CN101961505A - Methods for preparing medical anti-adhesion hemostatic material and medical anti-adhesion hemostatic washing fluid - Google Patents
Methods for preparing medical anti-adhesion hemostatic material and medical anti-adhesion hemostatic washing fluid Download PDFInfo
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- CN101961505A CN101961505A CN2010102948392A CN201010294839A CN101961505A CN 101961505 A CN101961505 A CN 101961505A CN 2010102948392 A CN2010102948392 A CN 2010102948392A CN 201010294839 A CN201010294839 A CN 201010294839A CN 101961505 A CN101961505 A CN 101961505A
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Abstract
The invention discloses a method for preparing a medical anti-adhesion hemostatic material and the method for preparing a medical anti-adhesion hemostatic washing fluid, which belong to the technical field of medical materials. The method for preparing the medical anti-adhesion hemostatic material comprises the following steps of: performing activation treatment on pre-treated viscose fibers or tencel serving as a raw material by using an NaOH alkaline treating fluid and ethanol; performing etherification treatment on the raw material subjected to the activation treatment by using a halogenated amino acid; neutralizing the raw material subjected to the etherification treatment by using the ethanol and a hydrochloric acid; and washing the neutralized raw material by using the ethanol and performing drying treatment on the washed raw material. The invention also provides the method for preparing the medical anti-adhesion hemostatic washing fluid. In the method for preparing the medical anti-adhesion hemostatic washing fluid, etherified cellulose and sodium chloride are dissolved into water for injection in percentage by weight. The medical anti-adhesion hemostatic material prepared by the method can provide a low-oxygen and weak-acid physiological environment for the surface of a wound, promote the absorption of necrotic tissues, reduce stomal leak and accelerate the healing of the tissues.
Description
Technical field
The present invention relates to medical material tech field, the preparation method of particularly a kind of medical hemostatic non-viscous material and flushing liquor.
Background technology
Postoperative intestinal adhesion is meant that connective fiber and adjacent tissue or organ combine and the anomalous structure that forms, and inevitable pathophysiological process when being the postoperative healing is to have to have existed both at home and abroad since the history of operation and one of unsolved difficult medical problem still always.After a large amount of operations are arranged every year the tissue adhesion being taken place, causes the problem of lifelong deformity of patient and even life danger.Operation wound, ischemia, hemorrhage and bacterial infection etc. all may cause tissue adhesion.According to statistics, the about 50-90% of tissue adhesion incidence rate also can cause severe complications.
So far, people come the prevention of postoperative adhesion at the searching the whole bag of tricks.Regulate surgical technic, use methods such as medicine and anti isolated material can both reach the purpose of anti.Wherein, implementing adherence preventing material in operation is a kind of effective method.But at present, do not have a kind of medicine or measure Film with Preventing Adhesion fully, and be the method for wide clinical application.
Summary of the invention
In order to solve the problem of postoperative intestinal adhesion, the invention provides a kind of preparation method of medical hemostatic non-viscous material, described method comprises:
With a pretreated viscose rayon or a day silk is raw material, and described raw material is carried out activation processing with NaOH alkaline processing liquid and ethanol;
Carrying out etherificate with the raw material of a haloalkyl acid after to activation processing handles;
With in ethanol and the hydrochloric acid and the raw material of etherificate after handling;
With the raw material after the washing with alcohol neutralisation treatment, and to the washing after raw material carry out dried.
The concentration of described NaOH alkaline processing liquid is 10%-50%, and the time of described activation processing is 1-3 hour, and the bath raio of described raw material and NaOH alkaline processing liquid is 1: 5-20.
The time that described etherificate is handled is 2-6 hour, and temperature is a room temperature-70 ℃, and bath raio is 1: 5-20.
Described concentration of ethanol is 70%-95%.
The present invention also provides a kind of preparation method of medical hemostasis anti-adhesive irrigation solution, and described method is for to be dissolved in etherified cellulose and sodium chloride in the water for injection according to following percentage by weight;
Etherified cellulose: 0.5%-10%;
Sodium chloride: 0.6-1.0%;
Water for injection: 89%-98.9%.
Described etherified cellulose and sodium chloride are specifically comprised according to the step that following percentage by weight is dissolved in the water for injection:
Etherified cellulose is dissolved in water for injection, forms first solution;
Sodium chloride is dissolved in water for injection, forms second solution;
Described first solution and second solution are mixed, and add water for injection again.
Described etherified cellulose and sodium chloride are specifically comprised according to the step that following percentage by weight is dissolved in the water for injection:
Sodium chloride is dissolved in the water for injection, forms first solution;
Etherified cellulose is joined in described first solution, stir, and add water for injection again.
Compared with prior art, the present invention has the following advantages:
The medical hemostatic non-viscous material of the present invention preparation can provide the physiological environment of the little acid of hypoxia for wound surface, can promote slough to absorb, and reduces anastomotic leakage, and organization healing is speeded up.
Description of drawings
Fig. 1 is the preparation method flow chart of the medical hemostatic non-viscous material that provides of the embodiment of the invention.
The specific embodiment
In order to understand the present invention in depth, the present invention is described in detail below in conjunction with drawings and the specific embodiments.
Referring to Fig. 1, the invention provides a kind of preparation method of medical hemostatic non-viscous material, this method comprises:
Step 101: with a pretreated viscose rayon or a day silk is raw material, and described raw material is carried out activation processing with NaOH alkaline processing liquid and ethanol;
In actual applications, can adopt through destarch and bleach pretreated viscose rayon or day silk for raw material;
Step 102: carry out etherificate with the raw material of a haloalkyl acid after and handle to activation processing;
Step 103: with in ethanol and the hydrochloric acid and the raw material of etherificate after handling;
Step 104:, and the raw material after the washing carried out dried with the raw material after the washing with alcohol neutralisation treatment.
In order to set forth technique scheme in further detail, be illustrated below by several concrete examples.
Embodiment 1
Get pretreated viscose fabric 50 grams and place in the continuous rotating reactor, add the NaOH alkaline processing liquid 90ml of concentration 40% and the ethanol 210ml of concentration 95%, stirred 2 hours; And then add the monochloroacetic acid alcoholic solution 100ml of concentration 30% therein, under 45 ℃, stirred 4 hours; Take out viscose fabric then, put into the ethanol of concentration 95%, use in the hydrochloric acid of concentration 10% and viscose fabric, make its pH value reach 6.5-7.5; With the washing with alcohol viscose fabric of concentration 80%, the sodium chloride content in viscose fabric is less than 1%; In sterilizing room, viscose fabric is carried out dried at last.
Embodiment 2
Get pretreated viscose rayon 40 grams and place in the airtight reactor, add the NaOH alkaline processing liquid 80ml of concentration 30% and the ethanol 180ml of concentration 95%, stirred 3 hours; And then add the monochloroacetic acid alcoholic solution 100ml of concentration 30% therein, under 50 ℃, stirred 2 hours; Take out viscose rayon then, put into the ethanol of concentration 80%, use in the hydrochloric acid of concentration 20% and viscose rayon, make its pH value reach 6.5-7.5; With the washing with alcohol viscose rayon of concentration 75%, the sodium chloride content in viscose rayon is less than 1%; In sterilizing room, viscose rayon is carried out dried at last.
Embodiment 3
Get pretreated sky silk fabrics 20 grams and place continuous rotating reactor, add the NaOH alkaline processing liquid 60ml of concentration 50% and the ethanol 140ml of concentration 95%, stirred 3 hours; And then add the monochloroacetic acid alcoholic solution 150ml of concentration 50% therein, under 40-50 ℃, stirred 3 hours; Take out a day silk fabrics then, put into the ethanol of concentration 80%,, make its pH value reach 6.5-7.5 with in the hydrochloric acid of concentration 10% and sky silk fabrics; With the washing with alcohol sky silk fabrics of concentration 75%, the sodium chloride content in the sky silk fabrics is less than 1%; In sterilizing room, the sky silk fabrics is carried out dried at last.
The present invention also provides a kind of preparation method of medical hemostasis anti-adhesive irrigation solution, and this method is for to be dissolved in etherified cellulose and sodium chloride in the water for injection according to following percentage by weight;
Etherified cellulose: 0.5%-10%;
Sodium chloride: 0.6-1.0%;
Water for injection: 89%-98.9%.
In order to set forth technique scheme in further detail, be illustrated below by several concrete examples.
Embodiment 4
With percentage by weight is that 6% viscose fabric is dissolved in the water for injection, forms first solution; With percentage by weight is that 0.6% sodium chloride is dissolved in the water for injection, forms second solution; After first solution and the mixing of second solution, add water for injection again, make the weight percent of water for injection reach 93.4%; At last, sterile filling obtains finished product.
Embodiment 5
With percentage by weight is that 0.9% sodium chloride is dissolved in the water for injection, forms first solution; With percentage by weight is that 1% sky silk fabrics joins in first solution, stirs; In first solution, add water for injection again, make the percentage by weight of water for injection reach 98.1%; At last, sterile filling obtains finished product.
The mechanism of action of the medical hemostatic non-viscous material of the present invention's preparation comprises: 1) biological iris action; 2) hemostasis reduces tissue fluid and oozes out; 3) alleviate fibrin deposition; 4) promote tissue repair; 5) antiinflammatory action; 6) reduce local organization cell TGF-β
1Expression.Prove through a series of toxicological experiment results, the medical hemostatic non-viscous material of the present invention's preparation has no side effect, to skin and mucosa nonirritant, do not produce immunizing antigen reaction and heat source response in vivo, not haemolysis, do not have mutagenicity and do not have the lethal mutation effect, but degradation in vivo also is absorbed by the body, and excrete by metabolic system, is that the good new body of a kind of histocompatibility is implanted into biomaterial.
The present invention uses synthesized degradable, has the good biological intermiscibility, nontoxic, the viscose rayon that has no side effect or day silk after chemical modification as the new material of medical hemostasis anti-adhesive, this novel adherence preventing material has good water solublity, can do various ways such as film forming, powder, fabric, fiber and flushing liquor.
Above-described specific embodiment further describes purpose of the present invention, technical scheme and beneficial effect.Will be appreciated that above said content is the specific embodiment of the present invention only, is not limited to the present invention.All within essence of the present invention and ultimate principle, any modification of being made, be equal to replacement, improvement etc., all should be included within protection scope of the present invention.
Claims (7)
1. the preparation method of a medical hemostatic non-viscous material is characterized in that, described method comprises:
With a pretreated viscose rayon or a day silk is raw material, and described raw material is carried out activation processing with NaOH alkaline processing liquid and ethanol;
Carrying out etherificate with the raw material of a haloalkyl acid after to activation processing handles;
With in ethanol and the hydrochloric acid and the raw material of etherificate after handling;
With the raw material after the washing with alcohol neutralisation treatment, and to the washing after raw material carry out dried.
2. the preparation method of medical hemostatic non-viscous material as claimed in claim 1 is characterized in that, the concentration of described NaOH alkaline processing liquid is 10%-50%, and the time of described activation processing is 1-3 hour, and bath raio is 1: 5-20.
3. the preparation method of medical hemostatic non-viscous material as claimed in claim 1 is characterized in that, the time that described etherificate is handled is 2-6 hour, and temperature is a room temperature-70 ℃, and bath raio is 1: 5-20.
4. the preparation method of medical hemostatic non-viscous material as claimed in claim 1 is characterized in that, described concentration of ethanol is 70%-95%.
5. the preparation method of a medical hemostasis anti-adhesive irrigation solution is characterized in that, described method is for to be dissolved in etherified cellulose and sodium chloride in the water for injection according to following percentage by weight;
Etherified cellulose: 0.5%-10%;
Sodium chloride: 0.6-1.0%;
Water for injection: 89%-98.9%.
6. the preparation method of medical hemostasis anti-adhesive irrigation solution as claimed in claim 5 is characterized in that, described etherified cellulose and sodium chloride is specifically comprised according to the step that following percentage by weight is dissolved in the water for injection:
Etherified cellulose is dissolved in water for injection, forms first solution;
Sodium chloride is dissolved in water for injection, forms second solution;
Described first solution and second solution are mixed, and add water for injection again.
7. the preparation method of medical hemostasis anti-adhesive irrigation solution as claimed in claim 5 is characterized in that, described etherified cellulose and sodium chloride is specifically comprised according to the step that following percentage by weight is dissolved in the water for injection:
Sodium chloride is dissolved in the water for injection, forms first solution;
Etherified cellulose is joined in described first solution, stir, and add water for injection again.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103627009A (en) * | 2013-01-14 | 2014-03-12 | 贵州金玖生物技术有限公司 | Preparation method for flushing fluid for operations |
| CN105148328A (en) * | 2015-08-29 | 2015-12-16 | 北京诺康达医药科技有限公司 | Medical tissue protecting and cleaning fluid and preparation method and application thereof |
| CN106265718A (en) * | 2016-08-17 | 2017-01-04 | 贵州金玖生物技术有限公司 | Surgical irrigating fluid and preparation method thereof |
| CN109125795A (en) * | 2018-10-18 | 2019-01-04 | 赛克赛斯生物科技股份有限公司 | A kind of polysaccharide hemostatic composition and the preparation method and application thereof |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047976A (en) * | 1989-06-12 | 1990-12-26 | 湖南省衡阳卫生材料厂 | A kind of improvement of hemostatic gauze production method |
| CN1201696A (en) * | 1998-04-30 | 1998-12-16 | 天津市快健高新技术研究所 | Preparation of nonadhesive dressing bactericidal and hemostatic |
| CN1286329A (en) * | 1999-08-30 | 2001-03-07 | 北京纺织科学研究所 | Water-soluble staltic cellulose fibre and its preparing process |
| CN1839875A (en) * | 2006-01-27 | 2006-10-04 | 刘万顺 | Surgical flush fluid and its preparing process and application |
| CN1850108A (en) * | 2006-05-12 | 2006-10-25 | 胡军 | Medical hemostasis anti-adhesive irrigation solution |
| CN101011606A (en) * | 2005-12-26 | 2007-08-08 | 沈晶 | Anti-sticking flush fluid |
| CN101259137A (en) * | 2007-03-09 | 2008-09-10 | 徐州市海尔滋生物工程化学制品有限公司 | Instant matched medical styptic anti-adhesive flush fluid |
| CN101491688A (en) * | 2008-01-23 | 2009-07-29 | 王学洲 | Soluble stanching gauze and preparation method thereof |
-
2010
- 2010-09-28 CN CN2010102948392A patent/CN101961505A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1047976A (en) * | 1989-06-12 | 1990-12-26 | 湖南省衡阳卫生材料厂 | A kind of improvement of hemostatic gauze production method |
| CN1201696A (en) * | 1998-04-30 | 1998-12-16 | 天津市快健高新技术研究所 | Preparation of nonadhesive dressing bactericidal and hemostatic |
| CN1286329A (en) * | 1999-08-30 | 2001-03-07 | 北京纺织科学研究所 | Water-soluble staltic cellulose fibre and its preparing process |
| CN101011606A (en) * | 2005-12-26 | 2007-08-08 | 沈晶 | Anti-sticking flush fluid |
| CN1839875A (en) * | 2006-01-27 | 2006-10-04 | 刘万顺 | Surgical flush fluid and its preparing process and application |
| CN1850108A (en) * | 2006-05-12 | 2006-10-25 | 胡军 | Medical hemostasis anti-adhesive irrigation solution |
| CN101259137A (en) * | 2007-03-09 | 2008-09-10 | 徐州市海尔滋生物工程化学制品有限公司 | Instant matched medical styptic anti-adhesive flush fluid |
| CN101491688A (en) * | 2008-01-23 | 2009-07-29 | 王学洲 | Soluble stanching gauze and preparation method thereof |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103627009A (en) * | 2013-01-14 | 2014-03-12 | 贵州金玖生物技术有限公司 | Preparation method for flushing fluid for operations |
| CN105148328A (en) * | 2015-08-29 | 2015-12-16 | 北京诺康达医药科技有限公司 | Medical tissue protecting and cleaning fluid and preparation method and application thereof |
| CN105148328B (en) * | 2015-08-29 | 2018-01-26 | 北京诺康达医药科技有限公司 | A kind of medical tissue protection cleaning fluid and its preparation method and application |
| CN106265718A (en) * | 2016-08-17 | 2017-01-04 | 贵州金玖生物技术有限公司 | Surgical irrigating fluid and preparation method thereof |
| CN109125795A (en) * | 2018-10-18 | 2019-01-04 | 赛克赛斯生物科技股份有限公司 | A kind of polysaccharide hemostatic composition and the preparation method and application thereof |
| CN109125795B (en) * | 2018-10-18 | 2021-06-15 | 赛克赛斯生物科技股份有限公司 | Polysaccharide hemostatic composition and preparation method and application thereof |
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Application publication date: 20110202 |