CN101810768B - Antithrombotic Chinese medicinal powder and preparation method thereof - Google Patents
Antithrombotic Chinese medicinal powder and preparation method thereof Download PDFInfo
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- CN101810768B CN101810768B CN2010101257043A CN201010125704A CN101810768B CN 101810768 B CN101810768 B CN 101810768B CN 2010101257043 A CN2010101257043 A CN 2010101257043A CN 201010125704 A CN201010125704 A CN 201010125704A CN 101810768 B CN101810768 B CN 101810768B
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Abstract
The invention relates to antithrombotic Chinese medicinal powder and a preparation method thereof, and belongs to the technical field of new medicaments. The antithrombotic Chinese medicinal powder consists of the following medicinal materials: a venin microcrystalline cellulose inclusion complex, leech polypeptide, Tuo tea CO2 extract powder, schisandra CO2 extract powder, fine ganoderma lucidum powder, fine red paeony root powder, fine kudzuvine root powder, fine thinleaf milkwort root-bark powder, fine membranous milkvetch root powder, fine dwarf lilyturf tuber powder, and fine grassleaf sweelflag rhizome powder; and the prepared medicinal material powder is uniformly mixed and packaged by weight for later use. The antithrombotic Chinese medicinal powder is orally taken 30 minutes before a meal, three times per day, and 1 g each time. The antithrombotic Chinese medicinal powder is disabled for hemorrhagic diseases, hematemesis, hemoptysis and people subjected to major internal organ operation within a month. The antithrombotic Chinese medicinal powder is developed on the basis of the basic treating principle for apoplexia in Chinese medical science, the main medicaments primarily play a role in promoting blood circulation and removing blood stasis, the adjuvants primarily play a role in promoting intelligence and tranquilizing the mind, and the adjunctive medicaments primarily play a role in tonifying Qi and regulating. The antithrombotic Chinese medicinal powder can effectively treat cerebral thrombosis, cerebral circulation insufficiency, miocardial infarction, angina, vasculitis, phlebothrombosis, hyperviscosity and the like.
Description
Affiliated technical field
The present invention relates to a kind of antithrombotic Chinese powder medicine and preparation method thereof, belong to the novel technique field.
Background technology
Thrombotic disease, particularly heart and brain arterial thrombus have become the first place of developing country and China's urban population cause of death.Human health is threatened very serious.Motherland's medicine and pharmacology have accumulated valuable treatment experience to the history in existing thousand of treatment of " apoplexy ".
The inventor has declared " a kind of antithrombotic Chinese powder medicine and preparation method thereof (01123530.6), and obtain the authorization on January 12nd, 2005 (CN1183928C) July 30 calendar year 2001.In the clinical practice in 10 years thereafter, science and technology and the theoretical new results of domestic and international Chinese and western medicine pharmacy have been drawn, new technology about thrombotic disease; Under the theoretical direction of combined traditional Chinese medicine; In conjunction with the clinical practice experience, in the clinical practice in nearly ten years thereafter, sum up and developed new prescription; Its prescription composition, processing technique, clinical efficacy have had major progress than the medicine of former patent, and therapeutic effect is better.
Summary of the invention
The objective of the invention is: a kind of antithrombotic Chinese powder medicine and preparation method thereof is provided, reaches effective treatment cerebral embolism, cerebral blood supply insufficiency, myocardial infarction, angina pectoris, vasculitis, phlebothrombosis, high blood viscosity etc.
A kind of antithrombotic Chinese powder medicine of the present invention, form by following weight component proportioning:
Snake venom microcrystalline Cellulose clathrate 2-3g leech polypeptide 1.0-1.4g
Tuo tea CO
2Extraction powder 140-160g Fructus Schisandrae Chinensis CO
2Extraction powder 56-86g
The smart powder 140-160g of red ganoderma d-catechin powder 70-90g
The smart powder 90-110g of Radix Puerariae senegin powder 90-110g
Radix Astragali essenc powder 115-125g essence Radix Ophiopogonis powder 90-110g
The smart powder 90-110g of Rhizoma Acori Graminei
The method for preparing of Chinese powder medicine of the present invention the steps include:
A. the preparation of snake venom microcrystalline Cellulose clathrate: get cobra venom 3g, agkistrodon halyx pallas venom 3g adds enteric solubility microcrystalline Cellulose 122g (or in this ratio), and machine grinds, drying is processed the clathrate powder.
B. the preparation of leech polypeptide: get fresh and alive Hirudo, be lyophilized into powder, extract leech polypeptide, extraction ratio 13%.
C. Tuo tea, Fructus Schisandrae Chinensis CO
2The preparation of extraction powder: Tuo tea, Fructus Schisandrae Chinensis carry out CO respectively
2The extraction of supercritical technological method for processing obtains the finished product powder after drying.Every 100Kg crude drug extraction 2.5Kg finished product powder.During deficiency 2.5kg, supply with the dextran powder.
D. the preparation of Radix Puerariae, Radix Polygalae, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Paeoniae Rubra, red ganoderma, Radix Astragali essenc powder: Radix Puerariae, Radix Polygalae, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Paeoniae Rubra, red ganoderma, the Radix Astragali carry out high temperature, high pressure extraction respectively separately.Temperature 90-100 ℃, two atmospheric pressure of pressure, divide and extract ingredient three times: each amount of water is ten times of drug weight, two hours for the first time, one and a half hours for the second time, one hour for the third time.Process smart powder through spray drying then.Every 100kg crude drug is processed the smart powder of 2.5kg, during not enough 2.5kg, supplies with the dextran powder.
E. medicament preparation: with the medical material powder after the above-mentioned preparation, by the components by weight percent mix homogeneously encapsulation of aforementioned medicament, subsequent use.
Instructions of taking: three times on the one, a 1g, 30 minutes ante cibum are oral.
Forbid in hemorrhage hematemesis, hemoptysis, person within the internal organs major operation one month.
The present invention develops the basic rule of treatment of apoplexy treatment according to the traditional Chinese medical science, and principal agent is main with blood circulation promoting and blood stasis dispelling, and accessory drugs is main with intelligence promoting and the mind tranquilizing, and left medicine is main with the QI invigorating mediation.
The principal agent blood circulation promoting and blood stasis dispelling is main:
Snake venom: among the present invention; Used agkistrodon halyx pallas venom and cobra venom, Agkistrodon halys, Naja temperature, sweet, salty, poisonous all have the effect of expelling wind and activating blood circulation collateral dredging; Snake venom then has the effect of anticoagulant, thrombolytic, depolymerization, viscosity reduction; Chinese Medical Sciences University isolates the peptide of releiving and strengthens peptide from agkistrodon halyx pallas venom, proved in the snake venom part enzyme after the post layer separates and under the gastric acid effect be to keep that it is active, and zoopery confirms to have thrombolytic effect.
Leech polypeptide is an extract at low temperature from fresh and alive Hirudo lyophilized powder, has kept the activity of hirudin in the Hirudo saliva.The strongest thrombin inhibitor that hirudin is up to now to be found is to the dissolving of thrombosis with fall that blood is sticking, anticoagulation is impayable.
Radix Puerariae, Radix Paeoniae Rubra all are medicines of blood circulation promoting and blood stasis dispelling, clearing away heat and cooling blood.Pharmaceutical research confirms that also two medicines have the anticoagulant and thrombolytic effect now.
Accessory drugs intelligence promoting and the mind tranquilizing, collateral dredging refreshment:
Tuo tea: cold nature, bitter in the mouth, nontoxic, heat-clearing and toxic substances removing, tonifying QI to produce body fluid, refreshment and collateral dredging, Fructus Alpiniae Oxyphyllae and calm the nerves.
The state-run health of France and Institute for Medical Research's test find that the Chinese yunnan Tuo tea has the magical curative effect of blood fat reducing, cholesterol reducing.For the collateral dredging refreshment provides scientific basis.
Rhizoma Acori Graminei: acrid in the mouth, warm in nature, GUIXIN liver, spleen channel, waking up the patient from unconsciousness by dissipating phlegm and in ward off turbidly, modern medicine confirms it is the treatment neurasthenia, the good medicine of amnesia.
Radix Polygalae: bitter in the mouth, suffering, warm in nature, GUIXIN lung meridian, effect intelligence promoting and the mind tranquilizing.
Radix Ophiopogonis, Fructus Schisandrae Chinensis: GUIXIN lung meridian.The function that excited brain, cardiac muscle are all arranged.It is the medicine of cardio cerebrovascular affection.
Adjuvant drug benefiting qi and nourishing blood, collateral dredging are in harmonious proportion, and principal agent snake venom, Hirudo all are poisonous medicines among the present invention, use red ganoderma, the Radix Astragali to be adjuvant drug, want QI invigorating to promote blood circulation exactly, coordinating the actions of various ingredients in a prescription, strengthening the body resistance.
Red ganoderma: research now confirms that enhancing immunity is arranged, purifies the blood, clean blood, reduce blood viscosity, repercussive blood, dispel the thrombosis effect.
The Radix Astragali: sweet, warm.Invigorating QI to consolidate the body surface resistance nourishes heart and promotes blood circulation, strengthening the body resistance.It is the strongest medicine of immunity function among the Chinese medicine.It is deficient not only can to control the motive, more can treat the disease of blood-vessel obstructive.
The invention has the beneficial effects as follows, since development in 1988, in the practice in more than 20 years, progressively improved prescription, treatment patient several thousand examples, curative effect is satisfied, and part statistics in recent years is following:
Criterion of therapeutical effect:
Recovery from illness: symptom and sign disappears basically.
Produce effects: the paralyzed limbs muscular strength improves more than the II level, and language, dysphagia obviously improve.
Take a turn for the better: the paralyzed limbs muscular strength improves more than the I level, and language, dysphagia improve.
Invalid: symptom and sign does not have improvement.
Therapeutic evaluation: 238 routine curative effect statistics
Recovery from illness: 48 examples account for 20.16%; Produce effects: 132 examples account for 53.22%;
Take a turn for the better: 33 examples account for 13.86%; Invalid: 25 examples account for 10.5%;
Total effective rate: 89.5%.
The specific embodiment
Embodiment 1
Snake venom microcrystalline Cellulose clathrate 2g, leech polypeptide 1.2g, Tuo tea extract 150g, Fructus Schisandrae Chinensis extract 56.8g; The smart powder 140g of red ganoderma, d-catechin powder 90g, the smart powder 90g of Radix Puerariae, senegin powder 90g; Radix Astragali essenc powder 160g, Radix Ophiopogonis smart powder 110kg, the smart powder 110g of Rhizoma Acori Graminei.
Embodiment 2
Snake venom microcrystalline Cellulose clathrate 2.5g, leech polypeptide 1.4g, Tuo tea extract 160g, Fructus Schisandrae Chinensis extract 56.1g; The smart powder 150g of red ganoderma, d-catechin powder 80g, the smart powder 100g of Radix Puerariae, senegin powder 100g; Radix Astragali essenc powder 150g, Radix Ophiopogonis smart powder 100kg, the smart powder 100g of Rhizoma Acori Graminei.
Embodiment 3
Snake venom microcrystalline Cellulose clathrate 3g, leech polypeptide 1.0g, Tuo tea extract 140g, Fructus Schisandrae Chinensis extract 86g; The smart powder 160g of red ganoderma, d-catechin powder 70g, the smart powder 110g of Radix Puerariae, senegin powder 110g; Radix Astragali essenc powder 140g, Radix Ophiopogonis smart powder 90kg, the smart powder 90g of Rhizoma Acori Graminei.
Embodiment 4
The method for preparing of a kind of antithrombotic Chinese powder medicine of the present invention: the step of the method for preparing of each the medicine raw material among the embodiment 1-3:
The preparation of a, snake venom microcrystalline Cellulose clathrate: get cobra venom 3g, agkistrodon halyx pallas venom 3g adds enteric solubility microcrystalline Cellulose 122g, grinds with machine and processes clathrate.
The preparation of b, leech polypeptide: get fresh and alive Hirudo 10kg and process lyophilized powder, extract leech polypeptide then, it is 1.3kg that the 10kg lyophilized powder extracts leech polypeptide.
C, Tuo tea, Fructus Schisandrae Chinensis CO
2The preparation of extraction powder: get Tuo tea 50kg, Fructus Schisandrae Chinensis 25kg, use supercritical CO respectively
2Extraction, every 100kg crude drug extracts finished product 2.5kg.
The preparation of d, Radix Puerariae, Radix Polygalae, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Paeoniae Rubra, red ganoderma, Radix Astragali essenc powder: get Radix Puerariae, Radix Polygalae, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Paeoniae Rubra, red ganoderma, each 50kg of the Radix Astragali; Every kind of medicine extracts separately; Temperature 90-100 ℃, two atmospheric pressure add the water of 10 times of medicine weight at every turn.Fried in shallow oil two hours for the first time, one and a half hours for the second time, one hour for the third time, spray-driedly then process smart powder.The finished product that every 100kg material medicine is processed is 2.5kg, during not enough 2.5kg, supplies with the dextran powder.
Encapsulate behind the above-mentioned medicine mix homogeneously.
Claims (2)
1. antithrombotic Chinese powder medicine is characterized in that: be made up of following components by weight percent proportioning:
The method for preparing of said antithrombotic Chinese powder medicine is described below:
A. snake venom microcrystalline Cellulose clathrate: according to cobra venom 3g and agkistrodon halyx pallas venom 3g, the ratio of enteric solubility microcrystalline Cellulose 122g is got cobra venom, and agkistrodon halyx pallas venom and enteric solubility microcrystalline Cellulose grind with machine and to process clathrate;
B. leech polypeptide: get fresh and alive Hirudo, be lyophilized into powder, extract leech polypeptide, extraction ratio 13%;
C. Tuo tea, Fructus Schisandrae Chinensis carry out supercritical CO respectively
2Extraction, every 100kg crude drug extract should be 2.5kg, if during not enough 2.5kg, supplies with the dextran powder;
D. Radix Puerariae, Radix Polygalae, Radix Ophiopogonis, Rhizoma Acori Graminei, Radix Paeoniae Rubra; Red ganoderma, the Radix Astragali carry out HTHP extraction, temperature 90-100 ℃, two atmospheric pressure respectively; Extract ingredient three times: every kind of medicine adds the water of ten times of weight at every turn, and two hours for the first time, one and a half hours for the second time, one hour for the third time; Spray-dried at last, process smart powder, every 100kg crude drug is processed smart powder 2.5kg;
E. medicament preparation: the medicated powder that a-d is prepared encapsulates by aforementioned composition by weight proportioning mix homogeneously.
2. antithrombotic Chinese powder medicine according to claim 1 is characterized in that: in the said method for preparing:
A. snake venom microcrystalline Cellulose clathrate: get cobra venom 3g and agkistrodon halyx pallas venom 3g, add enteric solubility microcrystalline Cellulose 122g, grind with machine and process clathrate.
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| CN101810768B true CN101810768B (en) | 2012-12-05 |
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| EP2524695A1 (en) * | 2011-05-17 | 2012-11-21 | Himalaya Global Holdings Limited | Herbal solid formulation and process for preparing the same |
| CN105076586A (en) * | 2014-05-15 | 2015-11-25 | 钱如力 | A Polypeptide lucid ganoderma tea and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1399976A (en) * | 2001-07-30 | 2003-03-05 | 滕树材 | Chinese medicine powder preparation for resisting thrombosis and its preparation method |
| CN1628845A (en) * | 2003-12-17 | 2005-06-22 | 昆明紫健生物技术有限公司 | Compound medicinal formulation with bioactivity |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1399976A (en) * | 2001-07-30 | 2003-03-05 | 滕树材 | Chinese medicine powder preparation for resisting thrombosis and its preparation method |
| CN1628845A (en) * | 2003-12-17 | 2005-06-22 | 昆明紫健生物技术有限公司 | Compound medicinal formulation with bioactivity |
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