CN101732112A - Development of instant bracket for bonding biliary tract or ureter - Google Patents
Development of instant bracket for bonding biliary tract or ureter Download PDFInfo
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- CN101732112A CN101732112A CN200810180504A CN200810180504A CN101732112A CN 101732112 A CN101732112 A CN 101732112A CN 200810180504 A CN200810180504 A CN 200810180504A CN 200810180504 A CN200810180504 A CN 200810180504A CN 101732112 A CN101732112 A CN 101732112A
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Abstract
The invention relates to a preparation method of a hollow instant bracket applied to a bonding technology of a biliary tract or a ureter, comprising the steps of preparing a soluble purified compound or preparing the soluble purified compound into a 50-90% double distilled water solution and heating into a uniform liquid state for later use; and preparing the compound into a hollow bracket main body with the diameter equivalent to the diameter of the bonded biliary tract or the ureter to be coincided with human body by using a injection molding method or other methods. The bracket material prepared by the method has the following advantages that the dissolving is rapid, bracket components are fully dissolved in the liquid, various adverse reactions are reduced and the consumption of materials is less. The invention is used for bonding the biliary tract or the ureter, ensures rapid coincidence, can prevent the narrowness and the leakage of coincident ports and remarkably improve the smooth rate for coincidence, has small wound, simple and convenient operation without special equipment, is suitable for various classes of hospitals and can replace the traditional sewing method.
Description
Technical field the present invention relates to a kind of auxiliary preparation method of carrying out the defeated or adherent instant bracket of urinary catheter of biliary tract that is used for, be used to improve biliary tract or ureteral identical quality, reduce the complication after biliary tract or ureter coincide, simplify the operation that coincide, improve biliary tract or ureteral identical speed, belong to technical field of biological materials.
Background technology biliary tract or ureter anastomosis are one of basic fundamentals of liver and gall and Urology Surgery, biliary tract or ureter coincide adopts sewings more, with a long history, undertaken to obtain higher patency rate by skilled doctor, use very extensive at present, by numerous doctors are accepted, but also there is inherent deficiency in it: surgery duration is longer, complicated operation; Need needlework will pass tube wall and knotting in the sewing process, inevitably wall is caused damage, and cause nonvolatil foreign body residual, the gap of pin hole and anastomotic stoma is the anastomotic stoma main cause of seepage, leakage is the common complication that biliary tract or ureter coincide, and also is one of ten minutes severe complications, treats very thorny, patient is agonizing, has a strong impact on patient's quality of life.Biliary tract or ureter adhering technique can fundamentally reduce the generation of biliary tract or ureter leakage, reason is that binding agent can well seal anastomotic stoma, in order to guarantee the unobstructed of anastomotic stoma and physiology shape and adherent effect, built-in support is necessary subsidiary conditions, and we have designed and have been specifically designed to biliary tract or the adherent instant bracket of ureter according to biliary tract or ureteral physiological characteristics and bonding needs.
Summary of the invention the objective of the invention is to propose a kind of biliary tract or adherent instant bracket of ureter of being used for, make support therewith bonding technology improve combination, improve original biliary tract or ureteral sewing method, biliary tract that is used for performing the operation or ureter coincide.
The present invention proposes is used for the instant bracket that biliary tract or ureter coincide, form by two parts, the rack body of hollow tubular and external surface coating constitute, but rack body is made of the macromolecular material that degradation in vivo such as Polyethylene Glycol, sugar, low molecular dextran have instant characteristic, external surface coating is made of macromolecular materials such as gelatin, mainly is to play effect instant and that the minimizing support damages inner-walls of duct.
The present invention proposes is used for the preparation method of the instant bracket that biliary tract or ureter coincide, and may further comprise the steps:
1, with the internal layer chemical compound heat fused of analytical pure level, and keep liquid, chemical compound can be Polyethylene Glycol (molecular weight 6000-20000), sucrose, and dextrans etc. can metabolic in vivo chemical compound.
2, will keep liquid above-claimed cpd to adopt the injection moulding method to pour into respectively in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, taking-up is made and biliary tract or the suitable fusiformis pipe of ureter diameter, length can intercept arbitrarily according to biliary tract or the adherent needs of ureter, forms the agent structure of support.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, thickness is at the 2-5 micron with the rack outer surface bag.
4, will wrap by the support of good coating and seal packing, indicate the length of support, internal diameter, external diameter, quality with rigid container .-60 sterilizations of ethylene oxide or cobalt, 4 ℃ of preservations.
Using method: according to the support for the treatment of identical biliary tract or ureteral diameter selection appropriate length, take out the support of suitable types in the art, earlier two parts of support are put into biliary tract to be coincide or ureteral two broken ends of fractured bone respectively, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
New-support with method preparation of the present invention has the following advantages:
(1) can avoid anastomotic stricture,, therefore fundamentally avoid the narrow of anastomotic stoma because the anastomotic stoma place by free stent support, can determine the size of anastomotic stoma as required.Because making, the application of tunicle and binding agent can not subside the anastomotic stoma state that can keep clear for a long time.
(2) can effectively prevent the anastomotic stoma seepage: because binding agent bonding to anastomotic stoma arranged, can play the effect of sealing, avoid the existence in pin hole and anastomotic stoma slit completely, fundamentally avoid the generation of the seepage of anastomotic stoma to anastomotic stoma.
(3) time easy and simple to handle is short.Because simple operating steps can significantly shorten operating time, and wound is little, does not need special equipment, is suitable for carrying out in hospitals at different levels, be expected to substitute fully biliary tract or ureter sewing method.
The specific embodiment
The raw material sources that use among the present invention: Polyethylene Glycol, gelatin, dextran, Beijing chemical reagents corporation, chemical pure level.
Embodiment one
1, it is standby with molecular weight to be that 5000 Polyethylene Glycol is heated to 70 degree back insulations.
2, will keep liquid Polyethylene Glycol 5000 to pour in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1 millimeter, external diameter is 1.5 millimeters, 10 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 2 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Embodiment two
1, it is standby with molecular weight to be that 5000 Polyethylene Glycol is heated to 70 degree back insulations.
2, will keep liquid Polyethylene Glycol 5000 to pour in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1.2 millimeters, external diameter is 1.8 millimeters, 15 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 3 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Embodiment three
1, it is standby with molecular weight to be that 10000 Polyethylene Glycol is heated to 70 degree back insulations.
2, will keep liquid cetomacrogol 1000 0 to pour in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1.5 millimeters, external diameter is 2 millimeters, 16 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 4 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Embodiment four
1, it is standby with molecular weight to be that 12000 Polyethylene Glycol is heated to 70 degree back insulations.
2, will keep liquid Polyethylene Glycol 12000 to pour in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1.5 millimeters, external diameter is 2.2 millimeters, 15 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 4 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Embodiment five
1, it is standby with molecular weight to be that 20000 Polyethylene Glycol is heated to 70 degree back insulations.
2, will keep liquid Macrogol 2000 0 to pour in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1.5 millimeters, external diameter is 2.5 millimeters, 20 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 5 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Embodiment six
1, sucrose being heated to 70 degree backs is incubated standby.
2, will keep liquid sucrose to pour in the prefabricated mould, slowly cooling makes it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1.2 millimeters, and external diameter is 1.8 millimeters, 15 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 3 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Embodiment seven
1, the solid dextran being heated to 70 degree backs is incubated standby.
2, will keep liquid dextran to pour in the prefabricated mould, slowly cooling, make it coagulation forming, open mould, take out and make and biliary tract or the suitable pipe support of ureter diameter, according to the suitable length of bonding needs intercepting, internal diameter is 1.2 millimeters, external diameter is 1.8 millimeters, 15 millimeters of length.
3, the agent structure with above-mentioned support adopts the method for spraying or the method for dipping, and by one deck gelatin coating, the concentration of gelatin is 2% with the rack outer surface bag, and its thickness is 4 microns.
4, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5, take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, reuse tunicle and binding agent are sticking
Close anastomotic stoma, treat the binding agent dry solidification after, with support dissolving, coincide and finish.
Accompanying drawing is the stereogram of support sample
Claims (5)
1. one kind is used for biliary tract or the adherent instant bracket of ureter, it is characterized in that this support is made of two parts, first hollow wall tubulose body constitutes, and the second portion bag is constituted by the coating in the first top layer, mainly is to be beneficial to instant and to prevent the scuffing of support to inner membrance.
2. preparation method that is used for the defeated and adherent hollow sting of urinary catheter of biliary tract as claimed in claim 1 is characterized in that this method may further comprise the steps:
(1) can metabolic in vivo chemical compound heat fused, and keep liquid standby;
(2) chemical compound with above-mentioned maintenance liquid state adopts injection moulding method respectively to pour in the prefabricated support mould, and slowly cooling makes it coagulation forming.
(3) the rack body surface is coated with the skim gelatin film.
3. method as claimed in claim 2 is characterized in that wherein saidly can metabolic in vivo chemical compound being: molecular weight is any in 5000-20000 Polyethylene Glycol, sucrose or the dextran.
4. the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5. take out the support of suitable types in the art, earlier support is put into biliary tract to be coincide or ureteral two broken ends of fractured bone, and make anastomotic stoma place biliary tract or ureter wall tightly involutory, the bonding anastomotic stoma of reuse tunicle and binding agent, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810180504A CN101732112A (en) | 2008-11-27 | 2008-11-27 | Development of instant bracket for bonding biliary tract or ureter |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810180504A CN101732112A (en) | 2008-11-27 | 2008-11-27 | Development of instant bracket for bonding biliary tract or ureter |
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| Publication Number | Publication Date |
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| CN101732112A true CN101732112A (en) | 2010-06-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200810180504A Pending CN101732112A (en) | 2008-11-27 | 2008-11-27 | Development of instant bracket for bonding biliary tract or ureter |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727944A (en) * | 2011-11-14 | 2012-10-17 | 上海市第一人民医院 | Anti-benign and malignant biliary stricture drug eluting stent and preparation method thereof |
| CN110366435A (en) * | 2017-02-24 | 2019-10-22 | 扩凡科技有限公司 | Face seal object for implantation material |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2523444Y (en) * | 2001-11-23 | 2002-12-04 | 浙江大学医学院附属邵逸夫医院 | Absorbable ureter supporter |
| CN1475193A (en) * | 2003-07-04 | 2004-02-18 | 中国人民解放军总医院 | Double layer hollow blood vessel internal support used for vascular anastomosis and its preparation method |
| CN1565648A (en) * | 2003-06-25 | 2005-01-19 | 成都拓泰医药科技开发有限公司 | Method for making degradable material of ureter bracket |
| CN2691521Y (en) * | 2003-06-25 | 2005-04-13 | 成都拓泰医药科技开发有限公司 | Biodegradable ureter holder |
| WO2008054054A1 (en) * | 2006-11-01 | 2008-05-08 | M.I.Tech Co., Ltd. | Stent and method of manufacturing the same |
-
2008
- 2008-11-27 CN CN200810180504A patent/CN101732112A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN2523444Y (en) * | 2001-11-23 | 2002-12-04 | 浙江大学医学院附属邵逸夫医院 | Absorbable ureter supporter |
| CN1565648A (en) * | 2003-06-25 | 2005-01-19 | 成都拓泰医药科技开发有限公司 | Method for making degradable material of ureter bracket |
| CN2691521Y (en) * | 2003-06-25 | 2005-04-13 | 成都拓泰医药科技开发有限公司 | Biodegradable ureter holder |
| CN1475193A (en) * | 2003-07-04 | 2004-02-18 | 中国人民解放军总医院 | Double layer hollow blood vessel internal support used for vascular anastomosis and its preparation method |
| WO2008054054A1 (en) * | 2006-11-01 | 2008-05-08 | M.I.Tech Co., Ltd. | Stent and method of manufacturing the same |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102727944A (en) * | 2011-11-14 | 2012-10-17 | 上海市第一人民医院 | Anti-benign and malignant biliary stricture drug eluting stent and preparation method thereof |
| CN110366435A (en) * | 2017-02-24 | 2019-10-22 | 扩凡科技有限公司 | Face seal object for implantation material |
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Application publication date: 20100616 |