achieved in that
Treatment psoriasis Chinese medicine preparation comprises following raw material of Chinese medicine composition and parts by weight:
Cortex Pini 10～35, Flos Lonicerae 10～30, Herba Hyperici Japonici 20～45, Caulis Sacchari sinensis 8～25, pharmaceutic adjuvant 0～20, medicinal solvent are 0～10 times of medicine raw material gross weight umber.
The dosage form of above-described psoriasis Chinese medicine preparation comprises oral bagged steeping drug, electuary, capsule, granule, tablet, oral liquid or and abrasive cleaner.
Above-described pharmaceutic adjuvant comprises medicinal filler and lubricant, and wherein: filler comprises starch, modified starch, dextrin, calcium hydrogen phosphate and other medicinal filleies; Lubricant comprises Polyethylene Glycol, calcium stearate, Pulvis Talci and other medicinal lubricants.
Above-described medicinal filler and lubricant, its proportioning parts by weight are 30～50: 0.3～0.6.
Above-described medicinal solvent comprises ethanol, propanol, butanols, first alcohol and water.
The method for preparing of treatment psoriasis Chinese medicine preparation, comprise oral bagged steeping drug, oral liquid, electuary, capsule, granule and tablet or and the method for preparing of external abrasive cleaner:
1, the step of preparation process of bagged steeping drug comprises:
(1) screening: crude drug is screened respectively, substandard products and moulding material medicine are rejected, the visible foreign material of the branch and leaf that weed a garden, stone and clod.
(2) washing: the crude drug that will pass through screening is put into service sink respectively, continues removal of contamination.
(3) oven dry: will put into heated-air circulation oven respectively through the washing crude drug and dry, temperature is controlled at 55～85 ℃, and stoving time is 1～10h, crude drug moisture≤10%.
(4) pulverize: the drying material medicine is pulverized with pulverizer respectively and sieved, and its granularity is 60～120 orders, each crude drug powder is subsequent use.
(5) mix: proportioning takes by weighing the raw material medicated powder through pulverizing by weight, adds in the batch mixer, and incorporation time is 10～90 minutes, after mixing finishes, and inspection mixed effect and oven dry.
(6) packing: the powder medicine that mixes metering 6～20g is packed in the inner bag, and seal with bagger.
(7) outer package: with pack into middle bag of small package bag infusion, refill close and case oral generation the infusion finished product.
This product uses as the external abrasive cleaner except that making oral agents in addition.
2, the step of preparation process of oral liquid comprises:
(1) screening: crude drug is screened respectively, substandard products and moulding material medicine are rejected, the visible foreign material of the branch and leaf that weed a garden, stone and clod.
(2) washing: the crude drug that will pass through screening is put into service sink respectively, continues removal of contamination.
(3) oven dry: will put into heated-air circulation oven respectively through the washing crude drug and dry, temperature is controlled at 55～85 ℃, and stoving time is 1～10h, crude drug moisture≤10%.
(4) lixiviate: press the crude drug after preparation technology (1) to (3) the step processing of bagged steeping drug, with crusher in crushing or pulverize the back with pulverizer and add in the lixiviate jar, add 3～8 times of solvents of raw material of Chinese medicine then; Extraction time 1～8h; Filter and remove residue gets solvent extraction liquid, with filtering residue again lixiviate once, filter and remove residue gets the secondary solvent extracting solution; Merge solvent extraction liquid, it is 1.05～1.30 thick clear paste that concentrating under reduced pressure becomes relative density.
(5) purify: thick clear paste is added ethanol stirs, leave standstill after-filtration to containing alcohol amount 50～70%, filtrating in concentration pan once more concentrating under reduced pressure to become relative density be 1.05～1.30 clear paste.The gained clear paste is subsequent use, reclaims solvent and reuses.
(6) dilution: clear paste is added 70～90 times of pure water agitation and dilutions, and the bottling of sterilization back, dress close and case.
This product uses as the external abrasive cleaner except that making oral agents in addition.
3, the step of preparation process of electuary, capsule, granule and tablet comprises:
(1) electuary or capsule: crude drug is screened respectively, substandard products and moulding material medicine are rejected, the visible foreign material of the branch and leaf that weed a garden, stone and clod.After will pass through screening crude drug put into service sink respectively, continue removal of contamination.To put into heated-air circulation oven respectively through the washing crude drug again and dry, temperature is controlled at 55～85 ℃, and stoving time is 1～10h, crude drug moisture≤10%.At 65～80 ℃ of drying under reduced pressure, crushing screening 80～200 orders add pharmaceutic adjuvant then; Get powder behind the mix homogeneously; Using every bag of powder weight of installation packing is 3～5g, and seals with bagger, and each capsule dress powder weight is that 0.2～0.5g promptly gets electuary and capsule finished product.
(2) granule or tablet: by conventional forming method pelletize or film-making, the every packed powder weight of granule is 3～5 grams with the powder of the above preparation, and every weight of tablet is 0.2～0.5g.
Below be that the present invention treats the fill a prescription pharmacological property of former medicine of psoriasis Chinese medicine preparation:
1, Cortex Pini: Cortex Pini Massonianae (Pinus massoniana bamb), claim Pinus densiflora skin, tongue squama, tongue skin and Cortex Pini again.Bitter in the mouth, suffering, temperature are returned lung and large intestine channel.Effect with expelling wind and removing dampness, promoting blood circulation and hemostasis, expelling pus and promoting granulation and enhancing human immune treats that various chronic surface ulcers, carbuncle do not close up for a long time, incised wound and bald in vain.
2, Flos Lonicerae: Flos Lonicerae (Lonicera japonica Thunb), claim Flos Lonicerae, Flos Lonicerae etc. again, sweet in the mouth, cold is returned lung, heart stomach function regulating warp.Kind of volatile oil surplus containing 30; Be mainly compositions such as chlorogenic acid, isochlorogenic acid; Ability heat-clearing and toxic substances removing wind-heat dissipating; Have effects such as broad-spectrum antiseptic, antiviral, antipyretic and anti-inflammatory antioxidation, immunomodulating and hypoglycemic, be used for the too fat to move toxication of pestilence, enteritis, bacillary dysentery, measles, parotitis and infectious intestinal disease etc.
3, Herba Hyperici Japonici: Herba Hyperici Japonici (Hypericum japonicum Thunb), claim Herba Hyperici Japonici, little Herba Hyperici Sampsonii, Stellaria alsine Grim., seven layers of tower etc. again.Sweet in the mouth, cool in nature is returned liver, gallbladder and large intestine channel.Contain embelin, Herba Ardisiae Japonicae quinone, triacontanol and 2; 5-dihydroxy 3-alkylbenzene naphthoquinone derivatives, it is plain also to contain trifolin, hyperin, isorhamnetin-3-galactoside, globulariacitrin, Quercetin-3-rhamanopyranosyl (1 → 2) galactoside, isorhamnetin-3-Robinia pseudoacacia L. two glucosides and Mauritanian Herba lysimachiae capillipedis.Effect with clearing away heat-damp and promoting diuresis, removing heat from blood and promoting blood circulation and removing toxic substances and promoting subsidence of swelling.Modern pharmacological research shows, multiple pharmacological effect such as that Herba Hyperici Japonici has is antibacterial, anti-liver injury, anticancer, adjusting immunologic function, antiviral, antioxidation and hemostasis.Herba Hyperici Japonici all has inhibitory action in various degree to staphylococcus aureus, streptococcus, bacillus tuberculosis bovis, streptococcus pneumoniae and hog cholera bacillus.
4, Caulis Sacchari sinensis: Caulis Sacchari sinensis (Saccharum).Sweet in the mouth, cold in nature is returned lung stomach function regulating warp.Contain abundant sugar, protein, fat, saccharide, calcium, phosphorus, ferrum, asparagine, aspartic acid, glutamic acid, serine, alanine, valine, leucine, several amino acids such as this propylhomoserin, lysine, alpha-amino-beta-hydroxybutyric acid, glutamine, proline, tyrosine, cystine, phenylalanine and GABA just in the Caulis Sacchari sinensis, organic acid and materials such as vitamin B1, B2, B6 and C such as Fumaric acid, succinic acid, glycolic acid, malic acid, citric acid and oxalic acid.Have heat-clearing and toxic substances removing, promoting the production of body fluid to quench thirst, stomach function regulating preventing or arresting vomiting and effect such as nourshing Yin and drynsessmoistening prescription.
Advantage of the present invention and good effect:
1, to treat the psoriasis Chinese medicine preparation be to adopt raw material of Chinese medicine Cortex Pini, Flos Lonicerae, Herba Hyperici Japonici and Caulis Sacchari sinensis to form in the present invention; Oral administration uses with outer the wiping simultaneously, makes the medicine focus of going directly, and has effectively changed psoriatic epidermis symptom; Dredging pore; Improve cell viability, endocrine regulation promotes the regeneration function of Skin Cell and promotes blood circulation of skin.
2, it is rapid-action that the present invention treats the psoriasis Chinese medicine preparation, and curative effect is high, and cure rate is high, and relapse rate is low, and treating both the principal and secondary aspects of a disease is safe and reliable, effectively strengthens the power of self exempting from service.
3, the present invention treats the psoriasis Chinese medicine preparation and can cure mainly various types of psoriasises; Particularly psoriasis vulgaris and psoriasis pustulosa therapeutic effect are higher, and psoriasis arthropathica, erythrodermic silver bits, neurodermatitis, eczema and convulsion skin ulcer are also had better therapeutic effect.
Description of drawings:
Fig. 1: be preparation technology's schematic flow sheet of bagged steeping drug.
Fig. 2: be preparation technology's schematic flow sheet of oral liquid, electuary, capsule, granule and tablet.
The specific embodiment:
Below in conjunction with accompanying drawing and embodiment, the present invention is described in further detail, listed embodiment only is the present invention is described and never is limited to the present invention.
One, preparation embodiment:
Embodiment 1 (preparation of bagged steeping drug):
The raw material of Chinese medicine composition and the parts by weight thereof of bagged steeping drug are: Cortex Pini 30, Flos Lonicerae 25, Herba Hyperici Japonici 40 and Caulis Sacchari sinensis 20.
Method for preparing: crude drug is screened respectively, substandard products and moulding material medicine is rejected, behind the visible foreign material of the branch and leaf that weed a garden, stone and clod, after will pass through screening crude drug put into service sink respectively, continue removal of contamination.To put into heated-air circulation oven respectively through the washing crude drug again and dry, temperature is controlled at 2 ℃ in 75 soil, and stoving time is 3 hours; The crude drug moisture reaches 6%; Then the drying material medicine is pulverized with pulverizer respectively and sieved, its granularity is 80～100 orders, each crude drug powder is subsequent use.Proportioning takes by weighing the raw material medicated powder through pulverizing by weight then, adds in the batch mixer, and incorporation time is 30～40 minutes, after mixing finishes, and inspection mixed effect and oven dry.The powder medicine that mixes metering 6～20g is packed in the inner bag, and seals with bagger, with the small package bag infusion middle bag of packing into, refill close and case oral generation the infusion finished product.
This product uses as the external abrasive cleaner except that making oral agents in addition.
Embodiment 2 (preparation of oral liquid):
The raw material of Chinese medicine composition and the parts by weight thereof of oral liquid are: Cortex Pini 25, Flos Lonicerae 30, Herba Hyperici Japonici 35, Caulis Sacchari sinensis 25, ethanol 800 and press the pure water of arts demand.
Method for preparing: crude drug is screened respectively, substandard products and moulding material medicine is rejected, behind the visible foreign material of the branch and leaf that weed a garden, stone and clod, after will pass through screening crude drug put into service sink respectively, continue removal of contamination.To put into heated-air circulation oven respectively through the washing crude drug again and dry, temperature is controlled at 2 ℃ in 80 soil, and stoving time is 2 hours; After the crude drug moisture reaches 8～10%,, add alcohol solvent lixiviate 3h then with adding in the lixiviate jar after the crusher in crushing; Filter and remove residue gets the alcohol solvent extracting solution, with filtering residue again lixiviate once, filter and remove residue gets secondary alcohol solvent extracting solution; Merge the alcohol solvent extracting solution, it is 1.10 thick clear paste that concentrating under reduced pressure becomes relative density.Again thick clear paste is added ethanol and stir to containing alcohol amount 60%, leave standstill after-filtration, filtrating is through decompression recycling ethanol, and to be condensed into relative density be 1.10 clear paste, and clear paste is added 80 times of pure water agitation and dilutions, the bottling of sterilization back, dress close and case the oral liquid finished product.Recovery ethanol is reused.
This product uses as the external abrasive cleaner except that making oral agents in addition.
Embodiment 3 (capsular preparation):
Capsular raw material of Chinese medicine composition and parts by weight thereof are: Cortex Pini 20, Flos Lonicerae 30, Herba Hyperici Japonici 25, Caulis Sacchari sinensis 15, pharmaceutic adjuvant 10, methanol solvate 600 and alcohol solvent 30.
Method for preparing: crude drug is screened respectively, substandard products and moulding material medicine is rejected, behind the visible foreign material of the branch and leaf that weed a garden, stone and clod, after will pass through screening crude drug put into service sink respectively, continue removal of contamination.To put into heated-air circulation oven respectively through the washing crude drug again and dry, temperature is controlled at 2 ℃ in 70 soil, and stoving time is 4 hours; After the crude drug moisture reaches 6～8%, pulverize the back with pulverizer and add in the lixiviate jar, add methanol solvate lixiviate 2h then; Filter and remove residue gets the methanol solvate extracting solution, with filtering residue again lixiviate once, filter and remove residue gets secondary methanol solvate extracting solution; Merge the methanol solvate extracting solution, it is 1.20 thick clear paste that reclaim under reduced pressure methanol is condensed into relative density.Again thick clear paste is added ethanol and stir to containing alcohol amount 70%, leave standstill after-filtration, filtrating is through decompression recycling ethanol; And to be condensed into relative density be 1.25 clear paste; At 80 ℃ of drying under reduced pressure, crushing screening 120～180 orders add pharmaceutic adjuvant; Get powder behind the mix homogeneously, each capsule dress powder weight is that 0.4g promptly gets capsule finished product.Reclaiming ethanol and methanol solvate reuses respectively.
Embodiment 4 (preparation of tablet):
The raw material of Chinese medicine composition and the parts by weight thereof of tablet are: Cortex Pini 35, Flos Lonicerae 20, Herba Hyperici Japonici 20, Caulis Sacchari sinensis 25, pharmaceutic adjuvant 20, pure water 800 and medicinal solvent ethanol are pressed the arts demand amount.
Method for preparing: crude drug is screened respectively, substandard products and moulding material medicine is rejected, behind the visible foreign material of the branch and leaf that weed a garden, stone and clod, after will pass through screening crude drug put into service sink respectively, continue removal of contamination.To put into heated-air circulation oven respectively through the washing crude drug again and dry, temperature is controlled at 2 ℃ in 75 soil, and stoving time is 2.5 hours; After the crude drug moisture reaches 8～10%,, add pure decocting in water 4h then with adding in the lixiviate jar after the crusher in crushing; Filter and remove residue gets the decocting in water extracting solution, and filtering residue is boiled once with pure water again, and filter and remove residue gets secondary decocting in water extracting solution; Merge the decocting in water extracting solution, it is 1.25 thick clear paste that concentrating under reduced pressure becomes relative density.Again thick clear paste is added ethanol and stir to containing alcohol amount 60%, leave standstill after-filtration, filtrating is through decompression recycling ethanol; And to be condensed into relative density be 1.30 clear paste, at 65 ℃ of drying under reduced pressure, and crushing screening 100～160 orders; Add pharmaceutic adjuvant; Get powder behind the mix homogeneously, then powder is pressed the conventional method film-making, every weight of tablet is that 0.4g promptly gets the tablet finished product.Reclaiming ethanol and pure water reuses respectively.
Two, treatment embodiment:
Embodiment 1
Treatment target: psoriasis vulgaris example 312 examples, skin lesion is mainly in scalp and extremity, is symmetrically distributed, and the lighter is clear-cut maculopapule; Desquamation is very itched, and weight person's maculopapule increases expansion; The class's of being fused into piece has inflammatory blush on every side, and the surface is covered with thicker silvery white squama.The course of disease is 3 months to 35 years, and the state of an illness takes place repeatedly.
Therapeutic Method: bagged steeping drug, day clothes 3 times or select oral liquid, electuary, capsule, granule and tablet etc. wherein a kind of, each 3～10 grams, various dosage forms can be used alternatingly, and the child reduces by half, but the affected part is cleaned in external when taking medicine.Treating 20 days is a course of treatment, 1～2 course of treatment of light disease, 3～4 courses of treatment of serious symptom.
Therapeutic effect: after taking medicine 20 days, the skin Pruritus alleviates or disappears, and maculopapule, abscess and erythema subtract late, and scurf reduces.Take medicine after 1～4 course of treatment, curing the patient is 296 people, cure rate 95%.Effectively the patient is 10 people, effective percentage 3%.Invalid patient 2 people, inefficiency 2%.In therapeutic process, do not see obvious adverse effect and toxic and side effects.
Embodiment 2
Treatment target: psoriasis pustulosa example 46 examples, acute onset is with hyperpyrexia, general malaise, weak and arthroncus.Whole body all has dermexanthesis everywhere, and extremity and wrinkle are started the place and morely seen.Occur intensive little dense skin ulcer, surface on the skin and be covered with squama, the dense scar of weight person merges in flakes, and the course of disease was periodical attack to 2.5 years in 3 months.
Therapeutic Method: bagged steeping drug, day clothes 3 times or select oral liquid, electuary, capsule, granule and tablet etc. wherein a kind of, each 3～10 grams, various dosage forms can be used alternatingly, and the child reduces by half, but the affected part is cleaned in external when taking medicine.Treating 20 days is a course of treatment, 1～2 course of treatment of light disease, 3～4 courses of treatment of serious symptom.
Therapeutic effect: after taking medicine 20 days, the skin Pruritus alleviates or disappears, and maculopapule, abscess and erythema subtract late, and scurf reduces.Take medicine after 1～4 course of treatment, curing the patient is 37 people, cure rate 80%.Effectively the patient is 8 people, effective percentage 18%.Invalid patient 1 people, inefficiency 2%.In therapeutic process, do not see obvious adverse effect and toxic and side effects.
Embodiment 3
Treatment target: mostly psoriasis arthropathica example 6 examples are to be shown effect repeatedly by psoriasis vulgaris.Except that having erythra, stiff with joint congestion and swelling pain, symptoms such as limitation of activity and heating, anemia.
Therapeutic Method: bagged steeping drug, day clothes 3 times or select oral liquid, electuary, capsule, granule and tablet etc. wherein a kind of, each 3～10 grams, various dosage forms can be used alternatingly, and the child reduces by half, but the affected part is cleaned in external when taking medicine.Treating 20 days is a course of treatment, 1～2 course of treatment of light disease, 3～4 courses of treatment of serious symptom.
Therapeutic effect: after taking medicine 20 days, the skin Pruritus alleviates or disappears, and maculopapule and erythema subtract late, and scurf reduces.Take medicine after 1～4 course of treatment, curing the patient is 4 people, cure rate 67%.Produce effects patient is 1 people, obvious effective rate 16%.Invalid patient 1 people, inefficiency 17%.In therapeutic process, do not see obvious adverse effect and toxic and side effects.
Embodiment 4
Treatment target: erythrodermic psoriasis example 82 examples, patient begins to be psoriasis vulgaris, adopts bigger medicine of zest or unsuitable medicine for a long time; Too fast or the drug withdrawal suddenly of decrement after the long-term hormone therapies of 53 examples is wherein arranged; Whole skin fills the air flushing, infiltration, swelling, and the surface is covered with a large amount of squamas, constantly comes off; With general malaise symptoms such as fear of cold, heating and headaches, the enlargement of superficial lymph knot.The course of disease 2～3 years, obstinate, normal recurrence.
Therapeutic Method: bagged steeping drug, day clothes 3 times or select oral liquid, electuary, capsule, granule and tablet etc. wherein a kind of, each 3～10 grams, various dosage forms can be used alternatingly, and the child reduces by half, but the affected part is cleaned in external when taking medicine.Treating 20 days is the course of treatment, 1～2 course of treatment of light disease, 3～4 courses of treatment of serious symptom.
Therapeutic effect: after taking medicine 20 days, the skin Pruritus alleviates or disappears, and maculopapule and erythema subtract late, and scurf reduces.Take medicine after 1～4 course of treatment, curing the patient is 57 people, cure rate 70%.Produce effects patient is 5 people, obvious effective rate 6%.Effectively the patient is 17 people, effective percentage 21%.Invalid patient 3 people, inefficiency 3%.In therapeutic process, do not see obvious adverse effect and toxic and side effects.
The treatment standard:
Cure: skin lesion and other clinical symptoms all disappear, and do not have recurrence more than 1 year.
Produce effects: skin lesion and other clinical symptoms disappear basically, more than 1 year recurrence are arranged.
Effectively: skin lesion and other clinical symptoms have minimizing in various degree, and after 4 courses of treatment, symptom still can not complete obiteration.
Invalid: take medicine 4 the course of treatment skin lesion and various symptom do not alleviate.
Claims (6)
1. treat the psoriasis Chinese medicine preparation for one kind, it is characterized in that: form by following material composition and parts by weight:
Cortex Pini 10～35, Flos Lonicerae 10～30, Herba Hyperici Japonici 20～45, Caulis Sacchari sinensis 8～25, pharmaceutic adjuvant 0～20, medicinal solvent, the consumption of said medicinal solvent are 0～10 times of medicine raw material gross weight umber;
The dosage form of described psoriasis Chinese medicine preparation is electuary, capsule, granule, tablet, oral liquid;
Described pharmaceutic adjuvant is medicinal filler and lubricant, and its proportioning parts by weight are 30～50: 0.3～0.6, and wherein filler is starch, dextrin, calcium hydrogen phosphate, and lubricant is Polyethylene Glycol, calcium stearate, Pulvis Talci;
Described medicinal solvent is medicinal solvent ethanol, propanol, butanols, first alcohol and water.
2. according to the method for preparing of the said treatment psoriasis of claim 1 Chinese medicine preparation, the method for preparing of oral liquid, electuary, capsule, granule and tablet is characterized in that:
(1) step of preparation process of oral liquid comprises: screening, washing, oven dry, fragmentation or pulverizing, lixiviate, cross and filter extracting solution, lixiviate once more, cross and filter that secondary raffinate, merge extractive liquid,, concentrating under reduced pressure get thick clear paste, purification, concentrating under reduced pressure gets clear paste, dilution, sterilization, bottling, dress box and vanning step once more;
(2) step of preparation process of electuary, capsule, granule and tablet comprises: screening, washing, oven dry, fragmentation or pulverizing, lixiviate, cross and filter extracting solution, lixiviate once more, cross and filter that secondary raffinate, merge extractive liquid,, concentrating under reduced pressure get thick clear paste, purification, concentrating under reduced pressure gets clear paste, drying under reduced pressure, pulverizes, sieves, mixes to such an extent that powder, packing get electuary or capsule finished product once more; Granule or tablet product are then pressed conventional method pelletize or film-making, back packing and outer package step with powder.
3. method for preparing according to claim 2 is characterized in that: described oven dry is warp washing crude drug to be put into heated-air circulation oven respectively dry, and temperature is controlled at 55～85 ℃, and stoving time is 1～10h, crude drug moisture≤10%.
4. method for preparing according to claim 2 is characterized in that: described lixiviate is with fragmentation or pulverizes in the raw material of Chinese medicine adding lixiviate jar, adds 3～8 times of solvents of raw material of Chinese medicine then, extraction time 1～8h.
5. method for preparing according to claim 2 is characterized in that: described concentrating under reduced pressure be in concentration pan concentrating under reduced pressure to become relative density be 1.05～1.30 thick clear paste or clear paste, reclaim solvent and reuse.
6. method for preparing according to claim 2 is characterized in that: described purification is thick clear paste to be added ethanol stir to containing alcohol amount 50～70%, leaves standstill after-filtration.
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| CN2010101700544A CN101810797B (en) | 2010-05-12 | 2010-05-12 | Chinese medicinal preparation for curing psoriasis and preparation method thereof |
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| CN2010101700544A CN101810797B (en) | 2010-05-12 | 2010-05-12 | Chinese medicinal preparation for curing psoriasis and preparation method thereof |
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| Publication Number | Publication Date |
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| CN101810797A CN101810797A (en) | 2010-08-25 |
| CN101810797B true CN101810797B (en) | 2012-02-29 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2010101700544A Expired - Fee Related CN101810797B (en) | 2010-05-12 | 2010-05-12 | Chinese medicinal preparation for curing psoriasis and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103961411B (en) * | 2014-04-16 | 2017-01-04 | 安徽杨森生物科技有限公司 | One treats psoriatic Chinese medicine and preparation method thereof |
| CN104367925A (en) * | 2014-11-07 | 2015-02-25 | 济南高达信息技术有限公司 | Traditional Chinese medicine lotion for treating erythroderma and preparation method thereof |
| CN109549964A (en) * | 2018-11-13 | 2019-04-02 | 李冠来 | Pine needle antibacterial liquid |
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