CN101288599A - Tumor micro-wound thermotherapy instrument with accurate test control - Google Patents
Tumor micro-wound thermotherapy instrument with accurate test control Download PDFInfo
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- CN101288599A CN101288599A CNA2008100842127A CN200810084212A CN101288599A CN 101288599 A CN101288599 A CN 101288599A CN A2008100842127 A CNA2008100842127 A CN A2008100842127A CN 200810084212 A CN200810084212 A CN 200810084212A CN 101288599 A CN101288599 A CN 101288599A
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Abstract
The invention relates to a needle-shaped tumor minimally invasive thermo-therapeutic device which can accurately measure and control the temperature. A heater of a temperature sensor and a guide wire are sequentially connected with each other in a needle-shaped insulated shell. The main application of the thermo-therapeutic device is that the accurate temperature is sent into a tumor focus to kill tumor cells. A plurality of needle-shaped tumor minimally invasive thermo-therapeutic devices make up an array with the needed shape according to the shape requirement of tumor, and the temperature which can kill the tumor cells is achieved in the array.
Description
One, affiliated technical field
The present invention relates to heating and the incorporate electric heating sensing technology of temperature sensing.This programme can directly apply to the clinical of tumor thermotherapy.
Two, background technology
The notion of the amount of not having is unscientific, does not have tumor thermotherapy without thermometric equally.Medical circle is known, tumor cell is just dead in more than 43 ℃ 20 minutes, tumor thermotherapy requires tumor temperature to reach 42-45 ℃ (generally acknowledging that human normal tissue damage temperature is more than 47 ℃), this has just proposed strict temperature requirements to tumor thermotherapy, and promptly tumor tissues will be controlled in the treatment temperature with interior and the normal structure of closing on will be beyond the damage temperature.That is to say that the temperature that the clinical tumor heat treatment unit is provided is a temperature that can the kill tumor cell injure the Normocellular strict limited range of periphery again.So, how predicting in real time and accurately control the treatment temperature that heat treatment unit provides a safety range, is the key point of problem.
From the seventies in last century so far, many heat treatment units and technology are arisen at the historic moment, as the microwave heat therapeutic technology, radio-frequency ablation technique, noinvasive radio-frequency (RF) thermotherapeutic technology, high intensity focused ultrasound technology etc.; The method of heating has frequency electromagnetic waves, ultrasound wave, infrared ray, extracorporeal circulation etc.; Temp measuring method has hot coupling electrode thermometric, liquid crystal thermometric, strong-electromagnetic field thermometric, ultrasonic temperature measurement, infrared imaging thermometric and MRI thermometry or the like.But these technical methods all exist the defective of general character: 1, heating and thermometric are isolating, and thermometric causes the secondary wound; 2, can not get rid of disturbing mutually between heating and the thermometric, strengthen operation easier; 3, thermometric does not reach in real time accurately, and then the probability of accurate temperature controlling can not be provided.
Temperature measurement tool should reach following requirement simultaneously: 1, survey tool and firing equipment should not interfere with each other; 2, temperature measurer can be got rid of electromagnetic wave or hyperacoustic noise, and is interference-free; 3, all to reach clinical requirement resolution capability, temperature space distribution resolving power and the time response to temperature; 4, the temperature value that is drawn only should reflect variations in temperature, should not contain other physiological changies; 5, the equipment probe size should be small and exquisite, can put into body through conduit; 6, measuring method is simple and easy to do, increases big trouble for patient, medical and technical staff.
Three, summary of the invention:
1, the technical problem that will solve:, the invention provides a kind of observing and controlling tumor micro-wound thermal therapeutic apparatus accurately in order to overcome because of heater separates the present situation that the thermometric that causes is inaccurate, estimate heating with thermal detector.This therapeutic instrument can provide accurate, real-time, the constant temperature that needs, and makes the not only disposable extinction tumor cell of possibility of this temperature, and does not damage the normal tissue cell that closes on again.
2, the technical solution adopted for the present invention to solve the technical problems is: this therapeutic instrument has several thermals source, and each thermal source respectively has a cover thermometric and a temperature-controlling system, cries its probe heating stylus (as Fig. 4) here.Heating element heater and temperature sensor in the probe heating stylus are elements, and heating and temperature survey are finished by probe heating stylus, and it and needle-like shell, lead etc. are formed an one needle body.
As Fig. 1 is the thermal field situation of heating stylus of popping one's head in separately.The situation of drawn probe heating stylus is the heating state that thrusts human body among Fig. 1.After human body is thrust in probe heating stylus,, reach hygral equilibrium by certain hour because the heat effect of probe heating stylus forms thermal field, and enlarges gradually around probe heating stylus.
As Fig. 2 is the thermal field situation of the array of a plurality of probe heating styluses compositions.The heating stylus of some probes is thrust human body according to tumor situation and ambient conditions, weave into three-dimensional heating electrodes, each cross point of array is a probe heating stylus pin mark position, the work of each probe heating stylus is separate, probe heating stylus can be according to tumor shape editor array, this array covers tumor, and heat is sent into tumor.
This thermal therapeutic apparatus belongs to the direct heating category, increases the density of probe heating stylus, can increase array temperature, and 44 ℃ of thermal field loop line inside as figure forms can not surpass probe heating stylus temperature.
Among Fig. 2, suppose that probe heating stylus is set in 45 ℃ of power supplies, according to the thermal field situation of independent probe heating stylus, the density of reasonable disposition probe heating stylus forms heat-field array.In the array inside that probe heating stylus is formed, temperature will raise in time, and the process certain hour reaches greater than 43 ℃ and is less than or equal to 45 ℃ hygral equilibrium.
Direct heating do not exist radio frequency, microwave, ultrasound wave 2 and the mutual interference of 2 above thermal source phases, the phenomenon that hot-spot causes burn appears.
Fig. 3 is a simulation knee tumor thermotherapy.Under same temperature of thermal field, the distance between the probe heating stylus is by the diameter decision of probe heating stylus, and diameter is big more, and distance is big more between the probe heating stylus.
Fig. 4 is a probe heating stylus structure:
(1), minimum thermal field that at first test can handled easily, determine the diameter of probe heating stylus according to experimental result.
(2), determine the length of probe heating stylus sensor heaters according to practical situation.Prevent mainly than trunk that to probe heating stylus in when heating, to the interference on the heating accuracy, bringing-up section is short more, disturbs more little.The diameter of suggestion probe heating stylus is selected in 2mm temporarily, and length is selected in 10mm.
3, the invention has the beneficial effects as follows: the survey of (1), thermal therapeutic apparatus, temperature control are precisely real-time, and operator can in time, accurately control the kill tumor cell and protect the temperature range of normal tissue cell; (2), thermometric and thermotherapy be synchronous, no repeated trauma; (3), spininess forms the array thermal field, continues heating, is expected to realize that tumor is disposable thoroughly kills.
Four, description of drawings:
Fig. 1: be the thermal field situation map of heating stylus of popping one's head in separately: 1, probe heating stylus and 45 ℃ of thermal field loop lines; 2,44 ℃ of thermal field loop lines; 3,43 ℃ of thermal field loop lines.
Fig. 2: be the array thermal field situation map that a plurality of probe heating styluses are formed: 1, probe heating stylus and 45 ℃ of thermal field loop lines; 2,44 ℃ of thermal field loop lines; 3,43 ℃ of thermal field loop lines.
Fig. 3: be the tumor thermotherapy situation map around the simulation knee.
Fig. 4: be probe heating stylus structure chart: 1, needle body; 2, temperature sensor heater; 3, hands handle; 4, lead
Five, the specific embodiment
The probe heating stylus of each road all works alone, independently-powered.Power supply is a voltage stabilization and current stabilization dc source independently.
Sensor heater is a critesistor, have pick off and heater dual-use function simultaneously, for the heating stylus of popping one's head in is operated in the safe voltage scope and is satisfying the requirement of power, to make to critesistor simultaneously and provide convenience, supply voltage may be selected between the 30V-36V.
In order to reduce diameter of wire, reduce electric current as far as possible, the power supply current limliting is limit at 200mA, and when temperature was heated to 45 ℃, balanced balanced current can not surpass 100mA.Power is no more than 7.2W.
When probe heating stylus power supply, heater begins to heat up, and is initially at 36.5 ℃ of human body temperature, and voltage is lower than 36V, saturation current 200mA.When temperature is raised to 45 ℃, the corresponding resistance of the temperature sensor in the probe heating stylus, resistance value is at this moment represented 45 ℃, and system enters the current stabilization state, and electric current will be lower than 200mA, and temperature will keep 45 ℃.
If voltage 36V-30V, electric current 0.2A, power satisfies 7.2W-6W, and critesistor equals 180 Ω-150 Ω, satisfies thermistor temp simultaneously, resistance concerns 45 ℃/180 Ω-150 Ω.Be that temperature-sensitive resistance temperature and resistance coefficient are 45 ℃/180 Ω-150 Ω.
Claims (1)
1, a kind of survey, controlling temperature tumor micro-wound thermal therapeutic apparatus accurately, in the needle-like insulation crust, temperature sensor heater, lead are linked in sequence, there is handle the outer rear end of shell, it is characterized in that: temperature sensor and heater are composition elements, i.e. the combination of temperature-sensitive power resistor and heating element heater is to critesistor power supply heating the time, utilize the coefficient of relationship of resistance and temperature, measure the real time temperature of this composition element of temperature sensor heater exactly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100842127A CN101288599A (en) | 2008-03-26 | 2008-03-26 | Tumor micro-wound thermotherapy instrument with accurate test control |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNA2008100842127A CN101288599A (en) | 2008-03-26 | 2008-03-26 | Tumor micro-wound thermotherapy instrument with accurate test control |
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| CN101288599A true CN101288599A (en) | 2008-10-22 |
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| CNA2008100842127A Pending CN101288599A (en) | 2008-03-26 | 2008-03-26 | Tumor micro-wound thermotherapy instrument with accurate test control |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803947A (en) * | 2010-03-11 | 2010-08-18 | 中国科学院理化技术研究所 | Cold and hot probe device used for cold and hot combination therapy of tumor |
| CN101803948A (en) * | 2010-03-29 | 2010-08-18 | 韩俊峰 | Reverse temperature control combined probe type tumor thermal-therapeutic apparatus |
| CN102551873A (en) * | 2010-12-10 | 2012-07-11 | 韩俊峰 | Accurate temperature control tumor therapeutic apparatus and control method thereof |
| CN103083176A (en) * | 2012-07-04 | 2013-05-08 | 邓雪勇 | Directly-heated constant-temperature miniature needle |
| CN107595384A (en) * | 2017-08-29 | 2018-01-19 | 南京亿高微波系统工程有限公司 | A kind of intelligent microwave ablation needle and its Poewr control method |
-
2008
- 2008-03-26 CN CNA2008100842127A patent/CN101288599A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101803947A (en) * | 2010-03-11 | 2010-08-18 | 中国科学院理化技术研究所 | Cold and hot probe device used for cold and hot combination therapy of tumor |
| CN101803947B (en) * | 2010-03-11 | 2012-09-05 | 中国科学院理化技术研究所 | Cold and hot probe device used for cold and hot combination therapy of tumor |
| CN101803948A (en) * | 2010-03-29 | 2010-08-18 | 韩俊峰 | Reverse temperature control combined probe type tumor thermal-therapeutic apparatus |
| CN102551873A (en) * | 2010-12-10 | 2012-07-11 | 韩俊峰 | Accurate temperature control tumor therapeutic apparatus and control method thereof |
| CN103083176A (en) * | 2012-07-04 | 2013-05-08 | 邓雪勇 | Directly-heated constant-temperature miniature needle |
| CN107595384A (en) * | 2017-08-29 | 2018-01-19 | 南京亿高微波系统工程有限公司 | A kind of intelligent microwave ablation needle and its Poewr control method |
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Open date: 20081022 |