CN101780079B - 左旋氨氯地平复方药物组合物 - Google Patents

左旋氨氯地平复方药物组合物 Download PDF

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Publication number
CN101780079B
CN101780079B CN2010101168675A CN201010116867A CN101780079B CN 101780079 B CN101780079 B CN 101780079B CN 2010101168675 A CN2010101168675 A CN 2010101168675A CN 201010116867 A CN201010116867 A CN 201010116867A CN 101780079 B CN101780079 B CN 101780079B
Authority
CN
China
Prior art keywords
levamlodipine
chlorthalidone
drug composition
compound drug
blood pressure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2010101168675A
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English (en)
Chinese (zh)
Other versions
CN101780079A (zh
Inventor
杨彦玲
薛传校
张喜田
许威
张严
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SHIHUIDA PHARMA GROUP (JILIN) CO Ltd
Original Assignee
SHIHUIDA PHARMA GROUP (JILIN) CO Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SHIHUIDA PHARMA GROUP (JILIN) CO Ltd filed Critical SHIHUIDA PHARMA GROUP (JILIN) CO Ltd
Priority to CN2010101168675A priority Critical patent/CN101780079B/zh
Priority to EP10846870.3A priority patent/EP2543373A4/en
Priority to CA2754839A priority patent/CA2754839C/en
Priority to US13/264,829 priority patent/US20120041035A1/en
Priority to JP2012502443A priority patent/JP2012522024A/ja
Priority to PCT/CN2010/074004 priority patent/WO2011106951A1/zh
Publication of CN101780079A publication Critical patent/CN101780079A/zh
Application granted granted Critical
Publication of CN101780079B publication Critical patent/CN101780079B/zh
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035—Isoindoles, e.g. phthalimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicinal Preparation (AREA)
CN2010101168675A 2010-03-03 2010-03-03 左旋氨氯地平复方药物组合物 Expired - Fee Related CN101780079B (zh)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CN2010101168675A CN101780079B (zh) 2010-03-03 2010-03-03 左旋氨氯地平复方药物组合物
EP10846870.3A EP2543373A4 (en) 2010-03-03 2010-06-17 PHARMACEUTICAL COMPOSITION COMPOSITION OF LEVOAMLODIPIN
CA2754839A CA2754839C (en) 2010-03-03 2010-06-17 Pharmaceutical composition comprising levamlodipine and chlorthalidone
US13/264,829 US20120041035A1 (en) 2010-03-03 2010-06-17 Levamlodipine compound pharmaceutical composition
JP2012502443A JP2012522024A (ja) 2010-03-03 2010-06-17 左旋性アムロジピン複合薬組成物
PCT/CN2010/074004 WO2011106951A1 (zh) 2010-03-03 2010-06-17 左旋氨氯地平复方药物组合物

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN2010101168675A CN101780079B (zh) 2010-03-03 2010-03-03 左旋氨氯地平复方药物组合物

Publications (2)

Publication Number Publication Date
CN101780079A CN101780079A (zh) 2010-07-21
CN101780079B true CN101780079B (zh) 2011-10-05

Family

ID=42520307

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2010101168675A Expired - Fee Related CN101780079B (zh) 2010-03-03 2010-03-03 左旋氨氯地平复方药物组合物

Country Status (6)

Country Link
US (1) US20120041035A1 (https=)
EP (1) EP2543373A4 (https=)
JP (1) JP2012522024A (https=)
CN (1) CN101780079B (https=)
CA (1) CA2754839C (https=)
WO (1) WO2011106951A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12336978B2 (en) 2019-04-08 2025-06-24 Shenzhen Ausa Pharmed Co., Ltd. Pharmaceutical composition containing amlodipine, chlorthalidone, and amiloride and application thereof

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110755429A (zh) * 2018-07-26 2020-02-07 北京市石景山区高血压联盟研究所 一种复方降压药组合物、其制剂及其用途
CN110372575A (zh) * 2019-07-10 2019-10-25 复旦大学 一种二氢吡啶钙拮抗剂共晶体及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070237815A1 (en) * 2006-04-06 2007-10-11 Lawrence Solomon Dosage forms and methods comprising amlodipine and chlorthalidone

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6057344A (en) * 1991-11-26 2000-05-02 Sepracor, Inc. Methods for treating hypertension, and angina using optically pure (-) amlodipine
US5721263A (en) * 1993-06-07 1998-02-24 Takeda Chemical Industries, Ltd. Pharmaceutical composition for angiotensin II-mediated diseases
US20050187262A1 (en) * 2004-01-12 2005-08-25 Grogan Donna R. Compositions comprising (S)-amlodipine and an angiotensin receptor blocker and methods of their use
CN1960712B (zh) * 2004-05-21 2011-04-20 阿库-伯雷克技术公司 包含多个片段的刻痕药片
US7625940B2 (en) * 2005-07-01 2009-12-01 Accu-Break Technologies, Inc. Method of treating hypertension with a very low dose of chlorthalidone
DE102006027794A1 (de) * 2006-06-16 2007-12-20 Lts Lohmann Therapie-Systeme Ag Antihypertonie-Kombinationswafer
CN101564536B (zh) * 2008-04-21 2010-12-15 鲁南制药集团股份有限公司 一种治疗高血压的药物组合物缓控释制剂

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070237815A1 (en) * 2006-04-06 2007-10-11 Lawrence Solomon Dosage forms and methods comprising amlodipine and chlorthalidone

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
刘文娟主编.马来酸左旋氨氯地平.《药物集成（VI）化学原料药及药用辅料》.中国医药科技出版社,2008,第5797页. *
程艳玲.左旋氨氯地平的临床药理及临床应用.《齐鲁药事》.2006,第25卷(第10期),第612-613页. *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12336978B2 (en) 2019-04-08 2025-06-24 Shenzhen Ausa Pharmed Co., Ltd. Pharmaceutical composition containing amlodipine, chlorthalidone, and amiloride and application thereof

Also Published As

Publication number Publication date
JP2012522024A (ja) 2012-09-20
CA2754839C (en) 2013-12-10
WO2011106951A1 (zh) 2011-09-09
US20120041035A1 (en) 2012-02-16
EP2543373A1 (en) 2013-01-09
CA2754839A1 (en) 2011-09-09
EP2543373A4 (en) 2013-07-31
CN101780079A (zh) 2010-07-21

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C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
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GR01 Patent grant
CF01 Termination of patent right due to non-payment of annual fee
CF01 Termination of patent right due to non-payment of annual fee

Granted publication date: 20111005

Termination date: 20190303