CN101808610A - 含来自聚氧化烯交联的硅氧烷弹性体的硅氧烷-有机凝胶的个人护理组合物 - Google Patents
含来自聚氧化烯交联的硅氧烷弹性体的硅氧烷-有机凝胶的个人护理组合物 Download PDFInfo
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- CN101808610A CN101808610A CN200880108942A CN200880108942A CN101808610A CN 101808610 A CN101808610 A CN 101808610A CN 200880108942 A CN200880108942 A CN 200880108942A CN 200880108942 A CN200880108942 A CN 200880108942A CN 101808610 A CN101808610 A CN 101808610A
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Abstract
公开了在载体流体内含硅氧烷有机弹性体的硅氧烷有机凝胶和凝胶糊剂组合物。该硅氧烷有机弹性体是直链或支链有机基氢硅氧烷、α,-不饱和聚氧化烯和氢化硅烷化催化剂的反应产物。该硅氧烷有机弹性体尤其可用于凝胶有机载体流体。该凝胶和凝胶糊剂还提供与许多个人和健康护理活性成分改进的相容性。
Description
相关申请的交叉参考
本申请要求2007年9月26日提交的US60/975318的优先权。
技术领域
本发明的公开内容涉及含硅氧烷有机凝胶或凝胶糊剂组合物的个人护理组合物。在载体流体内由硅氧烷有机弹性体形成凝胶或凝胶糊剂组合物。该硅氧烷有机弹性体是直链或支链有机基氢硅氧烷、α,ω-不饱和聚氧化烯和氢化硅烷化催化剂的反应产物。
背景技术
硅氧烷弹性体凝胶由于当施加时提供独特的感觉特征而广泛用于提高个人护理配制剂的美学性。通过SiH聚硅氧烷与含有不饱和烃取代基的另一聚硅氧烷,例如乙烯基官能的聚硅氧烷的交联性氢化硅烷化反应,或者通过SiH聚硅氧烷与烃二烯烃的交联,获得大多数硅氧烷弹性体凝胶。可在载体流体,例如挥发性硅氧烷存在下形成硅氧烷弹性体,从而导致胶凝的组合物。或者,可形成较高固体含量的硅氧烷弹性体,随后剪切并与载体流体混合,还产生凝胶或糊剂状组合物。在U.S.5880210和U.S.5760116中教导了这种硅氧烷弹性体的代表性实例。
尽管硅氧烷弹性体提供改进个人护理配制剂的显著进步,但它们具有限制其用途的数个缺点。例如,具有大多数二甲基硅氧烷含量的硅氧烷弹性体不那么有效地凝胶有机基溶剂和载体流体。具有高二甲基硅氧烷的硅氧烷弹性体凝胶组合物与许多个人护理成分的相容性有限。例如,广泛使用的防晒剂,甲氧基肉桂酸辛酯在许多这些硅氧烷弹性体凝胶内的可溶性有限。另一问题是在这种不相容的组分存在下,硅氧烷弹性体凝胶的粘度下降。因此,需要鉴定可胶凝有机溶剂的硅氧烷弹性体。此外,需要鉴定与许多个人护理成分的相容性改进同时维持与硅氧烷弹性体凝胶有关的美学性的硅氧烷弹性体凝胶。为此,进行了许多尝试来改进硅氧烷弹性体与各种个人护理成分的相容性,其中烷基、聚醚、胺或其他有机官能团已接枝到硅氧烷有机弹性体主链上。在US5811487、US5880210、US6200581、US5236986、US6331604、US6262170、US6531540和US6365670中教导了代表性的这种有机官能的硅氧烷弹性体。
然而,仍然需要改进硅氧烷弹性体基凝胶尤其与有机基挥发性流体和个人护理成分的相容性。这种改进的相容性不应当牺牲感觉美学特征。此外,应当维持或改进在载体流体内硅氧烷弹性体的胶凝或增稠效率。
本发明人已发现,基于一些聚氧化烯交联剂的硅氧烷有机弹性体有效地提供载体流体的胶凝组合物。所得胶凝组合物还具有额外的益处,例如与许多普通的个人护理成分的相容性改进,同时维持感觉美学性和因此可用于各种个人护理和健康护理配制剂内。
发明概述
本发明的公开内容涉及个人或健康护理组合物,它包含由下述衍生的硅氧烷有机弹性体:
i)含A)、B)、C)和D)的反应产物的硅氧烷有机弹性体:
A)含下述平均式的甲硅烷氧基单元的有机基氢硅氧烷:
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y,
其中,R1是氢或R2,
R2是单价烃基,
v≥2,x≥0,y≥2,
B)含下述平均式的聚氧化烯:
R3O-[(C2H4O)c(C3H6O)d(C4H8O)e]-R3
其中R3是含2-12个碳原子的单价不饱和脂族烃基,c为0-100,d为0-100,e为0-100,条件是(d+e)/(c+d+e)之比>0.5,
C)氢化硅烷化催化剂,和
D)具有一个不饱和脂族烃基端基的任选的有机化合物,
ii)载体流体,和
E)个人或健康护理活性成分。
详细说明
本发明公开内容的个人或健康护理组合物包含硅氧烷有机弹性体凝胶。本发明公开内容的硅氧烷有机凝胶和凝胶糊剂组合物含有i)硅氧烷有机弹性体(来自于组分A)、B)、C)和任选地D)的反应),ii)载体流体,和E)个人或健康护理活性成分。
(i)硅氧烷有机弹性体
本发明公开内容的硅氧烷有机弹性体可以有机基氢硅氧烷、α,ω-不饱和聚氧化烯和氢化硅烷化催化剂(分别为组分A)、B)和C))的反应产物形式获得。术语“氢化硅烷化”是指在催化剂(例如组分C))存在下含与硅键合的氢的有机基硅化合物(例如组分A))加成到含脂族不饱和键的化合物(例如组分B)上。氢化硅烷化反应是本领域已知的,和可使用任何这种已知方法或技术,进行组分A)、B)和C)的氢化硅烷化反应,来制备本发明公开内容的硅氧烷有机弹性体作为组分i)。
硅氧烷有机弹性体也可含有侧挂的非交联性部分,其独立地选自含2-30个碳的烃基、疏水聚氧化烯基、及其混合物。这种侧基来自于组分D′)具有一个不饱和脂族端基的含2-30个碳的烃和/或组分D″)具有一个不饱和脂族端基的聚氧化烯借助氢化硅烷化反应任选地加成到硅氧烷有机弹性体上。
可在溶剂存在下进行制备硅氧烷有机弹性体的氢化硅烷化反应,和随后通过已知技术除去溶剂。或者,可在溶剂中进行氢化硅烷化,其中溶剂与作为组分ii)描述的载体流体相同。
A)有机基氢硅氧烷
本发明的组分A)是每一分子平均具有至少两个SiH单元的直链或支链有机基氢硅氧烷。此处所使用的有机基氢硅氧烷是含与硅键合的氢原子(SiH)的任何有机基聚硅氧烷。有机基聚硅氧烷是含独立地选自(R3SiO0.5)、(R2SiO)、(RSiO1.5)或(SiO2)甲硅烷氧基单元中的甲硅烷氧基单元的聚合物,其中R可以是任何有机基团。当在有机基聚硅氧烷内的(R3SiO0.5)、(R2SiO)、(RSiO1.5)或(SiO2)甲硅烷氧基单元中的R是甲基时,该甲硅烷氧基单元常常分别称为M、D、T和Q单元。可以各种方式结合这些甲硅烷氧基单元,形成环状、直链或支链结构。所得聚合物结构的物理和化学性能可以变化。例如,有机基聚硅氧烷可以是挥发性或低粘度的流体,高粘度流体/胶料,弹性体或橡胶,和树脂。
有机基氢硅氧烷是具有含至少一个SiH的甲硅烷氧基单元的有机基聚硅氧烷,亦即在有机基聚硅氧烷内至少一个甲硅烷氧基单元具有通式(R2HSiO0.5)、(RHSiO)或(HSiO1.5)。因此,可用于本发明的有机基氢硅氧烷可包括任何数量的(R3SiO0.5)、(R2SiO)、(RSiO1.5)、(R2HSiO0.5)、(RHSiO)、(HSiO1.5)或(SiO2)甲硅烷氧基单元,条件是在该分子内平均具有至少两个SiH甲硅烷氧基单元,且该有机基氢硅氧烷是直链或支链的。此处所使用的“直链或支链”有机基氢硅氧烷不包括环状有机基氢硅氧烷结构。组分(A)可以是单一的直链或支链有机基氢硅氧烷,或含至少一种下述性能:结构、粘度、平均分子量、硅氧烷单元和序列不同的两种或更多种直链或支链有机基氢硅氧烷的组合。
有机基氢硅氧烷可具有下述平均式:
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y,
其中,R1是氢或R2,
R2是单价烃基,
v≥2,x≥0,或者x=1-500,或者x=1-200,
y≥2,或者y=2-200,或者y=2-100。
R2可以是取代或未取代的脂族或芳族烃基。单价未取代的脂族烃基例举但不限于烷基,例如甲基、乙基、丙基、戊基、辛基、十一烷基和十八烷基,和环烷基,例如环己基。单价取代的脂族烃基例举但不限于卤代烷基,例如氯甲基、3-氯丙基和3,3,3-三氟丙基。芳族烃基例举但不限于苯基、甲苯基、二甲苯基、苄基、苯乙烯基和2-苯乙基。
在一个实施方案中,有机基氢硅氧烷可含有额外的甲硅烷氧基单元且具有下述平均式:
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y(R2SiO1.5)z,
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y(SiO2)w,
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y(SiO2)w(R2SiO1.5)z,
或其任何的混合物,其中
R1是氢或R2,
R2是单价烃基,
和v≥2,w≥0,x≥0,y≥2,和z≥0。
在另一实施方案中,有机基氢硅氧烷选自具有下述平均式的二甲基、甲基氢聚硅氧烷:
(CH3)3SiO[(CH3)2SiO]x[(CH3)HSiO]ySi(CH3)3
其中x≥0,或者x=1-500,或者x=1-200,
和y≥2,或者y=2-200,或者y=2-100。
制备有机基氢硅氧烷的方法是众所周知的且许多在商业上销售。
B)聚氧化烯
组分B)是具有下述平均式的聚氧化烯:
R3O-[(C2H4O)c(C3H6O)d(C4H8O)e]-R3
其中R3是含2-12个碳原子的单价不饱和脂族烃基,c为0-100,d为0-100,e为0-100,条件是(d+e)/(c+d+e)之比>0.5,或者大于0.8,或者大于0.95。
可用作组分B)的聚氧化烯可以是在每一分子链端(即α和ω位置)处用含2-12个碳原子的不饱和脂族烃基封端的任何聚氧化烯。聚氧化烯可来自于环氧乙烷、环氧丙烷、环氧丁烷、1,2-环氧基己烷、1,2-环氧基辛烷、环状环氧化物,例如氧化环己烯或外(exo)-2,3-环氧基降冰片烷的聚合。聚氧化烯基可包括氧基亚乙基单元(C2H4O)、氧基亚丙基单元(C3H6O)、氧基亚丁基单元(C4H8O)或其混合物。典型地,聚氧化烯基包括大多数的氧基亚丙基或氧基亚丁基单元,这以摩尔为基础定义且在上式中用下标c、d和e表示。不饱和脂族烃基可以是链烯基或炔基。下述结构示出了链烯基的代表性、非限定性实例:H2C=CH-、H2C=CHCH2-、H2C=C(CH3)CH2-、H2C=CHCH2CH2-、H2C=CHCH2CH2CH2-和H2C=CHCH2CH2CH2CH2-。下述结构示出了炔基的代表性、非限定性实例:HC≡C-、HC ≡CCH2-、HC≡CC(CH3)-、HC ≡CC(CH3)2-和HC≡CC(CH3)2CH2-。
在每一分子末端处具有不饱和脂族烃基的聚氧化烯是本领域已知的,且许多可商购。在每一分子末端处具有不饱和脂族烃基的聚氧化烯的代表性、非限定性实例包括:
H2C=CHCH2O[C3H6O]dCH2CH=CH2
H2C=C(CH3)CH2O[C3H6O]dCH2C(CH3)=CH2
HC≡CCH2O[C3H6O]dCH2C≡CH
HC≡CC(CH3)2O[C3H6O]dC(CH3)2C≡CH
其中d如上所定义。
在每一分子末端处具有不饱和脂族烃基的聚氧化烯商购于NOF(Nippon Oil and Fat,Tokyo,日本)和ClariantCorp.(Charlottesville,NC)。
在氢化硅烷化反应中所使用的组分A)和B)的用量可以变化。典型地,组分A)中SiH单元与组分B)中脂族不饱和基团的摩尔比范围为10/1-1/10,或者5/1-1/5,或者2/1-1/2。
(C)氢化硅烷化催化剂
组分(C)包括典型地用于氢化硅烷化反应的任何催化剂。优选使用含铂族金属的催化剂。铂族金属是指钌、铑、钯、锇、铱和铂及其络合物。可用于制备本发明组合物的含铂族金属的催化剂是Willing的美国专利No.3419593和Brown等人的美国专利No.5175325中所述制备的铂络合物,其中每一篇在此通过参考引入,以显示这种络合物及其制备。有用的含铂族金属的催化剂的其他实例可发现于Lee等人的美国专利No.3989668、Chang等人的美国专利No.5036117、Ashby的美国专利No.3159601、Lamoreaux的美国专利No.3220972、Chalk等人的美国专利No.3296291、Modic的美国专利No.3516946、Karstedt的美国专利No.3814730和Chandra等人的美国专利No.3928629,所有这些在此通过参考引入,以显示有用的含铂族金属的催化剂及其制备方法。含铂的催化剂可以是铂金属;在载体,例如硅胶或粉化木炭上沉积的铂金属;或铂族金属的化合物或络合物。优选的含铂催化剂包括六水合形式或者无水形式的氯铂酸,和/或通过包括使氯铂酸与脂族不饱和有机硅化合物例如二乙烯基四甲基二硅氧烷反应的方法获得的含铂催化剂;或如在2001年12月7日提交的美国专利申请No.10/017229中所述链烯烃-铂-甲硅烷基络合物,例如(COD)Pt(SiMeCl2)2,其中COD是1,5-环辛二烯和Me是甲基。可例如通过混合0.015mol(COD)PtCl2与0.045mol COD和0.0612molHMeSiCl2,制备这些链烯烃-铂-甲硅烷基络合物。
催化剂的合适用量取决于所使用的特定催化剂。铂催化剂的存在量基于组合物内全部固体(所有非溶剂的成分)的重量百分数,应当足以提供至少2ppm,优选4-200ppm铂。基于相同的基础,铂的存在量典型地足以提供4-150重量ppm的铂。可以单一物质或者作为两种或更多种不同物质的混合物形式添加催化剂。
D)含一个不饱和脂族烃基端基的任选组分
硅氧烷有机弹性体也可含有独立地选自含2-30个碳的烃基、聚氧化烯基、及其混合物中的侧挂的非交联性部分。在硅氧烷有机弹性体上借助氢化硅烷化反应,通过加成组分D)具有一个不饱和脂族烃基端基的有机化合物,形成这些基团。组分D)可选自D′)具有一个不饱和脂族烃基端基的含6-30个碳的烃,和/或组分D″)具有一个不饱和脂族端基的聚氧化烯。
加成组分D)可改变硅氧烷有机弹性体的化学与物理性能。例如,选择D′会导致烃基加成到硅氧烷有机弹性体上,于是给硅氧烷有机弹性体增加更多的疏水特征。相反,选择具有大多数环氧乙烷单元的聚氧化烯会导致疏水性增加的硅氧烷有机弹性体,它随后可与硅氧烷有机弹性体一起掺入水或亲水组分,形成分散体或糊剂。
在D′或D″内的不饱和脂族烃基可以是链烯基或炔基。下述结构示出了链烯基的代表性非限定性实例:H2C=CH-、H2C=CHCH2-、H2C=C(CH3)CH2-、H2C=CHCH2CH2-、H2C=CHCH2CH2CH2-和H2C=CHCH2CH2CH2CH2-。下述结构示出了炔基的代表性非限定性实例:HC≡C-、HC≡CCH2-、HC≡CC(CH3)-、HC≡CC(CH3)2-和HC≡CC(CH3)2CH2-。
组分D′)具有一个不饱和脂族端基的含6-30个碳的烃可选自α烯烃,例如1-己烯、1-辛烯、1-癸烯、1-十一烯、1-十二烯和类似的同系物。组分D′)也可选自含芳基的烃,例如α甲基苯乙烯。
组分D″)可以选自具有下述平均式的那些聚氧化烯:
R3O-[(C 2H4O)c′(C3H6O)d′(C4H8O)e]-R4
其中R3是含2-12个碳原子的单价不饱和脂族烃基,c′为0-100,d′为0-100,e为0-100,条件是c′、d′和e之和>0。
R4是氢、酰基或含1-8个碳的单价烃基。可用作组分D″)的聚氧化烯的代表性非限定性实例包括:
H2C=CHCH2O(C2H4O)c′H
H2C=CHCH2O(C2H4O)c′CH3
H2C=CHCH2O(C2H4O)c′C(O)CH3
H2C=CHCH2O(C2H4O)c′(C3H6O)d′
H2C=CHCH2O(C2H4O)c′(C3H6O)d′CH3
H2C=CHCH2O(C2H4O)c′C(O)CH3
H2C=C(CH3)CH2O(C2H4O)c′H
H2C=CC(CH3)2O(C2H4O)c′H
H2C=C(CH3)CH2O(C2H4O)c′CH3
H2C=C(CH3)CH2O(C2H4O)c′C(O)CH3
H2C=C(CH3)CH2O(C2H4O)c′(C3H6O)d′H
H2C=C(CH3)CH2O(C2H4O)c′(C3H6O)d′CH3
H2C=C(CH3)CH2O(C2H4O)c′C(O)CH3
HC≡CCH2O(C2H4O)c′H
HC≡CCH2O(C2H4O)c′CH3
HC≡CCH2O(C2H4O)c′C(O)CH3
HC≡CCH2O(C2H4O)c′(C3H6O)d′H
HC≡CCH2O(C2H4O)c′(C3H6O)d′CH3
HC≡CCH2O(C2H4O)c′C(O)CH3
其中c′和d′如上所定义。
聚醚也可选自US6987157中所述的那些,在此通过参考引入其关于聚醚的教导。
可在形成过程中(即组分A)、B)、C)和D)同时反应),在第一反应中(例如组分A)中部分量SiH基与C)和D)反应,接着进一步与B)反应),将组分D′或D″加入到硅氧烷有机弹性体中,或者随后将其加入到所形成的具有SiH含量的硅氧烷有机弹性体(例如来自硅氧烷有机弹性体上存在的未反应的SiH单元)中。
在氢化硅烷化反应中所使用的组分D′或D″的用量可以变化,条件是来自组分B)和D)的在反应中存在的全部脂族不饱和基团的摩尔量使得组分A)中SiH单元与组分B)和D)中脂族不饱和基团的摩尔比范围为10/1-1/10。
(ii)载体流体
在载体流体(ii)内包含硅氧烷有机弹性体(i),以提供本发明的硅氧烷-有机凝胶组合物。典型地,载体流体是进行氢化硅烷化反应以形成硅氧烷有机弹性体所使用的溶剂。合适的载体流体包括有机液体(油和溶剂)、硅氧烷类、和这些的混合物。
典型地,载体流体是有机液体。有机液体包括被视为油或溶剂的那些。有机液体例举但不限于芳烃、脂族烃、醇、醛、酮、胺、酯、醚、二元醇、二元醇醚、烷基卤和芳基卤。烃包括异十二烷、异十六烷、Isopar L(C11-C13)、Isopar H(C11-C12)、氢化聚癸烯。醚和酯包括新戊酸异癸酯、新戊二醇庚酸酯、二元醇二硬脂酸酯、二辛酰基碳酸酯、碳酸二乙基己酯、丙二醇正丁醚、乙基-3-乙氧基丙酸酯、丙二醇甲醚乙酸酯、十三烷基新戊酸酯、丙二醇甲醚乙酸酯(PGMEA)、丙二醇甲醚(PGME)、十八烷基新戊酸酯、己二酸二异丁酯、己二酸二异丙酯、丙二醇二辛酸酯/二癸酸酯、和棕榈酸辛酯。适合于作为单独的化合物或者作为载体流体的成分的额外的有机载体流体包括脂肪、油、脂肪酸和脂肪醇。
载体流体也可以是在25℃下的粘度范围为1-1000mm2/s的低粘度的有机基聚硅氧烷或挥发性甲基硅氧烷或挥发性乙基硅氧烷或挥发性甲基乙基硅氧烷,例如六甲基环三硅氧烷、八甲基环四硅氧烷、十甲基环五硅氧烷、十二甲基环六硅氧烷、八甲基三硅氧烷、十甲基四硅氧烷、十二甲基五硅氧烷、十四甲基六硅氧烷、十六甲基七硅氧烷、七甲基-3-{(三甲基甲硅烷基)氧基}三硅氧烷、六甲基-3,3-双{(三甲基甲硅烷基)氧基}三硅氧烷、五甲基{(三甲基甲硅烷基)氧基}环三硅氧烷、以及聚二甲基硅氧烷、聚乙基硅氧烷、聚甲基乙基硅氧烷、聚甲基苯基硅氧烷、聚二苯基硅氧烷。
i)硅氧烷有机弹性体和ii)载体流体的用量使得组合物含有2-95wt%,或者5-95wt%,或者10-90wt%的i)硅氧烷有机弹性体,和5-98wt%,或者95-5wt%或者90-10wt%的ii)载体流体.
制备凝胶组合物的方法
可通过本发明公开的方法,制备凝胶组合物。所公开的方法涉及:
I)在ii)载体流体存在下,使下述物质反应,形成凝胶:
A)含下述平均式的甲硅烷氧基单元的有机基氢硅氧烷:
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y,其中
R1是氢或R2,
R2是单价烃基,
v≥2,x≥0,y≥2,
B)含下述平均式的聚氧化烯:
R3O-[(C2H4O)c(C3H6O)d(C4H8O)e]-R3
其中R3是含2-12个碳原子的单价不饱和脂族烃基,c为0-100,d为0-100,e为0-100,条件是(d+e)/(c+d+e)之比>0.5,
C)氢化硅烷化催化剂,和任选地
D′)含6-30个碳原子的具有一个不饱和脂族烃基端基的烃,
D″)具有一个不饱和脂族端基的聚氧化烯,或D′)和D″)的混合物。
本发明的方法中所使用的组分A)、B)、C)和D)与载体流体ii)以及用量与以上所述的相同。在步骤I)中,组分A)、B)、C)和任选地D)的添加顺序不是关键的。典型地,在混合下,结合组分A)、B)和任选地D)与载体流体,并加热混合物到70-90℃。然后添加催化剂C),引起氢化硅烷化反应。或者,结合组分A)和D),混合并加热到70-90℃,添加催化剂C),随后添加组分B)。
本发明公开内容的方法可进一步包括混合有机基乙烯基硅氧烷到凝胶组合物中的步骤。有机基乙烯基硅氧烷是具有至少一个含乙烯基(Vi是CH2=CH-)的甲硅烷氧基单元的有机基聚硅氧烷,亦即在有机基聚硅氧烷内的至少一个甲硅烷氧基单元的通式为(R2ViSiO0.5)、(RViSiO)或(ViSiO1.5)。添加有机基乙烯基硅氧烷可提高凝胶组合物的长期稳定性。尽管不希望束缚于任何理论,但本发明人认为添加有机基乙烯基硅氧烷可与可能残留在硅氧烷有机弹性体上的残留的SiH反应。
E)个人或健康护理活性成分
组分E)是选自任何个人或健康护理活性成分中的活性成分。此处所使用的“个人护理活性成分”是指本领域已知在个人护理配制剂中作为添加剂的任何化合物或化合物的混合物,它们典型地为了处理头发或皮肤以提供化妆和/或美学益处的目的而添加。“健康护理活性成分”是指本领域已知提供药学或医疗益处的任何化合物或化合物的混合物。因此,“健康护理活性成分”包括被美国健康和公共事业食品及药品管理局(Department of Health&Human Services Food andDrug Administration)定义的和常用的、包含在Code of FederalRegulation,标题21,第I章,200-299部分和300-499部分内的视为活性成分或者活性药物成分的物质。
因此,活性成分可包括拟在诊断、治愈、缓和、治疗或预防疾病,或者影响人类或其他动物身体的结构或任何功能中提供药物活性或其他直接效果的任何组分。该措辞可包括可在制备药物产品中经历化学变化且以拟提供特定活性或效果所打算的改性形式存在于药物产品内的那些组分。
活性成分的一些代表性实例包括药物;维生素;矿物;激素;局部抗微生物剂,例如用于治疗香港脚、股癣或癣的抗菌活性成分、抗真菌活性成分,和痤疮活性成分;收敛剂活性成分;除味剂活性成分;除疣剂活性成分;鸡眼和骨痂除去剂活性成分;用于治疗头虱、阴虱和体虱的灭虱剂活性成分;控制头皮屑、皮脂溢性皮炎皮肤病或牛皮癣的活性成分;和晒伤预防和治疗剂。
在本发明的方法中使用的有用的活性成分包括维生素及其衍生物,其中包括“维生素原”。此处可用的维生素包括但不限于维生素A1、视黄醇、视黄醇的C2-C18酯、维生素E、生育酚、维生素E的酯,及其混合物。视黄醇包括反式视黄醇、1,3-顺式视黄醇、11-顺式视黄醇、9-顺式视黄醇和3,4-二脱氢视黄醇、维生素C及其衍生物,维生素B1;维生素B2、维生素原B5、泛醇、维生素B6、维生素B12、烟酸、叶酸、生物素和泛酸。其他合适的维生素和此处包括的所考虑的维生素的INCI名称是二棕榈酸抗坏血酸酯、甲基硅烷醇果胶酸抗坏血酸酯、棕榈酸抗坏血酸酯、硬脂酸抗坏血酸酯、抗坏血酸基葡糖苷、抗坏血酸基磷酸酯钠、抗坏血酸钠、抗坏血酸基硫酸酯二钠、(抗坏血酸基/生育酚基)磷酸酯钾。
应当注意,视黄醇是由The Cosmetic,Toiletry,and FragranceAssociation(CTFA),Washington DC针对维生素A指定的化妆成分名称的国际命名(INCI)。此处包括的其他合适的维生素和被考虑的维生素的INCI名称是乙酸视黄酯、棕榈酸视黄酯、丙酸视黄酯、α-生育酚、托可索仑(TOCOPHERSOLAN)、乙酸生育酯、亚油酸生育酯、烟酸生育酯和琥珀酸生育酯。
适合于此处使用的可商购产品的一些实例是维生素A乙酸酯和维生素C,二者均是瑞典Fluka Chemie AG,Buchs的产品;COVI-OXT-50,一种Henkel Corporation,La Grange,Illinois的维生素E产品;COVI-OX T-70,Henkel Corporation,La Grange,Illinois的另一种维生素E产品;和维生素E乙酸酯,一种Roche Vitamins&Fine Chemicals,Nutley,New Jersey的产品。
在本发明的方法中所使用的活性成分可以是活性药物成分。可使用的一些合适的活性药物成分的代表性实例是氢化可的松、酮洛芬、噻吗洛尔、毛果芸香碱、阿霉素、丝裂霉素C、吗啡、氢吗啡酮、地尔硫卓、茶碱、羟基红比霉素、柔红霉素、肝素、青霉素G、羧苄西林、头孢噻吩、头孢酊、头孢噻肟、5-氟尿嘧啶、阿糖胞苷、6-氮尿苷、6-硫代鸟嘌呤、长春碱、长春新碱、硫酸博来霉素、金硫葡萄糖、苏拉明、甲苯哒唑、可乐定、东莨菪碱、普萘洛尔、苯丙醇胺盐酸盐、毒毛花苷G、阿托品、卤哌丁苯、异山梨醇、硝化甘油、布洛芬、辅酶Q、茚甲新、前列腺素类、甲氧萘丙酸、舒喘灵、氯压胍、柳胺苄心定、非尼腊明、敌百虫和类固醇。
对于本发明的目的来说,此处考虑作为活性药物成分包括的是抗痤疮剂,例如过氧化苯甲酰和维A酸;抗细菌剂,例如氯己二烯葡糖酸酯;抗真菌剂,例如硝酸咪康唑;消炎剂;皮质类甾醇药物;非类甾醇消炎剂,例如双氯酚酸钠;抗牛皮癣药,例如丙酸氯氟美松;麻醉剂,例如利多卡因;止痒药;抗皮炎剂;和通常考虑作为阻挡膜的试剂。
本发明的活性组分E)可以是蛋白质,例如酶。在这些组合物中内部包括酶的优点是,防止酶失活并较长时间地维持酶的生物活性效果。酶包括但不限于可商购的类型,改进的类型,重组的类型,野生类型,在自然界中找不到的变体,及其混合物。例如,合适的酶包括水解酶、角质酶、氧化酶、转移酶、还原酶、半纤维素酶、酯酶、异构酶、果胶酶、乳糖酶、过氧化物酶、漆酶、过氧化氢酶及其混合物。水解酶包括但不限于蛋白酶(细菌、真菌、酸、中性或碱性)、淀粉酶(α或β)、脂肪酶、甘露糖酶、纤维素酶、胶原酶、溶菌酶、超氧化物歧化酶、过氧化氢酶及其混合物。所述蛋白酶包括但不限于胰蛋白酶、胰凝乳蛋白酶、胃蛋白酶、胰酶和其它哺乳动物酶;木瓜蛋白酶、菠萝蛋白酶和其它植物酶;枯草杆菌蛋白酶、表皮素、乳链球菌肽、柚皮苷酶(L-rhammnosidase)尿激酶和其它细菌酶。所述脂肪酶包括但不限于三酰基甘油脂肪酶、单酰基甘油脂肪酶、脂蛋白脂肪酶,例如胰脂酶、肠肽酶、胃蛋白酶、其它哺乳动物、植物、细菌脂肪酶和纯化物质。优选天然木瓜蛋白酶作为所述酶。此外,刺激激素,例如胰岛素可与这些酶一起使用,增加它们的有效性。
组分E)也可以是防晒剂。防晒剂可选自本领域已知的保护皮肤以免暴露于阳光下的有害作用的任何防晒剂。防晒化合物典型地选自吸收紫外光(UV)的有机化合物、无机化合物或其混合物。因此,可用作防晒剂的代表性、非限定性实例包括氨基苯甲酸、对甲氧肉桂酸-2-乙氧乙酯、二乙醇胺甲氧基肉桂酸酯、二倍酰基三油酸酯、二羟苯酮、4-[双(羟丙基)]氨基苯甲酸乙酯、氨基苯甲酸甘油酯、水杨酸三甲环己酯、含二羟基丙酮的2-羟基-1,4-萘醌、邻氨基苯甲酸孟酯、奥克立林、甲氧基肉桂酸辛酯、水杨酸辛酯、羟甲氧苯酮、二甲基胺基苯甲酸戊酯O、磺酸苯基苯并咪唑、红矿脂、磺异苯酮、二氧化钛和三乙醇胺水杨酸酯、cetaminosalol、尿囊素对氨基苯甲酸、苄叉苯酞、二苯甲酮、二苯甲酮1-12,3-苄叉樟脑、苄叉樟脑水解胶原磺酰胺、苄叉樟脑磺酸、水杨酸苄酯、波尼酮、布美三唑(Bumetriozole)、丁基甲氧基二苯甲酰基甲烷、对氨基苯甲酸丁酯、氧化铈/二氧化硅、氧化铈/二氧化硅/滑石、对甲氧肉桂酸-2-乙氧乙酯、DEA-甲氧基肉桂酸酯、双苯并恶唑萘、二叔丁基羟基苄叉樟脑、二倍酰基三油酸酯、甲基肉桂酸二异丙酯、二甲基对氨基苯甲酸乙基鲸蜡基硬脂基二甲铵甲苯磺酸盐、二辛基丁酰胺基三嗪酮、二苯基甲氧基乙酰氧基萘并吡喃、双乙基苯基三氨基三嗪芪二磺酸二钠、二苯乙烯基二苯基三氨基三嗪芪二磺酸二钠、二苯乙烯基二苯基二磺酸二钠、苯并三唑基甲基苯酚、苯并三唑基甲基苯酚三硅氧烷、对氨基苯甲酸乙基二羟基丙基酯、二异丙基肉桂酸乙酯、甲氧基肉桂酸乙酯、对氨基苯甲酸乙酯、尿刊酸乙酯、2-氰基-3,3-二苯基丙烯酸己酯、阿魏酸、甘油基辛酸酯、二甲氧基肉桂酸酯、对氨基苯甲酸甘油酯、甘油水杨酸酯、水杨酸三甲环己酯、对甲氧基肉桂酸异戊酯、水杨酸异丙基苄酯、异丙基二苯甲酰基甲烷、甲氧基肉桂酸异丙酯、邻氨基苯甲酸孟酯、水杨酸孟酯、4-甲基苄叉、樟脑、氰双苯丙烯酸辛酯、辛酚三唑、对氨基苯甲酸辛基二甲基酯、甲氧基肉桂酸辛酯、水杨酸辛酯、辛基三嗪酮、对氨基苯甲酸、PEG-25对氨基苯甲酸酯、对氨基苯甲酸戊基二甲酯、苯基苯并咪唑磺酸、聚丙烯酰胺基甲基苄叉樟脑、甲氧基肉桂酸钾、苯基苯并咪唑磺酸钾、红矿脂、苯基苯并咪唑磺酸钠、尿刊酸钠、TEA-苯基苯并咪唑磺酸盐、TEA-水杨酸盐、对苯二亚甲基二樟脑磺酸、二氧化钛、二氧化锌、二氧化铈、三对氨基苯甲酸泛醇、尿刊酸和VA/巴豆酸酯/甲基丙烯酰氧基二苯甲酮-1共聚物。
组分E)也可以是香料或香精。香精可以是在香料工业中常用的任何香精或香料活性成分。这些组分典型地属于众多化学类型,例如以醇、醛、酮、酯、醚、乙酸酯、亚硝酸酯、萜烯烃、杂环含氮或硫化合物,以及天然或合成来源的精油形式变化。在标准教科书参考文献,例如Perfume and Flavour Chemicals,1969,S.Arctander,Montclair,New Jersey中详细地描述了许多这些香精成分。
香料可例举但不限于芳香酮和芳香醛。芳香酮的实例是buccoxime、异茉莉酮、甲基-β-萘基酮、麝香酮、吐纳麝香、α-二氢大马酮、β-二氢大马酮、δ-二氢大马酮、异-二氢大马酮、大马烯酮、大马玫瑰酮(Damarose)、甲基-二氢茉莉酮酸酯、薄荷酮、香芹酮、樟脑、葑酮、α-紫罗兰酮、β-紫罗兰酮、γ-甲基所谓紫罗兰酮、庚基环戊酮、二氢茉莉酮、顺式-茉莉酮、龙涎酮、甲基-柏木烯基-酮或甲基-柏木酮、苯乙酮、甲基-苯乙酮、对-甲氧基-苯乙酮、甲基-β-萘基-酮、苄基-丙酮、二苯甲酮、对-羟基-苯基-丁酮、芹菜酮、6-异丙基十氢-2-萘酮、二甲基-辛烯酮、鲜薄荷酮(Freskomenthe)、4-(1-乙氧基乙烯基)-3,3,5,5,-四甲基-环己酮、甲基-庚烯酮、2-(2-(4-甲基-3-环己烯-1-基)丙基)-环戊酮、1-(对孟烯-6(2)-基)-1-丙酮、4-(4-羟基-3-甲氧基苯基)-2-丁酮、2-乙酰基-3,3-二甲基-降冰片烷、6,7-二氢-1,1,2,3,3-五甲基-4(5H)-2,3-二氢-1-茚酮、4-大马醇、胡椒基丙酮、2-己基乙酰乙酸乙酯(Gelsone)、烯丙基紫罗兰酮(Hexalon)、龙涎酮、三甲基环己基甲基酮、甲基-熏衣草-酮、4-叔戊基环己酮(Orivon)、对-叔丁基环己酮、2-叔丁基环己酮(Verdone)、2-戊基环戊酮(Delphone)、麝香酮、新丁烯酮、药香酮(Plicatone)、凡路酮(Veloutone)、2,4,4,7-四甲基-辛-6-烯-3-酮和3,4,5,6-四氢假性紫罗兰酮(Tetrameran)。
更优选芳香酮根据其气味特征选自α-二氢大马酮、δ-二氢大马酮、异二氢大马酮、香芹酮、γ-甲基-紫罗兰酮、龙涎酮、2,4,4,7-四甲基-辛-6-烯-3-酮、苄基丙酮、β-二氢大马酮、大马烯酮、二氢茉莉酮酸甲酯、甲基柏木酮及其混合物。
优选地,芳香醛根据其气味特征选自2,6,10-三甲基十一烯-9-醛-1、茴香醛、cymal、乙基香草醛、花青醛、新洋茉莉醛、胡椒醛、羟基香茅醛、乙酰基二聚异戊烯(koavone)、月桂醛、新铃兰醛(lyral)、甲基壬基乙醛、芳香醋醛(P.T.bucinal)、苯基乙醛、十一烯醛、香草醛、2,6,10-三甲基-9-十一烯醛、3-十二烯-1-醛、α-正戊基肉桂醛、4-甲氧基苄醛、苄醛、3-(4-叔丁基苯基)-丙醛、2-甲基-3-(对-甲氧基苯基)丙醛、2-甲基-4-(2,6,6-三甲基-2(1)-环己烯-1-基)丁醛、3-苯基-2-丙烯醛、顺/反-3,7-二甲基-2,6-辛二烯-1-醛、3,7-二甲基-6-辛烯-1-醛、[(3,7-二甲基-6-辛烯基)氧基]乙醛、4-异丙基苄醛、1,2,3,4,5,6,7,8-八氢-8,8-二甲基-2-萘醛、2,4-二甲基-3-环己烯-1-醛、2-甲基-3-(异丙基苯基)丙醛、1-癸醛;癸醛、2,6-二甲基-5-庚烯醛、4-(三环[5.2.1.0(2,6)]-亚癸基-8)-丁醛、八氢-4,7-亚甲基-1H-茚醛、3-乙氧基-4-羟基苄醛、对-乙基-α,α-二甲基氢化肉桂醛、α-甲基-3,4-(亚甲基二氧基)-氢化肉桂醛、3,4-亚甲基二氧基苄醛、α-正己基肉桂醛、间散花烃-7-醛、α-甲基苯基乙醛、7-羟基-3,7-二甲基辛醛、十一烯醛、2,4,6-三甲基-3-环己烯-1-醛、4-(3)(4-甲基-3-戊烯基)-3-环己烯-醛、1-十二醛、2,4-二甲基环己烯-3-醛、4-(4-羟基-4-甲基戊基)-3-环己烯-1-醛、7-甲氧基-3,7-二甲基辛-1-醛、2-甲基十一醛、2-甲基癸醛、1-壬醛、1-辛醛、2,6,10-三甲基-5,9-十一碳二烯醛、2-甲基-3-(4-叔丁基)丙醛、二氢肉桂醛、1-甲基-4-(4-甲基-3-戊烯基)-3-环己烯-1-醛、5或6甲氧基10-六氢-4,7-亚甲基茚满-1或2-醛、3,7-二甲基辛-1-醛、1-十一醛、10-十一烯-1-醛、4-羟基-3-甲氧基苄醛、1-甲基-3-(4-甲基戊基)-3-环己烯醛、7-羟基-3,7-二甲基-辛醛、反式-4-癸烯醛、2,6-壬二烯醛、对甲苯基乙醛;4-甲基苯基乙醛、2-甲基-4-(2,6,6-三甲基-1-环己烯-1-基)-2-丁烯醛、邻-甲氧基肉桂醛、3,5,6-三甲基-3-环己烯醛、3,7-二甲基-2-亚甲基-6-辛烯醛、苯氧基乙醛、5,9-二甲基-4,8-癸二烯醛、牡丹醛(6,10-二甲基-3-氧-5,9-十一碳二烯-1-醛)、六氢-4,7-亚甲基茚满-1-醛、2-甲基壬醛、α-甲基-4-(1-甲基乙基)苯乙醛、6,6-二甲基-2-降蒎烯-2-丙醛、对甲基苯氧基乙醛、2-甲基-3-苯基-2-丙烯-1-醛、3,5,5-三甲基己醛、六氢-8,8-二甲基-2-萘醛、3-丙基-双环[2.2.1]-庚-5-烯-2-醛、9-癸烯醛、3-甲基-5-苯基-1-戊醛、甲基壬基乙醛、己醛、反式-2-己烯醛、1-p-孟烯-q-醛及其混合物。
更优选的醛根据其气味特征选自1-癸醛、苄醛、花青醛、2,4-二甲基-3-环己烯-1-醛、顺/反-3,7-二甲基-2,6-辛二烯-1-醛、胡椒醛、2,4,6-三甲基-3-环己烯-1-醛、2,6-壬二烯醛、α-正戊基肉桂醛、α-正己基肉桂醛、芳香醋醛、新铃兰醛、cymal、甲基壬基乙醛、己醛、反式-2-己烯醛及其混合物。
在以上列出的香料成分中,一些是本领域的技术人员常规地已知的商品名,且还包括异构体。这种异构体也适合于在本发明中使用。
组分E)也可以是一种或更多种植物提取物。这些组分的实例如下所述:明日叶提取物、鳄梨提取物、八仙花提取物、蜀葵根提取物、山金车花提取物、芦荟提取物、杏提取物、杏仁提取物、白果提取物、茴香提取物、姜黄提取物、乌龙茶提取物、营实提取物、松果菊提取物、黄芩根提取物、黄柏皮提取物、日本黄连提取物、大麦提取物、提取物、白荨麻提取物、豆瓣菜提取物、柑橘提取物、脱水的咸水、海藻提取物、水解弹性蛋白、水解小麦粉、水解蚕丝、甘菊提取物、胡萝卜提取物、艾属提取物、甘草提取物、木槿提取物、火棘果提取物、猕猴桃提取物、金鸡纳树提取物、黄瓜提取物、鸟苷、栀子提取物、竹叶提取物、槐属根提取物、核桃提取物、柚子提取物、铁线莲提取物、小球藻提取物、桑树提取物、龙胆提取物、黑茶提取物、酵母提取物、牛蒡提取物、米糠酵素提取物、大米胚芽油、聚合草提取物、胶原、越橘提取物、栀子提取物、细辛根提取物、柴胡属类提取物、脐带提取物、鼠尾草提取物、肥皂草提取物、竹子提取物、山楂果提取物、花椒果提取物、什塔克菇提取物、地黄根提取物、紫草提取物、紫苏提取物、菩提树提取物、蚊子草提取物、牡丹提取物、菖蒲根提取物、白桦提取物、马尾提取物、常春藤螺旋状物(Ivy)提取物、山楂提取物、西洋接骨木提取物、蓍草提取物、胡椒薄荷提取物、红根草提取物、锦葵提取物、川芎根提取物、日本绿龙胆提取物、大豆提取物、枣提取物、百里香提取物、茶提取物、丁香提取物、禾本科白茅属提取物、柑桔属温州蜜柑皮提取物、日本当归根提取物、金盏草提取物、桃仁提取物、苦橙皮提取物、鱼腥草提取物、西红柿提取物、纳豆提取物、人参提取物、绿茶提取物、咖喱提取物、蔷薇提取物、芙蓉提取物、麦冬块茎提取物、莲属nucifera提取物、欧芹提取物、蜂蜜、金缕梅提取物、墙草属提取物、溪黄草提取物、没药醇提取物、枇杷提取物、款冬提取物、蜂斗叶属提取物、茯苓提取物、金雀花提取物、葡萄提取物、蜂胶提取物、丝瓜提取物、红花提取物、薄荷提取物、椴树提取物、芍药属提取物、啤酒花提取物、松树提取物、七叶树提取物、堪察加鼬芋[Lysichiton camtschatcese]提取物、无患子果皮提取物、蜜蜂花提取物、桃子提取物、矢车菊提取物、桉树提取物、虎耳草提取物、香木缘提取物、薏苡属提取物、蒿叶提取物、熏衣草提取物、苹果提取物、莴苣提取物、柠檬提取物、紫云英提取物、玫瑰提取物、迷迭香提取物、罗马白花母菊提取物和蜂王浆提取物。
在硅氧烷凝胶组合物内存在的组分E)的用量可以变化,但其范围典型地如下所述:
基于组合物内存在的硅氧烷弹性体凝胶的重量,亦即在硅氧烷凝胶组合物内的组分A)、B)、C)和D)的总重量,为0.05-50wt%,或者1-25wt%,或者1-10wt%。
活性成分组分E)可在硅氧烷弹性体的制备过程中(预负载方法)加入到硅氧烷凝胶组合物内,或者在形成硅氧烷弹性体凝胶之后添加(后负载方法)。
含硅氧烷有机弹性体的凝胶糊剂组合物
可使用本发明的凝胶组合物,通过:
I)剪切以上所述的硅氧烷有机弹性体凝胶,
II)结合剪切过的硅氧烷有机弹性体凝胶与额外量的ii)以上所述的载体流体和任选地E)个人或健康护理活性成分,形成凝胶糊剂组合物,从而制备凝胶糊剂组合物。
本发明的硅氧烷有机弹性体凝胶组合物可被视为在载体流体内分散的离散、交联的硅氧烷有机弹性体。硅氧烷有机弹性体凝胶组合物还是许多有机和硅氧烷流体的有效流变学增稠剂。正因为如此,可使用它们制备有用的凝胶共混物组合物,例如“糊剂”组合物。
为了制备这种硅氧烷有机弹性体糊剂,剪切已知起始弹性体含量的前述硅氧烷有机弹性体凝胶,以获得小的粒度,可任选进一步稀释成最终的弹性体含量。此处所使用的“剪切”是指任何剪切混合工艺,例如由均化、超声获得的任何剪切混合工艺或本领域已知作为剪切混合的任何其他混合工艺。硅氧烷有机弹性体凝胶组合物的剪切混合导致粒度降低的组合物。随后粒度降低的组合物进一步与额外量的ii)载体流体结合。典型地,加入到凝胶中形成凝胶糊剂的载体流体的用量足以提供含30wt%硅氧烷有机弹性体,或者20wt%,或者10wt%的凝胶糊剂组合物。载体流体可以是以上所述的任何载体流体,但典型地是脂族烃。结合ii)载体流体与硅氧烷有机弹性体组合物的技术典型地涉及简单搅拌或混合。所得组合物可视为糊剂,其粘度为至少50Pa·s,或者至少100Pa·s,或者至少200Pa·s,这在具有Helipath固定装置的Brookfield DVII+粘度计上,使用锭子T-D(20.4mm十字顶梁)在2.5rpm下测量。
可通过:
I)在剪切下,制备(以上所述的)硅氧烷有机弹性体凝胶,
II)结合剪切的硅氧烷有机弹性体凝胶与额外量的ii)以上所述的载体流体和任选地E)个人或健康护理活性成分,形成凝胶糊剂组合物,从而形成凝胶糊剂组合物。
F)额外的任选组分
本发明组合物也可含有许多任选的成分。特别地,这些任选的组分选自本领域已知作为个人护理配制剂内成分的那些。例举的非限定性实例包括表面活性剂、溶剂、粉末、着色剂、增稠剂、蜡、稳定剂、pH调节剂和硅氧烷类。
可添加增稠剂,以提供方便的粘度。例如,在25℃下,范围为500-25,000mm2/s或者范围为3000-7000mm2/s的粘度通常是合适的。合适的增稠剂例举藻酸钠、阿拉伯胶、聚氧乙烯、瓜耳胶、羟丙基瓜耳胶、乙氧化醇(例如月桂基聚氧乙烯醚-4或聚乙二醇400)、纤维素衍生物(其中例举甲基纤维素、甲基羟丙基纤维素、羟丙基纤维素、聚丙基羟乙基纤维素)、淀粉和淀粉衍生物(其中例举羟乙基直链淀粉和直链淀粉)、刺豆槐胶、电解质(其中例举氯化钠和氯化铵)、和糖类(例如果糖和葡萄糖)和糖类的衍生物(例如PEG-120甲基葡萄糖二醇化物)、或这些中两种或更多种的混合物。或者,增稠剂选自纤维素衍生物、糖类衍生物和电解质、或者选自上述增稠剂的两种或更多种的组合,其中例举纤维素衍生物和任何电解质以及淀粉衍生物和任何电解质的组合。若使用增稠剂的话,其在本发明的香波组合物内的存在量足以提供最终香波组合物500-25,000mm2/s的粘度。或者,基于组合物的总重量,增稠剂的存在量为约0.05-10wt%和/或者0.05-5wt%。
可在组合物的水相中使用稳定剂。合适的水相稳定剂可单独或结合包括一种或多种电解质、多元醇、醇例如乙醇、和水解胶体。典型的电解质是碱金属盐和碱土金属盐,特别是钠、钾、钙和镁的盐酸盐、硼酸盐、柠檬酸盐和硫酸盐,以及水合氯化铝,和聚电解质,特别是透明质酸和透明质酸钠。当稳定剂是或者包括电解质时,其用量为组合物总重量的约0.1-5wt%或者0.5-3wt%。水解胶体包括树胶,例如黄原胶或硅酸镁铝和增稠剂,例如羧甲基纤维素。也可使用多元醇,例如甘油、二元醇和山梨醇。或者,多元醇是甘油、丙二醇、山梨醇和丁二醇。若使用大量多元醇,则不需要添加电解质。然而,典型的是使用电解质、多元醇和水解胶体的组合,以稳定水相,例如硫酸镁、丁二醇和黄原胶。
其他添加剂可包括粉末和颜料,特别是当本发明的组合物拟用于化妆品时。本发明的粉末组分通常可定义为粒度为0.02-50微米的干燥的粒状物质。该粒状物质可着色或未着色(例如白色)。合适的粉末包括但不限于氯氧化铋、钛酸化云母、热解法二氧化硅、球形二氧化硅珠粒、聚甲基丙烯酸甲酯珠粒、氮化硼、硅酸铝、淀粉辛烯基琥珀酸铝、膨润土、高岭土、硅酸铝镁、二氧化硅、滑石、云母、二氧化钛、高岭土、尼龙、蚕丝粉末。可表面处理以上提及的粉末,以在性质上赋予颗粒疏水性。
该粉末组分还包括各种有机和无机颜料。有机颜料通常是各种芳烃类,其中包括偶氮、靛类、三苯甲烷、蒽醌和叶黄素染料(它表示为D&C和FD&C蓝、棕、绿、橙、红、黄等)。无机颜料通常由合格的色料添加剂的不溶性金属盐(称为色淀或铁的氧化物)组成。通常以与着色颜料的混合物形式使用的粉状着色剂,例如炭黑、铬或铁的氧化物,群青、焦磷酸镁、铁蓝和二氧化钛、珠光剂,或者通常以与着色颜料的混合物形式使用且常用于化妆品工业中的一些有机染料可加入到组合物中。一般地,这些着色剂的存在量以重量计,相对于最终组合物的重量为0-20wt%。
也可添加粉状无机或有机填料,相对于最终组合物的重量,其用量以重量计通常为0-40%。这些粉状填料可选自滑石、云母、高岭土、锌或钛的氧化物,钙或镁的碳酸盐,二氧化硅,球形二氧化钛,玻璃或陶瓷珠粒,由具有8-22个碳原子的羧酸衍生的金属皂,非发泡的合成聚合物粉末,发泡粉末和来自天然有机化合物的粉末,例如谷类淀粉(它可以交联或者可以不交联),共聚物微球,例如EXPANCEL(NobelIndustries),Polytrap和有机硅树脂微球(例如获自Toshiba的TOSPEARL)。
可用于本发明组合物的蜡或蜡状材料在大气压下的熔点范围通常为35-120℃。在这一类别下的蜡包括合成蜡、地蜡、石蜡、天然地蜡、蜂蜡、巴西棕榈蜡、微晶蜡、羊毛脂、羊毛脂衍生物、小烛树蜡、可可脂、紫胶蜡、鲸蜡油、糠蜡、木棉(capok)蜡、甘蔗蜡、褐煤蜡、鲸蜡、杨梅蜡或其混合物。在能用作非硅氧烷脂肪物质的蜡当中,可提及动物蜡,例如蜂蜡;植物蜡,例如巴西棕榈蜡、小烛树蜡;矿物蜡,例如石蜡或褐煤蜡或微晶蜡或天然地蜡;合成蜡,其中包括聚乙烯蜡和通过费-托合成获得的蜡。在硅氧烷蜡当中,可以提及聚甲基硅氧烷烷基类、烷氧基类和/或酯类。
这种任选的组分包括其他硅氧烷类(其中包括以上已经描述的任何一种)、有机官能的硅氧烷类,烷基甲基硅氧烷类、硅氧烷树脂和硅氧烷胶料。
可在本发明的组合物内包括烷基甲基硅氧烷。这些硅氧烷聚合物的通式通常为Me3SiO[Me2SiO]y[MeRSiO]zSiMe3,其中R是含6-30个碳原子的烃基,Me代表甲基,和聚合度(DP),即y与z之和为3-50。烷基甲基硅氧烷的挥发性和液体物质也可在组合物中使用。
可在本发明的组合物内包括硅氧烷胶料。聚二有机基硅氧烷胶料是本领域已知的且可商购。它们通常由在25℃下粘度超过1,000,000厘沲(mm2/s),或者在25℃下大于5,000,000厘沲(mm2/s)的不溶性聚二有机基硅氧烷组成。这些硅氧烷胶料典型地以已经分散在合适溶剂内便于其处理的组合物形式销售。也可包括超高粘度的硅氧烷类作为任选的成分。这些超高粘度的硅氧烷类典型地在25℃下的运动粘度大于5百万厘沲(mm2/s)到在25℃下约2千万厘沲(mm2/s)。最优选悬浮体形式的这类组合物,且例如公开于美国专利6013682(2000年1月11日)中。
可在本发明的组合物内包括有机硅树脂。这些树脂组合物通常是高度交联的聚合物硅氧烷。通过掺入三官能和/或四官能的硅烷与在制备过程中所使用的单官能的硅烷和/或双官能的硅烷单体,获得交联。获得合适的有机硅树脂所要求的交联程度随在有机硅树脂的制备过程中掺入的硅烷单体单元的细节而变化。一般地,具有充足含量的三官能和四官能硅氧烷单体单元,进而具有充足交联水平,在干燥之后成为硬质或坚硬膜的任何硅氧烷可被视为适合于用作有机硅树脂。适合于此处应用的可商购的有机硅树脂通常以在低粘度的挥发性或非挥发性硅氧烷流体内的未硬化形式供应。应当将非硬化形式而不是硬化的树脂结构形式的有机硅树脂掺入到本发明的组合物内。
可在本发明的组合物内包括硅氧烷醇(carbinol)流体。在WO03/101412A2中公开了这些材料,且通常被描述为取代的烃基官能的硅氧烷流体或树脂。
可在本发明的组合物内包括水溶性或水分散性硅氧烷聚醚组合物。这些也称为聚氧化烯硅氧烷共聚物、硅氧烷聚氧化烯共聚物、硅氧烷二元醇共聚物或硅氧烷表面活性剂。这些可以是直链耙型或接枝类材料,或ABA类,其中B是硅氧烷聚合物嵌段,和A是聚氧化烯基。聚氧化烯基可由聚环氧乙烷、聚环氧丙烷或混合的聚环氧乙烷/聚环氧丙烷基组成。其他氧化物,例如环氧丁烷或氧化苯也是可行的。
可在使用硅氧烷乳化剂的w/o、w/s或多相乳液中使用本发明的组合物。典型地,在这一配制剂内,硅氧烷包水的乳化剂是非离子的,且选自聚氧化烯取代的硅氧烷,硅氧烷烷醇酰胺,硅氧烷酯,和硅氧烷糖苷。合适的硅氧烷基表面活性剂是本领域众所周知的且例如公开于U.S.4122029(Gee等人)、US5387417(Rentsch)和US5811487(Schulz等人)中。
当本发明的组合物是水包油乳液时,它包括制备乳液常用的普通成分,例如但不限于本领域制备o/w乳液众所周知的非离子表面活性剂。非离子表面活性剂的实例包括聚氧亚乙基烷基醚、聚氧亚乙基烷基苯酚醚、聚氧亚乙基月桂基醚、聚氧亚乙基脱水山梨醇单油酸酯、聚氧亚乙基烷基酯、聚氧亚乙基脱水山梨醇烷基酯、聚乙二醇、聚丙二醇、二甘醇、乙氧化三甲基壬醇和聚氧化烯二醇改性的聚硅氧烷表面活性剂。
本发明的组合物也可为与推进剂气体,例如二氧化碳、氮气、一氧化二氮、挥发性烃,例如丁烷、异丁烷或丙烷和氯化或氟化烃,例如二氯二氟甲烷和二氯四氟乙烷或二甲醚结合的气溶胶形式。
可在各种个人、家庭和健康护理应用中使用硅氧烷弹性体凝胶组合物。特别地,本发明的组合物可用作:增稠剂(如美国专利Nos.6051216、5919441、5981680中教导的);用于结构油中(如WO2004/060271和WO2004/060101中所公开的);用于防晒组合物中(如WO2004/060276中教导的);在还含有成膜树脂的化妆品组合物内用作结构化剂(如WO03/105801中所公开);用于化妆品组合物中(如美国专利申请公布2003/0235553、2003/0072730、2003/0170188、EP1266647、EP1266648、EP1266653、WO03/105789、WO2004/000247和WO03/106614中教导);用作结构化剂(如WO2004/054523中教导);在持久化妆品组合物中使用(如美国专利申请公布2004/0180032中教导的);在透明或半透明的护理和/或化妆组合物中使用(如WO2004/054524所讨论的),所有这些在此通过参考全部引入。
也可在止汗剂和除味剂组合物中以例如但不限于棒、软固体、滚珠、气溶胶和泵喷雾剂形式使用硅氧烷弹性体凝胶。止汗剂和除味剂的一些实例是氯化铝、水合四氯十二羟基铝锆与甘氨酸的配位化合物、水合四氯十二羟基铝锆与聚乙二醇的配位化合物、碱式氯化铝与丙二醇或聚乙二醇的配位化合物、水合四氯十二羟基铝锆与丙二醇的配位化合物、碱式氯化铝与聚乙二醇(4)的配位化合物、水合三氯十三羟基铝锆、碱式氯化铝与丙二醇的配位化合物、水合三氯十三羟基铝锆与甘氨酸的配位化合物、六氯酚、烷基苄基二甲基氯化铵、水合倍半氯4,5羟基二铝、碳酸氢钠、水合倍半氯4,5羟基二铝与聚乙二醇的配位化合物、叶氯酸-铜配位化合物、三氯生、水合八氯二十羟基铝锆和蓖麻醇酸锌。
本发明的个人护理组合物可以是霜、凝胶、粉末、糊剂或可自由倾倒的液体形式。一般地,若组合物内不存在在室温下为固体的材料,则使用简单的螺旋桨混合器、Brookfield反向旋转混合器或均化混合器,通常在室温下制备这种组合物。典型地不要求特殊设备或加工条件。取决于所制备的剂型类型,制备方法将不同,但这些方法是本领域众所周知的。
可通过标准方法使用本发明的组合物,例如使用施涂器、刷子,施加它们到人体,例如皮肤或头发上,或者用手施加,倾倒它们和/或可能地擦拭或按摩组合物到体表或体内。除去方法,例如除去彩色化妆品的方法也是公知的标准方法,其中包括洗涤、擦拭、剥离和类似方法。对于在皮肤上使用来说,可按照常规的方式,例如调理皮肤的常规方式使用本发明的组合物。将用于这一目的的有效量的组合物施加到皮肤上。这一有效量的范围通常是约1mg/cm2-约3mg/cm2。施加到皮肤上典型地包括将组合物操作到皮肤内。施加到皮肤上的这一方法包括接触皮肤与有效量的组合物,然后将该组合物擦拭到皮肤内的步骤。这些步骤可视需要反复多次,以实现所需的益处。
在头发上使用本发明的组合物可利用调理头发的常规方式。将调理头发有效量的组合物施加到头发上。这一有效量范围通常是约1-50g,优选约1-20g。施加到头发上典型地包括操作该组合物通过头发,以便大多数或所有的头发与该组合物接触。调理头发的这一方法包括施加有效量的头发护理组合物到头发上,然后操作该组合物通过头发的步骤,这些步骤可视需要重复多次,以实现所需的调理益处。当高硅氧烷含量掺入到本发明的头发护理组合物内时,它可以是分叉头发产品的有用材料。
可在人类或动物的皮肤上使用本发明的组合物,以例如增湿、着色或通常改进外观或施加活性成分,例如防晒剂、除味剂、驱虫剂等。
实施例
对于本领域的普通技术人员来说,这些实施例拟阐述本发明,不应当解释为限制权利要求书列出的本发明的范围。所有测量和实验在23℃下进行,除非另有说明。
材料
有机基氢硅氧烷1=平均式为(CH3)3SiO[(CH3)2SiO]x[(CH3)HSiO]ySi(CH3)3的二甲基、甲基氢聚硅氧烷,其中x和y的数值使得该有机基氢硅氧烷在23℃下的粘度为116mm2/s(cSt)且含有0.084wt%Si-H形式的H。
有机基氢硅氧烷2=平均式为(CH3)3SiO[(CH3)2SiO]x[(CH3)HSiO]ySi(CH3)3的二甲基、甲基氢聚硅氧烷,其中x和y的数值使得该有机基氢硅氧烷在23℃下的粘度为67mm2/s(cSt)且含有0.15wt%Si-H形式的H。
有机基乙烯基硅氧烷=通式为(ViMe2SiO0.5)2(Me2SiO)x的乙烯基端基的二甲基聚硅氧烷,其中x的数值使得该有机基乙烯基硅氧烷在23℃下的粘度为5mm2/s(cSt)。
在下表概述的这些实施例中使用具有一个或两个烯丙基端基和变化量的环氧丙烷或环氧乙烷单元的聚氧化烯:
聚氧化烯# | 平均结构 | MW(g/mol) | 乙烯基浓度(mmol/g) |
聚氧化烯1 | CH2=CHCH2O(CH3CH(CH3)O)7.05CH2CH=CH2 | 505.9 | 3.95 |
聚氧化烯2 | CH2=CHCH2O(CH3CH(CH3)O)17.3CH2CH=CH2 | 1086.5 | 1.84 |
聚氧化烯3 | CH2=CHCH2O(CH3CH(CH3)O)34.6CH2CH=CH2 | 2073.9 | 0.96 |
聚氧化烯4 | CH2=CHCH2O(CH3CH(CH3)O)17OBu | 1134.7 | 1.97 |
聚氧化烯5 | CH2=CHCH2O(CH2CH2O)17OCH3 | 837.0 | 5.06 |
由相应的OH端基的聚氧化烯通过与NaH反应,形成烷氧化物,然后使之与烯丙基氯反应,形成烯丙基端基的聚醚,从而合成二烯丙基官能的聚氧化烯。或者,在商业上可购买二烯丙基官能的聚氧化烯。
实施例1:含聚氧化烯交联的硅氧烷有机弹性体的凝胶的制备
首先,称取42.40g(35.5mmol Si-H)有机基氢硅氧烷1、9.83g聚氧化烯1和194g异十二烷到含特氟隆涂布的搅拌棒的16oz宽嘴罐内。然后,密封罐子并使用水浴或烘箱加热到70℃。除去罐的热量,然后在搅拌的同时,添加0.6g SYLOFF 4000催化剂(0.52wt%铂),以提供12ppm铂。给罐加盖,放置在70℃水浴内,并继续搅拌,直到反应混合物胶凝。在70℃下,在水浴或烘箱内保持混合物额外3小时,提供含21.1%硅氧烷-有机弹性体的凝胶。
使用以上所述的工序,合成含具有变化量环氧丙烷单元(17.3或34.6)的聚氧化烯交联的硅氧烷有机弹性体的凝胶。表1中概述了制备这些凝胶组合物所使用的配方。
表1
实施例# | 1A | 1B | 1C | 2A | 2B |
凝胶配方 | |||||
有机基氢硅氧烷1 | 42.40g | 34.94g | 26.86g | 34.15g | 27.67g |
聚氧化烯1 | 9.83g | 8.82g | |||
聚氧化烯2 | 17.26g | 15.30g | |||
聚氧化烯3 | 25.34g | ||||
异十二烷 | 194.4g | 194.4g | 194.4g | 225g | 225g |
Syloff 4000-Pt催化剂 | 0.6g | 0.6g | 0.6g | 0.6g | 0.6g |
实施例2(对比):含己二烯交联的硅氧烷有机弹性体的凝胶的制备
首先,称取50.32g(42.2mmol Si-H)有机基氢硅氧烷1、1.88g(46.3meq不饱和度)1,5-己二烯和194g异十二烷到含搅拌棒的16oz宽嘴罐内。然后,打算使烯烃过量8.5%(Si-H:Vi=0.92),以最小化残留的Si-H量。密封罐子并在烘箱内加热到70℃。除去罐的热量,然后在搅拌的同时,添加0.6g SYLOFF 4000催化剂(0.52wt%铂)。这使得混合物具有最多12ppm铂。给罐加盖,然后放置在70℃水浴内,继续搅拌直到胶凝。在70℃下,在烘箱内保持混合物34、时,形成含21.1%弹性体的凝胶。
实施例3:由弹性体凝胶制备凝胶糊剂
使用高剪切混合,将实施例1和实施例2制备的弹性体凝胶制成凝胶糊剂。剪切步骤包括添加异十二烷、有机基乙烯基硅氧烷和甲氧基肉桂酸辛酯(OMC),产生表2-5所示的糊剂。在Waring CommercialLaboratory Blender内剪切表2的材料。在剪切步骤1中,在设定1下剪切凝胶20秒,然后在设定3下剪切20秒,然后在设定5下剪切20秒。添加异十二烷和有机基乙烯基硅氧烷,接着在下述每一设定:1、2、3、3下剪切30秒。在每一设定之间,使用刮刀,从混合器杯的侧壁中刮擦材料。在第三剪切步骤之前,根据表2,添加额外的异十二烷和甲氧基肉桂酸辛酯,接着在下述每一设定:1、1、1下剪切20秒。在每一设定之间,从混合器杯的侧壁上刮擦材料。使用购自FlackTek Inc.的Hauschild Speed Mixer型号DAC 150FVZ,剪切表3-5中的材料。在第一剪切步骤中,在最大设定(约3500rpm)下剪切凝胶25秒。添加异十二烷和有机基乙烯基硅氧烷,接着在最大设定下剪切25秒。添加额外的异十二烷和甲氧基肉桂酸辛酯,并在最大设定下剪切材料25秒。按照与表3-5相同的方式加工表6中的材料,所不同的是两个剪切步骤的持续时间为30秒而不是25秒。
表2:添加OMC,加工己二烯-交联的硅氧烷有机弹性体糊剂
表3:添加OMC,加工二烯丙基聚醚-交联(7DP)的硅氧烷有机弹性体糊剂
表4:添加OMC,加工二烯丙基聚醚-交联(17DP)的硅氧烷有机弹性体糊剂
表5:添加OMC,加工二烯丙基聚醚-交联(35DP)的硅氧烷有机弹性体糊剂
表6:二烯丙基聚醚-交联的硅氧烷有机弹性体糊剂的加工
糊剂2B | 糊剂2A | |
凝胶2A | 63.75g | |
凝胶2B | 63.75g | |
异十二烷 | 21.26g | 21.26g |
有机基乙烯基硅氧烷 | 0.43g | 0.43g |
实施例4:含聚氧化烯交联的硅氧烷有机弹性体的凝胶与甲氧基肉桂酸辛酯的相容性
正如这一实施例所述,可通过增加聚丙二醇(PPG)交联剂的聚合度(DP),改进硅氧烷有机弹性体凝胶的有机相容性。当使用相同的有机基氢硅氧烷时,增加聚氧化烯内环氧丙烷单元的数量增加弹性体组分的有机物含量和有机相容性,这通过在这一实施例中,使用甲氧基肉桂酸辛酯,一种已知与硅氧烷有机弹性体凝胶的溶解性有限的有机防晒剂来证明。如表7所概述的,当环氧丙烷的含量增加(这通过DP或聚合度,即环氧丙烷单元数量来显示)时,硅氧烷有机弹性体与甲氧基肉桂酸辛酯的相容性增加,这以透明度为基础。
粘度的变化也提供相容性的指示。如表8所示,粘度随己二烯-交联的弹性体糊剂内较高的甲氧基肉桂酸辛酯水平而下降,而在聚丙二醇交联的弹性体糊剂内粘度得到维持或增加。在具有Helipath固定装置和T-D锭子(t-棒几何形状)的Brookfield DV-II+粘度计上,在2.5rpm下测量粘度。在合成样品之后1天测定粘度。将样品真空脱气,并在测试之前,允许静置不受干扰最小4小时。在上下通过样品的2个循环过程中获得数据。所报道的粘度是t棒首先向上和第二次向下通过样品的平均值。
表7:作为交联剂和OMC体积%的函数,弹性体共混物的相容性(透明度)
A=透明,C=半透明,E=浑浊
表8:作为交联剂和OMC体积%的函数,弹性体共混物的粘度
实施例5:含聚氧化烯交联的硅氧烷有机弹性体的凝胶糊剂与各种个人成分的相容性
表9概述了相对于基于己二烯交联剂的硅氧烷有机弹性体凝胶糊剂,在15wt%添加量下,用各种个人护理成分配制的基于聚丙二醇交联剂的硅氧烷有机弹性体凝胶糊剂的相容性数据。相容性以评估外观(透明度和均匀度)和增稠行为这二者为基础。表10示出了类似的相容性试验,但使用25wt%活性成分。正如这些表概述的,通过掺入聚丙二醇到弹性体内,相容性得到改进。
实施例6:含聚氧化烯交联的硅氧烷有机弹性体的凝胶的感觉行为
使用训练有素的专家感觉试验小组成员,评价纯弹性体凝胶糊剂的感觉美学性。在图1和2中示出了所得感觉数据,该图比较了聚氧化烯交联的硅氧烷有机弹性体糊剂(糊剂2A)与己二烯交联的硅氧烷有机弹性体糊剂的感觉美学性。结果表明感觉特征类似。
在异十二烷内弹性体共混物糊剂的感觉行为:比较用己二烯与双(烯丙基)聚(丙二醇)交联的材料
实施例7
含具有侧挂聚氧亚乙基的聚氧化烯交联的硅氧烷有机弹性体的凝胶的制备
将有机基氢硅氧烷2,单烯丙基聚醚基[或者聚(环氧丙烷)或者聚(环氧乙烷),聚氧化烯4或5]和异十二烷引入到反应容器内并加热到70℃。在搅拌的同时,添加0.7g 4000催化剂的溶液(Karstedt′s催化剂,与1,3-二乙烯基-1,1,3,3-四甲基二硅氧烷络合的铂(0))。在70℃下搅拌反应混合物15分钟。然后将聚氧化烯交联剂(#2)加入到该反应混合物中。最终的反应混合物保持在70℃下3小时,在此期间形成凝胶。表11和12中示出了实际的凝胶配制剂。使用表13所示的剪切和额外的溶剂,将凝胶制成糊剂。
表11:配制具有聚(环氧丙烷)侧基的双烯丙基聚醚交联凝胶
表12:配制具有聚(环氧乙烷)侧基的双烯丙基聚醚交联凝胶
表13:由表11和12中的凝胶加工配制硅氧烷有机弹性体糊剂
剪切步骤1 56.9g硅氧烷/聚醚弹性体凝胶 |
剪切步骤2 26.2g异十二烷 |
0.5g有机基乙烯基硅氧烷 |
混合该糊剂与水(2份糊剂,1份水)。具有聚(环氧乙烷)侧基的糊剂形成油包水乳液,而具有聚(环氧丙烷)侧基的糊剂没有形成乳液。
实施例8
含硅氧烷-有机凝胶的个人护理配制剂
如这一实施例中所述,制备本发明含代表性硅氧烷-有机凝胶的个人护理配制剂。在这些配制剂中所使用的硅氧烷-有机糊剂是来自表6的糊剂2A或2B(亦即,使用每一硅氧烷有机凝胶制备配制剂,除非另有说明)。
蓖麻油基口红配制剂
工序:
1.加热A相到85℃
2.添加B相
3.倾倒到口红模具内
4.在冷冻器内放置60分钟
5.从模具中取出。
具有5%弹性体共混物的环五硅氧烷基口红配制剂
原料 | INCI名称 | % |
A相 |
原料 | INCI名称 | % |
白色天然地蜡 | 4 | |
Cerilla G | 小烛树蜡 | 11 |
Eutanol G | 辛基十二烷醇 | 25 |
Dow Corning 245 | 环五硅氧烷 | 5 |
弹性体共混物 | 硅氧烷有机糊剂2A或2B | 5 |
Petrolatum | 凡士林 | 4 |
Fluilan | 羊毛脂油 | 9 |
鳄梨油 | 2 | |
Novol | 油醇 | 8 |
颜料共混物 | 27 | |
100 | ||
颜料共混物 | ||
Covasil TiO2 | 5 | |
Dow Corning 245 | 环五硅氧烷 | 77.5 |
Covasil red W3801 | 17.5 | |
100 |
工序:
1.加热除了颜料共混物以外的A相到85℃
2.添加颜料共混物
3.倾倒配制剂到口红模具内
4.在冷冻器内放置60分钟
5.从模具中取出。
Liptissime Duo Stick
工序:
1.采用高剪切混合器,在硅氧烷内粉碎A相的颜料
2.混合B相的成分并加热到80℃
3.在搅拌的同时,添加A相到B相中,并继续加热
4.在混合下添加C相
5.在搅拌下添加D相并维持在70℃的温度下
6.在模具内,在70℃下倾倒。
液体口红:长期持久
工序:
1.一起混合A相成分
2.使用高剪切混合器(Ultraturrax或Silverson类)均化
3.加热成分4到80℃
4.除去烧杯的皮重(最终的烧杯),加热异十二烷到40℃,用铝箔覆盖该烧杯
5.添加成分4到5中,终止加热并确保均匀的混合物
6.在轻轻混合下,添加A相到B相中
7.在混合下,添加C相
8.在缓慢混合下,添加D相
9.在缓慢混合下,添加E相
10.最后用异十二烷补偿溶剂的损失
具有弹性体共混物的粉底霜
工序:
1.混合A相成分并使用高剪切混合器均化
2.添加弹性体共混物,当熔融时,添加B相其余成分
3.在另一烧杯内混合C相成分
4.在搅拌下(1200rpm)下,将C相非常缓慢地添加到A+B相内
5.当完成添加时,保持搅拌额外5分钟并流过均化器
着色的防晒剂
工序:
1.一起混合A相成分
2.一起粉碎B相成分并在混合下加入到A相中
3.一起混合C相成分
4.检查水相的pH(5.5-6.5)并视需要校正
5.缓慢地并在涡流混合(约1000rpm)下,添加C相到AB共混物中
6.在相同速度下继续混合10分钟
7.使混合物流经高剪切装置,得到均匀的粒度分布
在触摸之后,具有光滑感的洗浴凝胶
工序:
1.混合A相成分
2.一起混合B相成分并在混合下加入到A相中
3.添加C相并混合
4.采用D相调节pH到5.5-6
5.倾倒在容器内。
Claims (15)
1.一种个人或健康护理组合物,它包含由下述物质衍生的硅氧烷有机弹性体凝胶:
i)含A)、B)、C)和D)的反应产物的硅氧烷有机弹性体:
A)含下述平均式的甲硅烷氧基单元的有机基氢硅氧烷:
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y,其中
R1是氢或R2,
R2是单价烃基,
v≥2,x≥0,y≥2,
B)含下述平均式的聚氧化烯:
R3O-[(C2H4O)c(C3H6O)d(C4H8O)e]-R3
其中R3是含2-12个碳原子的单价不饱和脂族烃基,c为0-100,d为0-100,e为0-100,条件是(d+e)/(c+d+e)之比>0.5,
C)氢化硅烷化催化剂,和
D)具有一个不饱和脂族烃基端基的任选的有机化合物,
ii)载体流体,和
E)个人或健康护理活性成分。
2.权利要求1的组合物,其中硅氧烷有机弹性体凝胶含有:
2-95wt%的i)硅氧烷有机弹性体,和
5-98wt%的ii)载体流体。
3.权利要求1或2的组合物,其中载体流体是有机液体。
4.权利要求3的组合物,其中有机液体是脂族烃。
5.权利要求1的组合物,其中B)内不饱和脂族烃基与A)内SiH单元的摩尔比大于1。
6.权利要求1的组合物,其中A)有机基氢硅氧烷选自具有下述平均式的有机基氢硅氧烷:
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y(R2SiO1.5)z,
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y(SiO2)w,
(R1 3SiO0.5)v(R2 2SiO)x(R2HSiO)y(SiO2)w(R2SiO1.5)z,
或其任何的混合物,其中
R1是氢或R2,
R2是单价烃基,
和v≥2,w≥0,x≥0,y≥2,和z≥0。
7.权利要求1的组合物,其中有机基氢硅氧烷是具有下述平均式的二甲基、甲基氢聚硅氧烷:
(CH3)3SiO[(CH3)2SiO]x[(CH3)HSiO]ySi(CH3)3
其中x≥0,和y≥2。
8.权利要求1的组合物,其中聚氧化烯选自:
H2C=CHCH2O[C3H6O]dCH2CH=CH2
H2C=C(CH3)CH2O[C3H6O]dCH2C(CH3)=CH2
HC≡CCH2O[C3H6O]dCH2C≡CH或
HC≡CC(CH3)2O[C3H6O]dC(CH3)2C≡CH
其中d为1-100。
9.权利要求1的组合物,其中氢化硅烷化催化剂是含铂族金属的催化剂。
10.权利要求1的组合物,其中有机基氢硅氧烷是具有下述平均式的二甲基、甲基氢聚硅氧烷:
(CH3)3SiO[(CH3)2SiO]x[(CH3)HSiO]ySi(CH3)3
其中x≥0,和y≥2;
聚氧化烯是H2C=CHCH2O[C3H6O]dCH2CH=CH2,其中d为1-100,和载体流体是脂族烃。
11.权利要求10的组合物,其中脂族烃是异十二烷。
12.权利要求1的组合物,其中E)是选自维生素、防晒剂、植物提取物或香料中的个人护理活性成分。
13.权利要求1的组合物,其中E)是选自局部药物活性成分、蛋白质、酶、抗真菌剂或抗微生物剂中的健康护理活性成分。
14.权利要求1的组合物,其中组分是甲氧基肉桂酸辛酯。
15.权利要求1的组合物,其中个人护理组合物选自彩色化妆品、口红、粉底、香波、头发调理剂、头发固定剂、洗浴凝胶、皮肤增湿剂、皮肤调理剂、身体调理剂、防晒产品、止汗剂和除味剂。
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US97531807P | 2007-09-26 | 2007-09-26 | |
US60/975,318 | 2007-09-26 | ||
PCT/US2008/077791 WO2009042832A2 (en) | 2007-09-26 | 2008-09-26 | Personal care compositions containing silicone-organic gels from polyalkyloxylene crosslinked silicone elastomers |
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CN101808610A true CN101808610A (zh) | 2010-08-18 |
CN101808610B CN101808610B (zh) | 2013-08-28 |
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US (1) | US20100215595A1 (zh) |
EP (2) | EP3093001A1 (zh) |
JP (1) | JP5663306B2 (zh) |
KR (1) | KR101521315B1 (zh) |
CN (1) | CN101808610B (zh) |
WO (1) | WO2009042832A2 (zh) |
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CN110028793A (zh) * | 2019-04-19 | 2019-07-19 | 浙江新安化工集团股份有限公司 | 一种有机硅弹性体、其制备方法及包含其的有机硅弹性体凝胶 |
CN111217965A (zh) * | 2020-02-24 | 2020-06-02 | 广东雷邦高新材料有限公司 | 一种高透明高折光有机硅弹性体凝胶及其制备方法 |
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WO2014132783A1 (ja) * | 2013-02-28 | 2014-09-04 | 株式会社マンダム | 皮膚用ジェル状組成物 |
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-
2008
- 2008-09-26 EP EP16171079.3A patent/EP3093001A1/en not_active Withdrawn
- 2008-09-26 JP JP2010527159A patent/JP5663306B2/ja active Active
- 2008-09-26 KR KR1020107006503A patent/KR101521315B1/ko active IP Right Grant
- 2008-09-26 WO PCT/US2008/077791 patent/WO2009042832A2/en active Application Filing
- 2008-09-26 EP EP08833137.6A patent/EP2194954B1/en active Active
- 2008-09-26 US US12/680,269 patent/US20100215595A1/en not_active Abandoned
- 2008-09-26 CN CN200880108942.4A patent/CN101808610B/zh active Active
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102271655A (zh) * | 2009-01-07 | 2011-12-07 | 道康宁公司 | 硅酮糊剂组合物 |
CN102271655B (zh) * | 2009-01-07 | 2014-07-09 | 道康宁公司 | 硅酮糊剂组合物 |
CN110028793A (zh) * | 2019-04-19 | 2019-07-19 | 浙江新安化工集团股份有限公司 | 一种有机硅弹性体、其制备方法及包含其的有机硅弹性体凝胶 |
CN111217965A (zh) * | 2020-02-24 | 2020-06-02 | 广东雷邦高新材料有限公司 | 一种高透明高折光有机硅弹性体凝胶及其制备方法 |
CN112571907A (zh) * | 2020-12-03 | 2021-03-30 | 安徽嘉明新材料科技有限公司 | 一种医疗防护服用tpu防水透湿阻隔膜 |
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WO2009042832A3 (en) | 2009-07-16 |
JP5663306B2 (ja) | 2015-02-04 |
KR101521315B1 (ko) | 2015-05-18 |
JP2010540727A (ja) | 2010-12-24 |
EP2194954A2 (en) | 2010-06-16 |
EP3093001A1 (en) | 2016-11-16 |
US20100215595A1 (en) | 2010-08-26 |
CN101808610B (zh) | 2013-08-28 |
WO2009042832A2 (en) | 2009-04-02 |
KR20100059905A (ko) | 2010-06-04 |
EP2194954B1 (en) | 2016-06-08 |
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