CN101801397A - 将治疗性细胞给予哺乳动物中枢神经系统的方法、药物组合物和制品 - Google Patents

将治疗性细胞给予哺乳动物中枢神经系统的方法、药物组合物和制品 Download PDF

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CN101801397A
CN101801397A CN200880107049A CN200880107049A CN101801397A CN 101801397 A CN101801397 A CN 101801397A CN 200880107049 A CN200880107049 A CN 200880107049A CN 200880107049 A CN200880107049 A CN 200880107049A CN 101801397 A CN101801397 A CN 101801397A
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cells
pharmaceutical composition
cell
therapeutic
nasal cavity
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威廉·H·弗雷二世
卢西·达尼埃良
克里斯托夫·H·格莱特
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases

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  • Obesity (AREA)
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  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
CN200880107049A 2007-09-11 2008-09-04 将治疗性细胞给予哺乳动物中枢神经系统的方法、药物组合物和制品 Pending CN101801397A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97128407P 2007-09-11 2007-09-11
US60/971,284 2007-09-11
US12/109,066 US8283160B2 (en) 2007-09-11 2008-04-24 Methods, pharmaceutical compositions and articles of manufacture for administering therapeutic cells to the animal central nervous system
US12/109,066 2008-04-24
PCT/US2008/075223 WO2009035901A1 (en) 2007-09-11 2008-09-04 Methods, pharmaceutical compositions and articles of manufacture for administering therapeutic cells to the animal central nervous system

Related Child Applications (1)

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CN2012105792811A Division CN103181932A (zh) 2007-09-11 2008-09-04 将治疗性细胞给予哺乳动物中枢神经系统的方法、药物组合物和制品

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CN200880107049A Pending CN101801397A (zh) 2007-09-11 2008-09-04 将治疗性细胞给予哺乳动物中枢神经系统的方法、药物组合物和制品
CN2012105792811A Pending CN103181932A (zh) 2007-09-11 2008-09-04 将治疗性细胞给予哺乳动物中枢神经系统的方法、药物组合物和制品

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US (3) US8283160B2 (https=)
EP (1) EP2200621B1 (https=)
JP (2) JP5600294B2 (https=)
KR (2) KR101504110B1 (https=)
CN (2) CN101801397A (https=)
AT (1) ATE554778T1 (https=)
AU (1) AU2008299124B2 (https=)
BR (1) BRPI0816325B8 (https=)
CA (1) CA2696892C (https=)
CR (1) CR11304A (https=)
CY (1) CY1113120T1 (https=)
DK (1) DK2200621T3 (https=)
ES (1) ES2388403T3 (https=)
HR (1) HRP20120560T1 (https=)
IL (1) IL204371A (https=)
MX (1) MX2010002738A (https=)
MY (1) MY154061A (https=)
PL (1) PL2200621T3 (https=)
PT (1) PT2200621E (https=)
RU (1) RU2468818C2 (https=)
SG (1) SG184724A1 (https=)
SI (1) SI2200621T1 (https=)
UA (1) UA98507C2 (https=)
WO (1) WO2009035901A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106924286A (zh) * 2017-02-16 2017-07-07 上海安集协康生物技术股份有限公司 一种经鼻腔给药用于帕金森病治疗的神经干细胞制剂
CN108096280A (zh) * 2017-12-28 2018-06-01 上海安集协康生物技术股份有限公司 一种神经干细胞滴鼻剂
CN108135547A (zh) * 2015-08-13 2018-06-08 戴埃克斯有限公司 用于评估接触系统激活的含有蛋白酶抑制剂的真空采血管

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8518390B2 (en) * 2003-06-27 2013-08-27 Advanced Technologies And Regenerative Medicine, Llc Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells
US8283160B2 (en) 2007-09-11 2012-10-09 Frey Ii William H Methods, pharmaceutical compositions and articles of manufacture for administering therapeutic cells to the animal central nervous system
EP2153844A1 (en) * 2008-08-14 2010-02-17 HAUBECK, Hans-Dieter Human hyaluronidases for axonal regrowth
KR20200011604A (ko) 2008-08-20 2020-02-03 안트로제네시스 코포레이션 개선된 세포 조성물 및 그의 제조 방법
US8609088B2 (en) 2011-05-10 2013-12-17 Regents Of The University Of Minnesota Intranasal delivery of therapeutic enzymes to the central nervous system for the treatment of lysosomal storage diseases
US10022083B2 (en) 2011-06-02 2018-07-17 Abdulmohsen E. A. H. Al-Terki Multiple oral and nasal surgical procedures method and kit
US8387798B1 (en) 2012-04-27 2013-03-05 Abdulmohsen E. A. H. Al-Terki Mutiple oral and nasal surgical procedures method and kit
US9821149B2 (en) * 2011-10-14 2017-11-21 Healthpartners Research & Education Methods for using ultrasound for enhancing efficiency and targeting of intranasal administration of therapeutic compounds to the central nervous system
EP2794854B1 (en) 2011-12-23 2018-06-20 DePuy Synthes Products, Inc. Detection of human umbilical cord tissue-derived cells
US20130336928A1 (en) * 2012-06-18 2013-12-19 Healthpartners Research & Education Methods and pharmaceutical compositions for treatment of central nervous system disorders with therapeutic agent(s) in patients with concurrent non-cns condition(s) or disorders contraindicating systemic administration of the therapeutic agent(s)
FR3001974B1 (fr) 2013-02-08 2016-02-12 Olivier Schussler Procede de purification de cellules
RU2522816C1 (ru) * 2013-02-12 2014-07-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Композиция для клеточно-заместительной терапии дефектов мягких тканей
US10279012B2 (en) * 2013-03-11 2019-05-07 Healthpartners Research & Education Methods of treating and preventing social communication disorder in patients by intranasal administration of insulin
CN105377039A (zh) 2013-05-15 2016-03-02 明尼苏达大学董事会 腺相关病毒介导的基因向中枢神经系统转移
US20170216286A1 (en) 2014-01-28 2017-08-03 Mayo Foundation For Medical Education And Research Killing senescent cells and treating senescence-associated conditions using a src inhibitor and a flavonoid
AU2015211021B2 (en) 2014-01-28 2020-07-02 Buck Institute For Research On Aging Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders
WO2015134869A2 (en) * 2014-03-06 2015-09-11 Children's National Medical Center Treatment of neonatal brain injury with hb-egf
EP3174584B1 (en) * 2014-07-29 2022-05-04 Edenhoffer, Peter Positive pressure inspiration device for delivery of medicaments
US11413408B2 (en) 2014-07-29 2022-08-16 Peter Edenhoffer Positive pressure inspiration device for delivery of medicaments
US10130657B2 (en) 2015-02-13 2018-11-20 John C. Hughes Formulation, apparatus, and methods for treatment of brain trauma
US10335435B2 (en) 2015-05-22 2019-07-02 Marco Merida Method for endoscopically delivering stem cells to the brain using an intranasal, injectable approach
US20160361253A1 (en) * 2015-06-13 2016-12-15 Noveome Biotherapeutics, Inc. Novel Methods for Delivering Therapeutic Agents to the Eye via Nasal Passages
WO2017011326A1 (en) 2015-07-10 2017-01-19 Sanjay Gupta Nasal foam via cribriform plate for medication delivery to the brain and/or body and for nasal moisturization and hygiene
IL305449B2 (en) 2016-04-15 2026-01-01 Univ Pennsylvania Gene therapy for the treatment of mucocutaneous type ii diabetes
CN108732355B (zh) * 2017-04-25 2021-06-25 首都医科大学附属北京安定医院 一种测定bace1酶切nrg1活性的检测方法及其试剂盒
US20190060109A1 (en) * 2017-08-31 2019-02-28 Gregory Todd Johnson Method of Preventing Traumatic Brain Injury (TBI)
TWI835747B (zh) 2017-09-22 2024-03-21 賓州大學委員會 用於治療黏多醣病 ii 型之基因治療
KR20220005900A (ko) * 2020-07-07 2022-01-14 가톨릭대학교 산학협력단 뇌신경계질환 예방 또는 치료용 약학적 조성물

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5624898A (en) * 1989-12-05 1997-04-29 Ramsey Foundation Method for administering neurologic agents to the brain
US20040266715A1 (en) * 1999-03-31 2004-12-30 Wong Liang Fong Neurite regeneration
US6667176B1 (en) * 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
ES2252993T3 (es) * 1998-12-09 2006-05-16 Chiron Corporation Administracion de agentes neurotroficos al sistema nervioso central.
CN100425287C (zh) * 1999-02-09 2008-10-15 理化学研究所 肿瘤疫苗
US6749850B1 (en) * 1999-08-18 2004-06-15 The General Hospital Corporation Methods, compositions and kits for promoting recovery from damage to the central nervous system
US20020169102A1 (en) * 2001-04-03 2002-11-14 Frey William H. Intranasal delivery of agents for regulating development of implanted cells in the CNS
JP3886346B2 (ja) * 2001-06-22 2007-02-28 サンバイオ，インコーポレイティド 骨髄間質細胞由来Ｓｃｈｗａｎｎ細胞を含む神経再生用医薬組成物
EP1438942A1 (en) * 2003-01-17 2004-07-21 Schering Oy An otorhinological drug delivery device
WO2005056755A2 (en) * 2003-12-02 2005-06-23 Catholic Healthcare West Compositions and methods for propagation of neural progenitor cells
WO2007002664A2 (en) * 2005-06-22 2007-01-04 Massachusetts Institute Of Technology Propagation of undifferentiated embryonic stem cells in hyaluronic acid hydrogel
US9456979B2 (en) * 2006-04-27 2016-10-04 Sri International Adminstration of intact mammalian cells to the brain by the intranasal route
US8168169B2 (en) * 2006-08-09 2012-05-01 Mclean Hospital Corporation Methods and compositions for the treatment of medical disorders
US8283160B2 (en) 2007-09-11 2012-10-09 Frey Ii William H Methods, pharmaceutical compositions and articles of manufacture for administering therapeutic cells to the animal central nervous system

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108135547A (zh) * 2015-08-13 2018-06-08 戴埃克斯有限公司 用于评估接触系统激活的含有蛋白酶抑制剂的真空采血管
US11458477B2 (en) 2015-08-13 2022-10-04 Takeda Pharmaceutical Company Limited Evacuated blood collection tubes containing protease inhibitors for the assessment of contact system activation
US11826758B2 (en) 2015-08-13 2023-11-28 Takeda Pharmaceutical Company Limited Evacuated blood collection tubes containing protease inhibitors for the assessment of contact system activation
CN106924286A (zh) * 2017-02-16 2017-07-07 上海安集协康生物技术股份有限公司 一种经鼻腔给药用于帕金森病治疗的神经干细胞制剂
CN108096280A (zh) * 2017-12-28 2018-06-01 上海安集协康生物技术股份有限公司 一种神经干细胞滴鼻剂

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SI2200621T1 (sl) 2012-09-28
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UA98507C2 (ru) 2012-05-25
CY1113120T1 (el) 2016-04-13
CA2696892C (en) 2016-05-17
HRP20120560T1 (hr) 2012-08-31
AU2008299124A1 (en) 2009-03-19
EP2200621B1 (en) 2012-04-25
US9445991B2 (en) 2016-09-20
RU2468818C2 (ru) 2012-12-10
PL2200621T3 (pl) 2012-10-31
ES2388403T3 (es) 2012-10-15
EP2200621A4 (en) 2011-03-16
MX2010002738A (es) 2010-08-04
BRPI0816325B1 (pt) 2020-04-22
WO2009035901A1 (en) 2009-03-19
DK2200621T3 (da) 2012-08-06
US20090068155A1 (en) 2009-03-12
SG184724A1 (en) 2012-10-30
BRPI0816325B8 (pt) 2021-05-25
CA2696892A1 (en) 2009-03-19
US8283160B2 (en) 2012-10-09
US20130028874A1 (en) 2013-01-31
PT2200621E (pt) 2012-07-31
US20160206554A1 (en) 2016-07-21
CN103181932A (zh) 2013-07-03
KR20100094450A (ko) 2010-08-26
JP5600294B2 (ja) 2014-10-01
CR11304A (es) 2010-05-03
IL204371A (en) 2015-02-26
JP2014098051A (ja) 2014-05-29
BRPI0816325A2 (pt) 2015-03-24
ATE554778T1 (de) 2012-05-15
RU2010113932A (ru) 2011-10-20
KR101504110B1 (ko) 2015-03-19
KR20150039197A (ko) 2015-04-09
JP2010539084A (ja) 2010-12-16
EP2200621A1 (en) 2010-06-30

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