CN101721691B - 一种用于感染创面治疗和修复的制剂及其制备方法 - Google Patents
一种用于感染创面治疗和修复的制剂及其制备方法 Download PDFInfo
- Publication number
- CN101721691B CN101721691B CN 200810043907 CN200810043907A CN101721691B CN 101721691 B CN101721691 B CN 101721691B CN 200810043907 CN200810043907 CN 200810043907 CN 200810043907 A CN200810043907 A CN 200810043907A CN 101721691 B CN101721691 B CN 101721691B
- Authority
- CN
- China
- Prior art keywords
- preparation
- chitosan
- wound surface
- collagen protein
- hydrogel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 230000001524 infective effect Effects 0.000 title claims abstract description 17
- 102000016943 Muramidase Human genes 0.000 claims abstract description 35
- 108010014251 Muramidase Proteins 0.000 claims abstract description 35
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 claims abstract description 35
- 241000191940 Staphylococcus Species 0.000 claims abstract description 35
- 229960000274 lysozyme Drugs 0.000 claims abstract description 34
- 235000010335 lysozyme Nutrition 0.000 claims abstract description 34
- 239000004325 lysozyme Substances 0.000 claims abstract description 34
- 229920001661 Chitosan Polymers 0.000 claims abstract description 32
- 229920001436 collagen Polymers 0.000 claims abstract description 30
- 102000008186 Collagen Human genes 0.000 claims abstract description 27
- 108010035532 Collagen Proteins 0.000 claims abstract description 27
- 238000004381 surface treatment Methods 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- 230000008439 repair process Effects 0.000 claims description 4
- 230000003301 hydrolyzing effect Effects 0.000 claims description 2
- 239000000017 hydrogel Substances 0.000 abstract description 44
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 3
- 230000035876 healing Effects 0.000 abstract description 3
- 239000003814 drug Substances 0.000 abstract description 2
- 238000004132 cross linking Methods 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
- 206010052428 Wound Diseases 0.000 description 45
- 208000027418 Wounds and injury Diseases 0.000 description 45
- 102000004169 proteins and genes Human genes 0.000 description 23
- 108090000623 proteins and genes Proteins 0.000 description 23
- 210000000416 exudates and transudate Anatomy 0.000 description 7
- 210000004027 cell Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- 230000001954 sterilising effect Effects 0.000 description 6
- 230000008961 swelling Effects 0.000 description 6
- 230000029663 wound healing Effects 0.000 description 6
- 238000003756 stirring Methods 0.000 description 5
- 241000191967 Staphylococcus aureus Species 0.000 description 4
- 230000001133 acceleration Effects 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 238000004108 freeze drying Methods 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000015556 catabolic process Effects 0.000 description 3
- 238000006731 degradation reaction Methods 0.000 description 3
- 210000002950 fibroblast Anatomy 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 238000005303 weighing Methods 0.000 description 3
- LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 208000035143 Bacterial infection Diseases 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- 206010059866 Drug resistance Diseases 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 2
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 2
- AZKVWQKMDGGDSV-BCMRRPTOSA-N Genipin Chemical compound COC(=O)C1=CO[C@@H](O)[C@@H]2C(CO)=CC[C@H]12 AZKVWQKMDGGDSV-BCMRRPTOSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical class N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 208000022362 bacterial infectious disease Diseases 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 239000012620 biological material Substances 0.000 description 2
- 230000002051 biphasic effect Effects 0.000 description 2
- 210000002421 cell wall Anatomy 0.000 description 2
- 229940088598 enzyme Drugs 0.000 description 2
- 210000002744 extracellular matrix Anatomy 0.000 description 2
- 230000003328 fibroblastic effect Effects 0.000 description 2
- AZKVWQKMDGGDSV-UHFFFAOYSA-N genipin Natural products COC(=O)C1=COC(O)C2C(CO)=CCC12 AZKVWQKMDGGDSV-UHFFFAOYSA-N 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- DCPMPXBYPZGNDC-UHFFFAOYSA-N hydron;methanediimine;chloride Chemical compound Cl.N=C=N DCPMPXBYPZGNDC-UHFFFAOYSA-N 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 230000008591 skin barrier function Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- FPQQSJJWHUJYPU-UHFFFAOYSA-N 3-(dimethylamino)propyliminomethylidene-ethylazanium;chloride Chemical compound Cl.CCN=C=NCCCN(C)C FPQQSJJWHUJYPU-UHFFFAOYSA-N 0.000 description 1
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 1
- 241000589220 Acetobacter Species 0.000 description 1
- 229920002101 Chitin Polymers 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 208000005422 Foreign-Body reaction Diseases 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 108090000988 Lysostaphin Proteins 0.000 description 1
- 108010006035 Metalloproteases Proteins 0.000 description 1
- 102000005741 Metalloproteases Human genes 0.000 description 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 description 1
- 241001597008 Nomeidae Species 0.000 description 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000004964 aerogel Substances 0.000 description 1
- 230000002924 anti-infective effect Effects 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 1
- 239000000227 bioadhesive Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 239000013553 cell monolayer Substances 0.000 description 1
- 230000003833 cell viability Effects 0.000 description 1
- 235000013351 cheese Nutrition 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 230000035605 chemotaxis Effects 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 239000003431 cross linking reagent Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 235000019253 formic acid Nutrition 0.000 description 1
- WBJINCZRORDGAQ-UHFFFAOYSA-N formic acid ethyl ester Natural products CCOC=O WBJINCZRORDGAQ-UHFFFAOYSA-N 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 108010025899 gelatin film Proteins 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 229930195712 glutamate Natural products 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- DWAYUNSAAKQFJZ-UHFFFAOYSA-G magnesium;dipotassium;trisodium;dihydrogen phosphate;hydrogen phosphate;dichloride;sulfate Chemical compound [Na+].[Na+].[Na+].[Mg+2].[Cl-].[Cl-].[K+].[K+].OP(O)([O-])=O.OP([O-])([O-])=O.[O-]S([O-])(=O)=O DWAYUNSAAKQFJZ-UHFFFAOYSA-G 0.000 description 1
- 239000012528 membrane Substances 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000000113 methacrylic resin Substances 0.000 description 1
- 229960003085 meticillin Drugs 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 230000035699 permeability Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- 238000000518 rheometry Methods 0.000 description 1
- 230000008470 skin growth Effects 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000000472 traumatic effect Effects 0.000 description 1
- 230000010388 wound contraction Effects 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Images
Landscapes
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims (1)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200810043907 CN101721691B (zh) | 2008-11-04 | 2008-11-04 | 一种用于感染创面治疗和修复的制剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN 200810043907 CN101721691B (zh) | 2008-11-04 | 2008-11-04 | 一种用于感染创面治疗和修复的制剂及其制备方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101721691A CN101721691A (zh) | 2010-06-09 |
CN101721691B true CN101721691B (zh) | 2013-07-10 |
Family
ID=42443639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 200810043907 Active CN101721691B (zh) | 2008-11-04 | 2008-11-04 | 一种用于感染创面治疗和修复的制剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101721691B (zh) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102228715A (zh) * | 2011-06-10 | 2011-11-02 | 青岛明药堂医药科技开发有限公司 | 一种含壳聚糖衍生物的液体敷料及其制备方法 |
CN102362853B (zh) * | 2011-11-07 | 2013-01-02 | 湛江师范学院 | 一种京尼平交联大豆蛋白基茶碱控释凝胶制剂及其制备方法 |
CN103099777B (zh) * | 2011-11-15 | 2014-05-07 | 上海高科生物工程有限公司 | 以多孔碳酸钙为载体的生物酶水凝胶剂及制备方法 |
CN103301501B (zh) * | 2013-06-18 | 2015-05-06 | 王珍 | 一种医用液体敷料及制备方法 |
CN104474535A (zh) * | 2014-12-10 | 2015-04-01 | 成都新际生物活性胶原开发有限公司 | 一种治疗糖尿病足的水溶性凝胶 |
CN105169374A (zh) * | 2015-10-23 | 2015-12-23 | 东莞市达庆医疗器械有限公司 | 一种重组人源胶原蛋白凝胶及其制备方法 |
CN105778126B (zh) * | 2016-03-31 | 2020-11-10 | 中国人民解放军军事医学科学院野战输血研究所 | 一种京尼平交联生物凝胶及其制备方法与应用 |
CN106511977A (zh) * | 2016-11-04 | 2017-03-22 | 广州赛莱拉干细胞科技股份有限公司 | 胶原贴敷料 |
CN109265691A (zh) * | 2017-07-18 | 2019-01-25 | 中国科学院苏州纳米技术与纳米仿生研究所 | 水凝胶及其制备方法与应用 |
CN110917339B (zh) * | 2019-12-27 | 2023-07-07 | 遵义医学院附属医院 | 一种溶葡萄球菌酶凝胶剂及其在mrsa感染创面中的应用 |
CN112438964A (zh) * | 2020-11-30 | 2021-03-05 | 威兰德(山东)生物科技有限公司 | 一种溶葡萄球菌酶与壳聚糖复合抗菌喷膜剂 |
CN113440645A (zh) * | 2021-06-29 | 2021-09-28 | 西安汇朴成医疗科技有限公司 | 一种用于创面的复合溶菌酶液体敷料及其制备方法 |
CN117159729B (zh) * | 2023-09-18 | 2024-04-02 | 大连医科大学附属第一医院 | 一种多孔的可负载干细胞的生物材料及其在疼痛治疗中的应用 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1640913A (zh) * | 2004-12-20 | 2005-07-20 | 重庆大学 | 交联壳聚糖-季铵化水解胶原蛋白制备方法 |
CN1911442A (zh) * | 2005-08-09 | 2007-02-14 | 上海高科联合生物技术研发有限公司 | 一种用于防治创面感染的溶葡萄球菌酶冻干粉剂 |
-
2008
- 2008-11-04 CN CN 200810043907 patent/CN101721691B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1640913A (zh) * | 2004-12-20 | 2005-07-20 | 重庆大学 | 交联壳聚糖-季铵化水解胶原蛋白制备方法 |
CN1911442A (zh) * | 2005-08-09 | 2007-02-14 | 上海高科联合生物技术研发有限公司 | 一种用于防治创面感染的溶葡萄球菌酶冻干粉剂 |
Non-Patent Citations (2)
Title |
---|
壳聚糖胶原生物敷料的安全性研究;王晓芹等;《中国临床康复》;20020430;第6卷(第7期);1030-1031 * |
王晓芹等.壳聚糖胶原生物敷料的安全性研究.《中国临床康复》.2002,第6卷(第7期),1030-1031. |
Also Published As
Publication number | Publication date |
---|---|
CN101721691A (zh) | 2010-06-09 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN101721691B (zh) | 一种用于感染创面治疗和修复的制剂及其制备方法 | |
AU2019265757B2 (en) | Wound dressing for treatment of damaged skin | |
Kamoun et al. | A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings | |
RU2455995C2 (ru) | Препарат для заживления ран и предотвращения адгезии повязки к ране, содержащий хитозан-глюкановый комплекс | |
He et al. | Bacterial cellulose: functional modification and wound healing applications | |
US7390499B2 (en) | Microbial cellulose wound dressing for treating chronic wounds | |
CN103356692B (zh) | 一种复合抗菌凝胶剂及其制备方法 | |
CN101574539A (zh) | 一种明胶海绵及其制备方法 | |
CN104784741B (zh) | 壳聚糖功能性水胶体医用敷料 | |
CN112300420A (zh) | 一种可注射抗菌互穿双网络水凝胶及其制备方法和应用 | |
Xiong et al. | Derma-like antibacterial polysaccharide gel dressings for wound care | |
RU2437681C1 (ru) | Раневое покрытие с лечебным действием | |
CN103755965A (zh) | 一种ε-聚赖氨酸水凝胶及其制备方法和应用 | |
CN102108211B (zh) | 一种壳聚糖胶原蛋白凝胶及应用 | |
CN105641735B (zh) | 一种抗菌性多糖止血棉基纱布的制备方法 | |
US20100172889A1 (en) | Degradable biomolecule compositions | |
CN111073001A (zh) | 一种两性葡聚糖水凝胶及应用 | |
CN102108138B (zh) | 一种壳聚糖胶原蛋白凝胶的制备方法 | |
CN104623721A (zh) | 一种创伤修复材料及其制备方法 | |
JP4486304B2 (ja) | 慢性創傷の治療用の微生物セルロース性創傷被覆材 | |
CN107049930B (zh) | 一种促愈合伤口凝胶及其制备方法 | |
CN110916900A (zh) | 一种水凝胶医用敷料及其制备方法 | |
CN113842492A (zh) | 一种负载积雪草提取物的水凝胶/非织造材料复合敷料 | |
CN104524619A (zh) | 一种壳聚糖敷料及其生产工艺 | |
Wang et al. | Tissue adhesives based on chitosan for skin wound healing: Where do we stand in this era? A review |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: GAOKE BIO-ENGINEERING CO LTD, SHANGHAI Free format text: FORMER OWNER: SHANGHAI GAOKE UNION BIOTECHNOLOGY DEVELOPMENT CO., LTD. Effective date: 20131115 Owner name: SHANGHAI GAOKE UNION BIOTECHNOLOGY DEVELOPMENT CO. Effective date: 20131115 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20131115 Address after: 201206 B building, No. 501 Jingang Road, Jinqiao Development Zone, Shanghai, Pudong New Area, 5 Patentee after: Shanghai Hi-tech Bioengineering Ltd. Patentee after: Shanghai Hi-Tech United Bio-Technological Research & Development Co.,Ltd. Patentee after: KUNSHAN BIOGREEN TECHNOLOGY Co.,Ltd. Address before: 201206, No. 3, building B, block 501, Jingang Road, Shanghai, Pudong New Area Patentee before: Shanghai Hi-Tech United Bio-Technological Research & Development Co.,Ltd. |
|
ASS | Succession or assignment of patent right |
Owner name: SHANGHAI GAOKE UNION BIOTECHNOLOGY DEVELOPMENT CO. Free format text: FORMER OWNER: SHANGHAI GAOKE UNION BIOTECHNOLOGY DEVELOPMENT CO., LTD. KUNSHAN BOQING BIO-TECHNOLOGY CO., LTD. Effective date: 20150521 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20150521 Address after: 201206 B building, No. 501 Jingang Road, new Jinqiao Development Zone, Shanghai, Pudong New Area, 5 Patentee after: Shanghai Hi-tech Bioengineering Ltd. Patentee after: Shanghai Hi-Tech United Bio-Technological Research & Development Co.,Ltd. Address before: 201206 B building, No. 501 Jingang Road, Jinqiao Development Zone, Shanghai, Pudong New Area, 5 Patentee before: Shanghai Hi-tech Bioengineering Ltd. Patentee before: Shanghai Hi-Tech United Bio-Technological Research & Development Co.,Ltd. Patentee before: KUNSHAN BIOGREEN TECHNOLOGY Co.,Ltd. |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |
Denomination of invention: A preparation and preparation method for treating and repairing infected wounds Effective date of registration: 20230811 Granted publication date: 20130710 Pledgee: Fumin Sub branch of Bank of Shanghai Co.,Ltd. Pledgor: Shanghai Hi-tech Bioengineering Ltd.|Shanghai Hi-Tech United Bio-Technological Research & Development Co.,Ltd. Registration number: Y2023310000457 |
|
PE01 | Entry into force of the registration of the contract for pledge of patent right |