CN101796014A - 多不饱和脂肪酸酯的制备和纯化 - Google Patents

多不饱和脂肪酸酯的制备和纯化 Download PDF

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Publication number
CN101796014A
CN101796014A CN200880104965A CN200880104965A CN101796014A CN 101796014 A CN101796014 A CN 101796014A CN 200880104965 A CN200880104965 A CN 200880104965A CN 200880104965 A CN200880104965 A CN 200880104965A CN 101796014 A CN101796014 A CN 101796014A
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CN
China
Prior art keywords
composition
acid
polyunsaturated fatty
esters
ester
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Pending
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CN200880104965A
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English (en)
Chinese (zh)
Inventor
克里什纳·拉曼
李祯洙
尼尔·莱宁格
克里斯·卢加特
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DSM IP Assets BV
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Martek Biosciences Corp
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Publication of CN101796014A publication Critical patent/CN101796014A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
    • C07C69/587—Monocarboxylic acid esters having at least two carbon-to-carbon double bonds
    • A—HUMAN NECESSITIES
    • A21—BAKING; EDIBLE DOUGHS
    • A21D—TREATMENT OF FLOUR OR DOUGH FOR BAKING, e.g. BY ADDITION OF MATERIALS; BAKING; BAKERY PRODUCTS
    • A21D2/00—Treatment of flour or dough by adding materials thereto before or during baking
    • A21D2/08—Treatment of flour or dough by adding materials thereto before or during baking by adding organic substances
    • A21D2/14—Organic oxygen compounds
    • A21D2/16—Fatty acid esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/158—Fatty acids; Fats; Products containing oils or fats
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/115—Fatty acids or derivatives thereof; Fats or oils
    • A23L33/12—Fatty acids or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/03—Preparation of carboxylic acid esters by reacting an ester group with a hydroxy group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/48—Separation; Purification; Stabilisation; Use of additives
    • C07C67/60—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification
    • C—CHEMISTRY; METALLURGY
    • C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
    • C11C—FATTY ACIDS FROM FATS, OILS OR WAXES; CANDLES; FATS, OILS OR FATTY ACIDS BY CHEMICAL MODIFICATION OF FATS, OILS, OR FATTY ACIDS OBTAINED THEREFROM
    • C11C3/00—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom
    • C11C3/003—Fats, oils, or fatty acids by chemical modification of fats, oils, or fatty acids obtained therefrom by esterification of fatty acids with alcohols

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Mycology (AREA)
  • Nutrition Science (AREA)
  • Medicinal Chemistry (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Fats And Perfumes (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN200880104965A 2007-06-29 2008-06-27 多不饱和脂肪酸酯的制备和纯化 Pending CN101796014A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94728407P 2007-06-29 2007-06-29
US60/947,284 2007-06-29
PCT/US2008/068613 WO2009006317A1 (en) 2007-06-29 2008-06-27 Production and purification of esters of polyunsaturated fatty acids

Publications (1)

Publication Number Publication Date
CN101796014A true CN101796014A (zh) 2010-08-04

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Family Applications (1)

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CN200880104965A Pending CN101796014A (zh) 2007-06-29 2008-06-27 多不饱和脂肪酸酯的制备和纯化

Country Status (8)

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US (3) US20090023808A1 (cg-RX-API-DMAC7.html)
EP (1) EP2173699A4 (cg-RX-API-DMAC7.html)
JP (1) JP2010532418A (cg-RX-API-DMAC7.html)
CN (1) CN101796014A (cg-RX-API-DMAC7.html)
AU (2) AU2008269989B2 (cg-RX-API-DMAC7.html)
CA (1) CA2692355C (cg-RX-API-DMAC7.html)
MX (2) MX374545B (cg-RX-API-DMAC7.html)
WO (1) WO2009006317A1 (cg-RX-API-DMAC7.html)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102843913A (zh) * 2010-02-17 2012-12-26 邦奇油类公司 十八碳四烯酸的油组合物
CN104394702A (zh) * 2012-05-29 2015-03-04 罗盖特兄弟公司 用于不断富集由微藻产生的、具有dha乙酯的一种油的方法
WO2016058284A1 (zh) * 2014-10-13 2016-04-21 浙江医药股份有限公司新昌制药厂 一种甘油酯型多不饱和脂肪酸的制备方法
CN105779123A (zh) * 2014-08-06 2016-07-20 石家庄搏澳增塑材料科技有限公司 一种富集不饱和脂肪酸甲酯的清洁工艺
CN108289470A (zh) * 2015-10-05 2018-07-17 帝斯曼知识产权资产管理有限公司 油组合物和制备方法
CN105848748B (zh) * 2013-12-11 2018-07-24 诺瓦塞普工艺公司 脂肪酸的色谱纯化方法
CN109337939A (zh) * 2018-09-30 2019-02-15 河北康睿达脂质有限公司 一种多不饱和脂肪酸结构脂质的制备方法
CN111164067A (zh) * 2017-08-07 2020-05-15 帝斯曼知识产权资产管理有限公司 用于产生浓缩的多不饱和脂肪酸油的过程
TWI706727B (zh) * 2018-06-21 2020-10-11 澳大利亞商努賽德私人有限公司 基於植物之脂質組合物、包括該組合物之類藥劑營養品組合物、包括該組合物之食品、以及用於產生該組合物之方法
CN112533483A (zh) * 2018-06-21 2021-03-19 纽希得私人有限公司 Dha富集的多不饱和脂肪酸组合物
TWI774896B (zh) * 2018-06-21 2022-08-21 美商努賽德營養美國股份有限公司 基於植物之脂質組合物及其用途、包含該脂質組合物之類藥劑營養品組合物及食品以及產生該脂質組合物脂之方法
TWI774898B (zh) * 2018-06-21 2022-08-21 美商努賽德營養美國股份有限公司 基於植物之脂質組合物、包含該脂質組合物之油漆或清漆，及用於產生該脂質組合物的方法

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX336435B (es) * 2005-07-08 2016-01-19 Dsm Ip Assets Bv Acidos grasos poliinsaturados para el tratamiento de demencia y condiciones relacionadas con pre-demencia.
US20090023808A1 (en) * 2007-06-29 2009-01-22 Martek Biosciences Corporation Production and Purification of Esters of Polyunsaturated Fatty Acids
WO2009018230A1 (en) * 2007-07-27 2009-02-05 Solix Biofuels, Inc. Continuous algal biodiesel production facility
WO2010088700A1 (en) 2009-02-02 2010-08-05 Martek Biosciences Corporation Methods for improving cognitive function and decreasing heart rate
US20110177061A1 (en) 2009-07-10 2011-07-21 Martek Biosciences Corporation Methods of treating and preventing neurological disorders using docosahexaenoic acid
DE102009038354B4 (de) * 2009-08-21 2018-09-20 Auto-Kabel Management Gmbh Batteriepolklemme
US20110082205A1 (en) * 2009-10-01 2011-04-07 Panker Cynthia A Docosahexaenoic Acid Gel Caps
CA2777367A1 (en) * 2009-10-13 2011-04-21 Martek Biosciences Corporation Reducing the risk of pathological effects of traumatic brain injury
US9247547B2 (en) * 2009-10-15 2016-01-26 Qualcomm Incorporated Downlink and uplink resource element mapping for carrier extension
JP5872483B2 (ja) 2009-12-30 2016-03-01 ビーエイエスエフ ファーマ（コーラニッシュ）リミテッド 擬似移動床式クロマトグラフ分離方法
WO2011097273A1 (en) * 2010-02-02 2011-08-11 Martek Biosciences Corporation Methods and compositions for treating non-alcoholic fatty liver disease with docosahexaenoic acid and n-acetyl lcystenine
US9585837B2 (en) 2010-04-09 2017-03-07 Dsm Ip Assets B.V. Thermally stable oil-in-water emulsions containing an oil that contains polyunsaturated fatty acids
WO2011159682A1 (en) 2010-06-14 2011-12-22 Raveendran Pottathil Methods for the production of algae derived oils
US9051260B2 (en) * 2010-09-03 2015-06-09 Stepan Speciality Products, Llc Elimination of organohalo and oxirane species in carboxylic acid ester streams
GB201111591D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Further new process
GB201111601D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New process
GB201111589D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New modified process
GB201111595D0 (en) 2011-07-06 2011-08-24 Equateq Ltd Improved process
GB201111594D0 (en) 2011-07-06 2011-08-24 Equateq Ltd New improved process
PL2734626T3 (pl) * 2011-07-21 2021-06-28 Dsm Ip Assets B.V. Oleje mikrobiologiczne wzbogacone w wielonienasycone kwasy tłuszczowe
WO2013024174A1 (en) 2011-08-18 2013-02-21 Dsm Ip Assets B.V. Dha triglyceride, dha free fatty acid, and dha ethyl ester emulsions, and methods of treating spinal cord injury
KR20200003227A (ko) 2011-11-01 2020-01-08 디에스엠 아이피 어셋츠 비.브이. 산화적으로 안정한 다중불포화된 지방산 함유 오일
PL2858496T3 (pl) 2012-05-10 2023-09-11 Solutex Na Llc Oleje o działaniu przeciwzapalnym zawierające naturalne wyspecjalizowane mediatory prorozdzielcze i ich prekursory
GB201300354D0 (en) 2013-01-09 2013-02-20 Basf Pharma Callanish Ltd Multi-step separation process
PE20151724A1 (es) * 2013-03-13 2015-12-11 Dsm Nutritional Products Ag Recuperacion de urea y aceite a partir de un complejo urea/aceite
WO2014152283A1 (en) 2013-03-15 2014-09-25 Heliae Development, Llc Direct transesterification of algal biomass for synthesis of fatty acid ethyl esters (faee)
US9428711B2 (en) 2013-05-07 2016-08-30 Groupe Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
US8802880B1 (en) 2013-05-07 2014-08-12 Group Novasep Chromatographic process for the production of highly purified polyunsaturated fatty acids
JP6302310B2 (ja) * 2013-08-30 2018-03-28 備前化成株式会社 高純度オメガ３系脂肪酸エチルエステルの生産方法
PL3101138T3 (pl) * 2013-12-04 2021-10-25 Nippon Suisan Kaisha, Ltd. Olej drobnoustrojowy, sposób wytwarzania oleju drobnoustrojowego, stężony olej drobnoustrojowy oraz sposób wytwarzania stężonego oleju drobnoustrojowego
EP3118186B1 (fr) 2013-12-11 2022-02-09 Novasep Process Installation chromatographique de production d acides gras polyinsatures
KR102165406B1 (ko) 2014-01-07 2020-10-14 노바셉 프로세스 방향족 아미노산의 정제 방법
HRP20201965T1 (hr) * 2015-05-13 2021-02-05 Epax Norway As Polinezasićene masne kiseline vrlo dugog lanca iz prirodnih ulja
SG10202001800WA (en) * 2015-08-25 2020-04-29 Dsm Ip Assets Bv Refined oil compositions and methods for making
US10653703B2 (en) 2015-09-03 2020-05-19 Solutex Na Llc Compositions comprising omega-3 fatty acids, 17-HDHA and 18-HEPE and methods of using same
KR101815110B1 (ko) 2015-10-16 2018-01-10 에이케이 앤 엠엔 바이오팜 주식회사 오메가-7계 불포화 지방산의 정제공정
KR102405390B1 (ko) 2016-07-13 2022-06-03 에보닉 오퍼레이션스 게엠베하 용해된 지질을 함유하는 바이오매스로부터 지질을 분리하는 방법
ES2872009T3 (es) 2016-12-27 2021-11-02 Evonik Degussa Gmbh Método de aislamiento de lípidos a partir de una biomasa que contiene lípidos
EP3470502A1 (en) 2017-10-13 2019-04-17 Evonik Degussa GmbH Method of separating lipids from a lysed lipids containing biomass
EP3527664A1 (en) 2018-02-15 2019-08-21 Evonik Degussa GmbH Method of isolating lipids from a lipids containing biomass
US11414621B2 (en) 2018-05-15 2022-08-16 Evonik Operations Gmbh Method of isolating lipids from a lipids containing biomass with aid of hydrophobic silica
BR112020023222A2 (pt) 2018-05-15 2021-03-23 Evonik Operations Gmbh método de isolamento de lipídios a partir de uma biomassa contendo lipídios lisados por inversão por emulsão
CN109061000A (zh) * 2018-09-13 2018-12-21 中国科学院海洋研究所 一种衍生化处理植物油脂的混合液及其衍生化方法和应用
NO20181574A1 (en) * 2018-12-06 2020-06-08 Epax Norway As Very long chain fatty acids
ES2915598T3 (es) * 2018-12-12 2022-06-23 Nippon Suisan Kaisha Ltd Una composición que contiene un ácido graso altamente insaturado o un éster alquílico del mismo y un método para producirla
RU2709620C1 (ru) * 2019-07-01 2019-12-19 Федеральное государственное автономное образовательное учреждение высшего образования "Новосибирский национальный исследовательский государственный университет" (Новосибирский государственный университет, НГУ) Водная эмульсия на основе диметоксинитробензиловых эфиров арахидоновой кислоты
FR3108622B1 (fr) 2020-03-27 2024-08-23 Polaris Procédé de fractionnement d’acides gras à deux carbones de différence par distillation moléculaire
LU102019B1 (de) * 2020-08-26 2022-02-28 K D Pharma Bexbach Gmbh Verfahren zur Herstellung von Öl aus einem Mikroalgenerzeugnis
WO2025114579A2 (en) 2023-12-01 2025-06-05 Tate & Lyle Solutions Usa Llc Methods of processing an oil composition

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019144A1 (en) * 1992-03-18 1993-09-30 F. Hoffmann-La Roche Ag Fatty acid esters
CN1204638A (zh) * 1997-07-02 1999-01-13 湖南天海林实业股份有限公司 二十二碳六烯酸的制备和酯化工艺
WO2002010322A1 (en) * 2000-08-02 2002-02-07 Dsm N.V. Purifying crude pufa oils
CN1208308C (zh) * 2003-05-08 2005-06-29 南京大学 从卤虾粉提取、制备、纯化二十二碳六烯酸乙酯的方法

Family Cites Families (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3082228A (en) * 1959-12-18 1963-03-19 Escambia Chem Corp Method for producing monoesters of polyunsaturated fatty acids
NL8300698A (nl) * 1983-02-24 1984-09-17 Univ Leiden Werkwijze voor het inbouwen van vreemd dna in het genoom van tweezaadlobbige planten; agrobacterium tumefaciens bacterien en werkwijze voor het produceren daarvan; planten en plantecellen met gewijzigde genetische eigenschappen; werkwijze voor het bereiden van chemische en/of farmaceutische produkten.
IT1205043B (it) * 1987-05-28 1989-03-10 Innova Di Ridolfi Flora & C S Procedimento per l'estrazione di esteri di acidi grassi poliinsaturi da olii di pesce e composizioni farmaceutiche e dietetiche contenenti detti esteri
GB2218984B (en) * 1988-05-27 1992-09-23 Renafield Limited Process for preparing high-concentration mixtures of polyunsaturated fatty acids & their esters and their prophylactic or therapeutic uses
GB8819110D0 (en) * 1988-08-11 1988-09-14 Norsk Hydro As Antihypertensive drug & method for production
US5340742A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Process for growing thraustochytrium and schizochytrium using non-chloride salts to produce a microfloral biomass having omega-3-highly unsaturated fatty acids
US5130242A (en) * 1988-09-07 1992-07-14 Phycotech, Inc. Process for the heterotrophic production of microbial products with high concentrations of omega-3 highly unsaturated fatty acids
US5340594A (en) * 1988-09-07 1994-08-23 Omegatech Inc. Food product having high concentrations of omega-3 highly unsaturated fatty acids
US5407957A (en) * 1990-02-13 1995-04-18 Martek Corporation Production of docosahexaenoic acid by dinoflagellates
US5658767A (en) * 1991-01-24 1997-08-19 Martek Corporation Arachidonic acid and methods for the production and use thereof
EP0567653A4 (en) * 1991-11-14 1994-06-01 Sagami Chem Res Drug for hepatic diseases
CA2197187C (en) * 1994-08-16 2007-03-27 Bernd Best Process for extracting native products which are not water-soluble from native substance mixtures by means of centrifugal force
ES2362476T3 (es) * 1996-07-23 2011-07-06 Nagase Chemtex Corporation Proceso para preparar ácido docosahexanoico y ácido docosapentanoico.
IN1998CH01219A (en) * 1997-06-04 2005-03-04 Calgene Llc Production of polyunsaturated fatty acid by expression of polyketide-like synthesis genes in plants
US6566583B1 (en) * 1997-06-04 2003-05-20 Daniel Facciotti Schizochytrium PKS genes
US6677145B2 (en) * 1998-09-02 2004-01-13 Abbott Laboratories Elongase genes and uses thereof
US7217856B2 (en) * 1999-01-14 2007-05-15 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7211418B2 (en) * 1999-01-14 2007-05-01 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
US7247461B2 (en) * 1999-01-14 2007-07-24 Martek Biosciences Corporation Nucleic acid molecule encoding ORFA of a PUFA polyketide synthase system and uses thereof
US7271315B2 (en) * 1999-01-14 2007-09-18 Martek Biosciences Corporation PUFA polyketide synthase systems and uses thereof
ATE273373T1 (de) * 1999-02-26 2004-08-15 Martek Biosciences Corp Verfahren zum abtrennen von einem docosahexaensäure enthaltenden triglyerid aus einem triglyceridgemisch
CA2273570A1 (en) * 1999-05-31 2000-11-30 Jfs Envirohealth Ltd. Concentration and purification of polyunsaturated fatty acid esters by distillation-enzymatic transesterification coupling
CA2311974A1 (en) * 1999-06-28 2000-12-28 Nisshin Flour Milling Co., Ltd. Processes of selectively separating and purifying eicosapentaenoic and docosahexaenoic acids or their esters
US6712867B1 (en) * 1999-08-18 2004-03-30 Biox Corporation Process for production of fatty acid methyl esters from fatty acid triglycerides
WO2001051598A1 (en) * 2000-01-11 2001-07-19 Monsanto Technology Llc Process for making an enriched mixture of polyunsaturated fatty acid esters
ATE485385T1 (de) * 2000-01-19 2010-11-15 Martek Biosciences Corp Lösungsmittelfreies extraktionsverfahren
DE60130737T3 (de) * 2000-01-28 2016-01-14 Dsm Ip Assets B.V. Verstärkte Produktion von Lipiden enthaltend mehrfachungesättigte Fettsäuren durch hochdichte Kulturen von eukariotischen Mikroben in Gärvorrichtungen
TWI324181B (en) * 2001-04-16 2010-05-01 Martek Biosciences Corp Product and process for transformation of thraustochytriales microorganisms
DE10224937A1 (de) * 2001-06-05 2002-12-12 Celanese Ventures Gmbh Festphasen-Extraktionsverfahren zur Gewinnung hochreiner ungesättigter Verbindungen bzw. Derivate dieser Verbindungen
US20030032826A1 (en) * 2001-07-20 2003-02-13 The Board Of Regents Of The University Of Nebraska Transesterification process for production of biodiesel
JP2003048831A (ja) * 2001-08-02 2003-02-21 Suntory Ltd 脳機能の低下に起因する症状あるいは疾患の予防又は改善作用を有する組成物
DE10151155A1 (de) * 2001-10-19 2003-05-08 Nutrinova Gmbh Native PUFA-Triglyceridmischungen mit einem hohen Gehalt an mehrfach ungesättigten Fettsäuren sowie Verfahren zu deren Herstellung und deren Verwendung
KR100556337B1 (ko) * 2002-02-05 2006-03-03 주식회사 가야에너지 단일단계 연속공정을 통한 고순도 지방산 알킬에스테르의제조방법
EP2266525B1 (en) * 2002-05-03 2012-07-11 Martek Biosciences Corporation High quality lipids and methods for producing by enzymatic liberation from biomass
US20060165735A1 (en) * 2002-06-18 2006-07-27 Abril Jesus R Stable emulsions of oils in aqueous solutions and methods for producing same
JP4771697B2 (ja) * 2002-09-24 2011-09-14 サントリーホールディングス株式会社 認知能力の正常応答の低下予防、改善又は向上作用を有する組成物
CA2499501A1 (en) * 2002-09-27 2004-04-08 Martek Biosciences Corporation Prophylactic docosahexaenoic acid therapy for patients with subclinical inflammation
US20040172682A1 (en) * 2003-02-12 2004-09-02 Kinney Anthony J. Production of very long chain polyunsaturated fatty acids in oilseed plants
CA2515816A1 (en) * 2003-03-20 2004-10-07 Michael F. Pelly Method and apparatus for refining biodiesel
US7208590B2 (en) * 2003-07-15 2007-04-24 Abbott Laboratories Genes involved in polyketide synthase pathways and uses thereof
EP1670880A4 (en) * 2003-10-02 2007-04-04 Univ Mississippi METHOD FOR PRODUCING BIODIESEL AND OTHER VALUABLE CHEMICALS FROM SLUDGE FROM WASTEWATER TREATMENT PLANTS
US7169946B1 (en) * 2004-03-05 2007-01-30 Twin Rivers Technologies, L.P. Alternatives to distilled oleo chemicals in derivatives and production thereof
BRPI0513082A (pt) * 2004-08-06 2008-04-22 Transform Pharmaceuticals Inc formulações de fenofibrato e métodos de tratamento relacionados
US7666234B2 (en) * 2004-10-20 2010-02-23 Council Of Scientific And Industrial Research Process for the preparation of fatty acid methyl ester from triglyceride oil by transesterification
DE102005003624A1 (de) * 2005-01-26 2006-07-27 Nutrinova Nutrition Specialties & Food Ingredients Gmbh Herstellung und Anwendung eines antioxidativ wirksamen Extraktes aus Crypthecodinium sp.
WO2006133437A1 (en) * 2005-06-09 2006-12-14 Biosphere Environmental Energy Llc Systems and methods for esterification and transesterification of fats and oils
US20090023808A1 (en) * 2007-06-29 2009-01-22 Martek Biosciences Corporation Production and Purification of Esters of Polyunsaturated Fatty Acids

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993019144A1 (en) * 1992-03-18 1993-09-30 F. Hoffmann-La Roche Ag Fatty acid esters
CN1204638A (zh) * 1997-07-02 1999-01-13 湖南天海林实业股份有限公司 二十二碳六烯酸的制备和酯化工艺
WO2002010322A1 (en) * 2000-08-02 2002-02-07 Dsm N.V. Purifying crude pufa oils
CN1208308C (zh) * 2003-05-08 2005-06-29 南京大学 从卤虾粉提取、制备、纯化二十二碳六烯酸乙酯的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JOHNATHAN A. NAPIER: "Plumbing the depths of PUFA biosynthesis: a novel polyketide synthase-like pathway from marine organisms", 《TREND IN PLANT SCIENCE》 *
LIANG 等人: "Fractionation of Squid Visceral Oil Ethyl Esters by Short-Path Distillation", 《J.AM.OIL CHEM.SOC.》 *

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US10030212B2 (en) 2014-10-13 2018-07-24 Zhejiang Medicine Co., Ltd. Xinchang Pharmaceutical Factory Method for preparing glyceride type polyunsaturated fatty acids
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