CN101757153A - Application of traditional Chinese medicine composition in preparation of medicines for treating kidney deficiency blood stasis type erectile dysfunction - Google Patents
Application of traditional Chinese medicine composition in preparation of medicines for treating kidney deficiency blood stasis type erectile dysfunction Download PDFInfo
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Abstract
The invention discloses an application of a traditional Chinese medicine composition in the preparation of medicines for treating kidney deficiency blood stasis type erectile dysfunction. The traditional Chinese medicine composition comprises ginseng, leech, centipede, scorpio, ground beeltle, cicada slough, radix paeoniae rubra, borneol and the like, has the effects of supplementing qi and activating blood circulation as well as eliminating blood-stasis and freeing channels. Clinical tests prove that the traditional Chinese medicine composition can effectively treat the kidney deficiency blood stasis type erectile dysfunction without adverse reactions found.
Description
Technical field
The present invention relates to a kind of new purposes of Chinese medicine composition, particularly, the present invention relates to the application of a kind of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine, belong to the Chinese medicine application.
Background technology
(Erectile dysfunction ED) is meant that penis continues can not reach or keep erection to satisfy sexual life to erection disturbance.Chinese medicine is referred to as sexual impotence, and think, the erection of penis is the result by a series of internal organs, meridians and the mutual coordinative role of qi-blood-body fluid, and inside and outside various pathological factors cause the functional activity imbalance of above-mentioned internal organs and meridians or impaired, all can produce erection disturbance.Because the factor that causes erection disturbance is complicated, thus the traditional Chinese medical science in accent liver collateral dredging, vital energy benefiting and the kidney invigorating, cautiously grasping pathogenesis, treatment according to the specific symptoms.
Current society, rhythm of life is accelerated, and social pressure and operating pressure are big, the overwork of shape will, dinner party increases, and night life is too much, so that feelings will changes too drasticly, and the kidney qi interior-deficiency causes the patient to be increased, and with the passing of time blood vessels are obstructed and cause kidney deficiency blood stasis type erectile dysfunction.Under modern society's condition erection disturbance with suffer from a deficiency of the kidney the closelyst, it is rather common the blood stasis due to renal deficiency syndrome with the passing of time to occur.
The Therapeutic Method of erection disturbance comprises: 1, vasoactive agent injection for curing; 2, topical treatment; 3, oral drug therapy mainly contains sildenafil citrate, Vardenafil hydrochloric acid and tadanafil etc.
Though rapid-action, outstanding effect advantage that the western medicine erection disturbance has, owing to act on the part, curative effect disappears also fast, and has certain untoward reaction complication and contraindication.The treatment by Chinese herbs onset is relatively slow, but acts on whole body, and curative effect is lasting, and side effect is little, is multi-target effect, is not single effect, has clinical efficacy preferably.
The present invention is the improvement invention of carrying out on the basis of No. 01131203.3 and No. 200410048292.2 patent, quotes in full the content of this two patent documents record at this.The application of unexposed this Chinese medicine composition of above-mentioned two patents in the treatment kidney deficiency blood stasis type erectile dysfunction.
Summary of the invention
The object of the invention provides the application of a kind of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine;
The present invention uses described Chinese medicine composition and mainly is made up of Radix Ginseng, Hirudo, Scorpio, Eupolyphaga Seu Steleophaga, Scolopendra, Periostracum Cicadae, Radix Paeoniae Rubra and Borneolum Syntheticum etc., function with benefiting QI for activating blood circulation, collateral dredging, can increase the vascular flow amount, improving blood vessel blood supplies, recover impaired effects such as vascular endothelial function, can effectively treat kidney deficiency blood stasis type erectile dysfunction.
Described Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10;
Preferably, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
Or:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5;
The active component of above-mentioned Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and the Olibanum (processed) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (parched) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
The present invention uses in the described Chinese medicine composition, as the latin name of the crude drug of active component and processing method thereof from " Chinese medicine voluminous dictionary " (in July, 1977, front page, Shanghai science tech publishing house) and " Chinese pharmacopoeia (version in 2005, Chemical Industry Press).
It is capsule, tablet, granule, powder, oral liquid or pill that the present invention uses the preparation formulation that also discloses above-mentioned Chinese medicine composition.
For above-mentioned dosage form can be realized, need when these dosage forms of preparation, to add the pharmacy acceptable auxiliary, for example: filler, disintegrating agent, lubricant, suspending agent, binding agent, sweeting agent, correctives, antiseptic, substrate etc.Filler comprises: starch, pregelatinized Starch, lactose, mannitol, chitin, microcrystalline Cellulose, sucrose etc.; Disintegrating agent comprises: starch, pregelatinized Starch, microcrystalline Cellulose, carboxymethyl starch sodium, crospolyvinylpyrrolidone, low-substituted hydroxypropyl cellulose, cross-linking sodium carboxymethyl cellulose etc.; Lubricant comprises: magnesium stearate, sodium lauryl sulphate, Pulvis Talci, silicon dioxide etc.; Suspending agent comprises: polyvinylpyrrolidone, microcrystalline Cellulose, sucrose, agar, hydroxypropyl emthylcellulose etc.; Binding agent comprises, starch slurry, polyvinylpyrrolidone, hydroxypropyl emthylcellulose etc.; Sweeting agent comprises: saccharin sodium, Aspartane, sucrose, cyclamate, enoxolone etc.; Correctives comprises: sweeting agent and various essence; Antiseptic comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its esters, benzalkonium bromide, fixed, the Folium eucalypti globueli (Eucalyptus globulus Labill.) wet goods of acetic acid chloroethene; Substrate comprises: PEG6000, PEG4000, insect wax etc.
The present invention uses described capsule and preferably makes by following preparation method: five kinds of Chinese medicine such as the Hirudo of said ratio, Scorpio, Periostracum Cicadae, Eupolyphaga Seu Steleophaga, Scolopendra cleaned, and oven drying at low temperature, standby; Lignum Santali Albi, Lignum Dalbergiae Odoriferae extract volatile oil, and medicinal residues and aqueous solution are standby; Radix Ginseng extracts secondary with 70% alcohol heating reflux, and 3 hours for the first time, 2 hours for the second time, merge extractive liquid, reclaimed ethanol to there not being the alcohol flavor; The medicinal residues of medicine residues of Radix Ginseng and Lignum Santali Albi, Lignum Dalbergiae Odoriferae merge with aqueous solution, add Radix Paeoniae Rubra, Semen Ziziphi Spinosae (stir-fry), decoct with water secondary, 3 hours for the first time, 2 hours for the second time, collecting decoction filters, and filtrate is concentrated into the clear paste that relative density is 1.20-1.25 (60 ℃), add above-mentioned panaxynol extract, mixing, cold drying is ground into fine powder; The five tastes such as Olibanum (system) and Hirudo are ground into fine powder altogether; The Borneolum Syntheticum porphyrize, with above-mentioned fine powder facing-up, mixing sprays into volatile oil respectively, and mixing incapsulates, promptly.
Perhaps, capsule was preferably made by following preparation method described in the present invention used:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (processed) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
Perhaps, capsule was preferably made by following preparation method described in the present invention used:
A) weight ratio of crude drug is: Radix Ginseng 3-10 part, Hirudo 3-11 part, Eupolyphaga Seu Steleophaga 5-10 part, Olibanum (system) 1-5 part, Radix Paeoniae Rubra 3-9 part, Lignum Dalbergiae Odoriferae 1-5 part, Lignum Santali Albi 1-5 part, Scorpio 3-9 part, Periostracum Cicadae 3-12 part, Scolopendra 1-3 part, Borneolum Syntheticum 1-7 part, Semen Ziziphi Spinosae (parched) 3-10 part;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
The present invention uses the consumption of described Chinese medicine composition, is converted to the weight of raw medicinal material, is each 0.8-3 gram, and take 2-4 every day, is preferably each 1.11-2.22 gram, takes every day three times.
The specific embodiment
Embodiment 1:
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 72.6g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 19.8g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 30-40 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge the water extract, after the filtration, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.1 alcohol-extracted extract, the water extract filter with above-mentioned all water extract mixings after be concentrated into 60 ℃ to measure relative densities be 0.9～1.1 clear paste, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make 1000 capsules behind the mixing.
Amount of drug of the present invention for each 2-4 grain, is taken three times every day.
Embodiment 2
A) the crude drug prescription is:
Radix Ginseng 66g Hirudo 52.8g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 59.4g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 70-90 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge the water extract, after the filtration, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, alcohol extract is condensed into relative density and is determined as 1.0～1.05 alcohol-extracted extracts at 60 ℃, the water extract filter with above-mentioned all water extract mixings after be concentrated into 60 ℃ to measure relative densities be 1.0～1.1 clear paste, standby;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, preparation process is pressed into 1000 routinely.
Amount of drug of the present invention for each 2-4 sheet, is taken three times every day.
Embodiment 3: the preparation of pill
A) the crude drug prescription is:
Radix Ginseng 39.6g Hirudo 66g Eupolyphaga Seu Steleophaga 46.2g Olibanum (system) 13.2g
Radix Paeoniae Rubra 33g Lignum Dalbergiae Odoriferae 13.2g Lignum Santali Albi 13.2g Scorpio 46.2g
Periostracum Cicadae 46.2g Scolopendra 6.6g Borneolum Syntheticum 33g Semen Ziziphi Spinosae (stir-fry) 33g
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes medicated powder mean diameter 10-20 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae add suitable quantity of water and decoct secondary, and each 3 hours, merge the water extract, after the filtration, extractum to be condensed into; Radix Ginseng is with an amount of 70% ethanol extraction secondary, each 3 hours, merge extractive liquid,, reclaim ethanol to there not being the alcohol flavor, the reuse water extraction, alcohol extract is condensed into 60 ℃, and to measure relative densities be 0.9～1.0 alcohol-extracted extract, the water extract filter with above-mentioned all water extract mixings after be concentrated into 60 ℃ to measure relative densities be 1.0～1.1 clear paste, standby;
D) preparation process:
Preparation process is made 1000 pills routinely.
Amount of drug of the present invention for each 2-4 grain, is taken three times every day.
Experimental example:
For illustrating the curative effect of traditional Chinese medicine composition for treating kidney deficiency blood stasis type erectile dysfunction of the present invention, carried out following test proving its curative effect with the capsule that makes by the foregoing description 1 method (to call medicine of the present invention in the following text), but it can not constitute any restriction to scope of the present invention.
1 data and method
1.1 physical data
Collect in JIUYUE, the 2005～2008 kidney deficiency blood stasis type erectile dysfunction patient that Hebei Yi Ling hospital outpatient is sought medical advice between year May, 72 routine patients all meet inclusion criteria, 23～54 years old age.Be divided into psychological 29 examples according to the erection function cause of disease, nerve 7 examples, incretion 23 examples, Combination 6 examples.The all voluntary accepting treatments of 72 examples.The patient is divided into treatment group and matched group at random, and 36 routine patients, 32.6 ± 3.4 years old mean age are organized in treatment; Matched group 36 routine patients, 33.5 ± 3.2 years old mean age, two groups of patient's physical data there was no significant differences.
1.2 inclusion criteria
1. have or do not have erectile ability, erection intensity is not hard, or hyposexuality.Part patient inserts the not enough 2min in back and promptly ejaculates; 2. the course of disease has fixedly spouse more than half a year, and 3. the IIEF-5 scoring is＜20 minutes; 4. period in a medicine at least sexual life weekly; 5. genitals and secondary sex characteristics are normal, no liver, kidney illness, the no genito-urinary system inflammation and the illness that is a cup too low; 6. there is not the contraindication of taking medicine of the present invention.
Traditional Chinese medical science inclusion criteria: kidney deficiency blood stasis type
Impotence, premature ejaculation, soreness of the waist and knees, body of the tongue is purple dim or petechia, hesitant pulse CHI-pulse being weak arranged;
1.3 method
Matched group and treatment group have all been taken flaccidity tonifying YANG granule (being produced by Tianjiang Pharmaceutical Industry Co., Ltd., Jiangyin), and 1 bag/time, 2 times/day, to take in 2 hours after the meal sooner or later, be a course of treatment March.The treatment group adds Chinese medicine composition of the present invention (Shijiazhuang Yiling Pharmaceutical Co., Ltd's production), and each 3, oral, every day 2 times.Require the patient at period in a medicine 1 sexual life at least weekly, the 6 all therapeutic effect of post-evaluation of taking medicine continuously.
1.4 observation index before and after the treatment
1. IIEF-5 scoring; 2. measure the total testosterone of blood; 3. utilize mighty force Nocturnal penile tumescence monitor to carry out the Nocturnal penile tumescence function monitoring; 4. untoward reaction.
1.5 curative effect judging standard
Took medicine continuously for 6 weeks, during under the sexual stimulus condition, cause erection, finish sexual life.6 weeks back employing IIEF-5 questionnaire carries out the erection function assessment, and marking＞21 fens or marking is divided into effectively than rising＞10 before the treatment; Scoring do not have to change or still＜21 minute person be invalid.
1.6 statistical analysis
Data are analyzed with the SPSS11.0 software kit, and statistical method is checked for pairing t.There is statistical significance P＜0.01 for difference.
2 results
2.1 therapeutic outcome relatively
In matched group and the treatment group, penis blood volume (NPT) when treatment back IIEF-5 scoring, the total testosterone levels of blood and nocturnal tumescence and is compared before the treatment, and P＜0.05 all has significant difference; Penis blood volume when the IIEF-5 scoring after the treatment group treatment, the total testosterone levels of blood and nocturnal tumescence and is compared after the treatment of control group, and P＜0.05 all has significant difference.Two groups of therapeutic outcomes relatively see Table 1.
Table 1 liang group therapeutic outcome relatively
Annotate: relatively preceding with the treatment of this group,
*P＜0.05; With comparison after the treatment of control group,
*P＜0.05.
2.2 untoward reaction
During the treatment, all do not find obvious adverse reaction.
3 conclusions
Above clinical and experimental study shows, by Drug therapy of the present invention, the penis blood volume all has obvious raising in various degree when patient IIEF-5 scoring, the total testosterone levels of blood and nocturnal tumescence, and non-evident effect during the treatment.Prove that Chinese medicine composition of the present invention can effectively treat kidney deficiency blood stasis type erectile dysfunction.
Claims (8)
1. the application of Chinese medicine composition in preparation treatment kidney deficiency blood stasis type erectile dysfunction medicine is characterized in that this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 3-10 Hirudo 3-11 Eupolyphaga Seu Steleophaga 5-10 Olibanum (system) 1-5 Radix Paeoniae Rubra 3-9 Lignum Dalbergiae Odoriferae 1-5
Lignum Santali Albi 1-5 Scorpio 3-9 Periostracum Cicadae 3-12 Scolopendra 1-3 Borneolum Syntheticum 1-7 Semen Ziziphi Spinosae (stir-fry) 3-10.
2. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 10 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 7 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
3. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 10 Hirudo 8 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 9 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
4. application as claimed in claim 1 is characterized in that, this Chinese medicine composition is made by following bulk drugs:
Radix Ginseng 6 Hirudo 11 Eupolyphaga Seu Steleophagas, 7 Olibanums (system) 2 Radix Paeoniae Rubra 5 Lignum Dalbergiae Odoriferaes 2
Lignum Santali Albi 2 Scorpios 3 Periostracum Cicadaes 7 Scolopendra 1 Borneolum Syntheticum, 5 Semen Ziziphi Spinosaes (stir-fry) 5.
5. as each described application among the claim 1-4, it is characterized in that the active component of described Chinese medicine composition is made up of following ingredients:
The a mean diameter is less than Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga, Periostracum Cicadae and Olibanum (system) medicated powder of 100 μ m;
B Borneolum Syntheticum medicated powder;
The volatile oil that c is extracted by Lignum Dalbergiae Odoriferae and Lignum Santali Albi;
The alcohol-extracted extract of the alcohol extract of d Radix Ginseng after after concentrating with ethanol extraction;
The water extracted immersing paste that is condensed into behind the water extract after the Lignum Dalbergiae Odoriferae behind the e extraction composition c and water extract, Radix Paeoniae Rubra and the Semen Ziziphi Spinosae (stir-fry) of Lignum Santali Albi medicinal residues decoct with water and the water extract filtration of the medicine residues of Radix Ginseng after the extraction ingredient d, the mixing.
6. as each described application among the claim 1-4, it is characterized in that the preparation formulation of this Chinese medicine composition is capsule, tablet, granule, powder, oral liquid or pill.
7. application according to claim 6 is characterized in that, described capsule is made by following steps:
A) take by weighing each crude drug according to the weight portion ratio;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste;
D) preparation process:
In Fluidbedgranulatingdrier, add the superfine powder flour, again the step c) gained is extracted extractum and spray into granulation; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
8. application according to claim 6 is characterized in that, described capsule is made by following steps:
A) take by weighing each crude drug according to the weight portion ratio;
B) pulverizing medicinal materials technology:
Scorpio, Hirudo, Scolopendra, Eupolyphaga Seu Steleophaga and five kinds of worm medicines of Periostracum Cicadae are prepared burden by prescription through the Olibanum (processed) that cleans, washes after handling the back and cleaning the process of preparing Chinese medicine, pulverized by pulverizer, the medicated powder fineness reaches more than 80 orders; Medicated powder behind the coarse powder carries out micronizing through various superfine communication techniques, makes the medicated powder mean diameter less than 100 μ m; Medical material to be pulverized is prepared burden after the cleaning, drying sterilization;
C) extract concentrated and drying process:
Reuse water extraction behind Lignum Dalbergiae Odoriferae and the Lignum Santali Albi elder generation extracting in water volatile oil, Radix Paeoniae Rubra and Semen Ziziphi Spinosae decoct with water, after the water extract filters, extractum to be condensed into; Radix Ginseng with ethanol extraction after, reuse water extraction, alcohol extract are condensed into alcohol-extracted extract after reclaiming ethanol, the water extract filter with all water extract mixings after be condensed into the water extracted immersing paste, extractum directly is spray dried to spray powder;
D) preparation process:
The superfine powder flour is added in the Fluidbedgranulatingdrier with step c) gained spray drying powder, sprays solvent again and make granule; The granule made through granulate, is added the Borneolum Syntheticum fine powder, spray into the volatile oil that extracts by Lignum Dalbergiae Odoriferae and Lignum Santali Albi, by the capsule filler filling, make capsule behind the mixing.
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Cited By (1)
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| CN112057529A (en) * | 2020-10-23 | 2020-12-11 | 江西五麟祥生物科技有限公司 | Traditional Chinese medicine spray for treating male erectile dysfunction |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112057529A (en) * | 2020-10-23 | 2020-12-11 | 江西五麟祥生物科技有限公司 | Traditional Chinese medicine spray for treating male erectile dysfunction |
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