CN101780239A - Four-herb anti-tumor and anti-AIDS soft capsules and preparation process thereof - Google Patents
Four-herb anti-tumor and anti-AIDS soft capsules and preparation process thereof Download PDFInfo
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- CN101780239A CN101780239A CN200910020900A CN200910020900A CN101780239A CN 101780239 A CN101780239 A CN 101780239A CN 200910020900 A CN200910020900 A CN 200910020900A CN 200910020900 A CN200910020900 A CN 200910020900A CN 101780239 A CN101780239 A CN 101780239A
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- diomphalia bates
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Abstract
The invention discloses four-herb anti-tumor and anti-AIDS soft capsules and a preparation process thereof and provides a pure Chinese medicinal modern compound preparation which has anti-tumor and anti-AIDS functions. The preparation is prepared by mixing extracts of four herbs including zanthoxylumbungeanum maxim, curcuma zedoary grub and liquoric root; and the processing method comprises three processes: material purchase and preparation, grub processing and mutual dissolution and capsule manufacturing. The combination of prescription is scientific and novel; and the preparation is bright and mutually soluble and the shelf life of the preparation is more than five years. The preparation has the functions of promoting the circulation of qi, removing blood stasis, relieving pains, resolving stagnation, resetting pulse, solidifying collapse, expelling toxin and removing tumor. The preparation can effectively relieve various cancers, inhibit the multiplication of AIDS viruses and quickly cure chronic stomach ulcer.
Description
Affiliated technical field
Two anti-soft capsules of the present invention's four flavors and preparation technology thereof belong to the biological medicine technology field, and relating in particular to is the antitumor modern compound preparation of pure Chinese medicine and the processing method thereof of anti-AIDS again.
Technical background
In recent years, confirm that through Dalian Inst. of Medical Science the Oleum Curcumae that extracts has the antiviral antitumor action from Rhizoma Curcumae, its main effective ingredient has been approved for national two class non-cell toxicity antitumor drug; Follow the technological break-through of from Semen zanthoxyli, extracting Semen zanthoxyli oil, Semen zanthoxyli oil has dropped into batch process, the Semen zanthoxyli oil soft capsule of The Fourth Military Medical University's development has obtained the nonstandard preparation of Army Hospital, adopts the green pepper cowherb soft capsule antitumor drug effect research project of Semen zanthoxyli oil and Oleum Curcumae development also to list Shaanxi Province's program for tackling key problems in science and technology in 2008 in; Through chemical constituent and the tackling key problem in 8 years of pharmacological action research, show that the Holotrichia diomphalia Bates extract also has antitumor action the scientific research personnel of Jilin Medical College to Holotrichia diomphalia Bates; Put down in writing the glycyrrhizin that extracts in the relevant Radix Glycyrrhizae of numerous scientific research personnel in " China's book on Chinese herbal medicine " and not only had antitumor action, also had the effect of anti AIDS virus.Above-mentioned research is given and is utilized Semen zanthoxyli, Rhizoma Curcumae, Holotrichia diomphalia Bates, Radix Glycyrrhizae four flavor Chinese crude drug extract formula exploitation antitumor, anti-AIDS modern Chinese medicine compound preparation to indicate direction.
Technical scheme
The objective of the invention is: adopt Semen zanthoxyli, Rhizoma Curcumae, Holotrichia diomphalia Bates, Radix Glycyrrhizae four flavor Chinese crude drug extracts to form compound preparation, have circulation of qi promoting removing blood stasis, pain relieving repercussive, multiple arteries and veins takes off admittedly and heal except that the function of tumor, and can effectively produce antitumor and anti-AIDS effect, and want preparation technology simple, with low cost.
In order to realize the foregoing invention purpose, technical scheme of the present invention is: utilize modernization of Chinese medicine technology, evenly dissolving each other with extract formula is innovative point, with directly kill oncocyte and directly inactivation of viruses is target, the two anti-soft capsule raw material weights of four flavors are made up of Semen zanthoxyli oil 920 grams, Oleum Curcumae 50 grams, Holotrichia diomphalia Bates alcohol extraction powder 15 grams and glycyrrhizin 15 grams.The two anti-soft capsules of production four flavors are divided into material and buy, Holotrichia diomphalia Bates processing, the system of dissolving each other capsule three road technologies, buy Semen zanthoxyli oil earlier, Oleum Curcumae, glycyrrhizin and live body Holotrichia diomphalia Bates, again the live body Holotrichia diomphalia Bates is dried with the clean back of flushing with clean water, grind 60 mesh sieves and got Holotrichia diomphalia Bates dry powder, get 6 times of amounts of the each adding of Holotrichia diomphalia Bates dry powder, 95% alcohol reflux 2 times, refluxed each time 1.5 hours, merging filtrate reclaims the ethanol oven dry, levigation is crossed 120 mesh sieves and is got Holotrichia diomphalia Bates alcohol extraction powder, press recipe quantity at last with Oleum Curcumae, glycyrrhizin, Holotrichia diomphalia Bates alcohol extraction powder adds respectively in the Semen zanthoxyli oil, the stirring and dissolving post-treatment become medicinal liquid weigh 0.45 the gram soft capsule get patent medicine.
The modern Chinese medicine theory confirms, in the two anticol capsules of four flavors, is rich in a-linolenic acid and medicinal components such as menthone, fagaronine in the Semen zanthoxyli oil, and the liver sausage Circulation is arranged, and can penetrate blood brain barrier, has antiviral, antitumor action; Oleum Curcumae is rich in medicinal ingredients such as curcumenol, curzerenone, beta-elemene, the liver sausage Circulation is also arranged, can penetrate blood brain barrier, except that the effect of directly killing tumor is arranged, can also strengthen the oncocyte immunogenicity, thereby bring out or promote the immunological rejection of body, have antiviral, antitumor action tumor; The Holotrichia diomphalia Bates extract is rich in number of chemical compositions such as vitamin A, vitamin B, vitamin E and calcium, acylate, steroidal compounds, and Holotrichia diomphalia Bates different solvents extract all has antiviral and antitumor action; Glycyrrhizin is potassium salt and the calcium salt of the glucuronic acid of the 18 β-enoxolone of 1 molecule and 2 molecules in conjunction with the glycyrrhizic acid that generates, and not only has the effect of direct inactivating AIDS virus and suppresses the effect of HIV (human immunodeficiency virus) (Human Immunodeficiency Virus) propagation, also has antineoplastic action.In preparation, all medicinal materials one of dissolving each other, under the anti-rotten effect of menthone, shelf-life was more than 5 years, had liver sausage circulation and penetrated the advantage of blood brain barrier, played circulation of qi promoting removing blood stasis, pain relieving repercussive altogether, multiple arteries and veins takes off admittedly and heal except that the function of tumor, the two anti-soft capsule preparation methods of four flavors have adopted the direct mixing system capsule of Chinese crude drug extraction of substance, production technology is simple, and is with low cost, convenient oral.
Of the present invention producing effect is: prescription compatibility of medicines science novelty, preparation is bright to dissolve each other, shelf-life reached more than 5 years, and production technology is simple, with low cost, convenient oral has circulation of qi promoting removing blood stasis, pain relieving repercussive, multiple arteries and veins takes off admittedly and heal except that the function of tumor, can not only effectively alleviate all kinds of cancer condition of illness and suppress HIV (human immunodeficiency virus) propagation, and can also effectively treat the intestine gastric ulcer disease.
The specific embodiment
One, the two anti-soft capsule preparation technologies of four flavors
1, the two anti-soft capsules of four flavors are by four flavor Chinese herbal medicine extract prescriptions, Semen zanthoxyli oil 920 grams of prescription proportional quantities for from Semen zanthoxyli, extracting, Oleum Curcumae 50 grams that from Rhizoma Curcumae, extract, Holotrichia diomphalia Bates alcohol extraction powder 15 grams that from Holotrichia diomphalia Bates, extract, glycyrrhizin 15 grams that from Radix Glycyrrhizae, extract, before the preparation by existing Chinese crude drug raw material standard purchase system Semen zanthoxyli oil, Oleum Curcumae respectively, the glycyrrhizin crude drug is standby, it is standby to buy the live body Holotrichia diomphalia Bates again.
2, get the live body Holotrichia diomphalia Bates with flushing with clean water clean back oven dry, ground 60 mesh sieves and get Holotrichia diomphalia Bates dry powder, get Holotrichia diomphalia Bates dry powder and add 6 times of amount 95% alcohol reflux 2 times at every turn, refluxed each time 1.5 hours, filter backflow and merge back recovery ethanol, the oven dry levigation is crossed 120 mesh sieves and is got Holotrichia diomphalia Bates alcohol extraction powder.
3, take by weighing Semen zanthoxyli oil, Oleum Curcumae, Holotrichia diomphalia Bates alcohol extraction powder, glycyrrhizin respectively by recipe quantity, respectively Oleum Curcumae, Holotrichia diomphalia Bates alcohol extraction powder, glycyrrhizin are added in the Semen zanthoxyli oil, the back that stirs is machined to medicinal liquid with the system capsule and weighs 0.45 and restrain soft capsule and get patent medicine.
Two, the two anti-soft capsule instructions of taking of four flavors
This medicament is adult's medicinal preparation for oral administration, and every day twice, each 3, early morning and evening service once before the sleep.
Claims (2)
1. two anti-soft capsules of flavor, it is characterized in that: raw material weight is made up of Semen zanthoxyli oil 920 grams, Oleum Curcumae 50 grams, Holotrichia diomphalia Bates alcohol extraction powder 15 grams and glycyrrhizin 15 grams.
2. two anti-soft capsule preparation technologies of four flavors according to claim 1, it is characterized in that: buy Semen zanthoxyli oil earlier, Oleum Curcumae, glycyrrhizin and live body Holotrichia diomphalia Bates, again the live body Holotrichia diomphalia Bates is dried with the clean back of flushing with clean water, grind 60 mesh sieves and got Holotrichia diomphalia Bates dry powder, get 6 times of amounts of the each adding of Holotrichia diomphalia Bates dry powder, 95% alcohol reflux 2 times, refluxed each time 1.5 hours, merging filtrate reclaims the ethanol oven dry, levigation is crossed 120 mesh sieves and is got Holotrichia diomphalia Bates alcohol extraction powder, press recipe quantity at last with Oleum Curcumae, glycyrrhizin, Holotrichia diomphalia Bates alcohol extraction powder adds respectively in the Semen zanthoxyli oil, the stirring and dissolving post-treatment become medicinal liquid weigh 0.45 the gram soft capsule get patent medicine.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910020900A CN101780239A (en) | 2009-01-15 | 2009-01-15 | Four-herb anti-tumor and anti-AIDS soft capsules and preparation process thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910020900A CN101780239A (en) | 2009-01-15 | 2009-01-15 | Four-herb anti-tumor and anti-AIDS soft capsules and preparation process thereof |
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| Publication Number | Publication Date |
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| CN101780239A true CN101780239A (en) | 2010-07-21 |
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| CN200910020900A Pending CN101780239A (en) | 2009-01-15 | 2009-01-15 | Four-herb anti-tumor and anti-AIDS soft capsules and preparation process thereof |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998082A (en) * | 2016-07-16 | 2016-10-12 | 周长征 | Effective part capable of resisting respiratory syncytial viruses in grubs and preparation method |
| CN106038725A (en) * | 2016-07-16 | 2016-10-26 | 周长征 | Method for separating anti-RSV-virus effective constituents after compatibility of pulsatilla chinensis and holotrichia diomphalia extracts |
| CN106109567A (en) * | 2016-07-16 | 2016-11-16 | 周长征 | The preparation method of anti-EV 71 virus after a kind of Herba Pogostemonis and Holotrichia diomphalia Bates compatibility of effective components |
| CN106109501A (en) * | 2016-07-16 | 2016-11-16 | 周长征 | Can the effective ingredient of anti-intestinal EV 71 virus and preparation method in a kind of Holotrichia diomphalia Bates |
-
2009
- 2009-01-15 CN CN200910020900A patent/CN101780239A/en active Pending
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105998082A (en) * | 2016-07-16 | 2016-10-12 | 周长征 | Effective part capable of resisting respiratory syncytial viruses in grubs and preparation method |
| CN106038725A (en) * | 2016-07-16 | 2016-10-26 | 周长征 | Method for separating anti-RSV-virus effective constituents after compatibility of pulsatilla chinensis and holotrichia diomphalia extracts |
| CN106109567A (en) * | 2016-07-16 | 2016-11-16 | 周长征 | The preparation method of anti-EV 71 virus after a kind of Herba Pogostemonis and Holotrichia diomphalia Bates compatibility of effective components |
| CN106109501A (en) * | 2016-07-16 | 2016-11-16 | 周长征 | Can the effective ingredient of anti-intestinal EV 71 virus and preparation method in a kind of Holotrichia diomphalia Bates |
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Application publication date: 20100721 |
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| RJ01 | Rejection of invention patent application after publication |