CN101774913A - 一种富马酸单甲酯的制备方法 - Google Patents
一种富马酸单甲酯的制备方法 Download PDFInfo
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- CN101774913A CN101774913A CN201010030129A CN201010030129A CN101774913A CN 101774913 A CN101774913 A CN 101774913A CN 201010030129 A CN201010030129 A CN 201010030129A CN 201010030129 A CN201010030129 A CN 201010030129A CN 101774913 A CN101774913 A CN 101774913A
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- maleic anhydride
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CN 201010030129 CN101774913B (zh) | 2010-01-08 | 2010-01-08 | 一种富马酸单甲酯的制备方法 |
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CN 201010030129 CN101774913B (zh) | 2010-01-08 | 2010-01-08 | 一种富马酸单甲酯的制备方法 |
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CN101774913A true CN101774913A (zh) | 2010-07-14 |
CN101774913B CN101774913B (zh) | 2013-05-29 |
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CN 201010030129 Expired - Fee Related CN101774913B (zh) | 2010-01-08 | 2010-01-08 | 一种富马酸单甲酯的制备方法 |
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Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8148414B2 (en) | 2008-08-19 | 2012-04-03 | Xenoport, Inc. | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
CN102442983A (zh) * | 2011-11-15 | 2012-05-09 | 江苏大学 | 防腐剂反-β甲氧羰基丙烯酸-6-L-抗坏血酸酯的制备方法 |
WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
US9416096B2 (en) | 2013-09-06 | 2016-08-16 | Xenoport, Inc. | Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use |
US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
US9597292B2 (en) | 2012-08-22 | 2017-03-21 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
US10406133B2 (en) | 2013-03-14 | 2019-09-10 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
CN112624919A (zh) * | 2020-10-13 | 2021-04-09 | 南京紫鸿生物科技有限公司 | 一种药用辅料硬脂富马酸钠的低成本制备方法 |
US11230548B2 (en) | 2013-03-14 | 2022-01-25 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2940845C (en) | 2014-02-24 | 2019-09-24 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
-
2010
- 2010-01-08 CN CN 201010030129 patent/CN101774913B/zh not_active Expired - Fee Related
Cited By (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8148414B2 (en) | 2008-08-19 | 2012-04-03 | Xenoport, Inc. | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
US8778991B2 (en) | 2008-08-19 | 2014-07-15 | Xenoport, Inc. | Prodrugs of methyl hydrogen fumarate, pharmaceutical compositions thereof, and methods of use |
US8785443B2 (en) | 2008-08-19 | 2014-07-22 | Xenoport, Inc. | Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof |
US9452972B2 (en) | 2008-08-19 | 2016-09-27 | Xenoport, Inc. | Methods of using prodrugs of methyl hydrogen fumarate and pharmaceutical compositions thereof |
CN102442983A (zh) * | 2011-11-15 | 2012-05-09 | 江苏大学 | 防腐剂反-β甲氧羰基丙烯酸-6-L-抗坏血酸酯的制备方法 |
US9597292B2 (en) | 2012-08-22 | 2017-03-21 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
US10940117B2 (en) | 2012-08-22 | 2021-03-09 | Arbor Pharmaceuticals, Llc | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
US10716760B2 (en) | 2012-08-22 | 2020-07-21 | Arbor Pharmaceuticals, Llc | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
US11083703B2 (en) | 2013-03-14 | 2021-08-10 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US11230548B2 (en) | 2013-03-14 | 2022-01-25 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US11905298B2 (en) | 2013-03-14 | 2024-02-20 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US11679092B2 (en) | 2013-03-14 | 2023-06-20 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US10406133B2 (en) | 2013-03-14 | 2019-09-10 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US10596140B2 (en) | 2013-03-14 | 2020-03-24 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
US11938111B2 (en) | 2013-03-24 | 2024-03-26 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
US9416096B2 (en) | 2013-09-06 | 2016-08-16 | Xenoport, Inc. | Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use |
US9682057B2 (en) | 2013-09-06 | 2017-06-20 | Xenoport, Inc. | Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use |
US11135296B2 (en) | 2014-03-24 | 2021-10-05 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of fumaric acid esters |
US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
CN112624919B (zh) * | 2020-10-13 | 2023-02-03 | 南京紫鸿生物科技有限公司 | 一种药用辅料硬脂富马酸钠的低成本制备方法 |
CN112624919A (zh) * | 2020-10-13 | 2021-04-09 | 南京紫鸿生物科技有限公司 | 一种药用辅料硬脂富马酸钠的低成本制备方法 |
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Publication number | Publication date |
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CN101774913B (zh) | 2013-05-29 |
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C53 | Correction of patent for invention or patent application | ||
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Inventor after: Gu Guotuan Inventor after: Xu Ying Inventor after: Di Cuiping Inventor after: Yang Hao Inventor after: Tian Yuping Inventor before: Gu Guotuan Inventor before: Xu Ying Inventor before: Tian Yuping |
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Free format text: CORRECT: INVENTOR; FROM: GU GUOTUAN XU YING TIAN YUPING TO: GU GUOTUAN XU YING ZHAI CUIPING YANG HAO TIAN YUPING |
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Granted publication date: 20130529 Termination date: 20140108 |