CN101779659B - Bactericidal composition - Google Patents
Bactericidal composition Download PDFInfo
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- CN101779659B CN101779659B CN 200910259847 CN200910259847A CN101779659B CN 101779659 B CN101779659 B CN 101779659B CN 200910259847 CN200910259847 CN 200910259847 CN 200910259847 A CN200910259847 A CN 200910259847A CN 101779659 B CN101779659 B CN 101779659B
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- propineb
- flusilazole
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- bactericidal composition
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Abstract
The invention relates to synergistic bactericidal composite, in particular to synergistic bactericidal composite which contains effective amount of synergistic flusilazole and propineb, wherein the weight ratio of the flusilazole and the propineb can vary in a wide range, preferentially 40:1-1:40, more preferentially 10:1-1:30, furthermore preferentially 3:1-1:30 and most preferentially 1:20.
Description
Technical field
The present invention relates to a kind of Synergistic bactericidal composition, particularly relate to a kind of Synergistic bactericidal composition that comprises Flusilazole and Propineb.
Background technology
Flusilazole (flusilazole), two (4-fluorophenyl) methyl (1H-1,2, the support of 4-triazol-1-yl methylene) silane, triazole bactericidal agent, be mainly the biosynthesis that destroys and stop the cell membrane important composition composition ergosterol of germ, cause cell membrane not form, make germ dead.Effective to disease due to the germ of Ascomycetes, Basidiomycetes and Fungi Imperfecti, invalid to oomycetes.
Propineb (propineb), acrylic bisdithiocarbamic zinc belongs to dithiocarbamates, act on the synthetic of fungal cell wall and protein, can suppress infecting and sprouting of spore, can suppress mycelial growth simultaneously, cause its distortion, death.And this medicine contains and is easy to zinc element absorbed by crops, the quality that is conducive to promote plant growth and improves fruit.
The inventor studies have shown that by a series of, and Flusilazole and Propineb are mixed the target fungi is had extremely strong synergistic effect, have greatly improved bactericidal activity, thereby have completed the present invention.
Summary of the invention
The object of the present invention is to provide a kind of mixed ratio reasonable, control efficiency is good, the Synergistic bactericidal composition that drug cost is low.
Another object of the present invention is to provide by formulations such as the formulated missible oil of this bactericidal composition, microemulsion, aqueous emulsion, suspending agent, wetting powder, water dispersible granules.
Another object of the present invention is to provide bactericidal composition is used for control by the purposes of the microbial powdery mildew of ascus etc.
Technical scheme of the present invention is as described below:
A kind of bactericidal composition, its feature are to contain Flusilazole and the Propineb of synergy effective dose on the way.
Wherein, the weight ratio of Flusilazole and Propineb can change in very wide scope, most preferably is 3: 1～1: 30.
In composition of the present invention, active component is 0.5% to 95% of gross weight.
Except the active component of bactericide, also comprise functional aid in bactericidal composition of the present invention.That is to say, the present composition can add other components such as functional aid, is mixed with the preparation of the formulations such as missible oil, aqueous emulsion, microemulsion, suspending agent, wetting powder, water dispersible granules.
In these preparations, except active component, all contain surfactant, and also can contain the thinners such as organic solvent or cosolvent, carrier (filler) or water according to different dosage form, add in case of necessity other functional aids such as antifreeze, thickener, stabilizing agent, defoamer, disintegrant.Surfactant can be emulsifier, dispersant, wetting agent or bleeding agent.Surfactant can be nonionic with ionic, can be also that two or more mixing are used.
Described emulsifier comprises alkylphenol-polyethenoxy (polyoxypropylene) ether, Ben-zylphenol Polyoxyethyl Ether, phenethyl phenol polyethenoxy ether, fatty alcohol-polyoxyethylene ether, polyoxyethylene carboxylate, phenethyl phenol polyethenoxy polyethenoxy ether, castor oil ethylene oxide adduct, alkylphenol polyoxyethylene formaldehyde condensation products, and the phosphate of these compounds, alkyl benzene sulphonate (calcium salt or sodium salt) or directly use commercially available emulsifier monomer and composite product.Concrete example is as agriculture breast 500
#Series, 600
#Series, 1600
#Series, NP is serial, OP is serial, AEO is serial, 700
#, 400
#Serial and composite kind 2201,0203B, 2021B, 4103 etc., these are all emulsifier productions well known in the art, market is on sale.
described dispersant, wetting agent, bleeding agent comprises: lignosulfonates (sodium salt or calcium salt), Negel, methyl naphthalene sulphur ester formaldehyde condensation products sulphate, naphthalene sulfonic acid-formaldehyde condensation product, methanonaphthalene sodium sulfonate dibutyl naphthalene sulfonic acid-formaldehyde condensation product, N-methyl fatty acyl group sodium taurocholate, alkylphenol polyoxyethylene formaldehyde condensation products sulphate, polymerization of carboxylic acid sodium, the alkylphenol polyoxyethylene phosphate, the withered powder of tea, saponin, lignosulfite, aliphatic alcohol sulfate, dodecyl sulphur ester sodium, alkyl sulfate, penetrant t, bleeding agent OT, fatty acid amide-N methyl taurine sodium salt, sodium sulfate of polyethenoxy ether of fatty alcohol, pull open powder, JFC, can use separately, also can mix use.Above-mentioned surfactant is all materials well known in the art, can obtain by various commercial channel.
Described solvent, cosolvent comprise: toluene, dimethylbenzene, chlorobenzene, solvent naphtha, alpha-methyl-naphthalene, turpentine oil, carrene, chloroform, methyl alcohol, ethanol, isopropyl alcohol, butanols, isoamyl alcohol, cyclohexanone, isophorone, acetophenone, ethyl acetate, butyl acetate, DMF, dimethyl sulfoxide (DMSO), methyl cellosolve, ethyl cellosolve etc.
Described antifreeze is: ethylene glycol, glycerine, propane diols, urea, glycerine, ether diglycol, polyethylene glycol, isopropyl alcohol etc.
Described carrier, filler comprise: white carbon, precipitated calcium carbonate, potter's clay, attapulgite, kaolin, diatomite, bentonite, sepiolite, zeolite, quartz sand, talcum powder etc., can use separately, but also two or more mixes use.
Described disintegrant has: sodium alginate, sodium carboxymethyl starch, sulfuric acid amine, bentonite, urea, calcium chloride.
Described defoamer has: bubble enemy, silicone, C
8-10Fatty alcohol, C
10-20Saturated fat acids (as capric acid, stearic acid etc.) and amide-type.
Described binding agent comprises: starch, dextrin, gum Arabic, soybean protein, gelatine, sodium sulphate, gypsum, polyvinyl alcohol, polyethylene glycol, rosin, paraffin, CMC, sodium silicate, can use separately, but also two or more is mixed.
Can contain toner in preparation, for example, inorganic pigment: iron oxide, titanium oxide or Prussian blue; Organic dyestuff is as A Lizhalin, azo dyes, metal phthalocyanine or kiton colors.In water-base preparation, for preventing moldy metamorphism, need to add a certain amount of preservative, described preservative has Sodium Benzoate, polyformaldehyde, sorbitol, formalin, citric acid, to the yl benzoic acid methyl esters, face phenyl phenol sodium, 1,2-benzisothiazole-3-ketone (code name BIT) etc.
The product that the present invention describes can be the finished product preparation form to be provided, and namely in composition, each material mixes, but the composition of composition also separately preparation provide, directly mixing in bucket (tank) before using.Concentrate of the present invention usually and water be mixed to get the concentration of required active substance.
Composition of the present invention can be used for control by the microbial powdery mildew of ascus.
Composition of the present invention also can with other compound with weeding, desinsection or bactericidal property particularly the protective fungicide agent composition use, also can use with nematocide, protective agent, growth regulator, nutrient for plants or soil conditioner mixture.Composition of the present invention can be used by common method, as cast, injection, spraying.Amount of application of the present invention is with weather condition or crop state variation, and time of application can be before or after crop be susceptible.The duration of protective effect is usually relevant with the content of individualized compound in composition, also relevant to extraneous factor, weather for example, but by using suitable formulation can slow down climatic influences.
The remarkable advantage of composition of the present invention: the one, composition shows extremely strong synergistic effect in certain ratio range, the bactericidal effect of mixed composition is significantly improved than its single dose, thereby reduced using dosage, when reducing peasant's drug cost, reduced influence degree.The 2nd, interracial structure differs larger, and the resistance that the application of said composition can delay single dose occurs and development.
Embodiment:
The present invention with below have example and be elaborated so that advantage of the present invention is more obvious, but the present invention is limited to absolutely not these examples.In the proportioning of all preparations, percentage all is weight percentage, and the processing of biologically-active moiety is effective content.
One, Preparation Example:
1. the preparation of missible oil
By the formula requirement, add respectively solvent, former medicine, emulsifier, mix, use in case of necessity the hot bath heating for dissolving, namely obtain transparence missible oil, fill a prescription as embodiment 1:
Embodiment 1 (30% missible oil)
Flusilazole 3%, Propineb 27%, agriculture breast 500#10%, agriculture breast OX-6355%, methyl iso-butyl ketone (MIBK) 10%, 1-METHYLPYRROLIDONE 10%, dimethylbenzene complements to 100%.
2. the preparation of wetting powder
By the formula requirement, former medicine, various auxiliary agent and filler etc. are fully mixed, after ultra-fine pulverizer disintegrating, namely obtain converted products.Fill a prescription as embodiment 2:
Embodiment 2 (60% wetting powder)
Flusilazole 5%, Propineb 55%, lauryl sodium sulfate 1.5%, carboxymethyl cellulose 1%, octylphenol polyethylene oxyethylene group sulphate 10%, white carbon 5%, precipitated calcium carbonate complements to 100%.
3. the preparation of aqueous emulsion
Former medicine, solvent, emulsifier are added together, make to be dissolved into even oil phase.Water, antifreeze etc. is mixed, becomes the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the aqueous emulsion of favorable dispersibility.Fill a prescription as embodiment 3:
Embodiment 3 (35% aqueous emulsion)
Flusilazole 4%, Propineb 31%, polyvinyl alcohol 0.9%, alkylaryl polyoxyethylene poly-oxygen propylene aether 8.5%, agriculture breast 220115%, dimethyl formamide 12%, ethylene glycol 10%, water complements to 100%.
4. the preparation of water-dispersible granules
Former medicine and powder carrier, wetting spreader-sticker and binding agent etc. are carried out co-grinding, then after adding water and mediating, add and carry out granulation in the comminutor that the certain specification screen cloth is housed, and then drying, screening (by the screen cloth scope) namely get granular product.
Fill a prescription as embodiment 4:
Embodiment 4 (60% water-dispersible granules)
Flusilazole 7%, Propineb 53%, methanonaphthalene sodium sulfonate 10%, neopelex 15%, polyvinylpyrrolidone 5%, attapulgite complements to 100%.
5. the preparation of suspending agent
By the formula requirement, take water as medium, former medicine, dispersant, suspending agent and antifreezing agent etc. are added in the sand milling still, carry out porphyrize, make suspending agent.Fill a prescription as embodiment 5:
Embodiment 5 (45% suspending agent)
Flusilazole 6%, Propineb 39%, calcium lignosulfonate 3%, white carbon 1%, 0203B 5%, 0201B 2%, ethylene glycol 8%, tributyl phosphate a little, water complements to 100%.
6. the preparation of microemulsion
Former medicine, solvent, emulsifier and co-emulsifier are added together, make dissolving be even oil phase.Water, antifreeze etc. is mixed, becomes the homogeneous water.Under high-speed stirred, water is joined oil phase or oil phase is joined water, form the microemulsion of favorable dispersibility.Fill a prescription as embodiment 6:
Embodiment 6 (30% microemulsion)
Flusilazole 4%, Propineb 26%, propyl alcohol 7%, phenethyl phenol polyethenoxy ether 10%, carrene 10%, glycerine 5%, water complements to 100%.
Two, biological Examples:
For the examination bacterium
Powdery mildew of cucumber (Sphaerotheca Fuligenea (Schlecht) Poll.)
For the examination cucumber variety
" the close thorn in Shandong ", cucumber is potted plant is cultured to two open and flat phases of few leaf in the greenhouse.
The experimental concentration design
Flusilazole single dose concentration for the treatment of is 6,3,1.5,0.75,0.375 μ g/ml, Propineb single dose concentration for the treatment of is 64,32,16,8,4 μ g/ml, five concentration gradients are also established in the test of combination medicament, separately establish the blank of not dosing, and each is processed 4 times and repeats.
Test method
With the pure water that is added with a small amount of surfactant (as Tween-80 etc.), wash and get the fresh spore that covers with on the Powdery Mildew plant leaf blade, filter with double gauze, making spore concentration is 1 * 10
5The suspension of individual spore/mL, standby.Liquid is evenly sprayed in the blade face to all wetting, standby after the liquid natural air drying.Use the spore suspension spray inoculation.24h inoculation before chemicals treatment.Then postvaccinal examination material natural air drying moves to thermostatic chamber, cultivates 7d～10d under the condition of 20 ℃～24 ℃ of temperature.
Investigation and method of counting
By medicine inspecting institute of the Ministry of Agriculture " farm-chemical indoor determination test rule " method, reach 80% when above until the sick leaf rate of blank, classification investigation is managed incidence everywhere, and 30 leaves are investigated in every processing at least, and grade scale is: 0 grade: anosis;
1 grade: lesion area accounts for below 5% of one-piece blade area;
3 grades: lesion area accounts for 5%～15% of one-piece blade area;
5 grades: lesion area accounts for 15%～25% of one-piece blade area;
7 grades: lesion area accounts for 25%～50% of one-piece blade area;
9 grades: lesion area accounts for 50%～75% of one-piece blade area;
11 grades: lesion area accounts for more than 75% of one-piece blade area.According to survey data, calculate disease index and control efficiency that each is processed.Do regression analysis according to each drug concentration logarithm value and preventive effect probability value, calculate the EC of each medicament
50, according to Wadley fungicide in mixture synergy evaluation assessment, calculate interactional ratio after two single dose mixtures (be that SR＜0.5 is antagonism, 0.5≤SR≤1.5 are summation action, and SR＞1.5 are synergistic effect).
Result of the test sees the following form 1.
The joint toxicity measuring result of table 1. Flusilazole and Propineb
Result of the test shows: the weight ratio of Flusilazole and Propineb is 1: 20 o'clock, and its interaction ratio is 1.95, and the bactericide interaction theory according to GiSi (1985) proposes has the notable synergistic effect.
Although above the present invention is described in detail with a general description of the specific embodiments, on basis of the present invention, can make some modifications or improvements it, this will be apparent to those skilled in the art.Therefore, these modifications or improvements, all belong to the scope of protection of present invention without departing from theon the basis of the spirit of the present invention.
Claims (4)
1. bactericidal composition, the weight ratio that it is characterized in that Flusilazole and Propineb is 3: 1～1: 30.
2. according to claim 1 a kind of bactericidal composition, is characterized in that the weight ratio of Flusilazole and Propineb most preferably is 1: 20.
3. formulated missible oil, microemulsion, aqueous emulsion, suspending agent, wetting powder, water dispersible granules or the granule of the described a kind of bactericidal composition of arbitrary claim of according to claim 1-2.
4. according to claim 3 described a kind of bactericidal composition is used for the purposes of the microbial powdery mildew of control ascus.
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| CN 200910259847 CN101779659B (en) | 2009-12-16 | 2009-12-16 | Bactericidal composition |
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| CN 200910259847 CN101779659B (en) | 2009-12-16 | 2009-12-16 | Bactericidal composition |
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| CN104286008B (en) * | 2012-08-15 | 2016-06-08 | 陕西美邦农药有限公司 | A kind of efficient bactericidal composite containing Hexanaphthene flusulfamide |
| CN102907448A (en) * | 2012-11-13 | 2013-02-06 | 利民化工股份有限公司 | Binary compound wettable powder and preparation method and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1870895A (en) * | 2003-10-23 | 2006-11-29 | 拜尔农作物科学股份公司 | Synergistic fungicidal active combinations |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1870895A (en) * | 2003-10-23 | 2006-11-29 | 拜尔农作物科学股份公司 | Synergistic fungicidal active combinations |
Non-Patent Citations (4)
| Title |
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| 关一鸣等.杀菌剂对黄花乌头叶斑病病原菌的抑制作用.《特产研究》.2009,(第03期), |
| 杀菌剂对黄花乌头叶斑病病原菌的抑制作用;关一鸣等;《特产研究》;20090915(第03期);46-49 * |
| 王文桥等.防治小麦纹枯病的杀菌剂筛选.《华北农学报》.2007,第22卷 |
| 防治小麦纹枯病的杀菌剂筛选;王文桥等;《华北农学报》;20071028;第22卷;230-234 * |
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