CN101778934B - Cd34干细胞相关方法和组合物 - Google Patents
Cd34干细胞相关方法和组合物 Download PDFInfo
- Publication number
- CN101778934B CN101778934B CN2008801001004A CN200880100100A CN101778934B CN 101778934 B CN101778934 B CN 101778934B CN 2008801001004 A CN2008801001004 A CN 2008801001004A CN 200880100100 A CN200880100100 A CN 200880100100A CN 101778934 B CN101778934 B CN 101778934B
- Authority
- CN
- China
- Prior art keywords
- stem cells
- genetically modified
- tumor
- mesenchymal stem
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/54—Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
- A61K35/545—Embryonic stem cells; Pluripotent stem cells; Induced pluripotent stem cells; Uncharacterised stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/18—Growth factors; Growth regulators
- A61K38/1858—Platelet-derived growth factor [PDGF]
- A61K38/1866—Vascular endothelial growth factor [VEGF]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/49—Platelet-derived growth factor [PDGF]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0662—Stem cells
- C12N5/0663—Bone marrow mesenchymal stem cells (BM-MSC)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K2035/124—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells the cells being hematopoietic, bone marrow derived or blood cells
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Hematology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Rheumatology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Reproductive Health (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Physical Education & Sports Medicine (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93162207P | 2007-05-24 | 2007-05-24 | |
| US60/931,622 | 2007-05-24 | ||
| US305007P | 2007-11-14 | 2007-11-14 | |
| US61/003,050 | 2007-11-14 | ||
| PCT/US2008/006434 WO2008150368A1 (en) | 2007-05-24 | 2008-05-20 | Cd34 stem cell-related methods and compositions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310125890.4A Division CN103263439B (zh) | 2007-05-24 | 2008-05-20 | Cd34干细胞相关方法和组合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN101778934A CN101778934A (zh) | 2010-07-14 |
| CN101778934B true CN101778934B (zh) | 2013-05-22 |
Family
ID=40093981
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN2008801001004A Expired - Fee Related CN101778934B (zh) | 2007-05-24 | 2008-05-20 | Cd34干细胞相关方法和组合物 |
| CN201310125890.4A Expired - Fee Related CN103263439B (zh) | 2007-05-24 | 2008-05-20 | Cd34干细胞相关方法和组合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310125890.4A Expired - Fee Related CN103263439B (zh) | 2007-05-24 | 2008-05-20 | Cd34干细胞相关方法和组合物 |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7998472B2 (enExample) |
| EP (4) | EP2851422A3 (enExample) |
| JP (2) | JP2010528008A (enExample) |
| CN (2) | CN101778934B (enExample) |
| AU (1) | AU2008260651B2 (enExample) |
| BR (1) | BRPI0811906A2 (enExample) |
| CA (1) | CA2688032C (enExample) |
| DK (1) | DK2223696T3 (enExample) |
| ES (3) | ES2430071T3 (enExample) |
| PL (1) | PL2162534T3 (enExample) |
| WO (1) | WO2008150368A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8574567B2 (en) | 2007-05-03 | 2013-11-05 | The Brigham And Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| EP2607477B1 (en) | 2007-05-03 | 2020-09-23 | The Brigham and Women's Hospital, Inc. | Multipotent stem cells and uses thereof |
| US12180549B2 (en) | 2007-07-23 | 2024-12-31 | The Chinese University Of Hong Kong | Diagnosing fetal chromosomal aneuploidy using genomic sequencing |
| EP3892736A1 (en) | 2007-07-23 | 2021-10-13 | The Chinese University of Hong Kong | Determining a nucleic acid sequence imbalance |
| CN102123717A (zh) | 2008-05-27 | 2011-07-13 | 普拉里斯坦有限公司 | 治疗炎性结肠疾病的方法 |
| KR20120088542A (ko) | 2009-04-13 | 2012-08-08 | 아프세스 게엠베하 & 씨오. 카게 | 종양 치료를 위한 조작된 중간엽 줄기세포 및 이를 사용하는 방법 |
| US20110027239A1 (en) * | 2009-07-29 | 2011-02-03 | Tissue Genesis, Inc. | Adipose-derived stromal cells (asc) as delivery tool for treatment of cancer |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| EP2601956B1 (en) | 2010-08-06 | 2017-04-12 | Osaka University | Islets of langerhans transplant using islets of langerhans and adipose tissue derived stem cells |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| US8961956B2 (en) | 2011-11-30 | 2015-02-24 | Ocata Therapeutics, Inc. | Mesenchymal stromal cells and uses related thereto |
| KR102108245B1 (ko) | 2011-11-30 | 2020-05-08 | 아스텔라스 인스티튜트 포 리제너러티브 메디슨 | 중간엽 간질 세포 및 이에 관련된 용도 |
| US20130171115A1 (en) * | 2011-12-30 | 2013-07-04 | Gang Li | Cell-mediated gene therapy for cancer using mesenchymal stem cells expressing a suicide gene |
| US20140369979A1 (en) * | 2012-02-01 | 2014-12-18 | Postech Academy-Industry Foundation | Vector simultaneously expressing dodecameric trail and hsv-tk suicide genes, and anticancer stem cell therapeutic agent using same |
| US9892230B2 (en) | 2012-03-08 | 2018-02-13 | The Chinese University Of Hong Kong | Size-based analysis of fetal or tumor DNA fraction in plasma |
| CN104471059B (zh) | 2012-07-12 | 2018-04-17 | 珠海横琴爱姆斯坦生物科技有限公司 | 人胚胎干细胞衍生的间充质样干细胞、方法及其应用 |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| CA2956987C (en) | 2014-08-18 | 2023-03-21 | Apceth Gmbh & Co. Kg | Genetically modified mesenchymal stem cells expressing an immune response-stimulating cytokine to attract and/or activate immune cells |
| US10364467B2 (en) | 2015-01-13 | 2019-07-30 | The Chinese University Of Hong Kong | Using size and number aberrations in plasma DNA for detecting cancer |
| CN104622903B (zh) * | 2015-01-20 | 2018-10-09 | 奥思达干细胞有限公司 | 抗恶性黑色素瘤的干细胞制剂及其制备方法 |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| CN108884440A (zh) | 2016-04-01 | 2018-11-23 | 埃普塞斯有限责任两合公司 | 用于增强免疫疗法的抗肿瘤活性的间充质干细胞 |
| US20190382732A1 (en) * | 2017-02-24 | 2019-12-19 | The Board Of Regents Of The University Of Texas System | Compositions and methods relating to myomixer-promoted muscle cell fusion |
| EP3366303B1 (en) * | 2017-02-28 | 2020-06-24 | Martin-Luther-Universität Halle-Wittenberg | Enhancing the targeted in vivo delivery of cellular therapies |
| SG10202111394XA (en) | 2017-04-13 | 2021-12-30 | Senti Biosciences Inc | Combinatorial cancer immunotherapy |
| US12054526B2 (en) | 2018-06-15 | 2024-08-06 | Children's Hospital Medical Center | Polypeptides, nucleic acid molecules, compositions, and related methods |
| US11419898B2 (en) | 2018-10-17 | 2022-08-23 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
| AU2019359890B2 (en) | 2018-10-17 | 2024-10-24 | Senti Biosciences, Inc. | Combinatorial cancer immunotherapy |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1423563A (zh) * | 1999-12-06 | 2003-06-11 | 通用医疗公司 | 胰腺干细胞及其在器官移植中的用途 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7514074B2 (en) * | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US20010038834A1 (en) * | 1998-01-26 | 2001-11-08 | Gary Balian | Bone cancer therapy |
| US20030100107A1 (en) * | 1998-05-29 | 2003-05-29 | Thomas Jefferson University | Compositions and methods for generating differentiated human cells |
| DE19833476B4 (de) * | 1998-07-24 | 2005-08-25 | Huss, Ralf, Dr. | Genetisch modifizierte CD34-Negative, adhärent wachsende hämatopoetische Stammzellen und deren Verwendung in der Gentherapie |
| US20030082155A1 (en) * | 1999-12-06 | 2003-05-01 | Habener Joel F. | Stem cells of the islets of langerhans and their use in treating diabetes mellitus |
| CA2430653A1 (en) * | 2000-11-27 | 2002-08-08 | Yissum Research Development Company Of The Hebrew University In Jerusalem | Transfection of human embryonic stem cells |
| DE60227519D1 (de) * | 2001-06-14 | 2008-08-21 | Takeda Pharmaceutical | Neuer ligand und dna davon |
| WO2003010305A1 (en) | 2001-07-27 | 2003-02-06 | Arhus Amt | Immortilized stem cells |
| US20050053587A1 (en) * | 2001-09-20 | 2005-03-10 | Jacques Galipeau | Cultured stromal cells and uses thereof |
| WO2003087333A2 (en) * | 2002-04-12 | 2003-10-23 | Celgene Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| JP2005532810A (ja) * | 2002-07-16 | 2005-11-04 | イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム | 組織修復および組織形成のために間葉性幹細胞を移植する方法 |
| US20040258669A1 (en) * | 2002-11-05 | 2004-12-23 | Dzau Victor J. | Mesenchymal stem cells and methods of use thereof |
| WO2005026335A2 (en) * | 2003-09-15 | 2005-03-24 | Ramot At Tel Aviv University Ltd. | Insulin-producing bone marrow derived cells and methods of generating and using same |
| EP1708757A4 (en) * | 2003-12-19 | 2007-01-17 | Viacell Inc | USE OF PLURIPOTENTIAL CELLS TAKEN FROM HUMAN CORDIAL BLOOD BLOOD FOR THE TREATMENT OF DISEASE |
| EP2298861B1 (en) * | 2004-03-22 | 2017-09-13 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| US20050233443A1 (en) * | 2004-03-30 | 2005-10-20 | Toby Freyman | Restenosis therapy using mesenchymal stem cells |
| JP2006345726A (ja) | 2005-06-14 | 2006-12-28 | Hamamatsu Univ School Of Medicine | 脳腫瘍治療用発現ベクター |
| KR101022401B1 (ko) * | 2005-09-29 | 2011-03-15 | 아주대학교산학협력단 | 자살유전자를 발현하는 중간엽 줄기세포를 포함하는 암치료용 조성물 |
-
2008
- 2008-05-20 BR BRPI0811906-6A2A patent/BRPI0811906A2/pt not_active IP Right Cessation
- 2008-05-20 PL PL08754569T patent/PL2162534T3/pl unknown
- 2008-05-20 DK DK10163667.8T patent/DK2223696T3/da active
- 2008-05-20 ES ES10163667T patent/ES2430071T3/es active Active
- 2008-05-20 ES ES10163663T patent/ES2401608T3/es active Active
- 2008-05-20 CA CA2688032A patent/CA2688032C/en not_active Expired - Fee Related
- 2008-05-20 ES ES08754569.5T patent/ES2507507T3/es active Active
- 2008-05-20 EP EP14172302.3A patent/EP2851422A3/en not_active Withdrawn
- 2008-05-20 WO PCT/US2008/006434 patent/WO2008150368A1/en not_active Ceased
- 2008-05-20 JP JP2010509362A patent/JP2010528008A/ja active Pending
- 2008-05-20 EP EP10163667.8A patent/EP2223696B1/en not_active Not-in-force
- 2008-05-20 CN CN2008801001004A patent/CN101778934B/zh not_active Expired - Fee Related
- 2008-05-20 CN CN201310125890.4A patent/CN103263439B/zh not_active Expired - Fee Related
- 2008-05-20 EP EP10163663A patent/EP2229948B1/en not_active Not-in-force
- 2008-05-20 AU AU2008260651A patent/AU2008260651B2/en not_active Ceased
- 2008-05-20 EP EP08754569.5A patent/EP2162534B1/en not_active Not-in-force
- 2008-05-20 US US12/154,059 patent/US7998472B2/en not_active Expired - Fee Related
-
2011
- 2011-07-08 US US13/179,374 patent/US20110268714A1/en not_active Abandoned
-
2014
- 2014-01-17 JP JP2014007144A patent/JP2014088432A/ja active Pending
-
2015
- 2015-05-08 US US14/707,872 patent/US20150238541A1/en not_active Abandoned
- 2015-05-08 US US14/707,739 patent/US20160136207A1/en not_active Abandoned
- 2015-05-08 US US14/707,654 patent/US20150238526A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1423563A (zh) * | 1999-12-06 | 2003-06-11 | 通用医疗公司 | 胰腺干细胞及其在器官移植中的用途 |
Non-Patent Citations (7)
| Title |
|---|
| Adult Stem Cell Lines in Regenerative Medicine andReconstructive Surgery;Conrad C,等;《J Surg Res》;20050430;第124卷(第2期);201-208 * |
| Cooper R.N.,等.In vivo satellite cell activation via Myf5 and MyoD in regenerating mouse skeletal muscle.《J Cell Sci》.1999,第112卷2895-2901. * |
| Identification of a putative pathway for the muscle homing of stem cells in a muscular dystrophy model;Torrente Y,等;《J.Cell. Bio.》;20030728;第162卷(第3期);511-520 * |
| Nonmyeloablative Stem Cell Therapy Enhances Microcirculation and Tissue Regeneration in Murine Inflammatory Bowel Disease;Khalil PN,等;《Gasteroenterology》;20070331;第132卷(第3期);944-954 * |
| Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells;DePalma M,等;《Nature Medicine》;20030630;第9卷(第6期);789-795 * |
| The biology of VEGF and its receptors;Ferrara N,等;《Nature Medicine》;20030630;第9卷(第6期);669-676 * |
| The Mouse Dystrophin Muscle Promoter/Enhancer Drives Expression of Mini-dystrophin in Transgenic mdx Mice and Rescues the Dystrophy in These Mice;Anderson C,等;《Molecular Therapy》;20061130;第14卷(第5期);724-734 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2688032C (en) | 2015-11-03 |
| EP2851422A3 (en) | 2015-06-24 |
| ES2430071T3 (es) | 2013-11-18 |
| US20160136207A1 (en) | 2016-05-19 |
| DK2223696T3 (da) | 2013-10-07 |
| EP2851422A2 (en) | 2015-03-25 |
| PL2162534T3 (pl) | 2015-02-27 |
| HK1146488A1 (en) | 2011-06-10 |
| JP2014088432A (ja) | 2014-05-15 |
| EP2162534B1 (en) | 2014-07-23 |
| US20110268714A1 (en) | 2011-11-03 |
| EP2229948A1 (en) | 2010-09-22 |
| ES2401608T3 (es) | 2013-04-23 |
| HK1188735A1 (en) | 2014-05-16 |
| AU2008260651B2 (en) | 2014-06-12 |
| EP2162534A1 (en) | 2010-03-17 |
| CN103263439A (zh) | 2013-08-28 |
| BRPI0811906A2 (pt) | 2014-11-18 |
| CA2688032A1 (en) | 2008-12-11 |
| US20150238526A1 (en) | 2015-08-27 |
| JP2010528008A (ja) | 2010-08-19 |
| US20090041735A1 (en) | 2009-02-12 |
| EP2223696B1 (en) | 2013-07-10 |
| AU2008260651A1 (en) | 2008-12-11 |
| ES2507507T3 (es) | 2014-10-15 |
| WO2008150368A1 (en) | 2008-12-11 |
| CN101778934A (zh) | 2010-07-14 |
| CN103263439B (zh) | 2015-04-22 |
| US7998472B2 (en) | 2011-08-16 |
| EP2229948B1 (en) | 2012-12-19 |
| EP2162534A4 (en) | 2010-09-22 |
| US20150238541A1 (en) | 2015-08-27 |
| EP2223696A1 (en) | 2010-09-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN101778934B (zh) | Cd34干细胞相关方法和组合物 | |
| Conrad et al. | Genetically engineered stem cells for therapeutic gene delivery | |
| Oggu et al. | Gene delivery approaches for mesenchymal stem cell therapy: strategies to increase efficiency and specificity | |
| Reiser et al. | Potential of mesenchymal stem cells in gene therapy approaches for inherited and acquired diseases | |
| CA2504019C (en) | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy | |
| CA2505213A1 (en) | Cell-based vegf delivery | |
| US20150322410A1 (en) | Hypoxia regulated conditionally silenced aav expressing angiogenic inducers | |
| Ebrahim et al. | Genetic modification of mesenchymal stem cells for neurological disease therapy: what effects does it have on phenotype/cell behavior, determining their effectiveness? | |
| HK1146488B (en) | Cd34 stem cell-related methods and compositions | |
| HK1188735B (en) | Cd34 stem cell-related methods and compositions | |
| CA2897188A1 (en) | Cd34 stem cell-related methods and compositions | |
| Quenneville et al. | Ex vivo modification of cells to induce a muscle-based expression | |
| Shah et al. | Genetic modification of adipose-derived stem cells for bone regeneration | |
| Gila et al. | Gene-edited cells: novel allogeneic gene/cell therapy for epidermolysis bullosa | |
| Lara-Pezzi et al. | Genetic enhancement of cardiac regeneration | |
| AU2008200822A1 (en) | Stromal cell-derived factor-1 mediates stem cell homing and tissue regeneration in ischemic cardiomyopathy |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1146488 Country of ref document: HK |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1146488 Country of ref document: HK |
|
| CF01 | Termination of patent right due to non-payment of annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20130522 Termination date: 20170520 |