CN101809034B - C3b抗体及用于预防和治疗补体相关病症的方法 - Google Patents
C3b抗体及用于预防和治疗补体相关病症的方法 Download PDFInfo
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- CN101809034B CN101809034B CN200880102282.9A CN200880102282A CN101809034B CN 101809034 B CN101809034 B CN 101809034B CN 200880102282 A CN200880102282 A CN 200880102282A CN 101809034 B CN101809034 B CN 101809034B
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
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- A—HUMAN NECESSITIES
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- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- A—HUMAN NECESSITIES
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y10S435/81—Packaged device or kit
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Diabetes (AREA)
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- Biochemistry (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Cardiology (AREA)
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- Mycology (AREA)
- Microbiology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93372107P | 2007-06-07 | 2007-06-07 | |
| US60/933,721 | 2007-06-07 | ||
| US5506808P | 2008-05-21 | 2008-05-21 | |
| US60/055,068 | 2008-05-21 | ||
| PCT/US2008/065771 WO2008154251A2 (en) | 2007-06-07 | 2008-06-04 | C3b antibodies and methods for the prevention and treatment of complement- associated disorders |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101809034A CN101809034A (zh) | 2010-08-18 |
| CN101809034B true CN101809034B (zh) | 2015-07-08 |
Family
ID=39712089
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880102282.9A Expired - Fee Related CN101809034B (zh) | 2007-06-07 | 2008-06-04 | C3b抗体及用于预防和治疗补体相关病症的方法 |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8012473B2 (https=) |
| EP (1) | EP2162470A2 (https=) |
| JP (3) | JP5683265B2 (https=) |
| KR (3) | KR20170023212A (https=) |
| CN (1) | CN101809034B (https=) |
| AR (1) | AR066916A1 (https=) |
| AU (1) | AU2008262048B2 (https=) |
| BR (1) | BRPI0812767A2 (https=) |
| CA (1) | CA2690124A1 (https=) |
| CL (1) | CL2008001656A1 (https=) |
| IL (1) | IL201820A0 (https=) |
| MX (1) | MX2009013082A (https=) |
| PE (1) | PE20090416A1 (https=) |
| RU (1) | RU2473563C2 (https=) |
| SG (2) | SG182165A1 (https=) |
| TW (2) | TWI441832B (https=) |
| WO (1) | WO2008154251A2 (https=) |
| ZA (1) | ZA200907575B (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7759304B2 (en) | 2006-06-21 | 2010-07-20 | Regents Of The University Of Colorado | Targeting complement factor H for treatment of diseases |
| CL2008003241A1 (es) * | 2007-11-02 | 2009-07-31 | Novartis Ag | Molecula de enlace que comprende una porcion de enlace de antigeno que se enlaza con un neoepitopo de c3b; composicion farmaceutica que la comprende; y su uso para tratar trastornos oculares |
| US20100291106A1 (en) * | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| WO2011003098A1 (en) | 2009-07-02 | 2011-01-06 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| CA2795311A1 (en) | 2009-11-05 | 2011-05-12 | Taligen Therapeutics, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria, hemolytic anemias and disease states involving intravascular and extravascular hemolysis |
| EP2513148B1 (en) * | 2009-12-16 | 2016-08-31 | AbbVie Biotherapeutics Inc. | Anti-her2 antibodies and their uses |
| AU2011233753A1 (en) * | 2010-03-31 | 2012-09-13 | Anamar Ab | Method to detect tissue degradation leading to inflammation |
| BR112012029067A2 (pt) | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| SG186397A1 (en) | 2010-06-22 | 2013-01-30 | Univ Colorado Regents | Antibodies to the c3d fragment of complement component 3 |
| US8940490B2 (en) | 2010-11-29 | 2015-01-27 | Novelmed Therapeutics, Inc. | Neoantibodies for diagnosing tissue injury |
| US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
| CA2869477C (en) * | 2012-04-03 | 2020-06-09 | Novelmed Therapeutics, Inc. | Humanized and chimeric anti-factor c3 antibodies and uses thereof |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| HK1218300A1 (zh) * | 2013-01-23 | 2017-02-10 | Musc Foundation For Research Development | 基於天然抗體的靶向結構體及其應用 |
| SI3011345T1 (sl) | 2013-08-07 | 2017-12-29 | Alexion Pharmaceuticals, Inc. | Biomarkerski proteini za atipični hemolitični uremični sindrom (ahus) |
| AU2014370404A1 (en) | 2013-12-24 | 2016-07-07 | Novelmed Therapeutics, Inc. | Compositions and methods of treating ocular diseases |
| ES2824262T3 (es) * | 2014-02-26 | 2021-05-11 | Allergan Inc | Anticuerpos contra componente C5 del complemento |
| CN110724691A (zh) | 2014-02-27 | 2020-01-24 | 阿勒根公司 | 补体因子Bb抗体 |
| EP3973994A1 (en) | 2014-06-12 | 2022-03-30 | RA Pharmaceuticals, Inc. | Modulation of complement activity |
| CN107074939B (zh) * | 2014-08-20 | 2021-09-07 | 桑昆血液供给基金会 | H因子增强抗体及其用途 |
| US9937222B2 (en) | 2015-01-28 | 2018-04-10 | Ra Pharmaceuticals, Inc. | Modulators of complement activity |
| RU2584582C1 (ru) * | 2015-03-16 | 2016-05-20 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Моноклональное антитело сс3-4 к конформационному эпитопу с3 человека, штамм гибридной днк мыши рккк(п)764д - продуцент моноклонального антитела сс3-4 |
| RU2733720C2 (ru) | 2015-12-16 | 2020-10-06 | Ра Фармасьютикалз, Инк. | Модуляторы активности комплемента |
| GB201608046D0 (en) * | 2016-05-09 | 2016-06-22 | Cambridge Entpr Ltd And Syndey Children S Hospitals Network Randwick And Westmead Incorporating The | Treatment of complement-mediated disorders |
| RU2630647C1 (ru) * | 2016-05-27 | 2017-09-11 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | ГУМАНИЗИРОВАННОЕ АНТИТЕЛО К КОНФОРМАЦИОННОМУ ЭПИТОПУ С3 КОМПОНЕНТА КОМПЛЕМЕНТА ЧЕЛОВЕКА, ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), ЭКСПРЕССИОННЫЙ ВЕКТОР, СОДЕРЖАЩИЙ ПОСЛЕДОВАТЕЛЬНОСТЬ ДНК (ВАРИАНТЫ), И ШТАММ КЛЕТОК ЯИЧНИКОВ КИТАЙСКОГО ХОМЯЧКА CHO-humC34-ПРОДУЦЕНТ ДАННОГО ГУМАНИЗИРОВАННОГО АНТИТЕЛА |
| US11007254B2 (en) | 2016-10-17 | 2021-05-18 | Musc Foundation For Research Development | Compositions and methods for treating central nervous system injury |
| KR20190093196A (ko) | 2016-12-07 | 2019-08-08 | 라 파마슈티컬스 인코포레이티드 | 보체 활성의 조절인자 |
| SG10202111663PA (en) * | 2017-02-27 | 2021-12-30 | Regeneron Pharma | Humanized model of kidney and liver disorders |
| CN111683672A (zh) | 2017-12-04 | 2020-09-18 | Ra制药公司 | 补体活性调节剂 |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| JP7477457B2 (ja) * | 2018-04-03 | 2024-05-01 | エヌジーエム バイオファーマシューティカルス,インコーポレーテッド | C3結合薬及びその使用方法 |
| RU2687609C1 (ru) * | 2018-05-30 | 2019-05-15 | Федеральное государственное унитарное предприятие "Государственный научно-исследовательский институт особо чистых биопрепаратов" Федерального медико-биологического агентства | Гуманизированное антитело к конформационному эпитопу сз компонента комплемента человека |
| US12110321B2 (en) | 2018-06-11 | 2024-10-08 | Aarhus Universitet | Single domain antibodies for complement regulation |
| GB2583560A (en) | 2018-12-11 | 2020-11-04 | Admirx Inc | Fusion protein constructs for complement associated disease |
| GB201821089D0 (en) | 2018-12-21 | 2019-02-06 | Gyroscope Therapeutics Ltd | Codon-optimised complement factor I |
| TW202100179A (zh) | 2019-03-08 | 2021-01-01 | 美商Ra製藥公司 | 補體活性之調節劑 |
| TW202102481A (zh) | 2019-03-29 | 2021-01-16 | 美商Ra製藥公司 | 補體調節劑和相關方法 |
| SG11202109837SA (en) | 2019-04-24 | 2021-10-28 | Ra Pharmaceuticals Inc | Compositions and methods for modulating complement activity |
| JP2022535411A (ja) | 2019-06-04 | 2022-08-08 | ラ ファーマシューティカルズ インコーポレイテッド | 補体阻害剤による炎症性疾患治療 |
| TWI851771B (zh) | 2019-07-17 | 2024-08-11 | 美商雙子治療子公司 | 因子h增強抗體及其用途 |
| CR20240265A (es) | 2021-12-22 | 2024-10-16 | Boehringer Ingelheim Int | Anticuerpos anti-c3 y fragmentos de unión al antígeno de estos y sus usos para tratar enfermedades oftálmicas u oculares |
| KR20230105972A (ko) | 2022-01-05 | 2023-07-12 | 주식회사 카나프테라퓨틱스 | 혈관신생 억제제가 결합된 항-C3b 항체 또는 항-C5 항체 및 이의 용도 |
| KR20250018169A (ko) * | 2022-04-29 | 2025-02-04 | 브로드윙 바이오 엘엘씨 | 이중특이적 항체 및 안구 질환의 치료 방법 |
| KR20250057830A (ko) | 2022-08-30 | 2025-04-29 | 롱바이오 파마 (수조우) 컴퍼니 리미티드 | 항-인간 보체 c5 항체 및 이의 융합 단백질 |
| EP4590697A2 (en) * | 2022-09-20 | 2025-07-30 | Visterra, Inc. | Treatment of complement mediated diseases and disorders with c3b-antibodies |
| WO2024099320A1 (zh) | 2022-11-10 | 2024-05-16 | 天辰生物医药(苏州)有限公司 | 补体抑制杂合蛋白突变体及其抗体融合蛋白 |
| WO2024227154A1 (en) * | 2023-04-28 | 2024-10-31 | Broadwing Bio Llc | Complement component 3 (c3)-specific antibodies and uses thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| CN1298308A (zh) * | 1998-02-20 | 2001-06-06 | 泰诺士公司 | 补体活化的抑制剂 |
| WO2006012621A2 (en) * | 2004-07-23 | 2006-02-02 | University Of Virginia Patent Foundation | Compositions and methods for regulating the alternative pathway of complement |
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