CN106913899A - Plant polyose styptic sponge is prepared using secondary freezing - Google Patents
Plant polyose styptic sponge is prepared using secondary freezing Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/046—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical & Material Sciences (AREA)
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- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Materials For Medical Uses (AREA)
Abstract
The present invention discloses a kind of absorbable hemostatic sponge being made using secondary freezing, and following composition is included according to parts by weight：1 ~ 10 part of the starch material of plant origin, 0.05 ~ 6 part of plasticizer, 0.05 ~ 5 part of thickener, described styptic sponge preparation method are as follows：1）Prepare solution：Take starch and be prepared into starch aqueous suspension；2）At 60 ~ 80 DEG C, by starch gelatinization, the time is 0.5 ~ 2h；3）Addition auxiliary agent：Addition thickener；4）Pre-freeze shaping：Pre-freeze 1h ~ 24h in 90 DEG C ~ 10 DEG C of refrigerating chamber, takes out to be placed in room temperature afterwards and thaws, and sponge semi-finished product are obtained；5）Secondary freeze forming：Plasticizer is added, it is under normal temperature that semi-finished product dispersed with stirring is uniform, it is molded in injection silica gel mould, pre-freeze 1h ~ 24h in 90 DEG C ~ 10 DEG C of refrigerating chamber is inserted again；6）It is lyophilized.Starch hemostatic sponge of the invention can be used for the hemostasis of body surface and wound healing, with easy to use, anthemorrhagic speed is fast, excellent adsorption, it be raw material to use plant polyose, can resolve into monose by body and absorbs and degrade, non-animal derived, safely and effectively.
Description
Technical field
The present invention relates to a kind of absorption that can degrade in vivo being made using secondary freezing plant polyose styptic sponge and
Its preparation method, belongs to medical material tech field.
Background technology
Biodegradable material is just causing the more and more extensive interest of people, especially in pharmaceutical sanitary field, raw nothing
Degradable medical material has obtained Devoting Major Efforts To Developing, is widely used in the neck such as organizational project, internal suture, surgery bonesetting material
Domain.Degradable biological medical material is typically all nontoxic to human body, is absorbed or excluded after voluntarily decomposing in vivo
In vitro.
In surgical operation, bleeding is effectively reduced, operating time can be shortened, equally there is material impact to Rehabilitation.
Medical sthptic sponge is one of current hemostatic material in wide clinical application, and styptic sponge in the market is mainly including bright
Gelatin sponge, chitosan sponge, human-like collagen class and starch styptic sponge.
The characteristics of gelfoam is poor hydrophily, and Engorged quantity is small, and adhesiveness is poor, it is easy to come off, and easily causes wound
Infection；And gelatin source and the collagen extract of animal, containing foreign protei, easily cause allergic reaction, can clinically cause
The symptoms such as heating.
Chitosan sponge then has an allergic reaction, induces bad similar with aminoglycoside medicaments of thrombophlebitis
Reaction, such as conjunctival congestion, Hearing, facial numbness, blurred vision, the microcirculation disorder of pain nervous system and tissue
Hypoxic-ischemic etc. is showed.
Human-like collagen class is animal sources, is foreign protei, and human body absorbs slow to it, and clinical signs are patient's mistake
Quick reaction, slow and wound infection the complication of wound healing, therefore clinically using by great limitation.
Starch, as a kind of plant polyose material, is one of most abundant renewable resource of nature, with good life
Thing compatibility and degradability, have no toxic side effect, nonirritant, metabolic mechanism clearly, will not in vivo deposit and cause inflammation,
Can be fully absorbed by human body, the advantage of the product totally nontoxic after decomposition is the desirable feedstock for preparing Absorbable hemostatic material,
Biomedical sector has wide application scenario.
Then the starch sponge of in the market is generally modified starch sponges, using physics or the method for chemical modification to starch
It is modified, then prepares styptic sponge using Vacuum Freezing ＆ Drying Technology.
But similar starch sponge remains some problems.Firstly, since freezing dry process, result in starch sponge
Viscosity is low, the gel poor adhesion formed after water suction, it is impossible to effective viscosity closure is produced to damaged tissue, blood vessel, thus
Influence the effect of hemostasis.Secondly, water imbibition is not strong enough, and the speed of water suction is slower, and bleeding stopping period is long, and haemostatic effect is not good enough.3rd,
In freezing dry process, the sponge quality of formation is stiff, curls easily rupturable, and the space of formation is uneven, influence water suction effect
Really.4th, common starch sponge in mold process is built, using the pallet of stainless steel, because of internal stress hold by the sponge of formation
Easily ftracture, influence the overall appearance of product.
The content of the invention
The invention aims to the medical sponge for solving the problems, such as to be made of starch in the prior art, there is provided
A kind of absorbable hemostatic sponge being made using secondary freezing and its production and use.
To achieve these goals, the technical solution adopted by the present invention is：
The absorbable hemostatic sponge being made using secondary freezing, following composition is included according to parts by weight：Plant origin
1~10 part of starch material, 0.05~6 part of plasticizer, 0.05~5 part of thickener, described styptic sponge preparation method is as follows：
1) solution is prepared：Take starch and be prepared into starch aqueous suspension, starch is 1 with the w/v of water:20~1:40；
2) at 60~80 DEG C, by starch gelatinization, the time is 0.5~2h；
3) auxiliary agent is added：Addition thickener；
4) a pre-freeze shaping：Pre-freeze 1h~24h in -90 DEG C~-10 DEG C of refrigerating chamber, takes out be placed in solution in room temperature afterwards
Freeze, sponge semi-finished product are obtained；
5) secondary freeze forming：Add plasticizer, it is under normal temperature that semi-finished product dispersed with stirring is uniform, in injection silica gel mould into
Type, inserts pre-freeze 1h~24h in -90 DEG C~-10 DEG C of refrigerating chamber again；
6) freeze：By step 5) in sponge semi-finished product be put into vacuum freeze drier, the sponge semi-finished product is existed
Between -40 DEG C~+50 DEG C of temperature, vacuum be more than 12h less than freeze-drying, total time under conditions of 100Pa, is carried out.
Described starch material is selected from farina, water caltrop starch, starch from sweet potato, tapioca, green starch, lotus seeds
Converted starch and its various shallow lakes of starch, cornstarch and thatch reality starch and its physical modification, chemical modification and its biological degeneration
One kind in powder derivative.
Described plasticizer be selected from polyethylene glycol, glycerine, propane diols, pentaerythrite, maltitol, mannitol and they
Polymer at least one.
Described thickener be selected from sodium carboxymethylcellulose and its derivative, hydroxypropyl cellulose, hydroxyethyl cellulose and
One kind in its derivative, hydroxybutyl cellulose and its derivative, hydroxyethyl ethylcellulose and its derivative.
Operation principle of the invention is as follows：After starch gelatinization, plasticizer and thickener are added, a freeze thawing is into equal spin coating
Slurry, is uniformly dispersed, secondary freeze forming, then is made by freeze-drying.
The present invention has the following technical effect that：
1) it is safe and reliable using plant polyose as raw material, non-animal source or people source, without anaphylaxis；
2) it is prepared using secondary freezing, uniform rubber cement can be formed, in moisture of the sponge in blood is absorbed
When, the hydrogel structure of uniqueness can be formed, play closure blutpunkte and the effect of preventing adhesion；In order to improve shape after styptic sponge absorbs water
Into the adsorptivity of hydrogel, thickener is added, this thickener is cellulose family, high viscosity, with strong hygroscopicity, green
Safety；The crackle produced to overcome stress concentration of the sponge in refrigerating process and fracture, using flexible glue mould, and two
The demoulding is carried out after secondary freeze forming, and is vacuum dried；While secondary freezing ensures that sample bottom pattern makes moderate progress
The uniformity of the planarization of sample surfaces and the size in internal aperture is improved, the haemostatic effect of sponge is improved.
Absorbable hemostatic sponge of the invention, article shape is white softness sponge.Product is used for clinical surgery operation, outer
The local hemostasis and post-operation adhesion preventing of wound are used.This product is applied to the flesh tissue surface of a wound and various suitable for surgical procedures
The hemostasis in the bleeding area of body surface wound.
Brief description of the drawings
Fig. 1 is the electron scanning micrograph of styptic sponge A sections.
Fig. 2 is the electron scanning micrograph of styptic sponge B sections.
Fig. 3 is the electron scanning micrograph of styptic sponge C sections.
Fig. 4 is the electron scanning micrograph of styptic sponge D sections.
Specific embodiment
Embodiment 1
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, includes as follows according to parts by weight
Composition：
Farina：1 part
Sodium carboxymethylcellulose：0.05 part
Glycerine：0.05 part.
The medical starch absorbable hemostatic sponge preparation method of the present embodiment is as follows：
1) solution is prepared：Take starch and be prepared into starch aqueous suspension, starch is 1 with the w/v of water:20；
2) at 60 DEG C, by starch gelatinization, the time is 2h；
3) auxiliary agent is added：Addition thickener；
4) a pre-freeze shaping：Pre-freeze 1h in -90 DEG C of refrigerating chamber, takes out to be placed in room temperature afterwards and thaws, and sponge half is obtained
Finished product；
5) secondary freeze forming：Add plasticizer, it is under normal temperature that semi-finished product dispersed with stirring is uniform, in injection silica gel mould into
Type, inserts pre-freeze 1h in -90 DEG C of refrigerating chamber again；
6) freeze：By step 5) in sponge semi-finished product be put into vacuum freeze drier, the sponge semi-finished product is existed
Between -40 DEG C~+50 DEG C of temperature, vacuum be more than 12h less than freeze-drying, total time under conditions of 100Pa, is carried out.Obtain
Styptic sponge A.
Embodiment 2
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, includes as follows according to parts by weight
Composition：
Tapioca：10 parts
Sodium carboxymethylcellulose：5 parts
Glycerine：6 parts.
The medical starch absorbable hemostatic sponge preparation method of the present embodiment is as follows：
1) solution is prepared：Take starch and be prepared into starch aqueous suspension, starch is 1 with the w/v of water:40；
2) at 80 DEG C, by starch gelatinization, the time is 0.5h；
3) auxiliary agent is added：Addition thickener；
4) a pre-freeze shaping：Pre-freeze 24h in -10 DEG C of refrigerating chamber, takes out to be placed in room temperature afterwards and thaws, and sponge half is obtained
Finished product；
5) secondary freeze forming：Add plasticizer, it is under normal temperature that semi-finished product dispersed with stirring is uniform, in injection silica gel mould into
Type, inserts pre-freeze 24h in -10 DEG C of refrigerating chamber again；
6) freeze：By step 5) in sponge semi-finished product be put into vacuum freeze drier, the sponge semi-finished product is existed
Between -40 DEG C~+50 DEG C of temperature, vacuum be more than 12h less than freeze-drying, total time under conditions of 100Pa, is carried out.Obtain
Styptic sponge B.
Embodiment 3
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, includes as follows according to parts by weight
Composition：
Cornstarch：6 parts
Sodium carboxymethylcellulose：1 part
Glycerine：1 part.
The medical starch absorbable hemostatic sponge preparation method of the present embodiment is as follows：
1) solution is prepared：Take starch and be prepared into starch aqueous suspension, starch is 1 with the w/v of water:30；
2) at 70 DEG C, by starch gelatinization, the time is 1h；
3) auxiliary agent is added：Addition thickener；
4) a pre-freeze shaping：Pre-freeze 12h in -50 DEG C of refrigerating chamber, takes out to be placed in room temperature afterwards and thaws, and sponge half is obtained
Finished product；
5) secondary freeze forming：Add plasticizer, it is under normal temperature that semi-finished product dispersed with stirring is uniform, in injection silica gel mould into
Type, inserts pre-freeze 12h in -50 DEG C of refrigerating chamber again；
6) freeze：By step 5) in sponge semi-finished product be put into vacuum freeze drier, the sponge semi-finished product is existed
Between -40 DEG C~+50 DEG C of temperature, vacuum be more than 12h less than freeze-drying, total time under conditions of 100Pa, is carried out.Obtain
Styptic sponge C.
Embodiment 4
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, includes as follows according to parts by weight
Composition：
Thatch reality starch：2 parts
Sodium carboxymethylcellulose：0.1 part
Polyethylene glycol：0.1 part.
Preparation method is with embodiment 1.Obtain styptic sponge D.
Embodiment 5
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Lotus seed starch：3 parts
Sodium carboxymethylcellulose：1.5 parts
Glycerine：1.5 parts.
Preparation method is with embodiment 2.
Embodiment 6
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：4 parts
Hydroxypropyl cellulose：2 parts
Glycerine：2 parts.
Preparation method is with embodiment 3.
Embodiment 7
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：5 parts
Hydroxyethyl cellulose：2.5 parts
Glycerine：2.5 parts.
Preparation method is with embodiment 1.
Embodiment 8
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：6 parts
Hydroxybutyl cellulose：3 parts
Glycerine：3 parts.
Preparation method is with embodiment 2.
Embodiment 9
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：7 parts
Hydroxyethyl ethylcellulose：3.5 parts
Glycerine：3.5 parts.
Preparation method is with embodiment 3.
Embodiment 10
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：8 parts
Sodium carboxymethylcellulose：4 parts
Polyethylene glycol：4 parts.
Preparation method is with embodiment 1.
Embodiment 11
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：9 parts
Sodium carboxymethylcellulose：4.5 parts
Propane diols：4.5 parts.
Preparation method is with embodiment 2.
Embodiment 12
The absorbable hemostatic sponge that the secondary freezing of utilization of the present embodiment is made, according to parts by weight include it is following into
Point：
Farina：10 parts
Sodium carboxymethylcellulose：5 parts
Pentaerythrite：5 parts.
Preparation method is with embodiment 3.
The zoopery of embodiment 13
Purpose：By observation, evaluate haemostatic effect of the styptic sponge to the piggy local skin surface of a wound.
Method：Using Experimental Miniature Pig 12, the about 2-3 months at age are big, and body weight is 10kg or so, and male and female are not limited, by moving
Thing cultivation center provides.Animal is divided into hemostatic gauze control group and styptic sponge group according to randomization.Little Bai pigs are tested
Preceding 3d ad libs.Test 8% sodium sulfide solution removal back wools of preceding 1d.After 24h, in preserved skin area, 70% ethanol disinfection,
10% hydration chloric acid intraperitoneal injection of anesthesia (1-1.5mL/kg).With surgical scissors and tweezers, in each pig back linea vertebralis both sides
6 a diameter of full thick-layer skins of 1.5 × 1.5cm are cut off, hemostatic gauze and styptic sponge is applied respectively on the bleeding surface of a wound, and
Apply and tiled on the surface of a wound of styptic sponge upper gauze, about 30s opens gauze observation bleeding, observes once within every 30 seconds later,
Observation records bleeding stopping period to not bleeding.By with the fertile biology wound-healing marine sponge control group of Jiangsu enlightening be compared, evaluate
Its haemostatic effect.
It is seen from the above data that the hemostasis of the absorbable hemostatic sponge being made using secondary freezing of the invention
Effect is all fine.
Embodiment 5 compares the product of embodiment 1-3 with like product
Claims (4)
1. the absorbable hemostatic sponge being made using secondary freezing, it is characterised in that according to parts by weight bag
Include following composition：1 ~ 10 part of the starch material of plant origin, 0.05 ~ 6 part of plasticizer, 0.05 ~ 5 part of thickener, it is described
Styptic sponge preparation method is as follows：
1）Prepare solution：Take starch and be prepared into starch aqueous suspension, starch is 1 with the w/v of water:20~1:40；
2）At 60 ~ 80 DEG C, by starch gelatinization, the time is 0.5 ~ 2h；
3）Addition auxiliary agent：Addition thickener；
4）Pre-freeze shaping：Pre-freeze 1h ~ 24h in -90 DEG C ~ -10 DEG C of refrigerating chamber, takes out to be placed in room temperature afterwards and thaws, and is obtained
Sponge semi-finished product；
5）Secondary freeze forming：Plasticizer is added, it is under normal temperature that semi-finished product dispersed with stirring is uniform, it is molded in injection silica gel mould,
Pre-freeze 1h ~ 24h in -90 DEG C ~ -10 DEG C of refrigerating chamber is inserted again；
6）It is lyophilized：By step 5）In sponge semi-finished product be put into vacuum freeze drier, make the sponge semi-finished product temperature-
Between 40 DEG C ~+50 DEG C, vacuum be more than 12h less than freeze-drying, total time under conditions of 100Pa, is carried out.
2. absorbable hemostatic sponge according to claim 1, it is characterised in that described starch material forms sediment selected from potato
Powder, water caltrop starch, starch from sweet potato, tapioca, green starch, lotus seed starch, cornstarch and thatch reality starch and its physics become
The combination of one or more in the converted starch and its various starch derivatives of property, chemical modification and its biological degeneration.
3. absorbable hemostatic sponge according to claim 1, it is characterised in that described plasticizer be selected from polyethylene glycol,
At least one in glycerine, propane diols, pentaerythrite, maltitol, mannitol and their polymer.
4. absorbable hemostatic sponge according to claim 1, it is characterised in that described thickener is selected from carboxymethyl cellulose
Plain sodium and its derivative, hydroxypropyl cellulose, hydroxyethyl cellulose and its derivative, hydroxybutyl cellulose and its derivative, hydroxyl
One kind in hydroxyethyl ethyl cellulose and its derivative.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710280874.0A CN106913899A (en) | 2017-04-26 | 2017-04-26 | Plant polyose styptic sponge is prepared using secondary freezing |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710280874.0A CN106913899A (en) | 2017-04-26 | 2017-04-26 | Plant polyose styptic sponge is prepared using secondary freezing |
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| Publication Number | Publication Date |
|---|---|
| CN106913899A true CN106913899A (en) | 2017-07-04 |
Family
ID=59567610
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710280874.0A Pending CN106913899A (en) | 2017-04-26 | 2017-04-26 | Plant polyose styptic sponge is prepared using secondary freezing |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200330A (en) * | 2018-08-06 | 2019-01-15 | 福建农林大学 | A kind of lotus seed starch-hydrophilic gel composite sponge and preparation method thereof |
| CN111228562A (en) * | 2020-03-26 | 2020-06-05 | 江苏德威兰医疗器械股份有限公司 | Starch hemostatic sponge and preparation method and application thereof |
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| CN101455857A (en) * | 2007-12-11 | 2009-06-17 | 美国淀粉医疗公司 | Biocompatibility modified starch sponges |
| CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
| CN104623720A (en) * | 2015-02-04 | 2015-05-20 | 北京爱特康科贸有限责任公司 | Starch-based hemostasis sponge and preparation method of hemostasis sponge |
| WO2015187103A1 (en) * | 2014-05-21 | 2015-12-10 | Punyanitya Sittiporn | Surgical hemostatic based rice starch |
| CN106421884A (en) * | 2016-12-12 | 2017-02-22 | 西北大学 | Method for preparing hemostatic sponge by two-step freezing method |
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2017
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Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101455857A (en) * | 2007-12-11 | 2009-06-17 | 美国淀粉医疗公司 | Biocompatibility modified starch sponges |
| CN101485897A (en) * | 2008-01-14 | 2009-07-22 | 纪欣 | Biocompatible hemostatic, antiblocking, healing-promoting and surgical wound-closing modified starch material |
| WO2015187103A1 (en) * | 2014-05-21 | 2015-12-10 | Punyanitya Sittiporn | Surgical hemostatic based rice starch |
| CN104623720A (en) * | 2015-02-04 | 2015-05-20 | 北京爱特康科贸有限责任公司 | Starch-based hemostasis sponge and preparation method of hemostasis sponge |
| CN106421884A (en) * | 2016-12-12 | 2017-02-22 | 西北大学 | Method for preparing hemostatic sponge by two-step freezing method |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109200330A (en) * | 2018-08-06 | 2019-01-15 | 福建农林大学 | A kind of lotus seed starch-hydrophilic gel composite sponge and preparation method thereof |
| CN109200330B (en) * | 2018-08-06 | 2021-05-25 | 福建农林大学 | Lotus seed starch-hydrophilic gel composite sponge and preparation method thereof |
| CN111228562A (en) * | 2020-03-26 | 2020-06-05 | 江苏德威兰医疗器械股份有限公司 | Starch hemostatic sponge and preparation method and application thereof |
| CN111228562B (en) * | 2020-03-26 | 2022-03-15 | 江苏德威兰医疗器械股份有限公司 | Starch hemostatic sponge and preparation method and application thereof |
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Application publication date: 20170704 |