CN101803947A - Cold and hot probe device used for cold and hot combination therapy of tumor - Google Patents
Cold and hot probe device used for cold and hot combination therapy of tumor Download PDFInfo
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- CN101803947A CN101803947A CN 201010122851 CN201010122851A CN101803947A CN 101803947 A CN101803947 A CN 101803947A CN 201010122851 CN201010122851 CN 201010122851 CN 201010122851 A CN201010122851 A CN 201010122851A CN 101803947 A CN101803947 A CN 101803947A
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Abstract
The invention discloses a cold and hot probe device and particularly relates to a probe device for cold and hot combination therapy by electric heating and liquid nitrogen refrigerating, which is suitable for treating various solid tumors. The cold and hot probe device comprises a low-temperature pressure vessel, a low-temperature working medium, a booster, a low-temperature fluid valve, a low-temperature working medium transport tube, a handle, a probe pole, a probe head, an electric heating element, a temperature sensor, a data acquisition/control unit, a DC power supply module, a computer and the like. The invention can cool and heat the probe head conveniently so as to implement the cold and hot combination treatment and prevent normal tissues around the probe pole from being frozen and damaged in the cooling process. The invention has the advantages of simple structure, low cost, good controllability, high safety, convenient use and the like.
Description
Technical field
The present invention relates to the cold and hot treatment probe in the cold and hot combination therapy of tumor, particularly a kind of cold and hot probe device that is used for cold and hot combination therapy of tumor that adopts electrical heating elements to implement heating; This cold and hot probe device is by means of the electrical heating elements on treatment probe interior or surface, can prevent that on the one hand refrigerating process middle probe bar from because of leaking heat to the cryolesion that normal structure on the way causes, also can implement to heat to treat to tumor tissues rapidly on the other hand after cold therapy stops.
Background technology
Around the unfolded research of technique of oncotherapy is one of key subjects of paying close attention to of domestic and international biomedical engineering circle always.In this respect, Wicresoft's insertion type naturopathy is just becoming the forward position of medical instruments field development.In the various minimally-invasive treatment technology of tumor, freezing treatment and high temperature thermotherapy are development in recent years two kinds of physiotherapys very rapidly.The two has remarkable advantages such as determined curative effect, directionality be strong, thereby has caused the extensive attention of medical circle.Particularly, this two big class oncotherapy technology has obtained the reputation of " green remedy " especially because of the radiation and chemotherapy of side effect far below routine in clinical tumor.Yet single cold therapy or thermotherapy are difficult to reach the best prognosis effect of killing and wounding and treat clinically.Reason is that traditional cold therapy may be because cooling be not thorough or the cryopreservation effect causes the residual recurrence then of tumor cell, and the blood circulation that the high temperature heating causes strengthens then may promoting tumor cell to other position diffusions of health.
Studies show that, simultaneously can significantly strengthen the tumor-killing effect, and can overcome single freezing or heat to treat the deficiency of pattern in conjunction with cold therapy and high temperature thermotherapy.Thereby, freezing and the heating a kind of new model that is combined into oncotherapy, be expected in clinical therapy of tumor, to play a significant role.The first term patent of this new treatment pattern aspect of cold and hot combination therapy is " alternately transporting high cryogenic fluid to realize the temperature probe-type apparats for treating tumor of lifting suddenly " (Liu Jing, Monday glad, Yu Tianhua, alternately transport high cryogenic fluid to realize the temperature probe-type apparats for treating tumor of lifting suddenly, the patent No.: 01268378.7), this therapeutic instrument system adopts high cryogenic fluid to implement heating and freezing respectively.After this, some new patent applications are arranged again successively, the wherein freezing cryogenic fluid (liquid nitrogen) that still adopts realizes that heating principle (Liu Jing, Rao Wei, cold-hot probe therapy system, application numbers: 200710098735.2) such as radio frequency or laser are then adopted in heating.In the above-mentioned patent, related heating technique such as high temperature fluid heating, radio frequency heating and LASER HEATING etc., relative complex aspect the equipment realization is preventing there is certain difficulty on the normal structure cryolesion on the way on the other hand on the one hand.In fact, electrical heating is expected to replace above-mentioned heating technique in cold and hot combination therapy, thereby provides a kind of controllability better and safer cold and hot combination therapy solution as a kind of simple and respond well mode of heating.
Based on above-mentioned consideration, the present invention will provide a kind of cold and hot probe device that is used for cold and hot combination therapy of tumor, this cold and hot probe device that is used for cold and hot combination therapy of tumor adopts cryogenic fluid (as liquid nitrogen) to implement cold therapy, adopt electrical heating to implement the high temperature thermotherapy, and electrical heating can also effectively prevent the cryolesion that probe rod causes normal structure on the way in the cold therapy process.
Summary of the invention
The objective of the invention is to overcome existing cold and hot combination therapy probe system complex structure and be difficult to prevent the probe shortcoming of normal structure cryolesion on the way, thereby provide a kind of safer and be used for the cold and hot probe device of cold and hot combination therapy of tumor efficiently; It not only can implement to cold and heat succeed each other treatment to tumor easily, but also can effectively prevent the cryolesion of cold therapy process middle probe bar normal surrounding tissue; And the present invention is simple in structure, and cooling, heating and cold injury protection all are easy to realization, and have advantages such as controllability is good, safe and easy to use, are applicable to the treatment of various entity tumors.
Technical scheme of the present invention is as follows:
The cold and hot probe device that is used for cold and hot combination therapy of tumor provided by the invention, it comprises:
One intracavity is provided with the low-temperature pressure container 1 of the interior dress cryogenic fluid 2 of booster 3;
End places the cryogenic fluid transfer tube 5 among the cryogenic fluid 2 in the low-temperature pressure container 1 one by one; Described cryogenic fluid transfer tube 5 is made up of the first incoming flow pipeline 52 and the first heat insulation tube chamber 51 that is set on these first incoming flow pipeline, 52 outer walls; The described first heat insulation tube chamber 51 is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; Described cryogenic fluid transfer tube 5 is equipped with cryogen valve 4 near in the tube chamber of described low-temperature pressure container 1 end;
One is connected in the probe rod 7 of described cryogenic fluid transfer tube 5 other ends; Described probe rod 7 by the second incoming flow pipeline 71, be set in first reflux line 72 on these second incoming flow pipeline, 71 outer walls, be set in the second heat insulation tube chamber 73 on described first reflux line, 72 outer walls and first heating 74 that is set on described second heat insulation tube chamber 73 outer walls is formed; The described second heat insulation tube chamber 73 is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; Be set with heat insulation bat-handle 6 on described probe rod 7 and the described cryogenic fluid transfer tube 5 junction outer walls; Be distributed with temperature sensor equably on first heating 74 of described probe rod 7;
One is connected in the probe 8 of described probe rod 7 front ends; Described probe 8 is formed by the 3rd incoming flow pipeline 81 with second heating 83 that described the 3rd incoming flow pipeline 81 surrounds wherein; Described second heating 83 is formed by the tubular rear portion that is positioned at the rear portion with into a single integrated structure the conical anterior of arc surfaced front end that have in described tubular rear portion; The space of leaving between described second heating 83 and described the 3rd incoming flow pipeline 81 is second reflux line 82; Described second heating, 83 inner chamber front ends are equipped with temperature sensor; The described first incoming flow pipeline 52, the described second incoming flow pipeline 72 and described the 3rd incoming flow pipeline 81 are connected; Described first reflux line 72 is connected with described second reflux line 82; The tube wall of described first reflux line 72 is provided with the air vent that is connected with outside atmosphere;
One direct current power module 12; Described DC power supplier 12 is electrically connected so that they are heated with described first heating 74, second heating 83 and described booster 3 respectively; The voltage of described DC power supplier 12 is 1～36V;
One data acquisition and control module 10 and a computer 11; Described data acquisition and control module 10 and computer 11 link to each other by data wire; The data acquisition channel of described data acquisition and control module 10 links to each other with described temperature sensor; The control channel of described data acquisition and control module 10 links to each other with described DC power supplier 12 with described cryogen valve 4 respectively; Described computer 11 is by the open and close of described data acquisition and the described cryogen valve 4 of control module 10 controls; Described data acquisition links to each other with the temperature of the described temperature sensor of real-time collection with described temperature sensor with control module 10, and the temperature sensing actuator temperature of gathering is sent to computer (11); Described computer 11 is controlled the heating power of described DC power supplier 12 by data acquisition and control module 10, thereby controls the heating-up temperature of described first heating 74, second heating 83.
The described cold and hot probe device that is used for cold and hot combination therapy of tumor is a separate type: at cryogenic fluid transfer tube 5 places near handle 6, with cryogenic fluid transfer tube 5 difference two parts, and by a fast joint 13 that two parts connection of described cryogenic fluid transfer tube 5 is in aggregates.
Described first heating, 74 resistance values and second heating, 83 resistance values are between 1 Ω～100 Ω; All be coated with the insulation enamelled coating on its outer surface.
Described low-temperature pressure container 1 is for the electrical heating pressure vessel or from the boost pressure container.
Described first heating 74 and described second heating 83 are constantan wire, nickel wire, film resistor, semiconductor resistor or positive temperature coefficient resistor.
The conical forward hollow cavity inner wall of described probe 8 is the inner fin structure.
The cold and hot probe device that is used for cold and hot combination therapy of tumor of the present invention, in low-temperature pressure container 1, be provided with booster 3 (specifically can adopt the electrical heating pressure vessel or cryogenic fluid 2 be carried out heating and gasifying) to realize boosting in the low-temperature (low temperature) vessel 1 from the boost pressure container; One end of cryogenic fluid transfer tube 5 immerses in the cryogenic fluid 2 in the low-temperature pressure container 1, and the other end is connected by the first incoming flow pipeline 52 and the probe rod 7 second interior incoming flow pipelines 71; Be provided with cryogen valve 4 (realizing the conveying and the cut-out of cryogenic fluid 2 by the switch of cryogen valve 4) near low-temperature pressure container 1 one ends in the cryogenic fluid transfer tube 5; Probe rod 7 is provided with circulation road and return flow line with probe 8, and links to each other respectively; Also have heating in probe rod 7 and the probe 8; Be provided with a plurality of first heatings that can independently control in the probe rod 7, in the cold therapy process, be subjected to cryolesion to prevent the probe rod normal surrounding tissue by electrical heating, but cause normal structure to scald for fear of heating simultaneously, need temperature in the heating process, and electrical heating power is implemented corresponding control according to this temperature by the real-time monitoring probe bar of temperature sensor; The function of second heating in the probe 8 is that tumor tissues is implemented to heat to treat, and can control heating power in real time by the temperature in the monitoring probe head in the heating process, to prevent tumor tissues carbonization or vaporization; Heating outer surface in probe rod 7 and the probe 8 is all done insulation and is handled; Be provided with heat insulation tube chamber (can adopt vacuum chamber or filling with insulation material to be achieved) in cryogenic fluid transfer tube 5 and the probe rod 7, can prevent effectively that on the one hand cryogenic fluid transfer tube 5 is low excessively with the surface temperature of probe rod 7, can also reduce the loss of cryogenic fluid 2 on the other hand; The end that cryogenic fluid transfer tube 5 links to each other with probe rod 7 is provided with handle 6 (made by heat-barrier material, be convenient to the operation of doctor in the operation process); All heatings are all powered by DC power supplier, and are accurately controlled by data acquisition and 10 pairs of heating powers of control module by computer, are to guarantee safety, and all heating voltages all are controlled in 1～36V.
In the technique scheme, come circulation road can adopt one or more thin-walled thin metal pipe, single thin metallic tubd is then adopted in the return flow line, and is positioned at the circulation road periphery, and the circulation road parcel within it in the future; First reflux line, 72 tube walls of probe rod 7 are provided with the air vent that is connected with outside atmosphere;
In the technique scheme, probe rod 7 is identical with the tubular rear portion diameter of probe 8, and its external diameter is between 1mm and 10mm; Probe 8 also has the conical front portion that has the arc surfaced front end that links to each other with the tubular rear portion, this taper shape front portion of probe 8 is a hollow cavity, this cavity inner wall can be processed as the inner fin structure, cryogenic fluid is flowed through and is gasified rapidly after this cavity absorbs a large amount of heats, thereby realizes the fast cooling to destination organization; In addition, probe 8 outer walls are made by the high heat conductivity metal material.
In the technique scheme, after boosting to enough pressure in the low-temperature pressure container 1, control by cryogen valve 4, can be with cryogenic fluid 2 first incoming flow pipeline 52 in the input cryogenic fluid transfer tube 5 in the low-temperature pressure container, the second incoming flow pipeline 71 and the 3rd incoming flow pipeline 81 in the probe 8 through probe rod 7 enters endothermic gasification in the conical forward hollow cavity of probe then, successively by second reflux line 82 of probe 8 and first reflux line 72 of probe rod 7, enter atmosphere at last after the gasification; In the cold therapy process, can prevent that probe rod 7 normal surrounding tissues are subjected to cryolesion by first heating 74 in the control probe rod 7; Close cryogen valve 4 and can stop cold therapy, can implement to heat to treat by 83 pairs of tumor tissues of second heating in the probe 8.So, can realize alternative cold and hot treatment to tumor tissues.
The cold and hot probe device that is used for cold and hot combination therapy of tumor provided by the invention has following advantage: the cold and hot probe device that is used for cold and hot combination therapy of tumor of the present invention not only can implement to cold and heat succeed each other treatment to tumor easily, but also can effectively prevent the cryolesion of cold therapy process middle probe bar normal surrounding tissue; And the present invention is simple in structure, and cooling, heating and cold injury protection all are easy to realization, and have advantages such as controllability is good, safe and easy to use, are applicable to the treatment of various entity tumors.
Description of drawings
Fig. 1 is the structural representation that is used for the cold and hot probe device of cold and hot combination therapy of tumor of the present invention;
Figure 1A is an A-A generalized section among Fig. 1;
Figure 1B is a B-B generalized section among Fig. 1;
Fig. 2 is the structural representation (arrow is depicted as the cryogenic fluid flow direction) of middle probe bar 7 of the present invention;
Fig. 2 A is a C-C generalized section among Fig. 2;
Fig. 3 is the structural representation (arrow is depicted as the cryogenic fluid flow direction) of middle probe head 8 of the present invention;
Fig. 3 A is a D-D generalized section among Fig. 3;
Fig. 4 is the structural representation of further embodiment of this invention.
The specific embodiment
Further describe the present invention below in conjunction with drawings and Examples.
Embodiment 1:
As shown in Figure 1, the invention provides a kind of cold and hot probe device that is used for cold and hot combination therapy of tumor, its structure is as follows: it comprises:
One intracavity is provided with the low-temperature pressure container 1 of the interior dress cryogenic fluid 2 of booster 3;
End places the cryogenic fluid transfer tube 5 among the cryogenic fluid 2 in the low-temperature pressure container 1 one by one; Described cryogenic fluid transfer tube 5 is made up of the first incoming flow pipeline 52 and the first heat insulation tube chamber 51 that is set on these first incoming flow pipeline, 52 outer walls; The described first heat insulation tube chamber 51 is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; Described cryogenic fluid transfer tube 5 is equipped with cryogen valve 4 near in the tube chamber of described low-temperature pressure container 1 end;
One is connected in the probe rod 7 of described cryogenic fluid transfer tube 5 other ends; Described probe rod 7 by the second incoming flow pipeline 71, be set in first reflux line 72 on these second incoming flow pipeline, 71 outer walls, be set in the second heat insulation tube chamber 73 on described first reflux line, 72 outer walls and first heating 74 that is set on described second heat insulation tube chamber 73 outer walls is formed; The described second heat insulation tube chamber 73 is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; Be set with heat insulation bat-handle 6 on described probe rod 7 and the described cryogenic fluid transfer tube 5 junction outer walls; Be distributed with temperature sensor equably on first heating 74 of described probe rod 7;
One is connected in the probe 8 of described probe rod 7 front ends; Described probe 8 is formed by the 3rd incoming flow pipeline 81 with second heating 83 that described the 3rd incoming flow pipeline 81 surrounds wherein; Described second heating 83 is formed by the tubular rear portion that is positioned at the rear portion with into a single integrated structure the conical anterior of arc surfaced front end that have in described tubular rear portion; The space of leaving between described second heating 83 and described the 3rd incoming flow pipeline 81 is second reflux line 82; Described second heating, 83 inner chamber front ends are equipped with temperature sensor; The described first incoming flow pipeline 52, the described second incoming flow pipeline 72 and described the 3rd incoming flow pipeline 81 are connected; Described first reflux line 72 is connected with described second reflux line 82; The tube wall of described first reflux line 72 is provided with the air vent that is connected with outside atmosphere;
One direct current power module 12; Described DC power supplier 12 is electrically connected so that they are heated with described first heating 74, second heating 83 and described booster 3 respectively; The voltage of described DC power supplier 12 is 1～36V;
One data acquisition and control module 10 and a computer 11; Described data acquisition and control module 10 and computer 11 link to each other by data wire; Described data acquisition is adopted passage with the number of control module 10 and is linked to each other with described temperature sensor; The control channel of described data acquisition and control module 10 links to each other with described DC power supplier 12 with described cryogen valve 4 respectively; Described computer 11 is by the open and close of described data acquisition and the described cryogen valve 4 of control module 10 controls; Described data acquisition links to each other with the temperature of the described temperature sensor of real-time collection with described temperature sensor with control module 10, and the temperature sensing actuator temperature of gathering is sent to computer 11; Described computer 11 is controlled the heating power of described DC power supplier 12 by data acquisition and control module 10, thereby controls the heating-up temperature of described first heating 74, second heating 83.
In the present embodiment, cryogenic fluid 2 adopts liquid nitrogen, and splendid attire is in low-temperature pressure container 1, and this low-temperature pressure container 1 device can choose or look for the customization of relevant manufacturer to get final product from market.Be provided with booster 3 in the low-temperature pressure container 1, booster 3 is a heating, is soaked in the cryogenic fluid 2, and when booster 3 was implemented heating by DC power supplier 12 power supplies, cryogenic fluid 2 gasified fast, thereby realizes boosting in the low-temperature pressure container 1; In the process of boosting, the pressure in the container can be read from the Pressure gauge outside placing low-temperature pressure container 1.Cryogenic fluid transfer tube 5 can adopt the rustless steel double-ply bellows to make, and comprises the first heat insulation tube chamber 51 and the first incoming flow pipeline 52 (shown in Figure 1A), and wherein the first heat insulation tube chamber 51 can adopt vacuum chamber or filling with insulation material to be achieved; One end of cryogenic fluid transfer tube 5 immerses in the cryogenic fluid 2 in the low-temperature pressure container 1, and the other end is connected by the first incoming flow pipeline 52 and the probe rod 7 second interior incoming flow pipelines 71; Cryogen valve 4 is arranged at an end of close low-temperature pressure container 1 in the cryogenic fluid transfer tube 5, can adopt low-temperature solenoid valve or cryogenic ball valve; As adopt electromagnetic valve, then can in operation process, implement to control its circulation automatically and close by data acquisition and control module 10 by computer 11; As adopt cryogenic ball valve, then need in operation process, manually control the circulation of cryogen valve 4 and close; Can realize the conveying and the cut-out of cryogenic fluid 2 easily by the switch of cryogen valve 4; The end that cryogenic fluid transfer tube 5 links to each other with probe rod 7 is provided with handle 6 (shown in Fig. 1 and Figure 1B), and handle 6 is made by heat-barrier material such as politef etc., is convenient to doctor's handheld probe in operation process and operates; Probe rod 7 comprises the second incoming flow pipeline 71, first reflux line, 72, the second heat insulation tube chamber 73, first heating 74 and temperature sensor 9 (shown in Fig. 2 and Fig. 2 A); Probe 8 comprises the 3rd incoming flow pipeline 81, second reflux line 82, second heating 83 and temperature sensor 9 (shown in Fig. 3 and Fig. 3 A); Temperature sensor 9 in probe rod 7 and the probe 8 all can be selected thermocouple or thermal resistance for use; The second incoming flow pipeline 71 and the 3rd of the probe 8 of probe rod 7 come circulation road 81 to be connected; First reflux line 72 of probe rod 7 is connected with second reflux line 82 of probe 8;
In the present embodiment, be provided with a plurality of first heatings 74 that can independently control in the probe rod 7, this first heating 74 is electrically connected with DC power supplier 12, can prevent effectively that by electrical heating the normal structure around the probe rod 7 is subjected to cryolesion in the cold therapy process; The second heat insulation tube chamber 73 in the probe rod 7 also can be similar to for fear of the heating of probe rod 7 normal structure is caused scald, can be in the heating process by the temperature of temperature sensor 9 real-time monitoring probe bars 7, and the heating power of each heating is implemented corresponding control respectively according to this temperature;
In the present embodiment, the purpose that is respectively arranged with the first heat insulation tube chamber 51 and the second heat insulation tube chamber 73 in cryogenic fluid transfer tube 5 and the probe rod 7 is, can prevent effectively that on the one hand cryogenic fluid transfer tube 5 is low excessively with the surface temperature of probe rod 7, can also reduce the loss of cryogenic fluid 2 in the cold therapy process on the other hand;
In the present embodiment, the first incoming flow pipeline 52, the second incoming flow pipeline 71 and the 3rd incoming flow pipeline 81 all can adopt one or more thin-walled thin metal pipe to make; First reflux line 72 and 82 of second reflux lines all adopt single thin metallic tubd to make, and lay respectively at the periphery of circulation road 71 and 81, in it is wrapped in; First reflux line 72 is provided with in the side near handle 6 and leads to atmospheric venthole in the probe rod 7; Probe rod 7 is identical with the tubular rear portion diameter of probe 8, between 1mm and 10mm; Probe 8 has conical anterior, and this taper shape front portion is a hollow cavity (as shown in Figure 3), and for strengthening the coefficient of heat transfer, this taper shape front group inwall can adopt the inner fin structure; Cryogenic fluid 2 is the 3rd incoming flow pipeline 81 of second incoming flow pipeline 71 of the first incoming flow pipeline 52, probe rod 7 and probe 8 in cryogenic fluid transfer tube 5 successively, flow into the conical anterior of probe 8 front ends, gasification rapidly after the forward cavity of this taper shape absorbs a large amount of heats, thus realization is to the fast cooling of destination organization; After cryogenic fluid 2 gasifies in the conical forward cavity of probe 8, again successively through second reflux line 82 of probe 8 and first reflux line 72 of probe rod 7, be discharged at last atmosphere ' consider clinical in to the treatment probe of getting involved inside of human body in the requirement of nuclear-magnetism aspect compatible, and in the cold and hot therapeutic process to the requirement of probe heat exchange property, probe should select for use the material (as rustless steel or titanium) that possesses low susceptibility and high heat conductance simultaneously to make.
In the present embodiment, cryogenic fluid 2 (as liquid nitrogen) splendid attire is in low-temperature pressure container 1, booster (being heating) is housed in the container 1, can and make it gasification to liquid nitrogen heating in it after the energising, ground pressure raises in the hermetic container 1 because gas expansion makes, when it rises to a certain size, just can open cryogen valve 4, cryogenic fluid 2 is delivered to the conical forward hollow cavity of probe 8 in the container 1 successively through the first incoming flow pipeline 52, the second incoming flow pipeline 71 and the 3rd incoming flow pipeline 81, can carries out cold therapy tissue; Cryogenic fluid 2 heat absorption back gasifications more successively by second reflux line 82 and first reflux line 72, enter atmosphere after the gasification at last; Close cryogen valve 4, can stop cold therapy; After cold therapy stops, can implement to heat to treat by 83 pairs of tumor tissues of the heating in the probe 8.So just realized the cold and hot combination therapy to tumor tissues, this cold and hot combination therapy can repeat a plurality of cold cycling according to needs.
Embodiment 2:
Fig. 4 is a kind of structural representation that is used for the cold and hot probe device of cold and hot combination therapy of tumor of present embodiment.
The structure of present embodiment and embodiment 1 is basic identical, and institute's difference is: the cold and hot probe device that is used for cold and hot combination therapy of tumor that present embodiment provided adopts detachable design; In clinical,, generally need take percutaneous puncture based on the Minimally Invasive Surgery of getting involved human body probe enforcement treatment at deep tumor; Adopt detachable design as probe, can increase the motility of operating in doctor's piercing process greatly undoubtedly, be convenient to implement hands art more accurately; In the present embodiment, only need be divided into two cryogenic fluid transfer tube 5 at the position of cryogenic fluid transfer tube 5 near handles 6, are connected by fast joint 13 then to get final product.The pipeline fast joint is a mature technology, can choose or entrust the customization of relevant manufacturer from market.Except that above-mentioned variation, other position component and structure are identical with embodiment 1.In the present embodiment, other all parts have carried out deep explaining in embodiment 1, therefore repeat no more in the present embodiment.
Embodiment 3:
The present embodiment structure is substantially the same manner as Example 1; The difference of the two is that low-temperature pressure container 1 no longer adopts electrical heating to implement to boost in the present embodiment, but adopts from the pressure and low-temperature pressure vessel;
On sale from pressure and low-temperature pressure vessel (as from the supercharging liquid nitrogen container) market, its principle of boosting is to manage the extension liquid nitrogen by the side in liquid nitrogen container, carries out heat exchange through coil heat exchanger and air, gasification then, thereby the pressure in the hoisting container; Compare with the electrical heating boosting mode, advantage from supercharging mode is: the temperature of liquid nitrogen in the container that can not raise, thereby can obtain on the one hand more also can significantly to reduce the consumption of liquid nitrogen in the therapeutic process on the other hand near the minimum cold therapy temperature of liquid nitrogen temperature.
In the present embodiment, other all parts have carried out deep explaining in embodiment 1, therefore repeat no more in the present embodiment.
Claims (6)
1. cold and hot probe device that is used for cold and hot combination therapy of tumor, it comprises:
One intracavity is provided with the low-temperature pressure container (1) of the interior dress cryogenic fluid (2) of booster (3);
End places the cryogenic fluid transfer tube (5) among the interior cryogenic fluid of low-temperature pressure container (1) (2) one by one; Described cryogenic fluid transfer tube (5) is made up of the first incoming flow pipeline (52) and the first heat insulation tube chamber (51) that is set on this first incoming flow pipeline (52) outer wall; The described first heat insulation tube chamber (51) is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; In the tube chamber of described cryogenic fluid transfer tube (5) near described low-temperature pressure container (1) end cryogen valve (4) is housed;
One is connected in the probe rod (7) of described cryogenic fluid transfer tube (5) other end; Described probe rod (7) by the second incoming flow pipeline (71), be set in first reflux line (72) on this second incoming flow pipeline (71) outer wall, be set in the second heat insulation tube chamber (73) on described first reflux line (72) outer wall and first heating (74) that is set on described second heat insulation tube chamber (73) outer wall is formed; The described second heat insulation tube chamber (73) is vacuum tube chamber or is the tube chamber of interior dress heat-barrier material; Be set with heat insulation bat-handle (6) on described probe rod (7) and described cryogenic fluid transfer tube (5) the junction outer wall; Be distributed with temperature sensor equably on first heating (74) of described probe rod (7);
One is connected in the probe (8) of described probe rod (7) front end; Described probe (8) is formed by the 3rd incoming flow pipeline (81) with second heating (83) that described the 3rd incoming flow pipeline (81) surrounds wherein; Described second heating (83) is formed by the tubular rear portion that is positioned at the rear portion with into a single integrated structure the conical anterior of arc surfaced front end that have in described tubular rear portion; The space of leaving between described second heating (83) and described the 3rd incoming flow pipeline (81) is second reflux line (82); Described second heating (83) inner chamber front end is equipped with temperature sensor; The described first incoming flow pipeline (52), the described second incoming flow pipeline (72) and described the 3rd incoming flow pipeline (81) are connected; Described first reflux line (72) is connected with described second reflux line (82); The tube wall of described first reflux line (72) is provided with the air vent that is connected with outside atmosphere;
One direct current power module (12); Described DC power supplier (12) is electrically connected so that they are heated with described first heating (74), second heating (83) and described booster (3) respectively; The voltage of described DC power supplier (12) is 1～36V;
One data acquisition and control module (10) and a computer (11); Described data acquisition links to each other by data wire with computer (11) with control module (10); The data acquisition channel of described data acquisition and control module (10) links to each other with described temperature sensor; The control channel of described data acquisition and control module (10) links to each other with described DC power supplier (12) with described cryogen valve (4) respectively; Described computer (11) is by the open and close of described data acquisition and control module (10) the described cryogen valve of control (4); Described data acquisition links to each other with the temperature of the described temperature sensor of real-time collection with described temperature sensor with control module (10), and the temperature sensing actuator temperature of gathering is sent to computer (11); Described computer (11) is controlled the heating power of described DC power supplier (12) by data acquisition and control module (10), thereby controls the heating-up temperature of described first heating (74), second heating (83).
2. by the described cold and hot probe device that is used for cold and hot combination therapy of tumor of claim 1, it is characterized in that: the described cold and hot probe device that is used for cold and hot combination therapy of tumor is a separate type: locate at the cryogenic fluid transfer tube (5) near handle (6), with cryogenic fluid transfer tube (5) difference two parts, and by a fast joint (13) that two parts connection of described cryogenic fluid transfer tube (5) is in aggregates.
3. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that described first heating (74) resistance value and second heating (83) resistance value are between 1 Ω～100 Ω; All be coated with the insulation enamelled coating on its outer surface.
4. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that: described low-temperature pressure container (1) is for the electrical heating pressure vessel or from the boost pressure container.
5. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that: described first heating (74) and described second heating (83) are constantan wire, nickel wire, film resistor, semiconductor resistor or positive temperature coefficient resistor.
6. by claim 1 or the 2 described cold and hot probe devices that are used for cold and hot combination therapy of tumor, it is characterized in that: the conical forward hollow cavity inner wall of described probe (8) is the inner fin structure.
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