CN101732113A - Preparation method of special instant dissolved stent for intestinal adhesion - Google Patents
Preparation method of special instant dissolved stent for intestinal adhesion Download PDFInfo
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- CN101732113A CN101732113A CN200810180505A CN200810180505A CN101732113A CN 101732113 A CN101732113 A CN 101732113A CN 200810180505 A CN200810180505 A CN 200810180505A CN 200810180505 A CN200810180505 A CN 200810180505A CN 101732113 A CN101732113 A CN 101732113A
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Abstract
The invention relates to a preparation method of a hollow instant dissolved stent for intestinal adhesion technology, comprising the steps of: firstly, taking soluble pure compounds or preparing the soluble pure compounds to a 50%-90%dual distilled water solution, heating the solution to be uniform liquid for later use, and preparing the compounds to two hollow stent main bodies with the diameters equivalent to the diameter of a human body intestine for matching by an injection molding method or other methods. In the invention, the stent material prepared by the method has the following advantages that the dissolving speed is high, the stent components are completely diluted in the blood so as to reduce various untoward reactions; and the utilization amount of the material is small. When the invention is used in the intestinal adhesion process, the anastomotic stoma can be inversed to be adhered, the anastomosis speed is fast, the anastomotic stoma is prevented from being narrow and leaked, the patency rate of the anastomosis is remarkably improved, the wound is small, the operation is simple, and special devices are not needed; in addition, the invention is suitable for development in various hospitals and can replace the traditional suturing method.
Description
Technical field the present invention relates to instant bracket and preparation method thereof in a kind of hollow intestinal that is used to satisfy intestinal adhesion, be used to improve the identical quality of intestinal, reduce the bowel anastomosis complication, simplify the operation that coincide, improve the identical speed of intestinal, belong to technical field of biological materials.
Background technology bowel anastomosis technology is one of basic fundamental of general surgery, bowel anastomosis adopts sewing more, with a long history, undertaken to obtain higher patency rate by skilled doctor, use very extensive at present, by numerous doctors are accepted, but also there is inherent deficiency in it: surgery duration is longer, complicated operation; Need needlework will pass tube wall and knotting in the sewing process, inevitably wall is caused damage, and cause nonvolatil foreign body residual, the gap of pin hole and anastomotic stoma is the anastomotic stoma main cause of seepage, it is the severe complication of bowel anastomosis that intestinal leaks, treat very thornyly, patient is agonizing, has a strong impact on patient's quality of life.The intestinal adhesion technology can fundamentally reduce the generation that intestinal leaks, reason is that binding agent can well seal anastomotic stoma, in order to guarantee the unobstructed of anastomotic stoma and physiology shape, built-in support is necessary subsidiary conditions, and we have designed the instant bracket that is specifically designed to intestinal adhesion the physiological characteristics of thorough investigation intestinal and bonding needs.
Summary of the invention the objective of the invention is to propose a kind of instant hollow stent that is used for bowel anastomosis, make support therewith bonding technology improve combination, improve original intestinal sewing method, the bowel anastomosis that is used for performing the operation.
The instant bracket that is used for bowel anastomosis that the present invention proposes is made up of two parts, with two parts intercalation, finishes bonding operation during operation, and purpose is to make anastomotic stoma turn over state in presenting after bonding.Main purpose is to make bonding more firmly, helps anastomotic healing.
The preparation method of the instant bracket that is used for bowel anastomosis that the present invention proposes may further comprise the steps:
1, with the internal layer chemical compound heat fused of analytical pure level, and keep liquid, chemical compound can be Polyethylene Glycol (molecular weight 6000-20000), sucrose, and dextrans etc. can metabolic in vivo chemical compound.
2, will keep liquid above-claimed cpd to adopt the injection moulding method to pour into respectively in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, opens mould, the fusiformis pipe suitable with the intestinal diameter made in taking-up, and length can intercept arbitrarily according to the intestinal diameter.
3, the support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality .-60 sterilizations of ethylene oxide or cobalt, 4 ℃ of preservations.
Using method: select suitable support according to the diameter for the treatment of identical intestinal, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, be stained with mutually so that embed back intestinal wall adventitia, again with the intestinal wall adventitia place of adhesive coated at the anastomotic stoma place at support, tightly support is embedded mutually, after treating the binding agent dry solidification,, coincide and finish the support dissolving.
New-support with method preparation of the present invention has the following advantages:
(1) can avoid anastomotic stricture,, therefore fundamentally avoid the narrow of anastomotic stoma because the anastomotic stoma place by free stent support, can determine the size of anastomotic stoma as required.
(2) can effectively prevent the anastomotic stoma seepage: because binding agent bonding to anastomotic stoma arranged, can play the effect of sealing, avoid the existence in pin hole and anastomotic stoma slit completely, fundamentally avoid the generation of the seepage of anastomotic stoma to anastomotic stoma.
(3) time easy and simple to handle is short.Because simple operating steps can significantly shorten operating time, and wound is little, does not need special equipment, is suitable for carrying out in hospitals at different levels, be expected to substitute fully the intestinal sewing method.
The specific embodiment
The raw material sources that use among the present invention: Polyethylene Glycol, gelatin, dextran, Beijing chemical reagents corporation, chemical pure level.
Embodiment one
1, it is standby with molecular weight to be that 6000 Polyethylene Glycol is heated to 70 degree back insulations.
2, will keep liquid polyethylene glycol 6000 to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, open mould, take out and make the pipe support suitable with the intestinal diameter, first's internal diameter is 1. centimetres, external diameter is 1.4 centimetres, 4 centimetres of length; The second portion internal diameter is 0.4 centimetre, and the embedded part external diameter is 1 centimetre, and the pipe section external diameter still is 1.4 centimetres, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Embodiment two
1, be that 8000 Polyethylene Glycol are made into 80% DDW solution to be heated to 70 degree back insulations standby with molecular weight.
2, will keep liquid Polyethylene Glycol 8000 to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, open mould, take out and make the pipe support suitable with the intestinal diameter, first's internal diameter is 1.1 centimetres, external diameter is 1.5 centimetres, 4 centimetres of length; The second portion internal diameter is 0.5 centimetre, and the embedded part external diameter is 1.1 centimetres, and the pipe section external diameter still is 1.5 centimetres, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Embodiment three
1, be that 10000 Polyethylene Glycol is made 60% DDW solution with molecular weight, it is standby to be heated to 80 degree back insulations.
2, will keep liquid cetomacrogol 1000 0 to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, open mould, take out and make the pipe support suitable with the intestinal diameter, first's internal diameter is 1.2 centimetres, external diameter is 1.6 centimetres, 4 centimetres of length; The second portion internal diameter is 0.5 centimetre, and the embedded part external diameter is 1.2 centimetres, and the pipe section external diameter still is 1.6 centimetres, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Embodiment four
1, is to become liquid state after 12000 Polyethylene Glycol is heated to 80 degree with molecular weight, is incubated standby.
2, will keep liquid Polyethylene Glycol 12000 to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, open mould, take out and make the pipe support suitable with the intestinal diameter, first's internal diameter is 1.3 centimetres, external diameter is 1.8 centimetres, 4 centimetres of length; The second portion internal diameter is 0.5 centimetre, and the embedded part external diameter is 1.3 centimetres, and the pipe section external diameter still is 1.8 centimetres, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Embodiment five
1, is to become liquid state after 20000 Polyethylene Glycol is heated to 90 degree with molecular weight, is incubated standby.
2, will keep liquid Macrogol 2000 0 to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, open mould, take out and make the pipe support suitable with the intestinal diameter, first's internal diameter is 1.5 centimetres, external diameter is 2 centimetres, 4 centimetres of length; The second portion internal diameter is 0.6 centimetre, and the embedded part external diameter is 1.5 centimetres, and the pipe section external diameter still is 2, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Embodiment six
1, sucrose being heated to liquid back is incubated standby.
2, will keep liquid sucrose to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, opens mould, takes out and makes the pipe support suitable with the intestinal diameter, and first's internal diameter is 1. centimetres, and external diameter is 1.4 centimetres, 4 centimetres of length; The second portion internal diameter is 0.4 centimetre, and the embedded part external diameter is 0.8 centimetre, and the pipe section external diameter still is 1.4 centimetres, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Embodiment seven
1, solid dextran heating liquid back insulation is standby.
2, will keep liquid dextran to pour in two kinds of prefabricated moulds, slowly cooling makes it coagulation forming, opens mould, takes out and makes the pipe support suitable with the intestinal diameter, and first's internal diameter is 1. centimetres, and external diameter is 1.4 centimetres, 4 centimetres of length; The second portion internal diameter is 0.4 centimetre, and the embedded part external diameter is 0.8 centimetre, and the pipe section external diameter still is 1.4 centimetres, inserts 2 centimetres of length, and outer length is 4 centimetres.
3, the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
4, take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Accompanying drawing is the generalized section of support aid adhesion intestinal.
Claims (5)
1. instant bracket that is used for intestinal adhesion, it is characterized in that this support is made of two parts, first's hollow wall tubulose body constitutes, and second portion is made of the tubular structure with various outer diameter, in adhesion process, both down are inserted use, finish bonding operation.
2. preparation method that is used for the hollow sting of intestinal adhesion as claimed in claim 1 is characterized in that this method may further comprise the steps:
(1) can metabolic in vivo chemical compound heat fused, and keep liquid standby;
(2) chemical compound with above-mentioned maintenance liquid state adopts injection moulding method respectively to pour in the prefabricated support mould, and slowly cooling makes it coagulation forming.
3. method as claimed in claim 2 is characterized in that wherein saidly can metabolic in vivo chemical compound being: molecular weight is any in 6000-20000 Polyethylene Glycol, sucrose or the dextran.
4. the above-mentioned support that makes is sealed packing with rigid container, indicate the length of support, internal diameter, external diameter, quality.Cobalt-60 sterilization, 4 ℃ of preservations.
5. take out the support of suitable types in the art, earlier two parts of support are put into two broken ends of fractured bone of intestinal to be coincide respectively, and make anastomotic stoma place intestinal wall cover the embedded part of support, so that embedding back intestinal wall adventitia at support is stained with mutually, with the intestinal wall adventitia place of adhesive coated, tightly support is embedded mutually again at the anastomotic stoma place, treat the binding agent dry solidification after, with the support dissolving, coincide and finish.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810180505A CN101732113A (en) | 2008-11-27 | 2008-11-27 | Preparation method of special instant dissolved stent for intestinal adhesion |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810180505A CN101732113A (en) | 2008-11-27 | 2008-11-27 | Preparation method of special instant dissolved stent for intestinal adhesion |
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| CN101732113A true CN101732113A (en) | 2010-06-16 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN200810180505A Pending CN101732113A (en) | 2008-11-27 | 2008-11-27 | Preparation method of special instant dissolved stent for intestinal adhesion |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110226990A (en) * | 2019-06-14 | 2019-09-13 | 温州医科大学附属第一医院 | A kind of intestinal anastomotic stoma leakage uses bracket |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19926008A1 (en) * | 1999-06-08 | 2000-12-14 | Peter Sterk | Biofragmentable tubular stent of cellulase-degradable material, especially used for operative maintenance of an intestinal anastomosis, can be degraded at required time by administration of cellulase |
| CN1475193A (en) * | 2003-07-04 | 2004-02-18 | 中国人民解放军总医院 | Double layer hollow blood vessel internal support used for vascular anastomosis and its preparation method |
| CN1792336A (en) * | 2005-12-23 | 2006-06-28 | 西安交通大学 | Stent used for cholangiojejunostomy |
| CN2836752Y (en) * | 2005-06-20 | 2006-11-15 | 中国人民解放军第二军医大学 | Multilayer plastic stent for bile duct |
| CN1965767A (en) * | 2005-11-14 | 2007-05-23 | 浙江大学 | Biliary duct jejunum anastomotic scaffold |
| US20080114466A1 (en) * | 2006-11-09 | 2008-05-15 | Shelton Frederick E | Method of Performing An End-to-End Anastomosis Using a Stent and an Adhesive |
-
2008
- 2008-11-27 CN CN200810180505A patent/CN101732113A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19926008A1 (en) * | 1999-06-08 | 2000-12-14 | Peter Sterk | Biofragmentable tubular stent of cellulase-degradable material, especially used for operative maintenance of an intestinal anastomosis, can be degraded at required time by administration of cellulase |
| CN1475193A (en) * | 2003-07-04 | 2004-02-18 | 中国人民解放军总医院 | Double layer hollow blood vessel internal support used for vascular anastomosis and its preparation method |
| CN2836752Y (en) * | 2005-06-20 | 2006-11-15 | 中国人民解放军第二军医大学 | Multilayer plastic stent for bile duct |
| CN1965767A (en) * | 2005-11-14 | 2007-05-23 | 浙江大学 | Biliary duct jejunum anastomotic scaffold |
| CN1792336A (en) * | 2005-12-23 | 2006-06-28 | 西安交通大学 | Stent used for cholangiojejunostomy |
| US20080114466A1 (en) * | 2006-11-09 | 2008-05-15 | Shelton Frederick E | Method of Performing An End-to-End Anastomosis Using a Stent and an Adhesive |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110226990A (en) * | 2019-06-14 | 2019-09-13 | 温州医科大学附属第一医院 | A kind of intestinal anastomotic stoma leakage uses bracket |
| CN110226990B (en) * | 2019-06-14 | 2021-01-15 | 温州医科大学附属第一医院 | Support for intestinal anastomotic stoma leakage |
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Application publication date: 20100616 |