CN101774958B - N-正丙基-3-(4-甲基苯基)-4-(4-甲磺酰基苯基)-2,5-二氢吡咯-2-酮的i型结晶及其制造方法 - Google Patents
N-正丙基-3-(4-甲基苯基)-4-(4-甲磺酰基苯基)-2,5-二氢吡咯-2-酮的i型结晶及其制造方法 Download PDFInfo
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- CN101774958B CN101774958B CN2009100030434A CN200910003043A CN101774958B CN 101774958 B CN101774958 B CN 101774958B CN 2009100030434 A CN2009100030434 A CN 2009100030434A CN 200910003043 A CN200910003043 A CN 200910003043A CN 101774958 B CN101774958 B CN 101774958B
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- propyl
- ketone
- pyrrolin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/36—Oxygen or sulfur atoms
- C07D207/38—2-Pyrrolones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
Claims (11)
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100030434A CN101774958B (zh) | 2009-01-13 | 2009-01-13 | N-正丙基-3-(4-甲基苯基)-4-(4-甲磺酰基苯基)-2,5-二氢吡咯-2-酮的i型结晶及其制造方法 |
PCT/CN2009/074688 WO2010081341A1 (zh) | 2009-01-13 | 2009-10-29 | N-正丙基-3-(4-甲基苯基)-4-(4-甲磺酰基苯基)-2,5-二氢吡咯-2-酮的i型结晶及其制造方法 |
HK10111666.8A HK1145674A1 (zh) | 2009-01-13 | 2010-12-15 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2009100030434A CN101774958B (zh) | 2009-01-13 | 2009-01-13 | N-正丙基-3-(4-甲基苯基)-4-(4-甲磺酰基苯基)-2,5-二氢吡咯-2-酮的i型结晶及其制造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101774958A CN101774958A (zh) | 2010-07-14 |
CN101774958B true CN101774958B (zh) | 2012-01-11 |
Family
ID=42339421
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN2009100030434A Active CN101774958B (zh) | 2009-01-13 | 2009-01-13 | N-正丙基-3-(4-甲基苯基)-4-(4-甲磺酰基苯基)-2,5-二氢吡咯-2-酮的i型结晶及其制造方法 |
Country Status (3)
Country | Link |
---|---|
CN (1) | CN101774958B (zh) |
HK (1) | HK1145674A1 (zh) |
WO (1) | WO2010081341A1 (zh) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104193664B (zh) * | 2014-08-22 | 2016-08-24 | 山东铂源药业有限公司 | 一种艾瑞昔布的合成方法 |
TWI751220B (zh) * | 2016-11-07 | 2022-01-01 | 大陸商江蘇恆瑞醫藥股份有限公司 | 一種GnRH受體拮抗劑的多晶型及其製備方法 |
CN109553564A (zh) * | 2017-09-25 | 2019-04-02 | 江苏恒瑞医药股份有限公司 | 一种艾瑞昔布的纯化方法 |
CN109553563A (zh) * | 2017-09-25 | 2019-04-02 | 江苏恒瑞医药股份有限公司 | 一种吡咯类化合物及其制备方法、用途 |
CN109678775B (zh) * | 2017-10-18 | 2020-12-04 | 江苏恒瑞医药股份有限公司 | 一种cox-2选择性抑制剂的晶型及其制备方法 |
CN114394972B (zh) * | 2021-12-22 | 2024-04-30 | 西安近代化学研究所 | 一种低熔点三乙烯二胺晶体及其制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1318541A (zh) * | 2000-04-17 | 2001-10-24 | 中国医学科学院药物研究所 | 含有磺酰基吡咯烷酮化合物及其制法和药物用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7112605B2 (en) * | 2002-08-08 | 2006-09-26 | Research Institute of Materia Medica Chinese Acadamy of Medical Sciences | Sulfonyl-containing 3,4-diaryl-3-pyrrolin-2-ones, preparation method, and medical use thereof |
-
2009
- 2009-01-13 CN CN2009100030434A patent/CN101774958B/zh active Active
- 2009-10-29 WO PCT/CN2009/074688 patent/WO2010081341A1/zh active Application Filing
-
2010
- 2010-12-15 HK HK10111666.8A patent/HK1145674A1/xx unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1318541A (zh) * | 2000-04-17 | 2001-10-24 | 中国医学科学院药物研究所 | 含有磺酰基吡咯烷酮化合物及其制法和药物用途 |
Non-Patent Citations (2)
Title |
---|
Ai Ping BAI, et al..Design, Synthesis and in vitro Evaluation of a New Class of Novel Cyclooxygenase-2 Inhibitors: 3, 4-diaryl-3-pyrrolin-2-ones.《Chinese Chemical Letters》.2001,第12卷(第9期),775 – 778. * |
AiPingBAI et al..Design |
Also Published As
Publication number | Publication date |
---|---|
WO2010081341A1 (zh) | 2010-07-22 |
HK1145674A1 (zh) | 2011-04-29 |
CN101774958A (zh) | 2010-07-14 |
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Effective date of registration: 20160829 Address after: 222002 No. 145, Renmin East Road, Sinpo District, Jiangsu, Lianyungang Patentee after: Hengrui Medicine Co., Ltd., Jiangsu Prov. Patentee after: Jiangsu Sheng Di Pharmaceutical Co., Ltd. Address before: 222002 No. 145, Renmin East Road, Sinpo District, Jiangsu, Lianyungang Patentee before: Hengrui Medicine Co., Ltd., Jiangsu Prov. |