CN106955370A - Composite starch styptic powder - Google Patents
Composite starch styptic powder Download PDFInfo
- Publication number
- CN106955370A CN106955370A CN201710072673.1A CN201710072673A CN106955370A CN 106955370 A CN106955370 A CN 106955370A CN 201710072673 A CN201710072673 A CN 201710072673A CN 106955370 A CN106955370 A CN 106955370A
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- CN
- China
- Prior art keywords
- farina
- emulsifying agent
- dispersant
- styptic powder
- blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0042—Materials resorbable by the body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/001—Use of materials characterised by their function or physical properties
- A61L24/0036—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
- A61L24/08—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/04—Materials for stopping bleeding
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- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention provides a kind of composite starch styptic powder, it is made up using one kind in purified water, farina, sodium alginate and sodium carboxymethylcellulose, emulsifying agent and dispersant of emulsifying raw material；Described emulsifying agent is selected from Span and tween；Described dispersant is selected from paraffin or vegetable oil.The present invention has the following technical effect that：The starch hemostatic material of the present invention, is to be extracted from plant amylum, when polysaccharide hemostasis granules are placed on the bleeding surface of a wound, moisture in the molecule absorption blood of particle, and the visible component in blood is gathered in particle surface, a kind of gelatinous mixture is formed, the effect stopped blooding in time is reached；Accelerate the activation of the intrinsic coagulation factor simultaneously, shorten the clotting time, form local sludged blood, anastalsis is completed within tens of seconds.
Description
Technical field
The present invention relates to a kind of composite starch styptic powder, belong to medical applications technical field.
Background technology
Hemostasis plays particularly important effect in surgical operation, occur because amount of bleeding is excessive it is a series of it is postoperative simultaneously
Disease is sent out, the work difficulty of doctor is not only increased, also causes patient in art or postoperative assume responsibility for very big risk.This is allowed for
One is that the topical hemostatic agent of class arises at the historic moment.At present, the hemostatic material of in the market mainly has gelatin class, collagen class, oxygen
Cellulose class, regenerated oxidised cellulose class, spherex class.Wherein gelatin class, collagen class product are due to using animal
Prepared by the raw material in source, soak time length, tissue inflammatory reactivity are high；Oxycellulose class and regenerated oxidised cellulose class be with
Plant cellulose is raw material, although tissue reaction is low, do not find complication, but it is long to there is bleeding stopping period, swift and violent to bleeding
Person's effect is poor, is not suitable for separately as hemostatic material, and loosely organized, to the poor adhesion of blutpunkte, has and causes the bleeding again can
Energy.The hemostatic material of spherex class is using farina as raw material, and dry spherex absorbs rapidly the moisture in blood,
Make the condensing hemostasis of blood, can just stop blooding in tens seconds, due to being reacted by raw material inorganization of plant amylum, can be obviously promoted
Organization healing, degradation time is short, easy to use, and forms gel in hemostasis and be more easy to stick on wound, as at present more
Outstanding topical hemostatic agent.
The styptic powder of starch in the market is mainly Arista micropore polysaccharide styptic powders produced in USA.Although
Haemostatic effect is excellent, but first is epichlorohydrin due to its crosslinking agent, and potential toxicant can be discharged when it is degraded；The
Two water absorption rates are nor very high so that haemostatic effect could be improved；3rd price is too high so that its utilization rate is received
Limitation.Document " preparing hemostatic material method using farina " (hygiene medical treatment is equipped, in March, 2014, the 3rd phase of volume 35,
23-25), using farina as raw material, farina styptic powder is prepared by the method for gelatinization, enzymolysis, crosslinking, should
Technique is more complicated, and the spherex water suction prepared is relatively slow, and using single farina, its haemostatic effect is not good.
The content of the invention
The purpose of the present invention is to overcome the deficiencies in the prior art part there is provided a kind of composite starch styptic powder, passes through and improves
Technology path, simplification of flowsheet is safer without using crosslinking agent, and with degradable biological material sodium alginate or
Its performance of sodium carboxymethylcellulose progress convergent improvement, reduces cost so that suitable while haemostatic effect and security is improved
It is more extensive with area.
The composite starch styptic powder of the present invention, with purified water, farina, sodium alginate and sodium carboxymethylcellulose
One kind, emulsifying agent and dispersant be made up of emulsifying raw material；
Described emulsifying agent is selected from Span and tween；
Described dispersant is selected from paraffin or vegetable oil；
Described farina and the w/v 1g of purified water:(20-80)ml；
Described farina and the w/v 1g of dispersant:(15-75)ml；
Described farina is 1 with the weight ratio of any one in sodium alginate/sodium carboxymethylcellulose:(0.01-
1)；
Described farina and the w/v of emulsifying agent are 1g:(0.5-5)ml；
Span and the volume ratio of tween are 1 in described emulsifying agent:(0.1-10)；
Span and the volume ratio of tween are 1 in described emulsifying agent:1 or 1：1.5.
The preparation method of the composite starch styptic powder of the present invention, comprises the following steps：
1. take starch to add purified water to stir to gelatinization, add sodium carboxymethylcellulose or sodium alginate, and use NaOH
To adjust pH to 7-11；
2. dispersant is added in reaction vessel, adds emulsifying agent；
3. 2. middle reaction 8-24h will be 1. mixed into；
4. separation of material, washing, suction filtration, are dried, grinding, sieve material, are packed, sterilizing.
Sodium alginate is a kind of sodium salt of the polyanionic polysaccharide extracted from natural brown alga, with non-toxic, biological slime
Attached property, biocompatibility and biological degradability, the attachment between styptic powder and tissue can be strengthened by mutually being cooperateed with farina
Power；Sodium carboxymethylcellulose has non-toxic, biocompatibility and biological degradability, and a large amount of anions that can dissociate, with blood
Positively charged iron ion is combined in Lactoferrin, forms brown blob of viscose, capillary breakage is blocked, while blood coagulation can be activated
Factor X II, starts intrinsic coagulation pathway, makes red blood cell, blood platelet rapid aggregation and adhesion, so as to play physiological hemostasis work
With while sodium carboxymethylcellulose can reduce microvascular permeability, greatly reducing oozing for fine lymph vessels and the tissue surface of a wound
Go out, with preferable impervious effect, CMC-Na contains substantial amounts of hydrophilic radical-OH, can provide Moist healing environment for the surface of a wound, enter
And provide hypoxemia slightly sour environment for the surface of a wound, suppress the growth of surface of a wound bacterium, and a variety of growths such as EGF can be promoted
The release of the factor, stimulates germiparity, is conducive to keeping cell viability, promotes wound healing, mutually cooperateed with farina
Anti- be adhered can be played a part of while the healing ability of wound is increased.
The present invention has the following technical effect that：The starch hemostatic material of the present invention, is to be extracted from plant amylum, micropore is more
Sugared hemostasis granules, when being placed on the bleeding surface of a wound, the moisture in the molecule absorption blood of particle, and by the visible component in blood
Particle surface is gathered in, a kind of gelatinous mixture is formed, reaches the effect stopped blooding in time；Accelerate the intrinsic coagulation factor simultaneously
Activation, shorten the clotting time, form local sludged blood, anastalsis is completed within tens of seconds.About three day time, polysaccharide
Grain, can be maltose or glucose by the Amylase Hydrolysis in human body fluid, fully absorb in vivo, absorption process is only
Start after the completion of blood effect, it is local not stay any vestige.Meanwhile, it is free of any ox source, pig source or people's derived components, without immune
Reaction, no allergic reaction, attached effect nontoxic to wound healing is a kind of more outstanding topical hemostatic agent.The scope of application：Respectively
Plant the hemostasis in wound and operation flesh tissue surface of a wound bleeding area.
In addition, the purposes of crosslinking agent is the generationization between the molecule of farina line style in composite microporous crosslinked starch
Key is learned, linear molecule is connected with each other, network structure is formed so that the structure of farina formation micropore, strengthens it
Water imbibition, the effect of the haemostatic effect and composite microporous crosslinked starch of the composite starch styptic powder without crosslinking agent of the invention is near
Seemingly, bleeding stopping period is short, and haemostatic effect is good, although illustrating that the present invention is free of crosslinking agent, haemostatic effect is not affected.
Embodiment
Equipment needed for embodiment and instrument：Mechanical agitator, water-bath, electronic balance, vacuum filtration pump.
Farina in the present invention is existing farina, public by the extensive and profound in meaning star biotechnology Limited Liability in Beijing
Department provides, and article No. is 01-102.
Embodiment 1
The composite starch styptic powder of the present embodiment, preparation method is as follows：
1. take 10g starch to add 200ml purified waters to stir to gelatinization, add 10g sodium carboxymethylcellulose, be used in combination
NaOH adjusts pH to 7.
2. 750ml atoleine is added in reactor, waits to be warming up to 75 DEG C, add 20ml Span 80 and 30ml
The mixture of Tween 80.
3. 2. middle reaction 8h, feeding will be 1. mixed into.
4. absolute ethyl alcohol separation of material is added, upper oil phase of inclining, then with absolute ethyl alcohol repeated washing, suction filtration 3 times, in baking
Dried in case, grinding, sieve material, packaging, sterilizing.
Embodiment 2
The composite starch styptic powder of the present embodiment, preparation method is as follows：
1. take 10g starch to add 800ml purified waters to stir to gelatinization, add 0.1g sodium alginate, and use NaOH
To adjust pH to 9.
2. 150ml vegetable oil is added in reactor, when being warming up to 65 DEG C, adds 2ml Spans 80 and 3ml tweens
80 mixture.
3. 2. middle reaction 16h, feeding will be 1. mixed into.
4. absolute ethyl alcohol separation of material is added, upper oil phase of inclining, then with absolute ethyl alcohol repeated washing, suction filtration 3 times, in baking
Dried in case, grinding, sieve material, packaging, sterilizing.
Embodiment 3
The composite starch styptic powder of the present embodiment, preparation method is as follows：
1. take 10g starch to add 500ml purified waters to stir to gelatinization, add 5g sodium carboxymethylcellulose, be used in combination
NaOH adjusts pH to 11.
2. 500ml vegetable oil is added in reactor, waits to be warming up to 70 DEG C, the Span 80 and 10ml for adding 10ml are told
The mixture of temperature 80.
3. 2. middle reaction 24h, feeding will be 1. mixed into.
4. add absolute ethyl alcohol and ethyl acetate separation of material, upper oil phase of inclining, then with absolute ethyl alcohol repeated washing, take out
Filter 3 times, is dried in baking oven, grinding, sieve material, packaging, sterilizing.
The animal experiment of embodiment 4
Purpose：By observation, evaluating combined starch hemostatic powder to the haemostatic effect of the piggy local skin surface of a wound.
Method：Using Experimental Miniature Pig 12, the about 2-3 months at age are big, and body weight is 10kg or so, and male and female are not limited, by moving
Thing cultivation center is provided.Animal is divided into hemostatic gauze control group and composite microporous starch group according to randomization.Little Bai pigs
3d ad libs before experiment.Preceding 1d is tested with 8% sodium sulfide solution removal back wool.After 24h, in preserved skin area, 70% ethanol
Sterilization, 10% hydration chloric acid intraperitoneal injection of anesthesia (1-1.5mL/kg).With surgical scissors and tweezers, in each pig back linea vertebralis
Both sides cut off 6 a diameter of full thick-layer skins of 1.5 × 1.5cm, applied respectively on the bleeding surface of a wound hemostatic gauze, sprinkle it is compound micro-
Hole crosslinked starch styptic powder and composite starch styptic powder, and sprinkling composite microporous crosslinked starch styptic powder and composite starch hemostasis
Tile upper gauze on the surface of a wound of powder, and about 30s opens gauze observation bleeding, and once, observation is not to going out for observation in every 30 seconds later
Untill blood, bleeding stopping period is recorded.
As can be seen from the above table, the haemostatic effect of the composite starch styptic powder without crosslinking agent and composite microporous crosslinked starch
Effect it is approximate, bleeding stopping period is short, and haemostatic effect is good, although illustrate the present invention without crosslinking agent, haemostatic effect does not have
It is affected.
Embodiment 5 compares embodiment 1-3 product with like product
Claims (3)
1. composite starch styptic powder, it is characterised in that with purified water, farina, sodium alginate and sodium carboxymethylcellulose
In one kind, emulsifying agent and dispersant be made up of emulsifying raw material；
Described emulsifying agent is selected from Span and tween；
Described dispersant is selected from paraffin or vegetable oil；
Described farina and the w/v 1g of purified water:（20-80）ml；
Described farina and the w/v 1g of dispersant:（15-75）ml；
Described farina is 1 with the weight ratio of any one in sodium alginate/sodium carboxymethylcellulose:（0.01-1）；
Described farina and the w/v of emulsifying agent are 1g:(0.5-5)ml；
Span and the volume ratio of tween are 1 in described emulsifying agent:（0.1-10）.
2. composite starch styptic powder according to claim 1, it is characterised in that Span and tween in described emulsifying agent
Volume ratio is 1:1 or 1：1.5.
3. the preparation method of the composite starch styptic powder as described in any one in claim 1-2, it is characterised in that including such as
Lower step：
1. take starch to add purified water to stir to gelatinization, add sodium carboxymethylcellulose or sodium alginate, and adjusted with NaOH
Save pH to 7-11；
2. dispersant is added in reaction vessel, adds emulsifying agent；
3. 2. middle reaction 8-24h will be 1. mixed into；
4. separation of material, washing, suction filtration, are dried, grinding, sieve material, are packed, sterilizing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710072673.1A CN106955370A (en) | 2017-02-10 | 2017-02-10 | Composite starch styptic powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710072673.1A CN106955370A (en) | 2017-02-10 | 2017-02-10 | Composite starch styptic powder |
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| Publication Number | Publication Date |
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| CN106955370A true CN106955370A (en) | 2017-07-18 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710072673.1A Pending CN106955370A (en) | 2017-02-10 | 2017-02-10 | Composite starch styptic powder |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010905A (en) * | 2018-10-10 | 2018-12-18 | 史跃 | A kind of preparation method of multi-functional emergency care of trauma styptic powder |
| CN109498833A (en) * | 2018-12-12 | 2019-03-22 | 济南格莱威医疗科技有限公司 | A kind of Medical absorbable polysaccharide composite material and application thereof |
| CN113912870A (en) * | 2021-11-12 | 2022-01-11 | 重庆联佰博超医疗器械有限公司 | Starch modification method and application |
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| CN103214683A (en) * | 2013-05-17 | 2013-07-24 | 文红梅 | Method for preparing polysaccharide hemostat |
| CN105056283A (en) * | 2015-07-29 | 2015-11-18 | 陕西博与再生医学有限公司 | Preparation method of composite styptic powder |
| CN105268014A (en) * | 2015-11-03 | 2016-01-27 | 重庆联佰博超医疗器械有限公司 | Composite starch hemostatic powder and preparation method |
| CN105617449A (en) * | 2016-03-18 | 2016-06-01 | 烟台正海生物科技股份有限公司 | Multifunctional microporous styptic powder and preparation method thereof |
| CN106377792A (en) * | 2016-09-29 | 2017-02-08 | 江苏华能药业有限公司 | Compound micro-porous cross-linked starch styptic powder |
-
2017
- 2017-02-10 CN CN201710072673.1A patent/CN106955370A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103214683A (en) * | 2013-05-17 | 2013-07-24 | 文红梅 | Method for preparing polysaccharide hemostat |
| CN105056283A (en) * | 2015-07-29 | 2015-11-18 | 陕西博与再生医学有限公司 | Preparation method of composite styptic powder |
| CN105268014A (en) * | 2015-11-03 | 2016-01-27 | 重庆联佰博超医疗器械有限公司 | Composite starch hemostatic powder and preparation method |
| CN105617449A (en) * | 2016-03-18 | 2016-06-01 | 烟台正海生物科技股份有限公司 | Multifunctional microporous styptic powder and preparation method thereof |
| CN106377792A (en) * | 2016-09-29 | 2017-02-08 | 江苏华能药业有限公司 | Compound micro-porous cross-linked starch styptic powder |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109010905A (en) * | 2018-10-10 | 2018-12-18 | 史跃 | A kind of preparation method of multi-functional emergency care of trauma styptic powder |
| CN109498833A (en) * | 2018-12-12 | 2019-03-22 | 济南格莱威医疗科技有限公司 | A kind of Medical absorbable polysaccharide composite material and application thereof |
| CN109498833B (en) * | 2018-12-12 | 2021-05-28 | 济南格莱威医疗科技有限公司 | Medical absorbable polysaccharide composite material and application thereof |
| CN113912870A (en) * | 2021-11-12 | 2022-01-11 | 重庆联佰博超医疗器械有限公司 | Starch modification method and application |
| CN113912870B (en) * | 2021-11-12 | 2024-05-24 | 重庆联佰博超医疗器械有限公司 | Starch modification method and application |
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