CN110522952A - A kind of preparation method of medical intervention material hydrophilic lubrication coating - Google Patents
A kind of preparation method of medical intervention material hydrophilic lubrication coating Download PDFInfo
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- CN110522952A CN110522952A CN201910710697.4A CN201910710697A CN110522952A CN 110522952 A CN110522952 A CN 110522952A CN 201910710697 A CN201910710697 A CN 201910710697A CN 110522952 A CN110522952 A CN 110522952A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/04—Macromolecular materials
- A61L29/06—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/08—Materials for coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L29/00—Materials for catheters, medical tubing, cannulae, or endoscopes or for coating catheters
- A61L29/14—Materials characterised by their function or physical properties, e.g. lubricating compositions
- A61L29/16—Biologically active materials, e.g. therapeutic substances
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G81/00—Macromolecular compounds obtained by interreacting polymers in the absence of monomers, e.g. block polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/30—Compounds of undetermined constitution extracted from natural sources, e.g. Aloe Vera
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/408—Virucides, spermicides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/606—Coatings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/18—Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2420/00—Materials or methods for coatings medical devices
- A61L2420/02—Methods for coating medical devices
Abstract
The present invention relates to a kind of preparation methods of medical intervention material hydrophilic lubrication coating, belong to medical material tech field.The present invention is with O2And NH3As working gas, corona treatment is carried out to epoxy resin, surface grafting beardie mucus after treatment, by graft ultra-violet curing on matrix surface, prepare a kind of medical intervention material hydrophilic lubrication coating, contain Misgurnus anguillicaudatus polysaccharides in beardie mucus, the polysaccharide has direct scavenging effect to active oxygen, therefore there is good anti-inflammatory effect, epoxy resin is after corona treatment, so that hydrophily and surface moist are improved, the medical intervention material hydrophilic lubrication coating of preparation has good Hydrophilic lubrication and anti-inflammatory effect；The gas of plasma treatment procedure is the donor for introducing functional group, plasma treated, is introduced on surface as hydroxyl (- OH), amino (- NH2) isopolarity group, then hydrophilic high mol and active group are grafted, the hydrophily of Lai Tigao material surface.
Description
Technical field
The present invention relates to a kind of preparation methods of medical intervention material hydrophilic lubrication coating, belong to medical material technology neck
Domain.
Background technique
Interventional therapy is a kind of new technology for growing rapidly to get up in recent years, it indicates the new page of medical field.
Interventional therapy is under the guiding of the medical imaging equipments such as fluoroscopic machine, angiography machine, CT, B ultrasound, by medical catheter, seal wire etc.
Accurate medical instrument reaches the medical skill that human lesion position carries out diagnosis and local treatment by human vas, stomach tube, urethra
Art.The small wound of 1 ~ 2mm is opened using local anaesthesia and only in human body surface because carrying out interventional therapy, intervention is controlled
Treatment is compared with traditional surgical operation to be haveed many advantages, such as, for example is reduced the difficulty of operation, improved the efficiency performed the operation, mitigate patient
The pain of operation shortens patient's hospital stays and post-operative recovery is fast, especially substantially reduces the expense of hospital and patient's operation.Always
For it, intervention operation be vast sufferer bringing Gospel.Interventional medical device is as the doctor to grow up with interventional therapy
Treat an important branch figure of instrument, the also favor increasingly by numerous researchers of relative project.
In vascular interventional treatment, the effect of interventional guide wire during surgery includes: that guiding catheter through epidermis enters blood vessel；Association
Assistant director of a film or play's pipe selectively enters minute blood vessel branch or other lesion lacunas；Replace the important tool of conduit.Therefore, when seal wire into
Blood vessel and when moving in the blood vessel out, the surface of high-lubricity is it is possible to prevente effectively from plasma protein, blood platelet etc. exist in blood
The adherency of material surface mitigates the damage to haemocyte and vascular wall, reduces the interference moved to blood laminar flow, while can press down
The generation of Coagulation test processed.Although high hydrophobicity and super hydrophilic surface can generate greasy property, due to intervening class device
Tool is directly contacted with body fluid, and body fluid will infiltrate medical instrument.So if it is desired that there is low friction when instrument with contacting in vivo
Power or instrument need to be soaked by body fluid not to be contaminated but, or is the formation of bubble in order to prevent, and high water-wetted surface is more suitable for.
But the outer layer high molecular material for making seal wire is mostly hydrophobic, such as polyurethane (TPU), polyetheramides
(Pebax), full fluorine copolymer (FEP) etc..Therefore seal wire surface is made to reach Hydrophilic lubrication right and wrong by surface hydrophilic modification
Often it is necessary to.
Ideal bio-medical material should have good lubricity and biocompatibility.Due to the process in intervention human body
In, bio-medical material inevitably can generate friction with the tissue of human body or blood vessel, will when this frictional force is larger
Epithelial tissue is caused to damage, the pain of caused patient or sense of burning, while the tissue being damaged also bacterium easy to breed, and
Cause inflammation.Therefore, lubricity is one of highly important performance of intervention material.Lubricity processing is done to intervention material surface,
Material can be made into human body and when body fluid contact becomes quite to lubricate, mitigating the pain of patient to the maximum extent, while can be with
The absorption for efficiently reducing bacterial adhesion and protein is the main path for improving material surface biocompatibility.When intervention material
Material when entering, exiting blood vessel and move in the blood vessel, high-lubricity can inhibit macromolecular such as plasma protein in blood,
The adherency on the surface of the material such as blood platelet reduces the damage to vascular wall and haemocyte, mitigates the disturbance moved to blood laminar flow, together
When can avoid Coagulation test generation.Therefore, very necessary to intervention material progress surface lubrication processing.Coating hydrophilic coating is
Improve the effective means of intervention material greasy property.Hydrophilic superslide coating is made by hydrogel, the biomembrane on similar loach surface,
Dedicated for medical instrument.The coating can adsorb and save moisture, significantly reduce frictional force, have extraordinary lubricating action.
The sense of discomfort of patient can effectively be mitigated and avoid the complication due to caused by mucous membrane and tissue cell insult in insertion process.
Therefore it needs this kind of hydrophilic coating that there is high lubricity, can be improved blood compatibility, reduce the damage to tissue
Wound；Lower coefficient of friction can be kept for a long time.
Summary of the invention
The technical problems to be solved by the invention: for during intervening human body, bio-medical material can not be kept away
It is exempting to generate friction with human body tissue or blood vessel, epithelial tissue will be caused to damage when this frictional force is larger, caused
Patient pain or sense of burning, while the tissue being damaged also bacterium easy to breed, and the problem of cause inflammation, provide one
The preparation method of the medical intervention material hydrophilic lubrication coating of kind.
In order to solve the above technical problems, the technical solution adopted by the present invention is that:
(1) epoxy resin is placed in plasma apparatus, corona treatment is to get pretreatment epoxy resin；
(2) phosphate buffer solution for taking pretreatment epoxy resin, beardie mucus, 0.1mol/L will pre-process epoxy resin, mud
The phosphate buffer solution of loach synovia and 0.1mol/L mix, and after stir process, are rapidly cooled to room temperature to get reaction solution；
(3) reaction solution and deionized water are mixed, carries out dialysis treatment to get dialyzate, dialyzate is placed in freeze drier
In, vacuum freeze drying processing is to get graft；
(4) graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide are taken
Butyl ether, by graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and reactive diluent propylene oxide
Butyl ether mixing, stir process is to get compo；
(5) compo is coated uniformly on medical intervention material surface, is dried to get semi-finished product, semi-finished product is placed in
In ultraviolet light curing apparatus between two ultraviolet lamps, ultraviolet irradiation processing is to get medical intervention material hydrophilic lubrication coating.
Plasma treatment step described in step (1) are as follows: epoxy resin is placed in plasma apparatus, with O2And NH3
It is 100~120Pa in pressure, power is 45~60s of corona treatment under 300~350W as working gas.
Ratio between the phosphate buffer solution of pretreatment epoxy resin, beardie mucus, 0.1mol/L described in step (2)
Example is respectively as follows: according to parts by weight, weighs 20~30 parts of pretreatment epoxy resin, 10~20 parts of beardie mucus, 50~60 respectively
The phosphate buffer solution of part 0.1mol/L.
Stir process step described in step (2) are as follows: the phosphoric acid of epoxy resin, beardie mucus and 0.1mol/L will be pre-processed
Salt buffer solution mixing is 60~100 DEG C in temperature, and mixing speed is that 30~50min is stirred under 150~200r/min.
Dialysis treatment step described in step (3) are as follows: mix reaction solution and deionized water at 1: 100 by volume, in temperature
Degree is dialysis 20 at 4~6 DEG C~for 24 hours.
Vacuum freeze drying processing step described in step (3) are as follows: dialyzate is placed in freeze drier, in temperature
It is 5~8h of vacuum freeze drying at -40~-50 DEG C.
Graft described in step (4), polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, activity are dilute
The ratio between agent epoxy propane butyl ether is released to be respectively as follows: according to parts by weight, weigh respectively 80~100 parts of grafts, 50~
60 parts of polyamide curing agents, 20~40 parts of photoinitiator triaryl sulphur hexafluoro antimonates, 10~12 parts of reactive diluent epoxies
Propane butyl ether.
Stir process step described in step (4) are as follows: by graft, polyamide curing agent, photoinitiator triaryl sulphur
Hexafluoro antimonate and reactive diluent epoxy propane butyl ether mixing, low whipping speed be 300~350r/min under stirring 10~
20min。
Drying process step described in step (5) are as follows: compo is coated uniformly on medical intervention material surface, juxtaposition
It is that 30~40min is dried at 60~70 DEG C in temperature.
Ultraviolet irradiation processing step described in step (5) are as follows: by semi-finished product be placed in ultraviolet light curing apparatus two it is ultraviolet
Between lamp, radiation length is 10~12cm, and dual light shines 3~5min.
The present invention is compared with other methods, and advantageous effects are:
(1) present invention is with O2And NH3As working gas, corona treatment is carried out to epoxy resin, surface after treatment
Grafting beardie mucus prepares a kind of medical intervention material hydrophilic lubrication coating by graft ultra-violet curing on matrix surface,
Contain Misgurnus anguillicaudatus polysaccharides in beardie mucus, is made of a high glycan and oligosaccharides, which has direct scavenging effect to active oxygen,
Therefore there is good anti-inflammatory effect, epoxy resin is after corona treatment, so that hydrophily and surface moist
Improved, the medical intervention material hydrophilic lubrication coating of preparation has good Hydrophilic lubrication and anti-inflammatory effect；
(2) plasma technology of the present invention is a general, effective technology, its important application is surface modification
Or activation, the gas of plasma treatment procedure is the donor for introducing functional group, for example generates amido functional group with ammonia, is passed through
After corona treatment, introduce on surface as hydroxyl (- OH), amino (- NH2) isopolarity group, then hydrophilic high mol with
Active group grafting, the hydrophily of Lai Tigao material surface；
(3) contain Misgurnus anguillicaudatus polysaccharides, SOD and microelement in beardie mucus of the present invention, loach has liver protection except Huang, clearing heat and detoxicating
The effect of, beardie mucus has the active constituent of liver protection effect, and Misgurnus anguillicaudatus polysaccharides can obviously inhibit mouse caused by thioacetamide
Transaminase activity and hepatomegaly in serum can also obviously inhibit Cyklokapren activity and icterus index in serum to increase, and significantly drop
Low liver swelling and bile pent-up have the function of anti-inflammatory, transaminase lowering, except jaundice；K rich in beardie mucus,
The microelements such as Na, Mg, Fe, Zn, Cu, Mn, Se, the wherein content highest of K and Na, Fe, Zn, Mn, Se are intracorporal to biology to exempt from
Epidemic disease system is coordinated and is controlled to organism metabolism function by enzyme system, improved the immunity of body, reach with to connect effect
To antibacterial and antiviral effect；
(4) epoxy resin is a kind of important ultraviolet photo-curing cementing agent material, C-C in epoxide resin polymer chain in the present invention
Key and ehter bond ensure that chemical resistance, epoxy group and hydroxyl access beardie mucus as reflecting point, with ultraviolet
Photocuring activity and good adhesiveness promote its adsorption capacity to metallic substrate surface and polar substances；
(5) ultra-violet curing technology is to belong to chemical method by ultraviolet light-initiated chemical reaction in the present invention, can be in several seconds, number
It is solidified into product in minute, production efficiency can be significantly improved, save production cost, ultra-violet curing belongs to low-temperature setting, thus can
Avoid high temperature on influence caused by thermo-responsive matrix (especially plastic products) (such as deformation, decomposition etc.).
Specific embodiment
Epoxy resin is placed in plasma apparatus, with O2And NH3It is 100~120Pa in pressure as working gas,
Power is 45~60s of corona treatment under 300~350W to get pretreatment epoxy resin；According to parts by weight, it weighs respectively
The phosphate buffer solution of 20~30 parts of pretreatment epoxy resin, 10~20 parts of beardie mucus, 50~60 parts of 0.1mol/L, will be pre-
The phosphate buffer solution mixing for handling epoxy resin, beardie mucus and 0.1mol/L is 60~100 DEG C in temperature, stirring speed
Degree is after stirring 30~50min under 150~200r/min, to be rapidly cooled to room temperature to get reaction solution；It incites somebody to action at 1: 100 by volume
Reaction solution and deionized water mixing, temperature be 4~6 DEG C at dialysis 20~for 24 hours to get dialyzate, dialyzate is placed in freezing
In drying machine, 5~8h of vacuum freeze drying is at being -40~-50 DEG C in temperature to get graft；According to parts by weight, claim respectively
Take 80~100 parts of grafts, 50~60 parts of polyamide curing agents, 20~40 parts of photoinitiator triaryl sulphur hexafluoro antimonates,
10~12 parts of reactive diluent epoxy propane butyl ethers, by graft, photoinitiator triaryl sulphur hexafluoro antimonate and activity
The mixing of diluent epoxy propane butyl ether, low whipping speed are that 10~20min of stirring applies under 300~350r/min to get mixing
Material, is coated uniformly on medical intervention material surface for compo, and being placed in temperature is dry 30~40min at 60~70 DEG C,
Up to semi-finished product, semi-finished product are placed in ultraviolet light curing apparatus between two ultraviolet lamps, radiation length is 10~12cm, two-sided
3~5min of illumination is to get medical intervention material hydrophilic lubrication coating.
Embodiment 1
Epoxy resin is placed in plasma apparatus, corona treatment is to get pretreatment epoxy resin；Take pretreatment epoxy
The phosphate buffer solution of resin, beardie mucus, 0.1mol/L will pre-process epoxy resin, beardie mucus and 0.1mol/L
Phosphate buffer solution mixes, and after stir process, is rapidly cooled to room temperature to get reaction solution；Reaction solution and deionized water are mixed
It closes, carries out dialysis treatment to get dialyzate, dialyzate is placed in freeze drier, vacuum freeze drying processing is to get grafting
Object；Take graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide butyl
Ether, by graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and reactive diluent propylene oxide butyl
Ether mixing, stir process is to get compo；Compo is coated uniformly on medical intervention material surface, is dried, i.e.,
Semi-finished product are obtained, semi-finished product are placed in ultraviolet light curing apparatus between two ultraviolet lamps, ultraviolet irradiation processing is to get medical intervention
Material hydrophilic lubricant coating.Plasma treatment step are as follows: epoxy resin is placed in plasma apparatus, with O2And NH3As
Working gas is 100Pa in pressure, and power is corona treatment 45s under 300W.Pre-process epoxy resin, beardie mucus,
Ratio between the phosphate buffer solution of 0.1mol/L is respectively as follows: according to parts by weight, weighs 20 parts of pretreatment epoxies respectively
The phosphate buffer solution of resin, 10 parts of beardie mucus, 50 parts of 0.1mol/L.Stir process step are as follows: asphalt mixtures modified by epoxy resin will be pre-processed
The phosphate buffer solution of rouge, beardie mucus and 0.1mol/L mixes, and is 60 DEG C in temperature, mixing speed is to stir under 150r/min
Mix 30min.Dialysis treatment step are as follows: 1: 100 reaction solution and deionized water are mixed, dialysed at being 4 DEG C in temperature by volume
20h.Vacuum freeze drying processing step are as follows: dialyzate is placed in freeze drier, vacuum refrigeration is dry at being -40 DEG C in temperature
Dry 5h.Graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide butyl
Ratio between ether is respectively as follows: according to parts by weight, weighs 80 parts of grafts, 50 parts of polyamide curing agents, 20 parts of light respectively and draws
Send out agent triaryl sulphur hexafluoro antimonate, 10 parts of reactive diluent epoxy propane butyl ethers.Stir process step are as follows: will be grafted
Object, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and the mixing of reactive diluent epoxy propane butyl ether, In
Mixing speed is to stir 10min under 300r/min.It is dried step are as follows: compo is coated uniformly on medical intervention material
Surface, being placed in temperature is dry 30min at 60 DEG C.Ultraviolet irradiation processing step are as follows: semi-finished product are placed in ultraviolet light solidification and are set
In standby between two ultraviolet lamps, radiation length 10cm, dual light shines 3min.
Embodiment 2
Epoxy resin is placed in plasma apparatus, corona treatment is to get pretreatment epoxy resin；Take pretreatment epoxy
The phosphate buffer solution of resin, beardie mucus, 0.1mol/L will pre-process epoxy resin, beardie mucus and 0.1mol/L
Phosphate buffer solution mixes, and after stir process, is rapidly cooled to room temperature to get reaction solution；Reaction solution and deionized water are mixed
It closes, carries out dialysis treatment to get dialyzate, dialyzate is placed in freeze drier, vacuum freeze drying processing is to get grafting
Object；Take graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide butyl
Ether, by graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and reactive diluent propylene oxide butyl
Ether mixing, stir process is to get compo；Compo is coated uniformly on medical intervention material surface, is dried, i.e.,
Semi-finished product are obtained, semi-finished product are placed in ultraviolet light curing apparatus between two ultraviolet lamps, ultraviolet irradiation processing is to get medical intervention
Material hydrophilic lubricant coating.Plasma treatment step are as follows: epoxy resin is placed in plasma apparatus, with O2And NH3As
Working gas is 110Pa in pressure, and power is corona treatment 52s under 325W.Pre-process epoxy resin, beardie mucus,
Ratio between the phosphate buffer solution of 0.1mol/L is respectively as follows: according to parts by weight, weighs 25 parts of pretreatment epoxies respectively
The phosphate buffer solution of resin, 15 parts of beardie mucus, 55 parts of 0.1mol/L.Stir process step are as follows: asphalt mixtures modified by epoxy resin will be pre-processed
The phosphate buffer solution of rouge, beardie mucus and 0.1mol/L mixes, and is 80 DEG C in temperature, mixing speed is to stir under 175r/min
Mix 40min.Dialysis treatment step are as follows: 1: 100 reaction solution and deionized water are mixed, dialysed at being 5 DEG C in temperature by volume
22h.Vacuum freeze drying processing step are as follows: dialyzate is placed in freeze drier, vacuum refrigeration is dry at being -45 DEG C in temperature
Dry 7h.Graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide butyl
Ratio between ether is respectively as follows: according to parts by weight, weighs 90 parts of grafts, 55 parts of polyamide curing agents, 30 parts of light respectively and draws
Send out agent triaryl sulphur hexafluoro antimonate, 11 parts of reactive diluent epoxy propane butyl ethers.Stir process step are as follows: will be grafted
Object, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and the mixing of reactive diluent epoxy propane butyl ether, In
Mixing speed is to stir 15min under 325r/min.It is dried step are as follows: compo is coated uniformly on medical intervention material
Surface, being placed in temperature is dry 35min at 65 DEG C.Ultraviolet irradiation processing step are as follows: semi-finished product are placed in ultraviolet light solidification and are set
In standby between two ultraviolet lamps, radiation length 11cm, dual light shines 4min.
Embodiment 3
Epoxy resin is placed in plasma apparatus, corona treatment is to get pretreatment epoxy resin；Take pretreatment epoxy
The phosphate buffer solution of resin, beardie mucus, 0.1mol/L will pre-process epoxy resin, beardie mucus and 0.1mol/L
Phosphate buffer solution mixes, and after stir process, is rapidly cooled to room temperature to get reaction solution；Reaction solution and deionized water are mixed
It closes, carries out dialysis treatment to get dialyzate, dialyzate is placed in freeze drier, vacuum freeze drying processing is to get grafting
Object；Take graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide butyl
Ether, by graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and reactive diluent propylene oxide butyl
Ether mixing, stir process is to get compo；Compo is coated uniformly on medical intervention material surface, is dried, i.e.,
Semi-finished product are obtained, semi-finished product are placed in ultraviolet light curing apparatus between two ultraviolet lamps, ultraviolet irradiation processing is to get medical intervention
Material hydrophilic lubricant coating.Plasma treatment step are as follows: epoxy resin is placed in plasma apparatus, with O2And NH3As
Working gas is 120Pa in pressure, and power is corona treatment 60s under 350W.Pre-process epoxy resin, beardie mucus,
Ratio between the phosphate buffer solution of 0.1mol/L is respectively as follows: according to parts by weight, weighs 30 parts of pretreatment epoxies respectively
The phosphate buffer solution of resin, 20 parts of beardie mucus, 60 parts of 0.1mol/L.Stir process step are as follows: asphalt mixtures modified by epoxy resin will be pre-processed
The phosphate buffer solution of rouge, beardie mucus and 0.1mol/L mixes, and is 100 DEG C in temperature, mixing speed is under 200r/min
Stir 50min.Dialysis treatment step are as follows: mix reaction solution and deionized water at 1: 100 by volume, at being 6 DEG C in temperature thoroughly
Analysis is for 24 hours.Vacuum freeze drying processing step are as follows: dialyzate is placed in freeze drier, vacuum refrigeration at being -50 DEG C in temperature
Dry 8h.Graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide fourth
Ratio between base ether is respectively as follows: according to parts by weight, weighs 100 parts of grafts, 60 parts of polyamide curing agents, 40 parts of light respectively
Initiator triaryl sulphur hexafluoro antimonate, 12 parts of reactive diluent epoxy propane butyl ethers.Stir process step are as follows: will be grafted
Object, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and the mixing of reactive diluent epoxy propane butyl ether, In
Mixing speed is to stir 20min under 350r/min.It is dried step are as follows: compo is coated uniformly on medical intervention material
Surface, being placed in temperature is dry 40min at 70 DEG C.Ultraviolet irradiation processing step are as follows: semi-finished product are placed in ultraviolet light solidification and are set
In standby between two ultraviolet lamps, radiation length 12cm, dual light shines 5min.
Medical intervention material hydrophilic lubrication coating prepared by the present invention is detected with existing medical lubricant coating, specifically
Testing result such as following table table 1:
Test method:
Friction test is carried out to embodiment 1-3 and comparative example 1, is carried out on improved MS-800A type four-ball tester.Take fresh go
Live pig skin (moisture content) is lower test piece, and the plastic sheet for being 25mm with diameter makees upper test piece and carries out end face friction, revolving speed 200r/
Min, experiment indicate greasy property with coefficient of friction.
The medical intervention material hydrophilic lubrication coating performance of table 1 characterization
The medical intervention material hydrophilic lubrication coating of pharmacy exhaust gas adsorbent material prepared by the present invention as shown in Table 1, can be largely
The frictional force for reducing instrument and tissue or blood vessel, effectively avoids mechanical injuries.
Claims (10)
1. a kind of preparation method of medical intervention material hydrophilic lubrication coating, it is characterised in that specific preparation step are as follows:
(1) epoxy resin is placed in plasma apparatus, corona treatment is to get pretreatment epoxy resin；
(2) phosphate buffer solution for taking pretreatment epoxy resin, beardie mucus, 0.1mol/L will pre-process epoxy resin, mud
The phosphate buffer solution of loach synovia and 0.1mol/L mix, and after stir process, are rapidly cooled to room temperature to get reaction solution；
(3) reaction solution and deionized water are mixed, carries out dialysis treatment to get dialyzate, dialyzate is placed in freeze drier
In, vacuum freeze drying processing is to get graft；
(4) graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent propylene oxide are taken
Butyl ether, by graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate and reactive diluent propylene oxide
Butyl ether mixing, stir process is to get compo；
(5) compo is coated uniformly on medical intervention material surface, is dried to get semi-finished product, semi-finished product is placed in
In ultraviolet light curing apparatus between two ultraviolet lamps, ultraviolet irradiation processing is to get medical intervention material hydrophilic lubrication coating.
2. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly plasma treatment step described in (1) are as follows: epoxy resin is placed in plasma apparatus, with O2And NH3As work gas
Body is 100~120Pa in pressure, and power is 45~60s of corona treatment under 300~350W.
3. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly the ratio between the phosphate buffer solution of pretreatment epoxy resin, beardie mucus, 0.1mol/L described in (2) is respectively as follows:
According to parts by weight, 20~30 parts of pretreatment epoxy resin, 10~20 parts of beardie mucus, 50~60 parts of 0.1mol/L are weighed respectively
Phosphate buffer solution.
4. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly stir process step described in (2) are as follows: the phosphate buffer solution of epoxy resin, beardie mucus and 0.1mol/L will be pre-processed
Mixing is 60~100 DEG C in temperature, and mixing speed is that 30~50min is stirred under 150~200r/min.
5. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly dialysis treatment step described in (3) are as follows: 1: 100 reaction solution and deionized water are mixed by volume, are 4~6 DEG C in temperature
It is lower dialysis 20~for 24 hours.
6. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly vacuum freeze drying processing step described in (3) are as follows: dialyzate is placed in freeze drier, is -40~-50 DEG C in temperature
5~8h of lower vacuum freeze drying.
7. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly graft, polyamide curing agent described in (4), photoinitiator triaryl sulphur hexafluoro antimonate, reactive diluent epoxy third
Ratio between alkane butyl ether is respectively as follows: according to parts by weight, weighs 80~100 parts of grafts, 50~60 parts of polyamide respectively
Curing agent, 20~40 parts of photoinitiator triaryl sulphur hexafluoro antimonates, 10~12 parts of reactive diluent epoxy propane butyl ethers.
8. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly stir process step described in (4) are as follows: by graft, polyamide curing agent, photoinitiator triaryl sulphur hexafluoro antimonate
It is mixed with reactive diluent epoxy propane butyl ether, low whipping speed is that 10~20min is stirred under 300~350r/min.
9. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that: step
Suddenly drying process step described in (5) are as follows: compo is coated uniformly on medical intervention material surface, being placed in temperature is 60
Dry 30~40min at~70 DEG C.
10. a kind of preparation method of medical intervention material hydrophilic lubrication coating according to claim 1, it is characterised in that:
Ultraviolet irradiation processing step described in step (5) are as follows: semi-finished product are placed in ultraviolet light curing apparatus between two ultraviolet lamps, spoke
Penetrating distance is 10~12cm, and dual light shines 3~5min.
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| CN201910710697.4A CN110522952A (en) | 2019-08-02 | 2019-08-02 | A kind of preparation method of medical intervention material hydrophilic lubrication coating |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407930A (en) * | 2020-03-19 | 2020-07-14 | 中国科学院长春应用化学研究所 | Polymer bionic coating and preparation method thereof |
| WO2023279663A1 (en) * | 2021-07-08 | 2023-01-12 | 深圳先进技术研究院 | Surface hydrophilic layer modification method for implantable medical device and application |
-
2019
- 2019-08-02 CN CN201910710697.4A patent/CN110522952A/en not_active Withdrawn
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111407930A (en) * | 2020-03-19 | 2020-07-14 | 中国科学院长春应用化学研究所 | Polymer bionic coating and preparation method thereof |
| CN111407930B (en) * | 2020-03-19 | 2021-01-08 | 中国科学院长春应用化学研究所 | Polymer bionic coating and preparation method thereof |
| WO2023279663A1 (en) * | 2021-07-08 | 2023-01-12 | 深圳先进技术研究院 | Surface hydrophilic layer modification method for implantable medical device and application |
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