CN103627009A - Preparation method for flushing fluid for operations - Google Patents
Preparation method for flushing fluid for operations Download PDFInfo
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- CN103627009A CN103627009A CN201310011118.XA CN201310011118A CN103627009A CN 103627009 A CN103627009 A CN 103627009A CN 201310011118 A CN201310011118 A CN 201310011118A CN 103627009 A CN103627009 A CN 103627009A
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- reaction
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- flushing fluid
- cleaning
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Abstract
A disclosed preparation method for a flushing fluid for operations comprises the following steps: a, selecting plant cellulosic material, putting in a reaction vessel loaded with a concentrated alkali solution, immersing for a period, taking out and centrifuging; b, putting cellulose into an etherification vessel, adding an etherification reagent and stirring for 3 g; c, completing the reaction, cleaning with a cleaning fluid for multiple times; d, performing natural air drying in a clean space, drying at 95 DEG C for 1-3 h; and e, dissolving an intermediate product in a solvent and disinfecting to obtain the flushing fluid. According to the method, the flushing fluid is obtained by performing the alkalization reaction and the etherification reaction on plant cellulose under controllable conditions, then cleaning the residual reaction solution with the organic solvent and dissolving the intermediate product in a solvent; the reaction is uniform, the product is stable and easy to store, and the cleaning fluid is recoverable for reuse and is economic and environment-friendly.
Description
Technical field
The invention belongs to biomedical materials field, relate in particular to a kind of operation by the preparation method of washing fluid.
Background technology
At present for the washing fluid of performing the operation, be mostly physiological saline or single purified water, function singleness, can not antiphlogistic antibacterial, can not stop blooding, consistency is poor, immune effect is poor, can not promote histocyte regeneration etc.Or the washing fluid that makes of chitosan class, this type of washing fluid is because being that animal derived material makes, and biocompatibility is poor, and security risk is larger.This product is after being processed by controllable oxidization by plant cellulose and the miscible a kind of sterile liquid being prepared into of purified water.This product has good adsorptivity and biocompatibility, has wide range of applications.
This product is colourless or micro-yellow liquid.There is certain lubricated, buffer action, can between tissue, form biological barrier.Energy protective tissue biological activity, the activity of protection plasminogen activating factors; Prevent oozing of blood, abirritate, promotes epithelium, wound repair, effectively prevents tissue adhesion.There is very important clinical meaning.
Summary of the invention
Technical problem to be solved by this invention is to provide a kind of and performs the operation with the new preparation process of washing fluid, method adopt plant cellulose under controlled condition by cleaning after residual reaction solution with organic solvent after quaternization, etherification reaction, be dissolved in solvent and obtain, reaction evenly, product is stable easily to be preserved, the recyclable recycling of its scavenging solution, not only economy but also environmental protection.
For solving the problems of the technologies described above, technical scheme of the present invention: the preparation method of washing fluid for operation.The method comprises the steps:
1, get plant cellulose material, put into the reactor that concentrated alkali solution is housed, after immersion for some time, take out, centrifugal.
2, Mierocrystalline cellulose is dropped in etherifying reactor, add etherifying reagent, stir 3 h.
3,, after reacting completely, with scavenging solution, clean for several times.
4, in clean room, naturally dry.The dry 1-3 hour of 95 degree.
5, intermediates are dissolved in to sterilizing in solvent, obtain.
Described operation is with in the preparation method of washing fluid, and described concentrated alkali solution concentration is 10-40%.
Described operation is used in the preparation method of washing fluid, the derivative that etherifying reagent is acetic acid and salt.
Described operation is with in the preparation method of washing fluid, and scavenging solution is volatile nontoxic organic solvent, as alcohols and the aqueous solution thereof.
Described operation is with in the preparation method of washing fluid, and solvent is 0.9% physiological saline, purified water, 5% glucose solution etc.
Described operation is with in the preparation method of washing fluid, and described plant cellulose material mainly contains corn cob, birch bits, and rice husk, bagasse regenerated cellulose fibre and fiber derivative etc., its main component is Mierocrystalline cellulose, xylogen and hemicellulose.
Beneficial effect of the present invention: compare with existing surgical flush fluid, the present invention utilizes the material extensively existing in the Nature as raw material, carries out under controlled condition, and reaction evenly.The product that makes is stable easily to be preserved, and the reaction solution using in reaction process and scavenging solution can reclaim and reuse, not only economy but also environmental protection.Greatly reduce cost.
Operation of the present invention has surgery washing simultaneously, prevents the effect of oozing of blood and prevention postoperative intestinal adhesion with washing fluid, and effective have good adsorptivity and a biocompatibility, and degradable absorbs, and has no side effect.
Embodiment
Embodiment 1
The cotton thread of degreasing bleaching is immersed in the high alkali liquid of 15-35% in proportion, soak approximately 30 min and take out.Liquid caustic soda can be recycled.Linter after immersion claims to flat-plate compressed crusher, with the pressure of 14 MPa, extrudes alkali lye, must alkalize cotton.To alkalize in cotton input etherificate still, and add 15 parts of alcohol and under agitation slowly add monochloroacetic acid spirituous solution, at 30 ℃, 2 h complete, and stir 3 h and obtain etherified cotton after adding at 40 ℃.Add (70%) 120 part of alcohol in etherified cotton, stir 0.5 h, add hydrochloric acid adjust pH to 7.With alcohol, wash twice, leach alcohol, forced air drying at 80 ℃, adds physiological saline by (1-3) after pulverizing: 10 make finished product after mixing.
Embodiment 2
Get in the alkali lye that natural wood pulp cotton immerses 10-30% in proportion and soak 1h.Take out the wood pulp cotton after soaking, with the pressure of 14Mpa, with flat-plate compressed crusher, extrude after alkali lye.Centrifuge dripping, is placed in etherifying reactor, adds ethyl acetate, after 27 ℃ of concussion reaction 2h, takes out, and cleans 3 times 60 ℃ of forced air dryings with 75% ethanol.After pulverizing, add physiological saline by (1-3): 10 make finished product after mixing.
Embodiment 3
Get bamboo pulp cotton, immerse 20-40%NAOH solution soaking 1h, take out, dry.The ratio of being placed in is ethanol and the chloroacetic mixing solutions of 5:1, after concussion reaction 3h, takes out, and with ethanol, cleans 3 times, after 60 ℃ of ancient customs are dry, pulverizes, in (1-3): 10 ratios add glucose solution to mix to make finished product.
Claims (2)
1. perform the operation by a preparation method for washing fluid, its feature comprises the steps:
A, get plant cellulose material, put into the reactor that concentrated alkali solution is housed, take out after soaking for some time, centrifugal.
B, Mierocrystalline cellulose is dropped in etherifying reactor, add etherifying reagent, stir 3 h.
C, react completely after, with scavenging solution, clean for several times.
D, dry.
E, intermediates are dissolved in to sterilizing in solvent, obtain.
2. the preparation method of washing fluid for operation according to claim 1, is characterized in that described scavenging solution is the aqueous solution of ethanol.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310011118.XA CN103627009A (en) | 2013-01-14 | 2013-01-14 | Preparation method for flushing fluid for operations |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201310011118.XA CN103627009A (en) | 2013-01-14 | 2013-01-14 | Preparation method for flushing fluid for operations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103627009A true CN103627009A (en) | 2014-03-12 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201310011118.XA Pending CN103627009A (en) | 2013-01-14 | 2013-01-14 | Preparation method for flushing fluid for operations |
Country Status (1)
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| CN (1) | CN103627009A (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265718A (en) * | 2016-08-17 | 2017-01-04 | 贵州金玖生物技术有限公司 | Surgical irrigating fluid and preparation method thereof |
| CN115634193A (en) * | 2022-10-13 | 2023-01-24 | 贵州金玖生物技术有限公司 | Preparation method of surgical irrigation glue solution, product and application thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961505A (en) * | 2010-09-28 | 2011-02-02 | 北京纺织科学研究所 | Methods for preparing medical anti-adhesion hemostatic material and medical anti-adhesion hemostatic washing fluid |
-
2013
- 2013-01-14 CN CN201310011118.XA patent/CN103627009A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101961505A (en) * | 2010-09-28 | 2011-02-02 | 北京纺织科学研究所 | Methods for preparing medical anti-adhesion hemostatic material and medical anti-adhesion hemostatic washing fluid |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265718A (en) * | 2016-08-17 | 2017-01-04 | 贵州金玖生物技术有限公司 | Surgical irrigating fluid and preparation method thereof |
| CN115634193A (en) * | 2022-10-13 | 2023-01-24 | 贵州金玖生物技术有限公司 | Preparation method of surgical irrigation glue solution, product and application thereof |
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Application publication date: 20140312 |