CN101803947B - Cold and hot probe device used for cold and hot combination therapy of tumor - Google Patents

Cold and hot probe device used for cold and hot combination therapy of tumor Download PDF

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CN101803947B
CN101803947B CN 201010122851 CN201010122851A CN101803947B CN 101803947 B CN101803947 B CN 101803947B CN 201010122851 CN201010122851 CN 201010122851 CN 201010122851 A CN201010122851 A CN 201010122851A CN 101803947 B CN101803947 B CN 101803947B
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cold
probe
low
ester
temperature
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CN 201010122851
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CN101803947A (en )
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刘静
邓中山
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中国科学院理化技术研究所
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Abstract

The invention discloses a cold and hot probe device and particularly relates to a probe device for cold and hot combination therapy by electric heating and liquid nitrogen refrigerating, which is suitable for treating various solid tumors. The cold and hot probe device comprises a low-temperature pressure vessel, a low-temperature working medium, a booster, a low-temperature fluid valve, a low-temperature working medium transport tube, a handle, a probe pole, a probe head, an electric heating element, a temperature sensor, a data acquisition/control unit, a DC power supply module, a computer and the like. The invention can cool and heat the probe head conveniently so as to implement the cold and hot combination treatment and prevent normal tissues around the probe pole from being frozen and damaged in the cooling process. The invention has the advantages of simple structure, low cost, good controllability, high safety, convenient use and the like.

Description

一种用于肿瘤冷热联合治疗的冷热探针装置 Cold cold probe apparatus for combination therapy of tumor

技术领域 FIELD

[0001] 本发明涉及肿瘤冷热联合治疗中的冷热治疗探针,特别涉及ー种采用电加热元件实施加热的用于肿瘤冷热联合治疗的冷热探针装置;该冷热探针装置借助于治疗探针内部或表面的电加热元件,一方面可防止冷冻过程中探针杆因漏热对沿途正常组织造成的冷冻损伤,另一方面还可在冷冻治疗停止后迅速对肿瘤组织实施加热治疗。 [0001] The present invention relates to the treatment of cold cold probe combination therapy of tumors, particularly to seed ー using cold probe device for cold treating a tumor combined electrical heating of the heating element embodiment; the cold probe device by means of electric heating elements inside the probe or surface treatment, on the one hand prevents freezing damage due to the probe shaft to the drain along the heat caused by normal tissues, tumor tissues other hand, may be rapidly performed after the freezing process is stopped cryotherapy heating treatment.

背景技术 Background technique

[0002] 围绕肿瘤治疗展开的技术攻关一直是国内外生物医学工程界所关注的重大课题之一。 [0002] revolves around the treatment of tumors of technical research at home and abroad has been one of the major topics of biomedical engineering concern. 在这方面,微创介入式物理治疗正成为医疗器械领域发展的前沿。 In this regard, minimally invasive type of physical therapy is becoming the forefront of the development of medical devices. 在肿瘤各种微创治疗技术中,低温冷冻治疗和高温热疗是近年来发展十分迅速的两种物理疗法。 In the minimally invasive treatment of various tumors in technology, cryogenic therapy and hyperthermia are very rapid development in recent years of two physical therapy. 二者具有疗效确切、定向性强等显著优点,因而已引起医学界的广泛重视。 Both have a curative effect, orientation, and other notable advantages, which has attracted wide attention of the medical profession. 特别是,这两大类肿瘤治疗技术因副作用远低于常规的放疗和化疗,在肿瘤临床中更是获得了“绿色疗法”之誉。 In particular, these two categories of cancer therapy due to side effects is much lower than conventional radiotherapy and chemotherapy in cancer clinical is to obtain a "green therapy" reputation. 然而,単一的冷冻治疗或热疗在临床上难以达到最佳的杀伤及治疗预后效果。 However, radiolabeling of a cryotherapy or hyperthermia in the clinical difficult to achieve the optimal treatment and prognosis of killing. 原因在于,传统的冷冻治疗可能由于降温不彻底或低温保存效应导致肿瘤细胞残留继而复发,而高温加热导致的血液循环加强则可能促进肿瘤细胞向身体其他部位扩散。 The reason is that the traditional cryotherapy may diffuse to other parts of the body due to the cooling effect is not complete or cryopreserved tumor cells left turn leads to recurrence and enhance blood circulation caused by high temperature heating may promote tumor cell.

[0003] 研究表明,同时结合冷冻治疗和高温热疗可以显著增强肿瘤杀伤效果,并且还可以克服単一冷冻或加热治疗模式的不足。 [0003] Studies have shown that combined hyperthermia and cryotherapy can significantly enhance antitumor effects, and can also overcome the disadvantages of radiolabeling a freezing or heating treatment mode. 从而,冷冻和加热的结合成为肿瘤治疗的ー种新模式,可望在肿瘤临床治疗中发挥重要作用。 Thus, the combination of freezing and heating ー become a new model species for cancer treatment, is expected to play an important role in cancer clinical treatment. 冷热联合治疗这一新治疗模式方面的首项专利为“交替输运高低温エ质以实现温度骤然升降的探针式肿瘤治疗仪”(刘静、周ー欣、干天骅,交替输运高低温エ质以实现温度骤然升降的探针式肿瘤治疗仪,专利号:01268378. 7),该治疗仪系分别采用高低温エ质实施加热和冷冻。 First patent cold combination therapy aspect of this new treatment modalities for "Eito alternating high and low mass transport to achieve a sudden elevation of temperature probe type cancer treatment" (Liu Jing, Yan ー weeks, dry days Hua, alternately input Ester mass transport in order to achieve high and low temperature probes sudden lifting of formula tumor treatment, Patent No: 012683787), the treatment instrument system using high and low, respectively, heating and refrigeration Ester quality embodiments. 此后,陆续又有ー些新的专利申请,其中冷冻仍然采用低温エ质(液氮)实现,加热则采用射频或激光等加热原理(刘静、饶伟,冷热探针治疗系统,申请号:200710098735. 2)。 Thereafter, it announced ー these new patent applications, wherein the frozen mass remains Ester low temperature (liquid nitrogen) to achieve, the use of heating or radio frequency heating principle like laser (Liu Jing, Wei Rao, cold treatment probe system, Application No. : 2007100987352). 上述专利中,所涉及的加热技术如高温流体加热、射频加热以及激光加热等,一方面在设备实现方面相对复杂,另一方面在防止沿途正常组织冷冻损伤上存在一定困难。 In the above patent, techniques involved heating fluid such as high temperature heating, radio frequency heating and laser heating or the like, on the one hand to achieve relatively complicated in terms of apparatus, the normal tissue along the other hand to prevent freezing damage certain difficulties. 事实上,电加热作为ー种简单而效果良好的加热方式,可望在冷热联合治疗中取代上述加热技术,从而提供ー种可控性更好和更安全的冷热联合治疗解决方案。 In fact, as the electric heating ー kinds of simple and good results in heating mode, the heating technology is expected to replace the hot and cold combination therapy, thereby providing ー kinds of controllability better and safer solutions for hot and cold combination therapy.

[0004] 基于上述考虑,本发明将提供一种用于肿瘤冷热联合治疗的冷热探针装置,该用于肿瘤冷热联合治疗的冷热探针装置采用低温エ质(如液氮)实施冷冻治疗,采用电加热实施高温热疗,并且电加热还可以在冷冻治疗过程中有效防止探针杆对沿途正常组织造成的冷冻损伤。 [0004] Based on the above considerations, the present invention provides a hot and cold probe device for the treatment of cancer combined cold, cold probe device for the combination therapy of tumor cold mass Ester low temperature (e.g. liquid nitrogen) embodiment cryotherapy, hyperthermia embodiment using electric heating, electric heating and also can prevent freeze damage to normal tissue along the probe shaft to cause the freezing treatment.

发明内容 SUMMARY

[0005] 本发明的目的在于克服现有冷热联合治疗探针系统结构复杂以及难以防止探针沿途正常组织冷冻损伤的缺点,从而提供一种更为安全和高效的用于肿瘤冷热联合治疗的冷热探针装置;其不仅可以非常方便地对肿瘤实施冷热交替治疗,而且还可以有效防止冷冻治疗过程中探针杆周围正常组织的冷冻损伤;而且本发明结构简単,降温、加热以及冻伤防护均易于实现,并且具有可控性好、安全性高以及使用方便等优点,适用于各种实体肿瘤的治疗。 [0005] The object of the present invention is to overcome the conventional probe system of hot and cold treatment of complex configuration and is difficult to prevent freezing damage normal tissue along the probe drawbacks, providing a safer and more effective combination therapies for tumor cold hot and cold probe apparatus; which can not only easily implemented alternating hot and cold therapy of tumor, but also can prevent damage to the surrounding refrigerating cryotherapy probe shaft during normal tissues; radiolabeling and simple structure of the present invention, cooling, heating protection and frostbite are easy to implement and has good controllability, safety and ease of use for the treatment of various solid tumors.

[0006] 本发明的技术方案如下: [0007] 本发明提供的用于肿瘤冷热联合治疗的冷热探针装置,其包括: [0006] aspect of the present invention is as follows: [0007] Tumor cold cold probe device for the combination therapy provided by the present invention, which comprises:

[0008] 一腔内设有升压器3的内装低温エ质2的低温压カ容器I ; [0008] The chamber is provided with a booster 3 Ester built on low temperature low pressure ka container 2 I;

[0009] 端置于低温压カ容器I内的低温エ质2之中的低温エ质传输管5 ;所述低温エ质传输管5由第一来流管道52和套装于该第一来流管道52外壁上的第一隔热管腔51组成;所述第一隔热管腔51为真空管腔或为内装隔热材料的管腔;所述低温エ质传输管5靠近所述低温压カ容器I端的管腔内装有低温流体阀4 ; [0009] The low pressure end disposed within the cryogenic container ka I Ester Ester low mass-transfer tubes 5 in the mass 2; mass Ester said cryogenic transfer pipe 5 to the first flow conduit 52 and to flow to the first set the outer wall 52 of the duct lumen 51 of the first insulating composition; the first lumen 51 is a vacuum insulated chamber or heat insulating material for the interior lumen; Ester said cryogenic substance transfer tube 5 close to the low pressure ka I luminal contents of the container end low-temperature fluid valve 4;

[0010] ー连接于所述低温エ质传输管5另ー端的探针杆7 ;所述探针杆7由第二来流管道71、套装于该第二来流管道71外壁上的第一回流管道72、套装于所述第一回流管道72外壁上的第二隔热管腔73和套装于所述第二隔热管腔73外壁上的第一电热元件74组成;所述第二隔热管腔73为真空管腔或为内装隔热材料的管腔;所述探针杆7与所述低温エ质传输管5连接处外壁上套装有绝热手柄6 ;所述探针杆7的第一电热元件74上均匀地分布有第一温度传感器; [0010] ー probe shaft connected to said low mass-transfer tubes 5 Ester ー another end 7; the probe shaft 7 to the second flow conduit 71, 71 set in the outer wall of the second stream to the first conduit return pipe 72, the pipe 72 set in the outer wall of lumen 73 and the second insulating first electrothermal member 73 set to the outer wall of the second lumen of said first insulating composition refluxed 74; the second compartment heat or lumen 73 of the evacuated interior lumen of heat insulating material; the probe shaft 7 and the low mass-transfer tubes Ester of the outer wall of the package 5 is connected with a heat insulating handle 6; 7, the probe rod 74 distributed uniformly heating element has a first temperature sensor;

[0011] ー连接于所述探针杆7前端的探针头8 ;所述探针头8由第三来流管道81和将所述第三来流管道81包围其中的第二电热元件83组成;所述第二电热元件83由位于后部的圆管形后部和与所述圆管形后部成一体结构的带有弧面形前端的圆锥形前部组成;所述第ニ电热元件83与所述第三来流管道81之间留有的空间为第二回流管道82;所述第二电热元件83内腔前端装有第二温度传感器;所述第一来流管道52、所述第二来流管道71和所述第三来流管道81相连通;所述第一回流管道72与所述第二回流管道82相连通;所述第一回流管道72的管壁上设有与外部大气相连通的排气ロ; [0011] ー probe shaft 7 is connected to the front end of the probe head 8; the probe head 8 by a third flow conduit 81 and to the third stream to a second conduit 81 which surrounds the heating element 83 composition; the second heating element 83 by the rear tube-shaped rear portion at the rear of the tube and a conical front portion formed with arc-shaped front end of the integral structure of the composition; the second Ni electric left between the element 83 and the third flow conduit 81 to the return conduit 82 to a second space; said second electrothermal member with a second distal lumen 83 temperature sensor; flow conduit 52 to the first, to the second flow conduit 71 and to the third flow conduit 81 in communication; the first return line 72 and return line 82 is connected to the second pass; disposed on the first wall 72 of the return line It has communicated with the outside air exhaust ro;

[0012] 一直流电源模块12 ;所述直流电源模块12分别与所述第一电热元件74、第二电热元件83和所述升压器3电连接以对它们进行加热;所述直流电源模块12的电压为I〜36V ; [0012] DC power module 12; the DC power supply module 12 with said first electric heating element 74, the second heating element 83 and the booster 3 are electrically connected to heating them; the DC power supply module 12 is a voltage I~36V;

[0013] 一数据采集和控制模块10和一计算机11 ;所述数据采集和控制模块10与计算机11通过数据线相连;所述数据采集和控制模块10的数据采集通道分别与所述第一温度传感器和第二温度传感器相连;所述数据采集和控制模块10的控制通道分别与所述低温流体阀4和所述直流电源模块12相连;所述计算机11通过所述数据采集和控制模块10控制所述低温流体阀4的开启与关闭;所述数据采集和控制模块10与所述温度传感器相连以实时采集所述温度传感器的温度,并将采集的温度传感器温度传送至计算机(11);所述计算机11通过数据采集和控制模块10控制所述直流电源模块12的加热功率,从而控制所述第一电热元件74、第二电热元件83的加热温度。 [0013] a data acquisition and control module 10 and a computer 11; the data acquisition and control module 10 and the computer 11 is connected via a data line; the data acquisition and control channel data acquisition module 10 are respectively the first temperature sensor and the second temperature sensor is connected; data acquisition and control modules of the control passage 10 are connected to the cryogenic fluid with the valve 4 and the DC power supply module 12; 10 controlling the computer 11 through the data acquisition and control modules the cryogenic fluid valve is opened and closed 4; said data acquisition and control module 10 is connected to the temperature sensor to acquire the temperature of the temperature sensor in real time, and the collected temperature sensor to a computer (11); the said computer 11 via a data acquisition and control module 10 controls the heating power of the DC power supply 12 to thereby control the first heating element 74, the heating temperature of the second heating element 83.

[0014] 所述用于肿瘤冷热联合治疗的冷热探针装置为分离式结构:在靠近手柄6的低温エ质传输管5处,将低温エ质传输管5分为两部分,并通过一,决接头13将所述低温エ质传输管5的两部分连接成一整体。 Cold probe device [0014] The combination therapy for tumors of the cold as a separate structure: the low mass-transfer tubes 5 Ester near handle 6, the low mass-transfer tubes 5 Ester divided into two parts, and by First, the connector 13 must Ester the cryogenic substance transfer tube 5 is connected to the two parts into a whole.

[0015] 所述第一电热元件74电阻值和第二电热元件83电阻值介于I Ω〜100 Ω之间;其外表面上均喷涂有绝缘漆层。 83 the resistance value of [0015] the first heating element 74 and the resistance value of the heating element is interposed between the second I Ω~100 Ω; are sprayed on its outer surface with an insulating paint. [0016] 所述低温压カ容器I为电加热压カ容器或自增压压カ容器。 The [0016] low pressure vessel I ka ka electric heating voltage from the boost pressure vessel or container ka.

[0017] 所述第一电热元件74和所述第二电热元件83为薄膜电阻、半导体电阻或正温度系数电阻。 [0017] The first heating element 74 and the second electric heating element 83 is a thin film resistors, semiconductor positive temperature coefficient resistor or resistors. 所述正温度系数电阻为康铜丝电阻或镍丝电阻。 The positive temperature coefficient of resistance of constantan wire or a nickel wire resistance resistor.

[0018] 所述探针头8的圆锥形前部的空心腔体内壁为内翅片结构。 [0018] the inner wall of the conical front portion of the hollow cavity of said probe head 8 of the fin structure.

[0019] 本发明的用于肿瘤冷热联合治疗的冷热探针装置,在低温压カ容器I内设置有升压器3 (具体可采用电加热压カ容器或自增压压カ容器对低温エ质2进行加热气化,以实现低温容器I内的升压);低温エ质传输管5的一端浸入低温压カ容器I内的低温エ质2中,另一端通过第一来流管道52与探针杆7内的第二来流管道71相连通;低温エ质传输管5内靠近低温压カ容器I 一端设有低温流体阀4 (通过低温流体阀4的开关来实现低温エ质2的输送和切断);探针杆7与探针头8均设置有来流通道和回流通道,且分别相连;探针杆7与探针头8内还带有电热元件;探针杆7内设置有多个可独立控制的第一电热元件,在冷冻治疗过程中通过电加热以防止探针杆周围正常组织受到冷冻损伤,但同时为了避免加热造成正常组织烫伤,加热过程中需通过温度传感器实时监测探针杆的温度 [0019] Combined cold probe device for cold treating a tumor according to the present invention, ka at low pressure in the container is provided with a booster 3 I (particularly grades can be electrically heated pressure vessel or from a container of pressurized-ka low mass Ester 2 is heated vaporized to effect the boost in the cryocontainer I); mass Ester end of a cryogenic transfer tube 5 is immersed in the low temperature low pressure Ester quality grades 2, the other end of the inner container to the first flow conduit by I and a second flow conduit 52 to the rod 71 in the probe 7 in communication; Ester low temperature near the low mass-transfer tubes 5 ka pressure vessel cryogenic fluid valve I is provided at one end 4 to achieve low mass Ester (valve switch 4 by cryogenic fluid 2 and cutting transport); probe rod 7 provided with the probe head 8 and the return flow channel to channel and are respectively connected; probe shaft 7 with the probe head further heating element 8; probe shaft 7 disposed within a first plurality of independently controllable heating elements, by electric heating to prevent freezing treatment probe shaft surrounding normal tissue damage by freezing, but in order to avoid burns caused by heating normal tissues, the temperature during heating for an real-time monitoring of the temperature sensor of the probe shaft ,井根据此温度对电加热功率实施相应控制;探针头8内的第二电热元件的功能是对肿瘤组织实施加热治疗,加热过程中可通过监测探针头内的温度实时控制加热功率,以防止肿瘤组织炭化或汽化;探针杆7和探针头8内的电热元件外表面均做绝缘处理;低温エ质传输管5与探针杆7内均设置有隔热管腔(可采用真空腔或填充隔热材料予以实现),一方面可以有效防止低温エ质传输管5与探针杆7的表面温度过低,另ー方面还可以減少低温エ质2的损耗;低温エ质传输管5与探针杆7相连的一端设置有手柄6 (由隔热材料制成,便于手术过程中医生的操作);所有电热元件均通过直流电源模块供电,并由计算机通过数据采集和控制模块10对加热功率予以精确控制,为保证安全性,所有加热电压均控制在I〜36V以内。 , According to the well temperature of heating power control corresponding embodiment; function of the second heating element within the probe head 8 is a heat treatment of the tumor tissue, the heating process the heating power can be controlled in real time by monitoring the temperature within the probe head, to prevent tumor tissue vaporization or carbonization; outer heating member 8 inside the probe shaft and probe head surface 7 are made insulated; Ester low mass-transfer tubes 5 are disposed within the probe shaft 7 a heat insulating lumen (employed or the vacuum chamber to be filled with insulating material to achieve), one can effectively prevent the surface quality low Ester transfer tubes 5 and 7 of the probe rod temperature is too low, other aspects may also reduce ー Ester low mass loss of 2; low quality transmission Ester 5 with the probe end of the tube connected to the rod 7 is provided with a handle 6 (made of insulating material, to facilitate the operation of a doctor during surgery); all heating elements are powered by a DC power supply, by a computer data acquisition and control module 10 pairs of heating power to be precisely controlled to ensure the safety of all heating voltage are controlled within I~36V.

[0020] 上述技术方案中,来流通道可采用ー根或多根薄壁细金属管,回流通道则采用单根薄壁金属管,并位于来流通道外围,将来流通道包裹在其内;探针杆7的第一回流管道72管壁上设有与外部大气相连通的排气ロ; [0020] The foregoing technical solution, the flow channel to be used or a plurality of thin-walled ー fine metal tube, the return channel uses a single thin-walled metal pipe, and positioned to the peripheral flow channel, flow channel future wrapped therein; probe shaft 7 is provided with a first exhaust gas return line 72 is connected to the outside atmosphere through ro of the wall;

[0021 ] 上述技术方案中,探针杆7与探针头8的圆管形后部直径相同,其外径在Imm和IOmm之间;探针头8还具有与圆管形后部相连的带有弧面形前端的圆锥形前部,探针头8的该圆锥形前部为一空心腔体,该腔体内壁可加工为内翅片结构,低温エ质来流经此腔体吸收大量热量后迅速气化,从而实现对目标组织的快速降温;此外,探针头8外壁由高热导率金属材料制成。 [0021] In the above technical solution, the same probe diameter round pipe-shaped bar 7 and the rear portion of the probe head 8, and an outer diameter between Imm IOmm; probe head 8 also has a circular tube is connected to the rear arc-shaped portion having a conical front tip of the conical front portion 8 of the probe head is a hollow cavity, the cavity inner wall processed into a fin structure, a low temperature to flow through this mass Ester cavity absorbent It evaporated quickly after a lot of heat, so that rapid cooling of the target tissue; in addition, the outer wall of the probe head 8 is made of a high thermal conductivity metal material.

[0022] 上述技术方案中,低温压カ容器I内升压至足够压カ后,通过低温流体阀4的控制,可将低温エ质2从低温压カ容器内输入低温エ质传输管5内的第一来流管道52,然后经探针杆7的第二来流管道71和探针头8内的第三来流管道81进入探针头圆锥形前部的空心腔体中吸热气化,气化后依次通过探针头8的第二回流管道82和探针杆7的第一回流管道72,最后排入大气;冷冻治疗过程中,可通过控制探针杆7内的第一电热元件74,防止探针杆7周围正常组织受到冷冻损伤;关闭低温流体阀4可停止冷冻治疗,可通过探针头8内的第二电热元件83对肿瘤组织实施加热治疗。 [0022] In the above technical solution, the cryogenic pressure boosted to a sufficient pressure ka ka, cryogenic fluid through the control valve 4, a low temperature may be from 2 Ester endoplasmic cryogenic pressure vessel ka input endoplasmic cryogenic transfer tube 5 within the container I Ester to a first flow conduit 52, and then through a conical probe shaft to a second flow conduit 7 to a third flow conduit 81 in the probe head 871 and the probe head into the hollow cavity in the front portion of the hot gas suction , post gasified passes through the second probe head 82 and the return conduit 8 of the probe shaft 7, a first return conduit 72, and finally discharged into the atmosphere; a first freezing during the treatment, can be controlled by the probe rod 7 heating elements 74, to prevent the probe shaft 7 surrounding normal tissue damage by freezing; cryogenic fluid valve 4 closed to stop cryotherapy, heat treatment may be implemented by a second tumor tissue heating element 83 in the probe head 8. 如此,即可对肿瘤组织实现交替的冷热治疗。 So, alternating hot and cold therapy to the tumor tissue can be realized.

[0023] 本发明提供的用于肿瘤冷热联合治疗的冷热探针装置具有如下优点:本发明的用于肿瘤冷热联合治疗的冷热探针装置不仅可以非常方便地对肿瘤实施冷热交替治疗,而且还可以有效防止冷冻治疗过程中探针杆周围正常组织的冷冻损伤;而且本发明结构简単,降温、加热以及冻伤防护均易于实现,并且具有可控性好、安全性高以及使用方便等优点,适用于各种实体肿瘤的治疗。 [0023] The present invention provides a cold probe apparatus for cold tumor has the advantage of combination therapy: tumor cold probe device for hot and cold combination therapy can not only easily cold tumor embodiment of the present invention alternation therapy, but also effectively prevent freeze damage to the surrounding cryotherapy probe shaft during normal tissues; radiolabeling and simple structure of the present invention, cooling, freezing protection and heat are easy to implement and has good controllability, safety and ease of use for the treatment of various solid tumors.

附图说明 BRIEF DESCRIPTION

[0024] 图I为本发明的用于肿瘤冷热联合治疗的冷热探针装置的结构示意图; [0024] The structure for the hot and cold cold probe device cancer combination therapy of the present invention is a schematic diagram of FIG. I;

[0025] 图IA为图I中AA剖面示意图; [0025] FIG IA is a schematic cross-sectional view AA of Figure I;

[0026] 图IB为图I中BB首I]面不意图; [0026] FIG IB is not intended to be the first line BB in FIG. I I] surface;

[0027] 图2为本发明中探针杆7的结构示意图(箭头所示为低温エ质流动方向); [0027] FIG. 2 is a schematic view of the structure of the invention (shown by arrow cryogenic Ester mass flow direction) of the probe shaft 7;

[0028] 图2A为图2中CC剖面示意图; [0028] FIG. 2A is a schematic cross-sectional view CC of FIG 2;

[0029] 图3为本发明中探针头8的结构示意图(箭头所示为低温エ质流动方向); Structural diagram [0029] Figure 3 is the probe head 8 of the invention (shown by arrow cryogenic Ester mass flow direction);

[0030] 图3A为图3中DD剖面示意图; [0030] FIG 3A is a schematic cross-sectional view DD in Figure 3;

[0031] 图4为本发明又一实施例的结构示意图。 [0031] Fig 4 a schematic structural diagram of another embodiment of the present invention.

具体实施方式 detailed description

[0032] 下面结合附图及实施例进ー步描述本发明。 [0032] The following embodiments of the present invention into ー accompanying drawings and further described.

[0033] 实施例I : [0033] Example I:

[0034] 如图I所示,本发明提供一种用于肿瘤冷热联合治疗的冷热探针装置,其结构如下:其包括: [0034] As shown in FIG I, the present invention provides a probe apparatus for hot and cold cold cancer combination therapy, the following structure: which comprises:

[0035] 一腔内设有升压器3的内装低温エ质2的低温压カ容器I ; [0035] The chamber is provided with a booster 3 Ester built on low temperature low pressure ka container 2 I;

[0036] 端置于低温压カ容器I内的低温エ质2之中的低温エ质传输管5 ;所述低温エ质传输管5由第一来流管道52和套装于该第一来流管道52外壁上的第一隔热管腔51组成;所述第一隔热管腔51为真空管腔或为内装隔热材料的管腔;所述低温エ质传输管5靠近所述低温压カ容器I端的管腔内装有低温流体阀4 ; [0036] The low pressure end disposed within the cryogenic container ka I Ester Ester low mass-transfer tubes 5 in the mass 2; mass Ester said cryogenic transfer pipe 5 to the first flow conduit 52 and to flow to the first set the outer wall 52 of the duct lumen 51 of the first insulating composition; the first lumen 51 is a vacuum insulated chamber or heat insulating material for the interior lumen; Ester said cryogenic substance transfer tube 5 close to the low pressure ka I luminal contents of the container end low-temperature fluid valve 4;

[0037] ー连接于所述低温エ质传输管5另ー端的探针杆7 ;所述探针杆7由第二来流管道71、套装于该第二来流管道71外壁上的第一回流管道72、套装于所述第一回流管道72外壁上的第二隔热管腔73和套装于所述第二隔热管腔73外壁上的第一电热元件74组成;所述第二隔热管腔73为真空管腔或为内装隔热材料的管腔;所述探针杆7与所述低温エ质传输管5连接处外壁上套装有绝热手柄6 ;所述探针杆7的第一电热元件74上均匀地分布有温度传感器; [0037] ー probe shaft connected to said low mass-transfer tubes 5 Ester ー another end 7; the probe shaft 7 to the second flow conduit 71, 71 set in the outer wall of the second stream to the first conduit return pipe 72, the pipe 72 set in the outer wall of lumen 73 and the second insulating first electrothermal member 73 set to the outer wall of the second lumen of said first insulating composition refluxed 74; the second compartment heat or lumen 73 of the evacuated interior lumen of heat insulating material; the probe shaft 7 and the low mass-transfer tubes Ester of the outer wall of the package 5 is connected with a heat insulating handle 6; 7, the probe rod 74 a uniformly distributed heating element with a temperature sensor;

[0038] ー连接于所述探针杆7前端的探针头8 ;所述探针头8由第三来流管道81和将所述第三来流管道81包围其中的第二电热元件83组成;所述第二电热元件83由位于后部的圆管形后部和与所述圆管形后部成一体结构的带有弧面形前端的圆锥形前部组成;所述第ニ电热元件83与所述第三来流管道81之间留有的空间为第二回流管道82;所述第二电热元件83内腔前端装有温度传感器;所述第一来流管道52、所述第二来流管道72和所述第三来流管道81相连通;所述第一回流管道72与所述第二回流管道82相连通;所述第一回流管道72的管壁上设有与外部大气相连通的排气ロ; [0038] ー probe shaft 7 is connected to the front end of the probe head 8; the probe head 8 by a third flow conduit 81 and to the third stream to a second conduit 81 which surrounds the heating element 83 composition; the second heating element 83 by the rear tube-shaped rear portion at the rear of the tube and a conical front portion formed with arc-shaped front end of the integral structure of the composition; the second Ni electric left between the element 83 and the third flow conduit 81 to the return line 82 to a second space; lumen 83 distal of the second heating element with a temperature sensor; to the first flow conduit 52, the to a second flow conduit 72 and to the third flow conduit 81 in communication; the first return line 72 and return line 82 to the second communicating; the first return pipe 72 is provided in the upper wall outside air vent communicating ro;

[0039] 一直流电源模块12 ;所述直流电源模块12分别与所述第一电热元件74、第二电热元件83和所述升压器3电连接以对它们进行加热;所述直流电源模块12的电压为I〜36V ; [0039] DC power module 12; the DC power supply module 12 with said first electric heating element 74, the second heating element 83 and the booster 3 are electrically connected to heating them; the DC power supply module 12 is a voltage I~36V;

[0040] 一数据采集和控制模块10和一计算机11 ;所述数据采集和控制模块10与计算机11通过数据线相连;所述数据采集和控制模块10的数采通道与所述温度传感器相连;所述数据采集和控制模块10的控制通道分别与所述低温流体阀4和所述直流电源模块12相连;所述计算机11通过所述数据采集和控制模块10控制所述低温流体阀4的开启与关闭;所述数据采集和控制模块10与所述温度传感器相连以实时采集所述温度传感器的温度,并将采集的温度传感器温度传送至计算机11 ;所述计算机11通过数据采集和控制模块10控制所述直流电源模块12的加热功率,从而控制所述第一电热元件74、第二电热元件83的加热温度。 [0040] a data acquisition and control module 10 and a computer 11; the data acquisition and control module 10 and the computer 11 is connected via a data line; connected to the data acquisition module and the data acquisition control channel and the temperature sensor 10; the data acquisition and control modules control passage 10 are connected to the cryogenic fluid with the valve 4 and the DC power supply module 12; 10 controlling the computer 11 through the data acquisition and control modules of the cryogenic fluid valve opening 4 and closing; the data acquisition and control module 10 is connected to the temperature sensor temperature to real-time acquisition of the temperature sensor, and the collected temperature sensor 11 to a computer; a computer 11 via a data acquisition and control modules 10 controlling the heating power of the DC power supply 12 to thereby control the first heating element 74, heating element 83 is a second heating temperature.

[0041] 本实施例中,低温エ质2采用液氮,盛装于低温压カ容器I中,该低温压カ容器I器可从市场选购或找相关厂商定制即可。 [0041] In this embodiment, cryogenic liquid nitrogen Ester mass 2, containing a low temperature pressure vessel grades I, the cryogenic pressure vessel grades I may purchase or find the relevant market from manufacturers to customize. 低温压カ容器I内设置有升压器3,升压器3为一电热元件,浸泡于低温エ质2内,升压器3通过直流电源模块12供电实施加热时,低温エ质2快速气化,从而实现低温压カ容器I内的升压;在升压过程中,容器内的压カ可从置于低温压カ容器I外的压カ表读出。 Low pressure when ka 3 is provided with a booster, the booster 3 is a heating element immersed in the cryogenic mass Ester 2, the booster 3 embodiment DC power supply module 12 is heated by the vessel I, 2 low fast gas mass Ester , thereby to achieve low pressure in the vessel booster ka I; in the boosting process, the pressure within the container may be pressed ka ka ka pressed sheet is read out from the container in a cool I. 低温エ质传输管5可采用不锈钢双层波纹管制作,包括第一隔热管腔51和第一来流管道52(如图IA所示),其中第一隔热管腔51可采用真空腔或填充隔热材料予以实现;低温エ质传输管5的一端浸入低温压カ容器I内的低温エ质2中,另一端通过第一来流管道52与探针杆7内的第二来流管道71相连通;低温流体阀4设置于低温エ质传输管5内靠近低温压カ容器I的一端,可采用低温电磁阀或低温球阀;如采用电磁阀,则可在手术过程中由计算机11通过数据采集和控制模块10实施自动控制其流通和关闭;如采用低温球阀,则需要在手术过程中手动控制低温流体阀4的流通和关闭;通过低温流体阀4的开关即可方便地实现低温エ质2的输送和切断;低温エ质传输管5与探针杆7相连的一端设置有手柄6 (如图I及图IB所示),手柄6由隔热材料如聚四氟こ烯等制成,便于医生在手术过 Ester low mass-transfer tube 5 can be made double wall corrugated pipe, comprising a first lumen 51 and the first heat flow to conduit 52 (shown in FIG. IA), wherein the first insulating vacuum chamber lumen 51 may be employed filling insulating material or be implemented; Ester end of a cryogenic substance transfer tubes immersed in 5 grades second low pressure to low flow within 7 mass Ester 2, the other end of the inner vessel I through the first flow conduit 52 to the probe shaft communicating conduit 71; cryogenic fluid valve 4 is provided close to the low temperature Ester low pressure mass transfer pipe 5 I ka end of the vessel, the solenoid valve can be low-temperature or cryogenic ball; the electromagnetic valve may be during the surgery by a computer 11 by data acquisition and control module 10 automatically controls its embodiment and flow off; low temperature such as a ball valve, it is necessary to manually control the flow of cryogenic fluid valve 4 is closed and during surgery; can be easily achieved by a low temperature cryogenic fluid valve switch 4 Ester mass transport and cutting 2; 7 connected to one end of a low-temperature mass Ester transfer tube 5 is provided with a handle and probe shaft 6 (shown in FIG. I and FIG. IB), the handle 6 of a heat insulating material such as polytetrafluoroethylene ko ene is made, the doctor had to facilitate surgery 程中手持探针进行操作;探针杆7包括第二来流管道71、第一回流管道72、第二隔热管腔73、第一电热元件74以及温度传感器9 (如图2及图2A所示);探针头8包含第三来流管道81、第二回流管道82、第二电热元件83以及温度传感器9 (如图3及图3A所示);探针杆7和探针头8内的温度传感器9均可选用热电偶或热电阻;探针杆7的第二来流管道71与探针头8的第三来流通道81相连通;探针杆7的第一回流管道72与探针头8的第二回流管道82相连通; Process is operated handheld probe; probe 7 comprises a lever to a second flow conduit 71, a first return line 72, a second insulation lumen 73, a first heating element 74 and a temperature sensor 9 (FIGS. 2 and 2A shown); to the probe head 8 comprises a third flow conduit 81, a second return line 82, a second heating element 83 and a temperature sensor 9 (FIGS. 3 and 3A); a probe head and probe shaft 7 the temperature sensor 89 can be selected thermocouple or RTD; probe shaft to a second flow conduit 71 and the probe head to the third flow path 7 8 81 communicating; probe shaft 7, a first return conduit the second return line 72 and the probe 82 is connected through the head 8;

[0042] 本实施例中,探针杆7内设置有多个可独立控制的第一电热元件74,该第一电热元件74与直流电源模块12电连接,在冷冻治疗过程中通过电加热可有效防止探针杆7周围的正常组织受到冷冻损伤;探针杆7内的第二隔热管腔73也可类似于为了避免探针杆7的加热对正常组织造成烫伤,加热过程中可通过温度传感器9实时监测探针杆7的温度,并根据此温度对各电热元件的加热功率分别实施相应控制; [0042] In this embodiment, there are provided a first plurality of independently controllable heating elements 74 within the probe shaft 7, the first heating element 74 is electrically connected to the DC power module 12, may be heated by an electrical process cryotherapy to effectively prevent the surrounding normal tissue by freezing damage the probe shaft 7; a second lumen 73 within the insulating rod 7 may be similar to the probe in order to avoid heating the probe shaft 7 causes burns to normal tissues during heating by real-time monitoring of the temperature sensor 9 temperature probe shaft 7, respectively, according to this embodiment corresponding to the temperature control of the heating power of each heating element;

[0043] 探针头8内的第二电热元件83与直流电源模块12电连接,其功能是对肿瘤组织实施加热治疗,加热过程中可通过监测探针头8的温度实时控制加热功率,以防止肿瘤组织温度过高发生炭化或汽化; [0043] The second heating element within the probe head 883 is electrically connected to the DC power supply module 12, which is a function of a heat treatment of the tumor tissue, the heating process the heating power can be controlled in real time by monitoring the temperature of the probe head 8 to prevent tumor tissue temperature carbonization or excessive vaporization occurs;

[0044] 探针杆7内的第一电热元件74和探针头8内的第二电热元件83可采用康铜丝、镍丝、薄膜电阻、半导体电阻或正温度系数电阻等制成,其电阻值介于1Ω〜100Ω之间;此夕卜,第一电热元件74和第二电热元件83的外表面均需做绝缘处理,具体可在采表面喷涂绝缘漆层,为保证安全性,所有第一电热元件74和第二电热元件83的加热电压均控制在I〜36V以内; The first element of the second electric heating element 83 may take the constantan wire, nickel wire, thin film resistors, semiconductor resistance or positive temperature coefficient resistor or the like, in the 8 [0044] within the probe shaft 774 and probe head thereof the resistance value between 1Ω~100Ω; Bu this evening, the outer surface of the first member 74 and the second electric heating element 83 is required to be insulated, particularly the surface coating may be recoverable insulating paint, to ensure security, all the first heating element 74 and the second heating element 83 is heating voltage are controlled within I~36V;

[0045] 本实施例中,低温エ质传输管5与探针杆7内分别设置有第一隔热管腔51和第二隔热管腔73的目的在干,一方面可以有效防止低温エ质传输管5与探针杆7的表面温度过低,另ー方面还可以減少低温エ质2在冷冻治疗过程中的损耗; [0045] In this embodiment, low quality Ester transfer tubes 5 are provided within the probe shaft 7 with a first object and a second thermal insulating lumen 51 in the dry lumen 73, one can effectively prevent hypothermia Ester mass transfer tube 5 and the surface temperature of the probe shaft 7 is too low, other aspects may also reduce low ー Ester 2 mass loss during cryosurgery;

[0046] 本实施例中,第一来流管道52、第二来流管道71以及第三来流管道81均可采用一根或多根薄壁细金属管制成;第一回流管道72及第二回流管道82则均采用单根薄壁金属管制成,井分别位于来流通道71和81的外围,将其包裹在内;探针杆7内第一回流管道72在靠近手柄6的一侧设有通往大气的出气孔;探针杆7与探针头8的圆管形后部直径相同,介于Imm和IOmm之间;探针头8具有圆锥形前部,该圆锥形前部为一空心腔体(如图3所示),为增强换热系数,该圆锥形前部组内壁可采用内翅片结构;低温エ质2依次经低温エ质传输管5内第一来流管道52、探针杆7的第二来流管道71及探针头8的第三来流管道81,流入探针头8前端的圆锥形前部,在该圆锥形前部的腔体吸收大量热量后迅速气化,从而实现对目标组织的快速降温;低温エ质2在探针头8的圆锥形前部的腔体中气化 [0046] In this embodiment, to the first flow conduit 52, to a second flow conduit 71 and the third flow conduit 81 may be employed for one or more of thin metal thin-walled tubing; a first and second return line 72 two return pipe 82 are made of a single thin-walled metal tubing, wells are located to the periphery of the flow channel 71 and 81, it will be encased; probe 7 of the first inner lever 72 in the return line of the near side of the handle 6 is provided with a hole leading to the atmosphere; the same tube-shaped probe shaft 7 and the rear portion of the diameter of the probe head 8, interposed between Imm and IOmm; probe head 8 has a conical front portion, the front portion of the conical is a hollow cavity (FIG. 3), to enhance the heat transfer coefficient, the front inner wall of the conical portion can be set within the fin structure; low mass Ester 2 successively flows through the low temperature to the first mass transfer tube 5 Ester the second flow conduit to conduit 52, and the probe shaft 7 of the probe head 71 to the third flow conduit 818 flows into the cone-shaped probe tip of the front portion 8, the cavity of the conical front portion of absorbing large quantities after rapid gasification heat, so that rapid cooling of the target tissue; low mass Ester 2 vaporized in a conical cavity of the probe head 8 of the front portion 后,再依次经探针头8的第二回流管道82和探针杆7的第一回流管道72,最后排往大气'考虑到临床中对介入人体内部的治疗探针在核磁兼容方面的要求,以及冷热治疗过程中对探针换热性能的要求,探针应选用同时具备低磁化系数和高热导率的材料(如不锈钢或钛)制作。 After then followed by a second probe head 82 and the return conduit 8 of the probe shaft 7, a first reflux pipe 72, and finally discharged into the atmosphere 'taking into account the clinical requirements for interventional therapeutic probe inside the body in terms of NMR-compatible , the course of treatment and cold heat transfer performance of the probe request, the probe should be used at the same time the material with low magnetic susceptibility and a high thermal conductivity (e.g., stainless steel or titanium) Preparation.

[0047] 本实施例中,低温エ质2(如液氮)盛装于低温压カ容器I内,容器I内装有升压器(即电热元件),通电后即可对其内液氮加热并使之气化,由于气体膨胀使密闭容器I内地压カ升高,当其升至一定大小时,便可开启低温流体阀4,将低温エ质2从容器I内依次经过第一来流管道52、第二来流管道71以及第三来流管道81输送至探针头8的圆锥形前部的空心腔体,即可对组织进行冷冻治疗;低温エ质2吸热后气化,气化后再依次通过第二回流管道82和第一回流管道72,最后排入大气;关闭低温流体阀4,即可停止冷冻治疗;冷冻治疗停止后,即可通过探针头8内的电热元件83对肿瘤组织实施加热治疗。 [0047] In this embodiment, the low-temperature mass Ester 2 (e.g., nitrogen) containing the container at low pressure grades I, I built with a booster container (i.e., heating elements) can heat the liquid nitrogen to its power and gasified, the gas is expanded so that the closed vessel interior I ka elevated pressure, when it is raised to a certain size, the low temperature fluid can open the valve 4, the low mass Ester I 2 from the container passes through the first flow conduit to 52, to a second flow conduit 71 and the third flow conduit 81 conveyed to the probe head to the front portion of the conical hollow cavity 8, to the tissue cryotherapy; 2 mass Ester endothermic low temperature gasification, gas then passes through a second of the return conduit 82 and a first return conduit 72, and finally discharged into the atmosphere; cryogenic fluid valve 4 closed, to stop cryotherapy; after freezing treatment is stopped, the probe head can be by heating element 8 in 83 pairs of a heat treating the tumor tissue. 这样就实现了对肿瘤组织的冷热联合治疗,这种冷热联合治疗可以依据需要重复多个冷热循环。 This realization of the combination therapy of tumor tissue to hot and cold, hot and cold this combination therapy can be repeated multiple thermal cycles according to need.

[0048] 实施例2 : [0048] Example 2:

[0049] 图4为本实施例的一种用于肿瘤冷热联合治疗的冷热探针装置的结构示意图。 [0049] FIG. 4 one kind of embodiment of the present embodiment schematic view of hot and cold tumor cold probe device for combination therapy.

[0050] 本实施例与实施例I的结构基本相同,所不同在于:本实施例所提供的用于肿瘤冷热联合治疗的冷热探针装置采用可分离式设计;临床中,针对深部肿瘤,基于介入人体探针实施治疗的微创手术一般需采取经皮穿刺木;如探针采用可分离式设计方式,无疑可以大大增加医生穿刺过程中操作的灵活性,便于实施更为精准的手术;本实施例中,只需在低温エ质传输管5靠近手柄6的部位将低温エ质传输管5 —分为ニ,然后通过快接头13予以连接即可。 Structure [0050] The present embodiment is substantially the same as Example I, except that: the present embodiment the cold heat is provided a probe apparatus for use in combination therapy tumor cold detachable design; clinic, for deep tumors based on the implementation of Interventional therapy minimally invasive surgical probe is generally to be taken percutaneous wood; such as the use of detachable probe design approach will undoubtedly greatly increase the flexibility of the doctor puncture during the operation, to facilitate the implementation of more precise surgery ; in this embodiment, only the portion of low mass-transfer tubes 5 Ester handle 6 near the low mass-transfer tubes Ester 5 - ni divided, and can be connected by a quick connector 13. 管道快接头是ー项成熟技术,可从市场选购或委托相关厂商定制。 Pipe joints is quick ー term mature technology, can buy from the market or commissioned vendor-specific. 除上述变化之外,其它部件的位置及结构与实施例I相同。 In addition to the above changes, the position, and other structural members same as in Example I. 本实施例中,其它所有部件已在实施例I中进行了深入的解释说明,因此在本实施例中不再赘述。 In this embodiment, all other components have conducted in-depth explanation in Example I, and therefore omitted in the embodiment of the present embodiment.

[0051] 实施例3: [0051] Example 3:

[0052] 本实施例结构与实施例I基本相同;二者的区别在于,本实施例中低温压カ容器I不再采用电加热实施升压,而是采用自增压低温压カ容器; [0052] Example embodiment of the present structure is substantially the same as in Example I; difference is that, in the present embodiment, the low temperature pressure vessel grades I no longer boosting electric heating embodiment, instead of using the pressure from the boost ka cryogenic container;

[0053]自增压低温压カ容器(如自增压液氮罐)市场有售,其升压原理是从液氮罐内通过旁管引出部分液氮,经盘管换热器与空气进行换热,然后气化,从而提升容器内的压カ;与电加热升压方式相比,自增压方式的优势在于:不会升高容器内液氮的温度,从而一方面可以获得更接近液氮温度的最低冷冻治疗温度,另ー方面还可显著減少治疗过程中液氮的消耗。 [0053] from the boost pressure cryogenic vessels grades (e.g., self-boosting liquid nitrogen tank) commercially available, which is the principle of the boosting liquid nitrogen tank tube leads from the liquid nitrogen through the bypass portion, a coil heat exchanger through the air a heat exchanger, then vaporized, so as to enhance the pressure in the vessel ka; boost mode compared to electric heating, the advantages of self-boosting mode is that: does not increase the temperature of liquid nitrogen in the vessel, so that one can get closer to cryotherapy minimum temperature of liquid nitrogen temperature, and the other ー aspects may also be significantly reduced during the treatment of liquid nitrogen consumption.

[0054] 本实施例中,其它所有部件已在实施例I中进行了深入的解释说明,因此在本实施例中不再赘述。 [0054] In this embodiment, all other components have conducted in-depth explanation in Example I, and therefore omitted in the embodiment of the present embodiment.

Claims (7)

  1. 1. 一种用于肿瘤冷热联合治疗的冷热探针装置,其包括: 一腔内设有升压器⑶的内装低温エ质⑵的低温压カ容器⑴; 一一端置于低温压カ容器(I)内低温エ质(2)之中的低温エ质传输管(5);所述低温エ质传输管(5)由第一来流管道(52)和套装于该第一来流管道(52)外壁上的第一隔热管腔(51)组成;所述第一隔热管腔(51)为真空管腔或为内装隔热材料的管腔;所述低温エ质传输管(5)靠近所述低温压カ容器(I)端的管腔内装有低温流体阀(4); ー连接于所述低温エ质传输管(5)另ー端的探针杆(7);所述探针杆(7)由第二来流管道(71)、套装于该第二来流管道(71)外壁上的第一回流管道(72)、套装于所述第一回流管道(72)外壁上的第二隔热管腔(73)和套装于所述第二隔热管腔(73)外壁上的第一电热元件(74)组成;所述第二隔热管腔(73)为真空管腔或为内装 A cold joint coldness tumor therapy probe device, comprising: a booster cavity is provided with built-in low-temperature low mass Ester ⑵ ⑶ the pressure vessel ka ⑴; end disposed a low pressure Ester Ester on low temperature low mass-transfer tubes (2) from among (5) grades vessel (the I); mass Ester said cryogenic transfer tube (5) to a first flow conduit (52) and set to be the first flow conduit (52) a first outer wall of the insulating lumen (51) composition; said first insulating lumen (51) is a vacuum chamber or heat insulating material for the interior lumen; Ester the low mass-transfer tubes (5) adjacent to the cryogenic pressure vessel ka (I) that has the end of the lumen cryogenic fluid valve (4); ー connected to the low mass-transfer tubes Ester (5) the other end of the probe ー rod (7); the a first return line (72) of the probe shaft (7) to the second flow conduit (71), to set to the second flow conduit (71) of the outer wall, a first set of said return line (72) of the outer wall a second insulating lumen (73) and packaged within the lumen of the second insulation (73) a first outer wall of the heating element (74) consisting of; the second insulating lumen (73) is vacuum chamber is built or 隔热材料的管腔;所述探针杆(7)与所述低温エ质传输管(5)连接处外壁上套装有绝热手柄¢);所述探针杆(7)的第一电热元件(74)上均匀地分布有第一温度传感器; ー连接于所述探针杆(7)前端的探针头(8);所述探针头(8)由第三来流管道(81)和将所述第三来流管道(81)包围其中的第二电热元件(83)组成;所述第二电热元件(83)由位于后部的圆管形后部和与所述圆管形后部成一体结构的带有弧面形前端的圆锥形前部组成;所述第二电热元件(83)与所述第三来流管道(81)之间留有的空间为第二回流管道(82);所述第二电热元件(83)内腔前端装有第二温度传感器;所述第一来流管道(52)、所述第二来流管道(71)和所述第三来流管道(81)相连通;所述第一回流管道(72)与所述第二回流管道(82)相连通;所述第一回流管道(72)的管壁上设有与外部大气相连通的 Lumen insulating material; the probe rod (7) and the cryogenic transfer tube mass Ester (5) of the outer wall of the heat insulating package handles ¢); said probe shaft (7) of the first heating element (74) uniformly distributed on a first temperature sensor; ー connected to said probe shaft (7) of the front end of the probe head (8); the probe head (8) to flow by a third conduit (81) and a second heating element (83) to said third flow conduit (81) which surrounds the composition; the second heating element (83) at the rear by the rear circular tube and the tube-shaped a rear portion with a conical front tip of the arc-shaped integral structure composed of; the second heating element (83) to flow between said third conduit (81) to leave room for a second return line (82); said second electrothermal member (83) provided with a second temperature sensor lumen distal end; to the first flow conduit (52), to the second flow conduit (71) and to the third flow conduit (81) communicating; the first return line (72) and the second return line (82) in communication; provided on the wall of the first return line (72) communicating with the outside air of 气n ; 一直流电源模块(12);所述直流电源模块(12)分别与所述第一电热元件(74)、第二电热元件(83)和所述升压器(3)电连接以对它们进行加热;所述直流电源模块(12)的电压为I〜36V ; 一数据采集和控制模块(10)和一计算机(11);所述数据采集和控制模块(10)与计算机(11)通过数据线相连;所述数据采集和控制模块(10)的数据采集通道分别与所述第一温度传感器和第二温度传感器相连;所述数据采集和控制模块(10)的控制通道分别与所述低温流体阀(4)和所述直流电源模块(12)相连;所述计算机(11)通过所述数据采集和控制模块(10)控制所述低温流体阀⑷的开启与关闭;所述数据采集和控制模块(10)与所述温度传感器相连以实时采集所述温度传感器的温度,并将采集的温度传感器温度传送至计算机(11);所述计算机(11)通过数据采集和控制模块(10) N-gas; DC power supply module (12); a DC power supply module (12) with said first heating element (74), a second heating element (83) and said boost electrical connector (3) heating them; voltage of the DC power supply module (12) is I~36V; a data acquisition and control module (10) and a computer (11); said data acquisition and control module (10) and the computer (11 ) is connected through a data line; the data acquisition and control module (10) of data acquisition channels connected to said first temperature sensor and second temperature sensors, respectively; the data acquisition and control module (10) and control channels, respectively the cryogenic fluid valve (4) and said DC power supply module (12) is connected; said computer (11) via said data acquisition and control module (10) controlling said cryogenic fluid ⑷ valve opening and closing; the data acquisition and control module (10) coupled to the temperature sensor to the temperature of the real-time acquisition of the temperature sensor, and transmits the collected temperature sensor to a computer (11); said computer (11) via a data acquisition and control modules (10) 制所述直流电源模块(12)的加热功率,从而控制所述第一电热元件(74)、第二电热元件(83)的加热温度。 The DC power module system (12) of the heating power to control the first heating element (74), the heating temperature of the second heating element (83).
  2. 2.按权利要求I所述的用于肿瘤冷热联合治疗的冷热探针装置,其特征在于:所述用于肿瘤冷热联合治疗的冷热探针装置为分离式结构:在靠近手柄(6)的低温エ质传输管(5)处,将低温エ质传输管(5)分为两部分,并通过一快接头(13)将所述低温エ质传输管(5)的两部分连接成一整体。 2. I claim the hot and cold probe device for the treatment of tumors of the cold joint, characterized in that: said probe means for tumor cold cold combination therapy for the separation structure: near the handle (6) mass Ester cryogenic transfer tube (5) at low temperature Ester mass transfer tube (5) is divided into two parts by a quick connector (13) the two portions of the low mass-transfer tubes Ester (5) integrally connected.
  3. 3.按权利要求I或2所述的用于肿瘤冷热联合治疗的冷热探针装置,其特征在于,所述第一电热兀件(74)电阻值和第二电热兀件(83)电阻值介于IQ〜100Q之间;其外表面上均喷涂有绝缘漆层。 3. I claim the cold heat probe device for the treatment of cancer combined cold or claim 2, wherein said first electrothermal Wu member (74) and a second electric resistance value Wu member (83) the resistance value between IQ~100Q; are sprayed on its outer surface with an insulating paint.
  4. 4.按权利要求I或2所述的用于肿瘤冷热联合治疗的冷热探针装置,其特征在于:所述低温压カ容器(I)为电加热压カ容器或自增压压カ容器。 4. I claim the cold heat probe device for the treatment of cancer combined cold or claim 2, wherein: the cryogenic pressure vessel ka (I) is electrically heated pressure vessel or from the pressurized-ka ka container.
  5. 5.按权利要求I或2所述的用于肿瘤冷热联合治疗的冷热探针装置,其特征在于:所述第一电热元件(74)和所述第二电热元件(83)为薄膜电阻、半导体电阻或正温度系数电阻。 5. I claim the cold heat probe device for the treatment of cancer combined cold or claim 2, wherein: said first heating element (74) and said second heating element (83) is a thin film resistors, semiconductor positive temperature coefficient resistor or resistors.
  6. 6.按权利要求I或2所述的用于肿瘤冷热联合治疗的冷热探针装置,其特征在于:所述探针头(8)的圆锥形前部的空心腔体内壁为内翅片结构。 6. I claim the cold heat probe device for the treatment of cancer combined cold or claim 2, wherein: the hollow cavity inner wall of the conical front portion of the probe head (8) of the wings sheet structure.
  7. 7.按权利要求5所述的用于肿瘤冷热联合治疗的冷热探针装置,其特征在于:所述的正温度系数电阻为康铜丝电阻或镍丝电阻。 7. The apparatus according to claim cold probe combination therapy for cancer cold claim 5, wherein: said positive temperature coefficient resistance constantan wire or a nickel wire resistance resistor.
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