CN101775704A - 一种制备纯透明质酸纳米纤维无纺布的方法 - Google Patents
一种制备纯透明质酸纳米纤维无纺布的方法 Download PDFInfo
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- CN101775704A CN101775704A CN201010137452.6A CN201010137452A CN101775704A CN 101775704 A CN101775704 A CN 101775704A CN 201010137452 A CN201010137452 A CN 201010137452A CN 101775704 A CN101775704 A CN 101775704A
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- hyaluronic acid
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- 229920002674 hyaluronan Polymers 0.000 title claims abstract description 80
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title claims abstract description 79
- 229960003160 hyaluronic acid Drugs 0.000 title claims abstract description 79
- 239000002121 nanofiber Substances 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims abstract description 21
- 239000004745 nonwoven fabric Substances 0.000 title claims abstract description 17
- 238000009987 spinning Methods 0.000 claims abstract description 38
- 238000010041 electrostatic spinning Methods 0.000 claims abstract description 26
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 claims abstract description 24
- 238000002360 preparation method Methods 0.000 claims abstract description 21
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 claims abstract description 12
- 235000019253 formic acid Nutrition 0.000 claims abstract description 12
- 239000012046 mixed solvent Substances 0.000 claims abstract description 10
- 239000000843 powder Substances 0.000 claims abstract description 10
- 208000012886 Vertigo Diseases 0.000 claims description 43
- 239000003125 aqueous solvent Substances 0.000 claims description 2
- 239000000243 solution Substances 0.000 abstract description 55
- 239000000835 fiber Substances 0.000 abstract description 24
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract description 11
- 239000012528 membrane Substances 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 239000011888 foil Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 abstract 1
- 239000007924 injection Substances 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000003068 static effect Effects 0.000 abstract 1
- 238000002604 ultrasonography Methods 0.000 abstract 1
- 238000001523 electrospinning Methods 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- 238000007664 blowing Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000002253 acid Substances 0.000 description 2
- 239000005030 aluminium foil Substances 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000012805 post-processing Methods 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 1
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229920002683 Glycosaminoglycan Polymers 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000009792 diffusion process Methods 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 230000000694 effects Effects 0.000 description 1
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- 239000003792 electrolyte Substances 0.000 description 1
- 230000005686 electrostatic field Effects 0.000 description 1
- 210000002744 extracellular matrix Anatomy 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003906 humectant Substances 0.000 description 1
- KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
- 229940099552 hyaluronan Drugs 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 238000003672 processing method Methods 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000008961 swelling Effects 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
Images
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- Nonwoven Fabrics (AREA)
- Spinning Methods And Devices For Manufacturing Artificial Fibers (AREA)
- Artificial Filaments (AREA)
Abstract
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CN2010101374526A CN101775704B (zh) | 2010-04-01 | 2010-04-01 | 一种制备纯透明质酸纳米纤维无纺布的方法 |
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CN2010101374526A CN101775704B (zh) | 2010-04-01 | 2010-04-01 | 一种制备纯透明质酸纳米纤维无纺布的方法 |
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CN101775704B CN101775704B (zh) | 2011-07-20 |
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Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102277654A (zh) * | 2011-06-30 | 2011-12-14 | 北京化工大学 | 一种透明质酸和壳聚糖复合聚电解质纳米纤维的制备方法 |
CN103741229A (zh) * | 2014-01-02 | 2014-04-23 | 上海大学 | 定向排列电纺纳米纤维的制备方法和静电纺丝装置 |
CN104480571A (zh) * | 2014-11-24 | 2015-04-01 | 张家港保税区冠祥贸易有限公司 | 一种壳层厚度可调节的聚电解质基核壳结构纳米纤维的制备方法 |
WO2015074631A1 (en) | 2013-11-21 | 2015-05-28 | Contipro Biotech S.R.O. | Voluminous nanofibrous material based on hyaluronic acid, its salt or their derivatives, method of preparation thereof, method of modification thereof, modified nanofibrous material, nanofibrous structure and use thereof |
CN111607844A (zh) * | 2020-06-02 | 2020-09-01 | 南京工业大学 | 一种基于改性透明质酸的超分子纳米纤维的制备方法 |
CN111793854A (zh) * | 2020-08-13 | 2020-10-20 | 山东华熙海御生物医药有限公司 | 一种透明质酸纤维材料及其制备方法 |
CN114108182A (zh) * | 2021-10-25 | 2022-03-01 | 吉林大学 | 一种用于酒精检测的低折射指数纳米纤维膜的制备方法 |
CN115305620A (zh) * | 2022-08-12 | 2022-11-08 | 江苏天章医用卫生新材料股份有限公司 | 一种高吸水棉纱布及其制备方法和应用 |
Citations (3)
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WO2008012848A1 (en) * | 2006-07-28 | 2008-01-31 | Inxel Trademark & Patents Sagl | Coating of inorganic pigments with aldehyde or ketone resins |
CN101172164A (zh) * | 2006-11-03 | 2008-05-07 | 中国科学院化学研究所 | 可生物降解及吸收的生物高分子纳米纤维膜材料及其制法和用途 |
CN101507835A (zh) * | 2009-03-10 | 2009-08-19 | 广州迈普再生医学科技有限公司 | 一种纳米仿生创面覆盖物及其制备方法 |
-
2010
- 2010-04-01 CN CN2010101374526A patent/CN101775704B/zh active Active
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2008012848A1 (en) * | 2006-07-28 | 2008-01-31 | Inxel Trademark & Patents Sagl | Coating of inorganic pigments with aldehyde or ketone resins |
CN101172164A (zh) * | 2006-11-03 | 2008-05-07 | 中国科学院化学研究所 | 可生物降解及吸收的生物高分子纳米纤维膜材料及其制法和用途 |
CN101507835A (zh) * | 2009-03-10 | 2009-08-19 | 广州迈普再生医学科技有限公司 | 一种纳米仿生创面覆盖物及其制备方法 |
Non-Patent Citations (4)
Title |
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《Biomacromolecules》 20041231 In Chul Um等 Electro-Spinning and Electro-Blowing of Hyaluronic Acid 1428-1436 1-7 第5卷, * |
《Macromolecular Rapid Communications》 20061231 Junxing Li等 Electrospinning of Hyaluronic Acid (HA) and HA/Gelatin Blends 第114-120页 1-7 第27卷, * |
《化学通报》 20071231 宋唐英等 生物高分子静电纺丝的研究进展 21-28 1-7 , 第1期 * |
《明胶科学与技术》 20070331 李欢 明胶、胶原的静电纺丝研究进展 第1-9页 1-7 第27卷, 第1期 * |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102277654A (zh) * | 2011-06-30 | 2011-12-14 | 北京化工大学 | 一种透明质酸和壳聚糖复合聚电解质纳米纤维的制备方法 |
CN102277654B (zh) * | 2011-06-30 | 2013-04-10 | 北京化工大学 | 一种透明质酸和壳聚糖复合聚电解质纳米纤维的制备方法 |
WO2015074631A1 (en) | 2013-11-21 | 2015-05-28 | Contipro Biotech S.R.O. | Voluminous nanofibrous material based on hyaluronic acid, its salt or their derivatives, method of preparation thereof, method of modification thereof, modified nanofibrous material, nanofibrous structure and use thereof |
CN103741229A (zh) * | 2014-01-02 | 2014-04-23 | 上海大学 | 定向排列电纺纳米纤维的制备方法和静电纺丝装置 |
CN104480571A (zh) * | 2014-11-24 | 2015-04-01 | 张家港保税区冠祥贸易有限公司 | 一种壳层厚度可调节的聚电解质基核壳结构纳米纤维的制备方法 |
CN111607844A (zh) * | 2020-06-02 | 2020-09-01 | 南京工业大学 | 一种基于改性透明质酸的超分子纳米纤维的制备方法 |
CN111607844B (zh) * | 2020-06-02 | 2023-01-03 | 南京工业大学 | 一种基于改性透明质酸的超分子纳米纤维的制备方法 |
CN111793854A (zh) * | 2020-08-13 | 2020-10-20 | 山东华熙海御生物医药有限公司 | 一种透明质酸纤维材料及其制备方法 |
CN111793854B (zh) * | 2020-08-13 | 2023-03-10 | 山东华熙海御生物医药有限公司 | 一种透明质酸纤维材料及其制备方法 |
CN114108182A (zh) * | 2021-10-25 | 2022-03-01 | 吉林大学 | 一种用于酒精检测的低折射指数纳米纤维膜的制备方法 |
CN115305620A (zh) * | 2022-08-12 | 2022-11-08 | 江苏天章医用卫生新材料股份有限公司 | 一种高吸水棉纱布及其制备方法和应用 |
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