CN101790535A - 制备普兰林肽的方法 - Google Patents

制备普兰林肽的方法 Download PDF

Info

Publication number
CN101790535A
CN101790535A CN200880022433A CN200880022433A CN101790535A CN 101790535 A CN101790535 A CN 101790535A CN 200880022433 A CN200880022433 A CN 200880022433A CN 200880022433 A CN200880022433 A CN 200880022433A CN 101790535 A CN101790535 A CN 101790535A
Authority
CN
China
Prior art keywords
asn
peptide
ser
side chain
pro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880022433A
Other languages
English (en)
Chinese (zh)
Inventor
安德烈·布伦纳
奥列格·韦布特斯基
史蒂芬·瓦尔瑞
弗朗西斯卡·夸特里尼
霍尔格·赫尔曼
安德鲁·斯壮
费尔南多·阿尔贝利西欧
茱蒂特·图拉一普赫
耶西卡·加西亚·拉莫斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of CN101790535A publication Critical patent/CN101790535A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN200880022433A 2007-06-29 2008-06-30 制备普兰林肽的方法 Pending CN101790535A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP07012806 2007-06-29
EP07012806 2007-06-29
EP07022380 2007-11-19
EP07022380 2007-11-19
PCT/EP2008/005325 WO2009003666A1 (en) 2007-06-29 2008-06-30 Process for the production of pramlintide

Publications (1)

Publication Number Publication Date
CN101790535A true CN101790535A (zh) 2010-07-28

Family

ID=39885153

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880022433A Pending CN101790535A (zh) 2007-06-29 2008-06-30 制备普兰林肽的方法

Country Status (7)

Country Link
US (1) US20100249370A1 (https=)
EP (1) EP2181118A1 (https=)
JP (1) JP2010531828A (https=)
KR (1) KR20100036326A (https=)
CN (1) CN101790535A (https=)
AU (1) AU2008271608A1 (https=)
WO (1) WO2009003666A1 (https=)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102180943A (zh) * 2010-12-16 2011-09-14 深圳市健元医药科技有限公司 一种辅助降血糖多肽药物的生产工艺
CN102816213A (zh) * 2012-05-29 2012-12-12 南京工业大学 使用固相和液相组合技术制备普兰林肽的方法
WO2012174817A1 (zh) * 2011-06-23 2012-12-27 成都圣诺科技发展有限公司 奈西立肽的制备方法
CN111499719A (zh) * 2020-03-19 2020-08-07 杭州固拓生物科技有限公司 一种合成普兰林肽的方法
CN118530332A (zh) * 2024-07-26 2024-08-23 南京羚诺生物医药技术研究院有限公司 一种普兰林肽的制备方法

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100081788A1 (en) * 2008-09-03 2010-04-01 Scinopharm Taiwan Ltd. Process for the Preparation of Pramlintide
CN101747426B (zh) * 2009-12-18 2013-01-16 深圳翰宇药业股份有限公司 一种合成普兰林肽的方法
US8846614B2 (en) * 2011-08-25 2014-09-30 Usv Limited Process for the synthesis of 37-mer peptide pramlintide
US10450343B2 (en) 2013-03-21 2019-10-22 Sanofi-Aventis Deutschland Gmbh Synthesis of cyclic imide containing peptide products
CA2907454C (en) 2013-03-21 2021-05-04 Sanofi-Aventis Deutschland Gmbh Synthesis of hydantoin containing peptide products
DK3517543T3 (da) 2018-01-30 2020-12-07 Bachem Ag Fremstilling af glucagonpeptider
WO2024110477A2 (en) * 2022-11-21 2024-05-30 Janssen Pharmaceutica Nv Synthesis of a cyclic peptide

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU222249B1 (hu) * 1991-03-08 2003-05-28 Amylin Pharmaceuticals Inc. Eljárás amilin agonista peptidszármazékok és ezeket tartalmazó gyógyszerkészítmények előállítására
WO1992015317A1 (en) * 1991-03-08 1992-09-17 Amylin Pharmaceuticals, Inc. Synthetic preparation of amylin and amylin analogues
US7910548B2 (en) * 1997-06-06 2011-03-22 Amylin Pharmaceuticals, Inc. Methods for treating obesity
US6281331B1 (en) * 1998-03-23 2001-08-28 Trimeris, Inc. Methods and compositions for peptide synthesis
ATE469912T1 (de) * 2004-10-04 2010-06-15 Novetide Ltd Gegenionenaustauschverfahren für peptide
TW200637872A (en) * 2004-10-26 2006-11-01 Lonza Ag Thiol group protection and cyclization in solid-phase peptide synthesis
US20100081788A1 (en) * 2008-09-03 2010-04-01 Scinopharm Taiwan Ltd. Process for the Preparation of Pramlintide

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102180943A (zh) * 2010-12-16 2011-09-14 深圳市健元医药科技有限公司 一种辅助降血糖多肽药物的生产工艺
WO2012174817A1 (zh) * 2011-06-23 2012-12-27 成都圣诺科技发展有限公司 奈西立肽的制备方法
CN102816213A (zh) * 2012-05-29 2012-12-12 南京工业大学 使用固相和液相组合技术制备普兰林肽的方法
CN111499719A (zh) * 2020-03-19 2020-08-07 杭州固拓生物科技有限公司 一种合成普兰林肽的方法
CN118530332A (zh) * 2024-07-26 2024-08-23 南京羚诺生物医药技术研究院有限公司 一种普兰林肽的制备方法

Also Published As

Publication number Publication date
KR20100036326A (ko) 2010-04-07
EP2181118A1 (en) 2010-05-05
AU2008271608A1 (en) 2009-01-08
JP2010531828A (ja) 2010-09-30
US20100249370A1 (en) 2010-09-30
WO2009003666A1 (en) 2009-01-08

Similar Documents

Publication Publication Date Title
CN101790535A (zh) 制备普兰林肽的方法
DK2421887T3 (en) A process for the preparation of degarelix
CN102264757B (zh) 制备比伐卢定的方法
WO1998011125A1 (en) Improved solid-phase peptide synthesis and agent for use in such synthesis
KR20130127443A (ko) 데가렐릭스 및 이의 중간 화합물의 제조 방법
AU1054997A (en) Collagen-like peptoid residue-containing structures
Romanovskis et al. Preparation of head‐to‐tail cyclic peptides via side‐chain attachment: implications for library synthesis
AU2014282839B9 (en) Peptide-resin conjugate and use thereof
KR101238133B1 (ko) 엡티피바타이드 및 관련 중간체 화합물의 제조 방법
US20030191049A1 (en) Oligomers of nonpeptide restricted mimetics of dipeptides of tripeptides, and the use thereof in the synthesis of synthetic proteins and polypeptides
CN102816213A (zh) 使用固相和液相组合技术制备普兰林肽的方法
WO2005087794A1 (en) Process for octreotide synthesis
EP2195329B1 (en) Method for chemical synthesis of polypeptides and proteins
Nishino et al. Cyclo (-arginyl-sarcosyl-aspartyl-phenylglycyl-) 2. Simple synthesis of an RGD-related peptide with inhibitory activity for platelet aggregation
CA3238634A1 (en) Synthetic process for production of modified gcc receptor agonists
MXPA00010056A (en) Process for the preparation of resin-bound cyclic peptides
HK1099313B (en) Processes for preparing eptifibatide and pertinent intermediate compounds
HK1145691B (en) Processes for preparing eptifibatide and pertinent intermediate compounds

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100728