CN101778634A - 作为抗淀粉样蛋白的物质的哌仑西平和其衍生物 - Google Patents

作为抗淀粉样蛋白的物质的哌仑西平和其衍生物 Download PDF

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Publication number
CN101778634A
CN101778634A CN200880103247A CN200880103247A CN101778634A CN 101778634 A CN101778634 A CN 101778634A CN 200880103247 A CN200880103247 A CN 200880103247A CN 200880103247 A CN200880103247 A CN 200880103247A CN 101778634 A CN101778634 A CN 101778634A
Authority
CN
China
Prior art keywords
compound
alkyl
amyloid
halo
amino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN200880103247A
Other languages
English (en)
Chinese (zh)
Inventor
A·普法伊费尔
A·施拉藤霍茨
A·穆斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AC Immune SA
ProteoSys AG
Original Assignee
AC Immune SA
ProteoSys AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AC Immune SA, ProteoSys AG filed Critical AC Immune SA
Publication of CN101778634A publication Critical patent/CN101778634A/zh
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Virology (AREA)
  • Ophthalmology & Optometry (AREA)
  • AIDS & HIV (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN200880103247A 2007-07-02 2008-07-02 作为抗淀粉样蛋白的物质的哌仑西平和其衍生物 Pending CN101778634A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP07111491 2007-07-02
EP07111491.2 2007-07-02
PCT/EP2008/058527 WO2009004038A2 (en) 2007-07-02 2008-07-02 Therapeutic compound

Publications (1)

Publication Number Publication Date
CN101778634A true CN101778634A (zh) 2010-07-14

Family

ID=40020257

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880103247A Pending CN101778634A (zh) 2007-07-02 2008-07-02 作为抗淀粉样蛋白的物质的哌仑西平和其衍生物

Country Status (13)

Country Link
US (1) US20100247688A1 (https=)
EP (1) EP2173355A2 (https=)
JP (1) JP2010531854A (https=)
KR (1) KR20100038424A (https=)
CN (1) CN101778634A (https=)
AU (1) AU2008270247A1 (https=)
BR (1) BRPI0812849A2 (https=)
CA (1) CA2691844A1 (https=)
IL (1) IL202768A0 (https=)
MX (1) MX2009014126A (https=)
NZ (1) NZ582314A (https=)
RU (1) RU2010103105A (https=)
WO (1) WO2009004038A2 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010081825A2 (en) 2009-01-13 2010-07-22 Proteosys Ag Pirenzepine as an agent in cancer treatment
EP2708540B1 (en) 2011-05-10 2018-07-25 Kyowa Hakko Kirin Co., Ltd. Pyrimido-diazepinone compound
WO2013068592A1 (en) * 2011-11-10 2013-05-16 Fondation Jerome Lejeune Inhibitors of cystathionine beta synthase to reduce the neurotoxic overproduction of endogenous hydrogen sulfide
CN116635034A (zh) * 2020-09-22 2023-08-22 K·E·克拉伦斯-史密斯 用于治疗人低胆碱能障碍的药物组合
JP2023544224A (ja) * 2020-09-22 2023-10-20 キャスリーン、イー．クラレンス－スミス ヒト低コリン作動性障害の処置のための医薬の組合せ
WO2023137098A1 (en) * 2022-01-16 2023-07-20 Winsantor, Inc. Compositions and methods for improving sexual sensory disorders

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1795183B1 (de) * 1968-08-20 1972-07-20 Thomae Gmbh Dr K 5,11-Dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-on-derivate und Arzneimittel
DE3818299A1 (de) * 1988-05-30 1989-12-07 Thomae Gmbh Dr K Neue kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
DE4112014A1 (de) * 1991-04-12 1992-10-15 Thomae Gmbh Dr K Kondensierte diazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende mittel zur behandlung von erkrankungen des zentralnervensystems und zur foerderung der cerebralen durchblutung
US8466144B2 (en) * 2004-07-16 2013-06-18 Proteosys Ag Muscarinic antagonists with parp and sir modulating activity as cytoprotective agents
MX2008000461A (es) * 2005-07-12 2008-03-10 Abbott Gmbh & Co Kg Compuestos de piridazina como inhibidores de la glucogeno sintasa cinasa 3.

Also Published As

Publication number Publication date
AU2008270247A1 (en) 2009-01-08
AU2008270247A2 (en) 2010-01-28
KR20100038424A (ko) 2010-04-14
CA2691844A1 (en) 2009-01-08
BRPI0812849A2 (pt) 2014-12-09
NZ582314A (en) 2012-04-27
WO2009004038A8 (en) 2010-03-11
JP2010531854A (ja) 2010-09-30
EP2173355A2 (en) 2010-04-14
WO2009004038A2 (en) 2009-01-08
US20100247688A1 (en) 2010-09-30
IL202768A0 (en) 2010-06-30
MX2009014126A (es) 2010-03-29
WO2009004038A3 (en) 2009-11-26
RU2010103105A (ru) 2011-08-10

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