CN101757279A - Gastrointestinal disease-treating traditional Chinese medicine composition containing Chinese eaglewood and preparation method thereof - Google Patents

Gastrointestinal disease-treating traditional Chinese medicine composition containing Chinese eaglewood and preparation method thereof Download PDF

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CN101757279A
CN101757279A CN200810154412A CN200810154412A CN101757279A CN 101757279 A CN101757279 A CN 101757279A CN 200810154412 A CN200810154412 A CN 200810154412A CN 200810154412 A CN200810154412 A CN 200810154412A CN 101757279 A CN101757279 A CN 101757279A
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standby
moschus
powder
semen crotonis
crotonis pulveratum
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CN101757279B (en
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陈坚
王磊
袁学海
王伟
杨瑾
王春晨
郝忻
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Lerentang Pharmaceutical Factory Of Jinyao Darentang Group Co ltd
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Lerentang Pharmaceutical Factory of Tianjin Zhongxin Pharmaceutical Group Co Ltd
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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Abstract

The invention relates to a gastrointestinal disease-treating traditional Chinese medicine composition containing Chinese eaglewood and a preparation method thereof. The traditional Chinese medicine composition is prepared with costustoot, Chinese eaglewood, immature bitter orange, sandalwood, golden thread or baical skullcap root, officinal magnolia bark or swordlike atractylodes rhizome, musk, defatted croton seed powder, Chinese date, Szechuan lovage rhizome and the like. Clinically, the traditional Chinese medicine composition mainly treats diseases such as acute diarrhea and irritable bowel syndrome.

Description

A kind of Lignum Aquilariae Resinatum treatment gastrointestinal disease Chinese medicine composition and preparation method thereof that contains
Technical field
The present invention relates to field of medicaments, particularly relate to a kind of Lignum Aquilariae Resinatum treatment gastrointestinal disease Chinese medicine composition and preparation method thereof that contains.
Background technology
Diarrhoea can be divided into infectious and non-infectious two classes.Infectious diarrhea is divided into bacterial infection and viral infection again; Noninfectious diarrhea then can be caused by the change of improper diet, food anaphylaxis, rule of life, abrupt change of climate even multiple reason such as nervous.Motherland's medical science thinks to have loose bowels and is meant that defecation frequency increases, feces is rare clearly, even as water sample.The major lesions of having loose bowels is taste and intestine and small intestine.Its pathogenesis has being invaded by exogenous pathogen, injury due to diet, seven emotions discord, damp internal resistance and internal organs weakness etc.The clinical findings damp is caused a disease cold-damp and damp and hot branch.The spleen and stomach function obstacle is to be caused by multiple factor, has exopathogen influence, taste weakness itself, incoordination between the liver and spleen and gastrointestinal function deficiency etc. all can cause spleen and stomach function not normal and have loose bowels.Survey data shows that diarrhoea sickness rate in urban population reaches 0.4 time/people, and the rural population sickness rate reaches 0.5 time/people.Though diarrhoea is minor illness, pathogenic factor also is diversified, and changes with epoch, environment.We can say that the diarrhoea of today and the diarrhoea before 20 years have had the change of essence from pathogeny.Along with development of times, people's living standard attains the well-off standard substantially, and sanitary condition is improved greatly, fewer and feweri by the diarrhoea ratio that bacterial infection causes, on the contrary, because rhythm of life is accelerated, the functional diarrhea ratio that struggle for existence fierceness, pressure cause greatly obviously rises.One studies show that, the diarrhoeal diseases people of China about 30% needs antibiosis usually to treat, and 70% does not need should not use antibiotic therapy yet.Consumer also more and more notices the untoward reaction of products such as berberine, norfloxacin, and the harm that abuse of antibiotics brought.Diarrhoea market is except low side antibiotic products such as berberine, norfloxacin, some non-antibiotic products have also been introduced in recent years, such as dioctahedral smectite, Birid Triple Viable etc., but be positioned at high-end consumer groups, for most of consumer groups, its price positioning does not conform to the consumption location of such minor illness of suffering from diarrhoea with consumer.Analysis expert thinks, mainly is based on viral in urban market diarrhoea, and based on bacterial infection, if according to the principle of the market segments, at present a lot of products all are difficult to cover the whole market in the rural area.For alteration of intestinal flora person, available little ecological active bacteria formulation provides probiotics, improves intestinal environment, improves intestinal absorption, kinestate.As: bifidobacteria viable bacteria preparation (the happy capsule of beautiful pearl intestinal), Birid Triple Viable capsule, bacillus cicheniformis (whole intestinal rubber capsule); The intestinal mucosa protective agent: two eight body Montmorillonitums (dioctahedral smectite), the protection intestinal mucosa can suppress fixedly mycin, promotes the intestinal mucosal lesion reparation; Contain the creosote component preparation: the excessive secretion that can suppress intestinal juice.
At present gastrointestinal disease treating pill on the market is mainly used in treatment diarrhoea, enteritis, and bacillary dysentery, distension and fullness in the abdomen, stomachache, the food stagnation infantile dyspepsia, its pharmacological action is higher than like product: diarrhea, antibiotic, antiviral, four kinds of functions of adjusting gastrointestinal function are also deposited.But contain Cinnabaris in its prescription, its effect is a tranquillizing the mind by relieving convulsion, but contain hydrargyrum in the Cinnabaris, hydrargyrum is very big to the harm of human body, it is the process of a subtle lasting absorption, and human body contacts hydrargyrum for a long time can cause chronic poisoning: nerve, digestion, hormonal system and kidney to the people produce harm; Neurasthenic crowd may cause symptoms such as headache, dizziness, insomnia, hypomnesis, malaise; And anemia of pregnant woman and the women of age of sucking contact hydrargyrum for a long time, also may endanger fetus and baby's health.Mercurous in addition medicine has been subjected to certain restriction when exporting other countries, require mercury content to require then strict more for some European countries less than 0.5ppm as Singapore.
Summary of the invention
The purpose of this invention is to provide a kind of Lignum Aquilariae Resinatum treatment gastrointestinal disease Chinese medicine composition that contains.
Another object of the present invention provides a kind of preparation method that contains Lignum Aquilariae Resinatum treatment gastrointestinal disease Chinese medicine composition.
It is to be made by Lignum Aquilariae Resinatum, the Radix Aucklandiae, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Coptidis or Radix Scutellariae, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong ten flavor flavour of a drug that the present invention treats the gastrointestinal disease Chinese medicine composition.
The present invention treats the gastrointestinal disease Chinese medicine composition, is to adopt following materials of weight proportions to make: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii Immaturus 150～600g, Lignum Santali Albi 90～360g, Rhizoma Coptidis or Radix Scutellariae 150～600g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g and Rhizoma Chuanxiong 90～360g.
The present invention preferably treats the gastrointestinal disease Chinese medicine composition, is to adopt following materials of weight proportions to make: the Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii Immaturus 250～400g, Lignum Santali Albi 150～250g, Rhizoma Coptidis or Radix Scutellariae 200～400g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g and Rhizoma Chuanxiong 150～250g.
The further preferred treatment gastrointestinal disease of the present invention Chinese medicine composition is to adopt following materials of weight proportions to make: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis or Radix Scutellariae 300g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g.
The present invention treats the gastrointestinal disease Chinese medicine composition, can adopt following method to prepare active component for crude drug: as one or several use in conjunction preparations in extraction, water extraction, decoction and alcohol sedimentation technique, infusion process, percolation, reflux extraction, continuous backflow extraction method, the macroreticular resin absorbing method.But in order to make each crude drug of this medicine bring into play drug effect better, the present invention preferably adopts following technology to extract active component to raw material, and makes the present invention and treat the gastrointestinal disease Chinese medicine composition, but this can not limit protection scope of the present invention.
The present invention treats the gastrointestinal disease Chinese medicine composition, and employing is prepared as follows method and makes:
A. get the weight proportion crude drug: the Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii Immaturus 150～600g, Lignum Santali Albi 90～360g, Rhizoma Coptidis or Radix Scutellariae 150～600g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g and Rhizoma Chuanxiong 90～360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Six-element medicated powder such as Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
The present invention preferably treats the gastrointestinal disease Chinese medicine composition, and employing is prepared as follows method and makes:
A. get the weight proportion crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis or Radix Scutellariae 300g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Six-element medicated powder such as Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
A kind of preparation method that contains Lignum Aquilariae Resinatum treatment gastrointestinal disease Chinese medicine composition, step is as follows:
A. get the weight proportion crude drug: Lignum Aquilariae Resinatum, the Radix Aucklandiae, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Coptidis or Radix Scutellariae, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Six-element medicated powder such as Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
The present invention preferably treats the preparation method of gastrointestinal disease Chinese medicine composition, and step is as follows:
A. get the weight proportion crude drug: Lignum Aquilariae Resinatum, the Radix Aucklandiae, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Coptidis or Radix Scutellariae, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Six-element medicated powder such as Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
Fructus Aurantii Immaturus among the present invention is a Fructus Aurantii Immaturus (parched with bran); Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
The present invention treats the application of gastrointestinal disease Chinese medicine composition in preparation treatment irritable bowel syndrome medicine.
The present invention treat the gastrointestinal disease Chinese medicine composition at preparation treatment diarrhoea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, functional gastrointestinal disease medicine.
More than form when producing and to increase or to reduce according to corresponding ratio, as large-scale production can be unit with kilogram or with the ton, small-scale production can be unit with the gram also, and weight can increase or reduce, but the crude drug material weight proportion constant rate between each composition.
In order to understand the present invention better, further set forth the beneficial effect of medicine of the present invention below by Drug therapy chronic gastrointestinal disease 100 routine clinical verification case summaries of the present invention.Below used medicine of the present invention prepares according to embodiment 6 methods in the test.
One, observational technique
(1) object of observation: this group case is the out-patient, and untreated or treatment be person more, comprises functional diarrhea, functional dyspepsia, and irritable bowel syndrome, chronic and infective diarrhea is the object of observation.
(2) diagnostic criteria
Adopt " Rome II standard in 1999 ", selected case meets the diagnostic criteria of functional diarrhea, functional dyspepsia, irritable bowel syndrome, chronic and infective diarrhea.All cases are got rid of stomach, duodenum, colon organic disease all through stomach, colon scope or X line barium examination.
(3) rejecting standard
1, organic digestive system disease person is arranged, as polyp, tumor etc.
2, Liver and kidney is arranged, endocrine, the serious protopathy person of immune system and blood system: diabetes, uremia, hepatopathy etc.
3, anemia of pregnant woman and women breast-feeding their children.
4, do not meet diagnostic criteria.
(4) symptom degree evaluation standard
With reference to " new Chinese medicine clinical guidance principle ": according to symptom light, in, severe remembers 1,2,3 fen respectively.
1, symptom scoring method:
(1) asymptomatic (-): remember 0 fen;
(2) slight (+): occur note 1 minute once in a while;
(3) moderate (++): note 2 minutes often occur;
(4) severe (+++): continue to exist note 3 minutes.
2, have loose bowels:
(1) the asymptomatic and soft change (-) that is shaped: every day, 1-2 note was 0 minute;
(2) slight (+): symptom is slight, does not influence live and work, can stand, and stool every day 2-3 time, mushy stool or Mucous Stool are remembered 1 fen;
(3) moderate (++): symptom is heavier, has influenced work, life, still can stand, and stool is the egg style, every day 4-5 time, or the Mucous Stool moderate is remembered 2 fens;
(4) severe (+++): serious symptom, hinder one's work and live, be difficult to stand, rare watery stool, every day is more than 6 times, or a large amount of notes of Mucous Stool 3 minutes.
3, the deciding degree standard of disease
(1) severe: the cardinal symptom integration=＞total mark 70%;
(2) moderate: 70% of 30%＜=cardinal symptom integration＜total mark;
(3) slight: 30% of cardinal symptom integration＜=total mark;
(5) curative effect determinate standard and statistical method
Reference " new Chinese medicine clinical guidance principle " is as standard.
1, curative effect determinate standard:
(1) cure: cardinal symptom disappears, and stool is shaped, and every day 1-2 time, therapeutic index is 100%;
(2) produce effects: main clinic symptoms disappears substantially, times of defecation every day 2-3 time, 75%＜=therapeutic index＜100%;
(3) effective: main clinic symptoms takes a turn for the better, and stool shape and time number average take a favorable turn 30%＜=therapeutic index＜75%;
(4) invalid: main clinic symptoms does not have change, therapeutic index＜30%;
The total score value of cardinal symptom * 100% before curative effect of disease index=(the total score value of cardinal symptom before the treatment-total score value of treatment back cardinal symptom)/treatment.
2, individual event symptom therapeutic evaluation standard:
(1) cure: after finishing the course of treatment, transference cure;
(2) produce effects: after curative effect finished, the symptom classification reduced 2 grades;
(3) effective: after curative effect finished, the symptom classification reduced 1 grade;
(4) invalid: as not reach above-mentioned standard.
(6) observation index
1, health giving quality is observed:
(1) before the treatment, the variation of sings and symptoms in the course of treatment.
(2) every day times of defecation, amount.
(3) stool shape is just wait as bloody purulent stool, Mucous Stool and rare water.
(4) stool routine examination inspection: erythrocyte, leukocyte and pus cell quantity in the stool have or not indigestion dietary fiber, fat drop etc.
(5) the part patient does just and cultivates.
(6) the part patient does colonoscope, intestinal radiography, gastroscope.
3, safety is observed:
(1) blood, routine urianlysis.
(2) just routine test.
4, main clinic symptoms is observed:
(1) functional diarrhea: diarrhoea, with tenesmus, watery stool, Mucous Stool.
(2) functional dyspepsia: upper abdomen is glutted, morning is full, belch, Upper abdominal pain, nausea and vomiting, acid regurgitation.
(3) irritable bowel syndrome: stomachache, abdominal distention, diarrhoea, just not to the utmost, times of defecation, shape.
(4) chronic and infective diarrhea: diarrhoea, stomachache, tenesmus, the dense hemafecia of mucus.
Two, clinical data
Therapeutic Method
All the cases other treatment medicine of stopping using during medication uses medicine of the present invention merely, usage and dosage be 10 balls/time, 3 times/day, be 4 weeks the course of treatment.
Statistical method
Enumeration data is used X 2Check, measurement data are used the t check.
Observed result
1, each sick clinical treatment front and back total effects of planting is observed, and is as shown in table 1
Each sick clinical treatment front and back total effects table of planting of table 1
2, each sick clinical treatment front and back obvious effective rate comparable situation of planting is as shown in table 2
Each sick clinical treatment front and back obvious effective rate comparison sheet of planting of table 2
Figure G2008101544125D0000082
Four kinds of sick X 2Relatively, P＞0.05 not statistically significant illustrates that this medicine all has significant therapeutic effect to above-mentioned 4 kinds of diseases.
Three, the result shows
1, various chronic gastrointestinal disease had the good curing effect
Clinical effectiveness shows that the sick statistical effect of planting of each of Drug therapy chronic gastrointestinal disease of the present invention is learned there was no significant difference, and illustrating all has good therapeutical effect to various chronic gastrointestinal disease.
2, has the obvious effect that improves chronic gastrointestinal disease patient clinical symptoms
Clinical effectiveness shows that medicine of the present invention can obviously be alleviated clinical symptoms.To single sick plant primary symptom to improve effect obvious, total effective rate is all more than 85%.
3, do not find apparent side effect during the medication.
The specific embodiment
Further set forth the preparation method of medicine of the present invention by the following examples.
Embodiment 1
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Lignum Santali Albi 90g, Rhizoma Coptidis 150g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g and Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby; Make tablet according to method for preparing tablet thereof.
Embodiment 2
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Rhizoma Coptidis 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g and Rhizoma Chuanxiong 360g are standby;
B. go up ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Rhizoma Coptidis coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby; Make granule according to process for producing granula, promptly.
Embodiment 3
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g and Rhizoma Chuanxiong 300g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds Semen Crotonis Pulveratum, Moschus powder in above-mentioned thick paste, and mixing is standby; Get an amount of polyethylene glycol 6000, heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus mixture of powders, mixing, and adopting a speed is 85～90/min, splashes in the refrigerative liquid paraffin, makes drop pill, promptly.
Embodiment 4
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 200g, Lignum Santali Albi 150g, Rhizoma Coptidis 250g, Rhizoma Atractylodis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g and Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, and mixing is standby; Get an amount of Macrogol 4000, heating makes fusion, adds said mixture, mixing, and adopting a speed is 60～80/min, splashes in the refrigerative methyl-silicone oil, makes drop pill, promptly.
Embodiment 5
A. take off column weight amount proportioning crude drug: Lignum Aquilariae Resinatum 300g, Radix Aucklandiae 400g, Fructus Aurantii Immaturus 400g, Lignum Santali Albi 250g, Radix Scutellariae 250g, Cortex Magnoliae Officinalis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g and Rhizoma Chuanxiong 250g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 6
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 200g, Lignum Santali Albi 180g, Rhizoma Coptidis or 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was standby; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=4: 3 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopting a speed is 40～60/min, splashes in the refrigerative liquid paraffin, make drop pill, promptly.
Embodiment 7
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 200g, Fructus Aurantii Immaturus (parched with bran) 250g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was standby; Get an amount of polyethylene glycol 6000: the polyethylene glycol 6000 and the Macrogol 4000 mixture of Macrogol 4000=5: 1 add above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, heating dissolves, and adopting a speed is 65～75/min, splashes in the refrigerative liquid paraffin, make drop pill, promptly.
Embodiment 8
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 160g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 150g, Radix Scutellariae 250g, Rhizoma Atractylodis 250g, Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g and Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was standby; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=3: 2 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopt dripping speed is 50～60/min, splashes into methyl-silicone oil: in the condensed fluid of liquid Paraffin=4: 1, promptly get drop pill, promptly.
Embodiment 9
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 280g, Lignum Aquilariae Resinatum 220g, Fructus Aurantii Immaturus 360g, Lignum Santali Albi 180g, Radix Scutellariae 200g, art 400g, Moschus 8g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 900g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, and relative density 1.28-1.32 when being concentrated into 60 ℃ (60 ℃, drying, standby with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, make granule.
Embodiment 10
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Radix Scutellariae powder are broken into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, reclaiming ethanol to relative density is that 1.25-1.30 (60 ℃) is standby; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate is concentrated into relative density 1.25-1.30 (60 ℃), and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby, makes tablet according to method for preparing tablet thereof.
Embodiment 11
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Lignum Santali Albi 150g, Rhizoma Coptidis 190g, Rhizoma Atractylodis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g and Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby, encapsulated, promptly.
Embodiment 12
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 320g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Radix Scutellariae 360g, Rhizoma Atractylodis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g and Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, standby, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, promptly.
Embodiment 13
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 3 times, and each 1 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby, encapsulated, promptly.
Embodiment 14
A. take off column weight amount proportioning crude drug: Lignum Aquilariae Resinatum 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii Immaturus 250g, Lignum Santali Albi 150g, Rhizoma Coptidis 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g and Rhizoma Chuanxiong 150g are standby;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Encapsulated, promptly.
Embodiment 15
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Radix Scutellariae powder are broken into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Encapsulated, promptly.
Embodiment 16
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, standby with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, add appropriate amount of auxiliary materials, make 36000 capsules, promptly.
Embodiment 17
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 250g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, drying, promptly.
Embodiment 18
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 400g, Lignum Santali Albi 150g, Rhizoma Coptidis 250g, Cortex Magnoliae Officinalis 250g, Moschus 10g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 1200g and Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Add sodium carboxymethyl cellulose, Icing Sugar, mixing, the system granule sieves, drying, promptly.
Embodiment 19
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Lignum Santali Albi 90g, Radix Scutellariae 390g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g and Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Radix Scutellariae are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby; Add an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 20
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 180g, Fructus Aurantii Immaturus 200g, Lignum Santali Albi 360g, Radix Scutellariae 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g and Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby; Add an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 21
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Rhizoma Coptidis 490g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g and Rhizoma Chuanxiong 300g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 3 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Add mixings such as starch, microcrystalline Cellulose, sieve, make granule, add volatile oil such as the Radix Aucklandiae again, mixing, drying adds an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 22
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Scutellariae powder are broken into 60 purpose powder, CO 2Supercritical extraction, extracting pressure 12MPa, 50 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Add 2 ‰ magnesium stearate, mixing, compacting is in blocks, promptly.
Embodiment 23
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 170g, Fructus Aurantii Immaturus 400g, Lignum Santali Albi 250g, Radix Scutellariae 250g, Rhizoma Atractylodis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g and Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 10 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Add 12 ‰ magnesium stearate, mixing, compacting is in blocks, promptly.
Embodiment 24
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Add 6 ‰ magnesium stearate, mixing is pressed into 33000, promptly.
Embodiment 25
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii Immaturus 150g, Lignum Santali Albi 90g, Rhizoma Coptidis 190g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g and Rhizoma Chuanxiong 90g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 26
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 180g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Radix Scutellariae 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g and Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 12 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; It is an amount of to add vegetable oil, and mixing is made soft capsule, promptly.
Embodiment 27
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis powder are broken into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 17MPa, 40 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; It is an amount of to add vegetable oil, makes 36000 soft capsules, promptly.
Embodiment 28
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii Immaturus (parched with bran) 350g, Lignum Santali Albi 200g, Radix Scutellariae 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 200g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; It is an amount of to add vegetable oil, and mixing is made soft capsule, promptly.
Embodiment 29
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Lignum Santali Albi 90g, Rhizoma Coptidis 200g, Rhizoma Atractylodis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g and Rhizoma Chuanxiong 90g are standby;
B. Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Coptidis, Rhizoma Atractylodis, Fructus Jujubae and Rhizoma Chuanxiong eight flavors are ground into fine powder; With Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves; Get above-mentioned hybrid medicine powder 569g, add glycerol 6000g, Al (OH) 380g, sodium acrylate 1500g mix homogeneously are component A; Get tartaric acid 40g, add distilled water 13500g, acrylate copolymer 800g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 30
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Radix Scutellariae 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g and Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Scutellariae powder are broken into 70 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 30L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 4000g, add glycerol 23550g, Al (OH) 3156g, sodium acrylate 2758g mix homogeneously are component A; Get tartaric acid 72g, add distilled water 17340g, acrylate copolymer 1236g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 31
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Rhizoma Coptidis 150g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g and Rhizoma Chuanxiong 300g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get above-mentioned hybrid medicine powder 2200g, add glycerol 12000g, Al (OH) 3150g, sodium acrylate 2800g mix homogeneously are component A; Get tartaric acid 95g, add distilled water 26000g, acrylate copolymer 2500g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 32
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 250g, Lignum Santali Albi 150g, Radix Scutellariae 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g and Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder wood 1800g, add glycerol 8000g, Al (OH) 345g, sodium acrylate 2000g mix homogeneously are component A; Get tartaric acid 90g, add distilled water 27000g, acrylate copolymer 1800g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 33
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, sodium acrylate 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 34
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. go up ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 2869g, add glycerol 13770g, Al (OH) 3183g, sodium acrylate 2754g mix homogeneously are component A; Get tartaric acid 92g, add distilled water 27540g, acrylate copolymer 1836g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 35
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 200g, Fructus Aurantii Immaturus (parched with bran) 200g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Scutellariae powder are broken into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 108g, add water 9000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2869g, grinds evenly, promptly.
Embodiment 36
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 250g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis powder are broken into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 158g, add water 8000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1869g, grinds evenly, promptly.
Embodiment 37
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 88g, add water 10000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2500g, grinds evenly, promptly.
Embodiment 38
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 180g, Fructus Aurantii Immaturus 200g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get carbomer 85g, add water 7500g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2059g, grinds evenly, promptly.
Embodiment 39
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 450g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii Immaturus (parched with bran) 350g, Lignum Santali Albi 200g, Rhizoma Coptidis 200g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 200g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis powder are broken into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 20MPa, 55 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 188g, add water 14000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1800g, grinds evenly, promptly.
Embodiment 40
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Lignum Santali Albi 90g, Rhizoma Coptidis 250g, Cortex Magnoliae Officinalis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g and Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 22
L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 1000g, fat-soluble ointment base 4000g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly.
Embodiment 41
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 500g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Radix Scutellariae 360g, Cortex Magnoliae Officinalis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g and Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Radix Scutellariae powder are broken into 75 purpose powder, CO 2Supercritical extraction, extracting pressure 35MPa, 55 ℃ of temperature, CO 2Flow velocity 30L/h, extraction 4h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 3500g, PEG40015000g and poloxamer 1500g are heated to 80 ℃ of mix homogeneously, are stirred to room temperature, promptly.
Embodiment 42
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 600g, Lignum Santali Albi 360g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g and Rhizoma Chuanxiong 300g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 43
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii Immaturus 250g, Lignum Santali Albi 150g, Radix Scutellariae 250g, Cortex Magnoliae Officinalis 250g, Moschus 6g, Semen Crotonis Pulveratum 100g, Fructus Jujubae 800g and Rhizoma Chuanxiong 150g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder wood 1500g, PEG 4003000g and poloxamer 2000g are heated to 65 ℃ of mix homogeneously, are stirred to room temperature, promptly.
Embodiment 44
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii Immaturus 400g, Lignum Santali Albi 250g, Rhizoma Coptidis 250g, Rhizoma Atractylodis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g and Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 8 times of water gagings, soak 3 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 50 ℃, and medicinal residues and Rhizoma Coptidis coarse powder add 60% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 50 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, sieving is component A; Octadecanol 750g, white vaseline 750g, ethyl hydroxybenzoate 7g are heated to 80 ℃ and are molten into B component; Get sodium lauryl sulphate 70g, add glycerol 700g, water 10000g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 45
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 180g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis, Rhizoma Chuanxiong, Rhizoma Coptidis powder are broken into 60 purpose powder, CO 2Supercritical extraction, extracting pressure 10MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder wood 2869g, fat-soluble ointment base 9100g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly.
Embodiment 46
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 250g, Lignum Aquilariae Resinatum 120g, Fructus Aurantii Immaturus (parched with bran) 250g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis (Rhizoma Zingiberis Recens is processed) 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get above-mentioned hybrid medicine powder 2869g, PEG 4006100g and poloxamer 2900g are heated to 60 ℃ of mix homogeneously, are stirred to room temperature, promptly.
Embodiment 47
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 3 times, and each 3 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, sieving is component A; Octadecanol 1430g, white vaseline 1430g, ethyl hydroxybenzoate 14.3g are heated to 80 ℃ and are molten into B component; Get sodium lauryl sulphate 143g, add glycerol 1430g, water 5740g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add 2869g component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 48
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Lignum Aquilariae Resinatum, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, sieving is component A; Octadecanol 1230g, white vaseline 1330g, ethyl hydroxybenzoate 12g are heated to 90 ℃ and are molten into B component; Get sodium lauryl sulphate 120g, add glycerol 1200g, water 6740g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add 2000g component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 49
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 600g, Rhizoma Coptidis 600g, Lignum Santali Albi 90g, Rhizoma Atractylodis 600g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste, adds Semen Crotonis Pulveratum, Moschus powder in above-mentioned thick paste, and mixing is standby; Get an amount of polyethylene glycol 6000, heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder wood mixture, mixing, and adopting a speed is 85～90/min, splashes in the refrigerative liquid paraffin, makes drop pill, promptly.
Embodiment 50
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 200g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; Eight flavor medicines such as all the other Radix Aucklandiae, Lignum Aquilariae Resinatum decoct with water 2 times, and each 2 hours, collecting decoction filters, and is condensed into thick paste, and was standby; Taking polyethylene glycol 6000: the mixture Polyethylene Glycol of Macrogol 4000=4: 3 is an amount of, and heating makes fusion, adds above-mentioned thick paste and Semen Crotonis Pulveratum, Moschus powder, mixing, adopting a speed is 40～60/min, splashes in the refrigerative liquid paraffin, make drop pill, promptly.
Embodiment 51
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 280g, Lignum Aquilariae Resinatum 220g, Fructus Aurantii Immaturus 360g, Rhizoma Coptidis 600g, Lignum Santali Albi 200g, Rhizoma Atractylodis 600g, Moschus 8g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 900g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, standby with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, make granule.
Embodiment 52
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 230g, Fructus Aurantii Immaturus (parched with bran) 350g, Rhizoma Coptidis 180g, Lignum Santali Albi 200g, Rhizoma Atractylodis 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 40 purpose powder, CO 2Supercritical extraction, extracting pressure 5MPa, 35 ℃ of temperature, CO 2Flow velocity 20L/h, extraction 2h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, reclaiming ethanol to relative density is that 1.25-1.30 (60 ℃) is standby; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate is concentrated into relative density 1.25-1.30 (60 ℃), and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby, makes tablet according to method for preparing tablet thereof.
Embodiment 53
A. take off column weight amount proportioning crude drug: Lignum Aquilariae Resinatum 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Rhizoma Coptidis 150g, Lignum Santali Albi 90g, Rhizoma Atractylodis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are pulverized CO 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby, encapsulated, promptly.
Embodiment 54
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 320g, Fructus Aurantii Immaturus 600g, Rhizoma Coptidis 360g, Lignum Santali Albi 360g, Rhizoma Atractylodis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as this perfume (or spice), Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, standby, encapsulated with Semen Crotonis Pulveratum, Moschus mixing, promptly.
Embodiment 55
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, standby with the above-mentioned fine powder that is dried and crushed into Semen Crotonis Pulveratum, Moschus mixing, add appropriate amount of auxiliary materials, make 36000 capsules, promptly.
Embodiment 56
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 180g, Fructus Aurantii Immaturus 200g, Rhizoma Coptidis 360g, Lignum Santali Albi 360g, Rhizoma Atractylodis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Lignum Santali Albi coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby; Add an amount of magnesium stearate, mixing, compacting, promptly.
Embodiment 57
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 170g, Fructus Aurantii Immaturus 400g, Rhizoma Coptidis 250g, Lignum Santali Albi 250g, Rhizoma Atractylodis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 10 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Add 12 ‰ magnesium stearate, mixing, compacting is in blocks, promptly.
Embodiment 58
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Add 6 ‰ magnesium stearate, mixing is pressed into 33000, promptly.
Embodiment 59
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 600g, Lignum Aquilariae Resinatum 180g, Fructus Aurantii Immaturus 600g, Rhizoma Coptidis 360g, Lignum Santali Albi 360g, Rhizoma Atractylodis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 12 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; It is an amount of to add vegetable oil, and mixing is made soft capsule, promptly.
Embodiment 60
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 100g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 300g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 17MPa, 40 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; It is an amount of to add vegetable oil, makes 36000 soft capsules, promptly.
Embodiment 61
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 600g, Fructus Aurantii Immaturus 600g, Rhizoma Coptidis 360g, Lignum Santali Albi 360g, Rhizoma Atractylodis 600g, Moschus 18g, Semen Crotonis Pulveratum 240g, Fructus Jujubae 2000g, Rhizoma Chuanxiong 360g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 30L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder wood 4000g, add glycerol 23550g, Al (OH) 3156g, sodium acrylate 2758g mix homogeneously are component A; Get tartaric acid 72g, add distilled water 17340g, acrylate copolymer 1236g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 62
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 200g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 600g, Rhizoma Coptidis 360g, Lignum Santali Albi 90g, Rhizoma Atractylodis 200g, Moschus 10g, Semen Crotonis Pulveratum 80g, Fructus Jujubae 1500g, Rhizoma Chuanxiong 300g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get above-mentioned hybrid medicine powder 2200g, add glycerol 12000g, Al (OH) 3150g, sodium acrylate 2800g mix homogeneously are component A; Get tartaric acid 95g, add distilled water 26000g, acrylate copolymer 2500g, dissolving is B component; B component slowly adds among the component A, stirs, and coating, compound with protecting film, cut promptly.
Embodiment 63
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus (parched with bran) 250g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1200g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 80 purpose powder, CO 2Supercritical extraction, extracting pressure 40MPa, 60 ℃ of temperature, CO 2Flow velocity 35L/h, extraction 5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 158g, add water 8000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1869g, grinds evenly, promptly.
Embodiment 64
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii Immaturus 300g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as the Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing; Get carbomer 88g, add water 10000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder wood 2500g, grinds evenly, promptly.
Embodiment 65
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 180g, Fructus Aurantii Immaturus 200g, Rhizoma Coptidis 300g, Lignum Santali Albi 180g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g, Rhizoma Chuanxiong 180g are standby;
B. above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby; Get carbomer 85g, add water 7500g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 2059g, grinds evenly, promptly.
Embodiment 66
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 450g, Lignum Aquilariae Resinatum 350g, Fructus Aurantii Immaturus (parched with bran) 350g, Rhizoma Coptidis 200g, Lignum Santali Albi 200g, Rhizoma Atractylodis 300g, Moschus 7g, Semen Crotonis Pulveratum 120g, Fructus Jujubae (enucleation) 1000g, Rhizoma Chuanxiong 200g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 50 purpose powder, CO 2Supercritical extraction, extracting pressure 20MPa, 55 ℃ of temperature, CO 2Flow velocity 25L/h, extraction 3h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get carbomer 188g, add water 14000g and stir, NaOH regulates pH to 7, adds above-mentioned hybrid medicine powder 1800g, grinds evenly, promptly.
Embodiment 67
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 150g, Lignum Aquilariae Resinatum 150g, Fructus Aurantii Immaturus 150g, Rhizoma Coptidis 90g, Lignum Santali Albi 90g, Rhizoma Atractylodis 150g, Moschus 4.5g, Semen Crotonis Pulveratum 60g, Fructus Jujubae 500g, Rhizoma Chuanxiong 90g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong, Lignum Santali Albi are ground into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 15MPa, 40 ℃ of temperature, CO 2Flow velocity 22L/h, extraction 2.5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.25-1.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby; Get above-mentioned hybrid medicine powder 1000g, fat-soluble ointment base 4000g is heated to 60 ℃ of mix homogeneously, is stirred to room temperature, promptly.
Embodiment 68
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 400g, Lignum Aquilariae Resinatum 250g, Fructus Aurantii Immaturus 400g, Rhizoma Coptidis 250g, Lignum Santali Albi 250g, Rhizoma Atractylodis 400g, Moschus 12g, Semen Crotonis Pulveratum 150g, Fructus Jujubae 1200g, Rhizoma Chuanxiong 250g are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Six-element medicated powder such as Lignum Aquilariae Resinatum, the Radix Aucklandiae, Rhizoma Coptidis, Fructus Aurantii Immaturus, Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 8 times of water gagings, soak 3 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 50 ℃, and medicinal residues and Lignum Santali Albi coarse powder add 60% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 50 ℃, drying, with the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, sieving is component A; Octadecanol 750g, white vaseline 750g, ethyl hydroxybenzoate 7g are heated to 80 ℃ and are molten into B component; Get sodium lauryl sulphate 70g, add glycerol 700g, water 10000g dissolving, be component C; Component C is slowly added in the B component, continue to stir, add component A when being cooled to 40 ℃, fully stir, be condensed to and partly solidify shape, promptly.
Embodiment 69
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 70
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 71
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Cortex Magnoliae Officinalis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.
Embodiment 72
A. take off column weight amount proportioning crude drug: Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Radix Scutellariae 300g, Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g are standby;
B. above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby; Use water pill, cold drying, promptly.

Claims (9)

1. one kind contains Lignum Aquilariae Resinatum treatment gastrointestinal disease Chinese medicine composition, it is characterized in that it being to be made by following weight proportioning raw material:
The Radix Aucklandiae 150～600g, Lignum Aquilariae Resinatum 150～600g, Fructus Aurantii Immaturus 150～600g, Lignum Santali Albi 90～360g, Rhizoma Coptidis or Radix Scutellariae 150～600g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 150～600g, Moschus 4.5～18g, Semen Crotonis Pulveratum 60～240g, Fructus Jujubae 500～2000g and Rhizoma Chuanxiong 90～360g.
2. treat the gastrointestinal disease Chinese medicine composition according to claim 1, it is characterized in that it being to make by following weight proportioning raw material:
The Radix Aucklandiae 250～400g, Lignum Aquilariae Resinatum 250～400g, Fructus Aurantii Immaturus 250～400g, Lignum Santali Albi 150～250g, Rhizoma Coptidis or Radix Scutellariae 200～400g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 250～400g, Moschus 6～12g, Semen Crotonis Pulveratum 100～150g, Fructus Jujubae 800～1200g and Rhizoma Chuanxiong 150～250g.
3. as treatment gastrointestinal disease Chinese medicine composition as described in the claim 2, it is characterized in that it being to make by following weight proportioning raw material:
Radix Aucklandiae 300g, Lignum Aquilariae Resinatum 300g, Fructus Aurantii Immaturus 300g, Lignum Santali Albi 180g, Rhizoma Coptidis or Radix Scutellariae 300g, Cortex Magnoliae Officinalis or Rhizoma Atractylodis 300g, Moschus 9g, Semen Crotonis Pulveratum 120g, Fructus Jujubae 1000g and Rhizoma Chuanxiong 180g.
As claim 1～3 arbitrary as described in treatment gastrointestinal disease Chinese medicine composition, it is characterized in that Fructus Aurantii Immaturus is a Fructus Aurantii Immaturus (parched with bran); Cortex Magnoliae Officinalis is a Cortex Magnoliae Officinalis (processed with ginger); Fructus Jujubae is that Fructus Jujubae, the Moschus of enucleation is the artificial Moschus.
As claim 1～3 arbitrary as described in the preparation method of treatment gastrointestinal disease Chinese medicine composition, it is characterized in that:
A. get the weight proportion crude drug: the Radix Aucklandiae, Lignum Aquilariae Resinatum, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Coptidis or Radix Scutellariae, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; The Radix Aucklandiae, Lignum Aquilariae Resinatum, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae are pulverized, C O 2Supercritical extraction; Get extract, add an amount of anhydrous alcohol solution, carry out enclose with an amount of β-CD, drying promptly gets clathrate, and is standby; With the medicinal residues ethanol extraction secondary behind the above-mentioned supercritical extraction, merge secondary filtrate, reclaim ethanol and concentrate standby; Get Fructus Jujubae and decoct with water secondary, filter; Merging filtrate concentrates, and with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Six-element medicated powder such as Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add water, soak, and decocting boils distillation, collect volatile oil, and are with after β-CD inclusion, standby; Decocting liquid filters, and filtrate concentrates standby, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add alcohol reflux 2 times, filters; Merge secondary filtrate, concentrate, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, filter; Merge secondary filtrate, concentrate, drying, the above-mentioned fine powder that is dried and crushed into, with Semen Crotonis Pulveratum, Moschus mixing, standby;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 1～3 time, and each 1～3 hour, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
6. as the preparation method of treatment gastrointestinal disease Chinese medicine composition as described in as described in the claim 5, it is characterized in that:
A. get the weight proportion crude drug: Lignum Aquilariae Resinatum, the Radix Aucklandiae, Fructus Aurantii Immaturus, Lignum Santali Albi, Rhizoma Coptidis or Radix Scutellariae, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Moschus, Semen Crotonis Pulveratum, Fructus Jujubae and Rhizoma Chuanxiong are standby;
B. above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Rhizoma Atractylodis, Rhizoma Chuanxiong, Rhizoma Coptidis or Radix Scutellariae powder are broken into 40-80 purpose powder, CO 2Supercritical extraction, extracting pressure 5-40MPa, temperature 35-60 ℃, CO 2Flow velocity 20-35L/h, extraction 2-5h; Get extract, add an amount of anhydrous alcohol solution,, adopt polishing to carry out enclose,, promptly get clathrate in 40 ℃ of vacuum dryings with an amount of β-CD, standby; Medicinal residues behind the above-mentioned supercritical extraction are added 60% ethanol extraction secondary, merge secondary filtrate, relative density is that 1.251.30 is standby when reclaiming ethanol to 60 ℃; Get Fructus Jujubae and decoct with water secondary, each 2h filters; Merging filtrate, relative density 1.25-1.30 when being concentrated into 60 ℃, with above-mentioned alcohol extract condensed cream mixing, drying is ground into fine powder, with clathrate, Semen Crotonis Pulveratum, the Moschus mixing that sieves, crosses 80 mesh sieves again, and is standby;
Perhaps above ten flavor medicines, Semen Crotonis Pulveratum, that Moschus powder is broken into fine powder is standby; Lignum Aquilariae Resinatum, the Radix Aucklandiae, Lignum Santali Albi, Fructus Aurantii Immaturus, Cortex Magnoliae Officinalis or Six-element medicated powder such as Rhizoma Atractylodis, Rhizoma Chuanxiong are broken into coarse powder, add 16 times of water gagings, soak 4 hours, and decocting boils distillation 8h altogether, collects volatile oil, and is with after β-CD inclusion, standby; Decocting liquid filters, and relative density 1.25-1.30 was standby when filtrate was concentrated into 60 ℃, and medicinal residues and Rhizoma Coptidis or Radix Scutellariae coarse powder add 70% alcohol reflux 2 times, for the first time 2h; 1h filters for the second time; Merge secondary filtrate, relative density 1.20-1.25 when being concentrated into 60 ℃, drying, standby; Get Fructus Jujubae, add decocting and boil secondary, each 2h filters; Merge secondary filtrate, relative density 1.28-1.32 when being concentrated into 60 ℃, drying, with the above-mentioned fine powder that is dried and crushed into,, standby with Semen Crotonis Pulveratum, Moschus mixing;
Perhaps above ten flavors, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other eight flavor medicines decoct with water 2 times, and each 2 hours, collecting decoction filtered, and is condensed into thick paste; In above-mentioned thick paste, add Semen Crotonis Pulveratum, Moschus powder, mixing, standby;
Perhaps above crude drug, Semen Crotonis Pulveratum, Moschus pulverize separately become fine powder; All the other crude drug are ground into fine powder, and with Semen Crotonis Pulveratum, Moschus powder facing-up, mixing sieves, and is standby;
C. the active component that step b is obtained is made preparation.
7. as the preparation method of treatment gastrointestinal disease Chinese medicine composition as described in as described in the claim 6, it is characterized in that the preparation among the step c is tablet, granule, honey pill agent, watered pill, drop pill, hard capsule, soft capsule, patch, cataplasma, ointment, gel.
As claim 1～3 arbitrary as described in the application of treatment gastrointestinal disease Chinese medicine composition in preparation treatment irritable bowel syndrome medicine.
As claim 1～3 arbitrary as described in treatment gastrointestinal disease Chinese medicine composition at preparation treatment diarrhoea, poor appetite, feel sick, the application in the vomiting, abdominal distention, stomachache, dyspepsia, dysentery, enteritis, functional gastrointestinal disease medicine.
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* Cited by examiner, † Cited by third party
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CN101912592A (en) * 2010-08-02 2010-12-15 朱惠芬 Traditional Chinese medicine preparation for treating irritable bowel syndrome
CN102935122A (en) * 2012-09-30 2013-02-20 广西梧州三鹤药业有限公司 Antidiarrheal particle and preparation method thereof
CN103223011A (en) * 2013-03-29 2013-07-31 阚兆云 Extract product of traditional Chinese medicine
CN107746749A (en) * 2017-09-28 2018-03-02 江永百润福天然植物科技发展有限公司 A kind of preparation method and Lignum Aquilariae Resinatum extract from agalloch eaglewood residue production Lignum Aquilariae Resinatum extract
CN109674977A (en) * 2019-01-24 2019-04-26 天津中新药业集团股份有限公司乐仁堂制药厂 For treating Chinese medicine composition, application and the compound preparation of stomach intestinal disease

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CN100446793C (en) * 2006-09-27 2008-12-31 天津中新药业集团股份有限公司乐仁堂制药厂 Chinese-medicinal composition for treating enterogastric diseases

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101912592A (en) * 2010-08-02 2010-12-15 朱惠芬 Traditional Chinese medicine preparation for treating irritable bowel syndrome
CN102935122A (en) * 2012-09-30 2013-02-20 广西梧州三鹤药业有限公司 Antidiarrheal particle and preparation method thereof
CN102935122B (en) * 2012-09-30 2014-04-30 广西梧州三鹤药业有限公司 Antidiarrheal particle and preparation method thereof
CN103223011A (en) * 2013-03-29 2013-07-31 阚兆云 Extract product of traditional Chinese medicine
CN107746749A (en) * 2017-09-28 2018-03-02 江永百润福天然植物科技发展有限公司 A kind of preparation method and Lignum Aquilariae Resinatum extract from agalloch eaglewood residue production Lignum Aquilariae Resinatum extract
CN109674977A (en) * 2019-01-24 2019-04-26 天津中新药业集团股份有限公司乐仁堂制药厂 For treating Chinese medicine composition, application and the compound preparation of stomach intestinal disease

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