CN101775348B - Health-care vinegar, brewing method and application in preventing cardiovascular diseases thereof - Google Patents
Health-care vinegar, brewing method and application in preventing cardiovascular diseases thereof Download PDFInfo
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- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses health-care vinegar, a brewing method and application in preventing cardiovascular diseases thereof. The method comprises the following steps: (1) removing peel of 6 to 7 weight percent of fresh kudzuvine root after the fresh kudzuvine root is cleaned, adding water or medicinal extract for homogenating, and regulating the quality concentration of starch to be over 10 percent; (2) heating the homogenated fresh kudzuvine root for 10 to 20 minutes at the temperature of between 120 and 125 DEG C; (3) adding rhizopus, activated dried yeast, aroma-producing yeast and lactic acid bacteria into the sterilized mixture to ferment distilled wort, adding 10 percent lactic acid bacteria seed fermentation broth into the mixture when the alcohol content is detected to be between 6 and 8 percent, leading the fermentation temperature to be between 26 and 34 DEG C, adding edible salt into the mixture when the acidity of the fermentation broth is not changed, and stopping alcoholic fermentation; and (4) ageing the fermented acid solution for over 15 days at the temperature of between 12 and 20 DEG C, and filtering the solution to obtain the health-care vinegar. The health-care vinegar obtained by the brewing method can effectively inhibit CPK activity caused by myocardial ischemia and myocardial infarction, can reduce ET content (P is less than 0.05), has inhibition effect on LDH, can be used in preparation of medicament for preventing cardiovascular diseases, and has wide application prospect.
Description
Technical field
The present invention relates to a kind of health vinegar and brewing method thereof with preventing cardiovascular disease function.
Background technology
At the beginning of 21 century, facing mankind the severe challenge that cardiovascular disorder is brought." World Health Report in 2002 " pointed out, the mortality ratio of cardiovascular and cerebrovascular diseases is the highest, and annual approximately 1,700 ten thousand people in the whole world die from cardiovascular and cerebrovascular diseases.From domestic and international research and clinical practice, all can find out, tackle this challenge, new concept more, translative mode turns to the upstream prevention from the downstream treatment.
The root of kudzu vine is the perennial defoliation liana of pulse family, the most of provinces and regions of distribution China.Pueraria starch content is high, can be used for fermentation, and contains flavonol, puerarin, daizeol etc., can prevent and treat cardiovascular and cerebrovascular diseases.
Be the per nnial herb Ophiopogon plant dried root of the tuber of dwarf lilyturf tuber of dwarf lilyturf.Cure mainly in the traditional Chinese medical science that stagnation of QI in chest and abdomen, dryness of the lung dry cough, thirsty, the interior heat of Tianjin wound are quenched one's thirst the tuber of dwarf lilyturf, the dry constipation of intestines etc.The activeconstituents of the tuber of dwarf lilyturf mainly contains steroidal saponin, polysaccharide, homoisoflavone class etc.Show according to the study to contain a large amount of saponin constituents the tuber of dwarf lilyturf, have the protection myocardial function, but in the application of hypoglycemia healthcare food seldom.
The Radix Astragali is the root of leguminous plants Radix Astragali or Radix Astagali.The main chemical compositions of the Radix Astragali is polysaccharide, saponin(e, flavones etc., and wherein Radix Astragali total saponins has the better protecting effect to cardiovascular system.
The root of kudzu vine is widely distributed, and rich in starch is used for the raw material of fermentation, and is not only with low cost and be conducive to save food and protection of the environment.Cost vinegar has long history in China, is people's traditional habit with vinegar sterilization and health, and vinegar itself just has good nourishing function, such as enhancing liver function, vasodilation, enhancing renal function, cosmetology etc.As fermenting the root of kudzu vine, the Radix Astragali and the tuber of dwarf lilyturf that will have health-care effect, can increase the added value of vinegar, can make again the comprehensive utilization of the root of kudzu vine, the tuber of dwarf lilyturf and the Radix Astragali more complete, avoided the waste in the Chinese medicine skilled worker process.In addition, yet there are no corresponding product on the China market, and also had no relevant Product Report.
Summary of the invention
The object of the invention is to provide a kind of health vinegar and brewing method thereof of tool protection cardiovascular function, and the health vinegar of utilizing the method to produce has abundant nutritive substance and activeconstituents, has the effect of protection cardiovascular systems.
To achieve these goals, the present invention realizes by following technical scheme:
A kind of brewing method of health vinegar comprises the steps:
(1) get bright Pueraria lobota 6-7 weight part and clean after in peeling, add water or drug extract and carry out homogenate, adjust the mass concentration of starch more than 10%;
(2) the bright Pueraria lobota of homogenate was heated 10-20 minute under 120-125 ℃ of condition;
(3) mixture after will sterilizing adds head mold, activation dry yeast, SHENGXIANG yeast and becomes distiller's wort with lactobacillus-fermented, detects to add the acetic bacteria seed liquid that accounts for fermented liquid cumulative volume 10% when the alcohol volume content is 6-8%; Leavening temperature is 26-34 ℃, until fermented liquid acidity adds salt when no longer changing, stops fermentation;
4) ageing under 12-20 ℃ of condition of the vinegar liquid after will fermenting filtered more than 15 days, namely got this health vinegar.
In above-mentioned brewing method, the described drug extract of step (1) is with the tuber of dwarf lilyturf 3-4 weight part and Radix Astragali 2-3 weight part, decocts and extracts 1～3 time, 5～10 times of volume water of each adding, extracted 0.5～3 hour, and filtered, be concentrated to that relative density 1.05～1.15 obtains.
Compared with prior art, the present invention has following beneficial effect:
The CPK that the resulting health vinegar energy establishment myocardial ischemia of brewing method of the present invention and myocardial infarction cause is active, can reduce ET content (P＜0.05), and LDH is had restraining effect; The effect of energy reducing blood-fat, LDL-C (LDL-C) and high density lipoprotein increasing-cholesterol (HDL-C), and good dose-effect relationship is arranged.Can for the preparation of the medicine of preventing cardiovascular disease, have a extensive future.
Embodiment
Below the invention will be further described by specific embodiment and test example.
Embodiment 1:
1) get bright Pueraria lobota 100kg and clean after in peeling, add water and carry out homogenate, adjust the concentration of starch more than 10%;
2) the bright Pueraria lobota of homogenate was heated 10 minutes under 120 ℃ of conditions;
3) mixture after will sterilizing adds 3% head mold, 0.02% activation dry yeast becomes distiller's wort with 0.01% SHENGXIANG yeast and 0.1% lactobacillus-fermented, detects to add the acetic bacteria seed liquid that accounts for cumulative volume 10% when the alcohol volume content is 6%.Leavening temperature is 27 ℃, until fermented liquid acidity adds salt when no longer changing, stops fermentation;
4) ageing 25 days under 12 ℃ of conditions of the vinegar liquid after will fermenting filters, and namely gets this health vinegar.
Embodiment 2:
(1) get bright Pueraria lobota 100kg and clean after in peeling, add water and carry out homogenate, adjust the concentration of starch more than 10%;
(2) the bright Pueraria lobota of homogenate was heated 10 minutes under 125 ℃ of conditions;
(3) mixture after will sterilizing adds 2% head mold, 0.01% activation dry yeast becomes distiller's wort with 0.03% SHENGXIANG yeast and 0.2% lactobacillus-fermented, detects to add the acetic bacteria seed liquid that accounts for cumulative volume 10% when the alcohol volume content is 8%.Leavening temperature is 27 ℃, until fermented liquid acidity adds salt when no longer changing, stops fermentation;
(4) ageing 25 days under 12 ℃ of conditions of the vinegar liquid after will fermenting filters, and namely gets this health vinegar.
Embodiment 3:
(1) get bright Pueraria lobota 100kg and clean after in peeling, add water and carry out homogenate, adjust the concentration of starch more than 10%;
(2) the bright Pueraria lobota of homogenate was heated 10 minutes under 122 ℃ of conditions;
(3) mixture after will sterilizing adds 3% head mold, 0.02% activation dry yeast becomes distiller's wort with 0.01% SHENGXIANG yeast and 0.1% lactobacillus-fermented, detects to add the acetic bacteria seed liquid that accounts for cumulative volume 10% when the alcohol volume content is 6%.Leavening temperature is 34 ℃, until fermented liquid acidity adds salt when no longer changing, stops fermentation;
(4) ageing 20 days under 15 ℃ of conditions of the vinegar liquid after will fermenting filters, and namely gets this health vinegar.
Embodiment 4:
(1) get bright Pueraria lobota 100kg and clean after in peeling, add water and carry out homogenate, adjust the concentration of starch more than 10%;
(2) the bright Pueraria lobota of homogenate was heated 10 minutes under 120 ℃ of conditions;
(3) mixture after will sterilizing adds 2% head mold, 0.01% activation dry yeast becomes distiller's wort with 0.03% SHENGXIANG yeast and 0.2% lactobacillus-fermented, detects to add the acetic bacteria seed liquid that accounts for cumulative volume 10% when the alcohol volume content is 8%.Leavening temperature is 34 ℃, until fermented liquid acidity adds salt when no longer changing, stops fermentation;
(4) ageing 20 days under 15 ℃ of conditions of the vinegar liquid after will fermenting filters, and namely gets this health vinegar.
Embodiment 5:
Press embodiment 1 used brewing method and produce blood sugar reducing health vinegar, the extracting solution that only decocts with integration of drinking and medicinal herbs in step (1) replaces water to adjust starch concentration, and the preparation method of this extracting solution is as follows:
(1) selecting full, even-grained dry 100kg cleans up to shred after drying the tuber of dwarf lilyturf;
(2) get Radix Astragali 75kg and clean up then with dividing the tuber of dwarf lilyturf of step (1) and add 10 times of volume decoctings and boil three times, merges three times cooking liquor, filter, concentrate.
Embodiment 6:
Press embodiment 2 used brewing methods and produce blood sugar reducing health vinegar, the extracting solution that only decocts with integration of drinking and medicinal herbs in step (1) replaces water to adjust starch concentration, and the preparation method of this extracting solution is as follows:
(1) selecting full, even-grained dry 100kg cleans up to shred after drying the tuber of dwarf lilyturf;
(2) get Radix Astragali 75kg and clean up then with dividing the tuber of dwarf lilyturf of step (1) and add 10 times of volume decoctings and boil three times, merges three times cooking liquor, filter, concentrate.
Embodiment 7:
Press embodiment 3 used brewing methods and produce blood sugar reducing health vinegar, the extracting solution that only decocts with integration of drinking and medicinal herbs in step (1) replaces water to adjust starch concentration, and the preparation method of this extracting solution is as follows:
(1) selecting full, even-grained dry 100kg cleans up to shred after drying the tuber of dwarf lilyturf;
(2) get Radix Astragali 75kg and clean up then with dividing the tuber of dwarf lilyturf of step (1) and add 10 times of decoctings and boil three times, merges three times cooking liquor, filter, concentrate.
Embodiment 8:
Press embodiment 4 used brewing methods and produce blood sugar reducing health vinegar, the extracting solution that only decocts with integration of drinking and medicinal herbs in step (1) replaces water to adjust starch concentration, and the preparation method of this extracting solution is as follows:
(1) selecting full, even-grained dry 100kg cleans up to shred after drying the tuber of dwarf lilyturf;
(2) get Radix Astragali 75kg and clean up then with dividing the tuber of dwarf lilyturf of step (1) and add 10 times of volume decoctings and boil three times, merges three times cooking liquor, filter, concentrate.
Embodiment 9:
Press the health vinegar of embodiment 1-8 gained, carry out the evaluation of effective constituent, adopt nutrition and functional component in the analysis evaluation health vinegar such as HPLC-MS, gas chromatograph-mass spectrometer, gas-chromatography, infrared spectroscopy.Analyze after testing this health vinegar contain semi-lactosi is arranged, oligose, oxysuccinic acid, citric acid, succsinic acid, acetic acid, amino acid, saponin(e, puerarin etc.
Embodiment 10:
(1) medicine of the present invention is on the impact of tentative myocardial ischemia infarct dog blood parameters:
Adopt the ligation coronary artery, cause the dog Model of Acute Myocardial Ischemia, then enter this health vinegar through the duodenum gavage, to coronary sinus vein, measure before and after the ligation coronary artery medicine and serum creatine phosphokinase (CPK), serum lactic dehydrogenase (SLDH) (LDH) and the endothelin level (ET) of different tests time point behind the medicine through the external jugular vein intubate.Test-results shows, compares with control group, and the CPK active (P＜0.01) that this product energy establishment myocardial ischemia and myocardial infarction cause can reduce ET content (P＜0.05), and LDH is had restraining effect (P＜0.05).Confirmation to Acute Myocardial Ischemia Tissues and Acute Myocardial Infarction CPK, LDH, and ET restraining effect (table 1,2,3) is arranged.
Table 1 vinegar gavage is processed the variation of myocardial infarction dog plasma LDH
Table 2 vinegar gavage is processed the variation of myocardial infarction dog plasma ET
Table 3 vinegar gavage is processed the variation of myocardial infarction dogs plasma C PK
(2) pharmacological testing of reducing blood-fat
Rat sooner or later gavage self-control every day high-fat emulsion (1ml/100gBW).The gavage high-fat emulsion is after 30 days continuously, difference A (Radix Puerariae extract), B (kudzu root vinegar), C (root of kudzu vine compound health vinegar), gavage is 30 days continuously, measure blood fat, A, B, C all have reducing blood-fat and reduce the effect of LDL-C (LDL-C) and high density lipoprotein increasing-cholesterol (HDL-C), and good dose-effect relationship is arranged, and test sees Table 4.
The variation of blood fat, LDL-C and HDL-C behind the table 4 vinegar filling rat
Claims (3)
1. the brewing method of a health vinegar is characterized in that comprising the steps:
(1) gets bright Pueraria lobota 6-7 weight part and clean rear peeling, add the medicine extracting solution and carry out homogenate, adjust the mass concentration of starch more than 10%;
(2) the bright Pueraria lobota of homogenate was heated 10-20 minute under 120-125 ℃ of condition;
(3) mixture after will sterilizing adds head mold, activation dry yeast, SHENGXIANG yeast and becomes distiller's wort with lactobacillus-fermented, detects to add the acetic bacteria seed liquid that accounts for fermented liquid cumulative volume 10% when the alcohol volume content is 6-8%; Leavening temperature is 26-34 ℃, until fermented liquid acidity adds salt when no longer changing, stops fermentation;
(4) ageing under 12-20 ℃ of condition of the vinegar liquid after will fermenting filtered more than 15 days, namely got this health vinegar;
The described drug extract of step (1) is with 3-4 weight part and the Radix Astragali 2-3 weight part tuber of dwarf lilyturf, decocts and extracts 1～3 time, adds 5～10 times of volume water at every turn, extracts 0.5～3 hour, and filtration is concentrated to that relative density 1.05～1.15 obtains.
2. the health vinegar that obtains of the described brewing method of claim 1.
3. the application of the described health vinegar of claim 2 in preparation preventing cardiovascular disease medicine.
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788623A (en) * | 2004-12-17 | 2006-06-21 | 新昌县天叶兴葡萄酒有限公司 | Acetic acid drink |
| CN101455350A (en) * | 2007-12-11 | 2009-06-17 | 西安天健医药科学研究所 | Health-care beverage with sobering-up function and preparation method thereof |
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2010
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1788623A (en) * | 2004-12-17 | 2006-06-21 | 新昌县天叶兴葡萄酒有限公司 | Acetic acid drink |
| CN101455350A (en) * | 2007-12-11 | 2009-06-17 | 西安天健医药科学研究所 | Health-care beverage with sobering-up function and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 邵伟等.野生葛根保健醋发酵工艺研究.《江苏调味副食品》.2004,第21卷(第3期),第5页右栏第4段，第6页右栏倒数第2段-第7页左栏第5段. * |
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