CN101721425A - Fulvic acid health-care product with sober-up and anti-drunk function - Google Patents
Fulvic acid health-care product with sober-up and anti-drunk function Download PDFInfo
- Publication number
- CN101721425A CN101721425A CN200910218269A CN200910218269A CN101721425A CN 101721425 A CN101721425 A CN 101721425A CN 200910218269 A CN200910218269 A CN 200910218269A CN 200910218269 A CN200910218269 A CN 200910218269A CN 101721425 A CN101721425 A CN 101721425A
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- CN
- China
- Prior art keywords
- fulvic acid
- sober
- health
- drunk
- care product
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- PUKLDDOGISCFCP-JSQCKWNTSA-N 21-Deoxycortisone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2=O PUKLDDOGISCFCP-JSQCKWNTSA-N 0.000 title claims abstract description 33
- FCYKAQOGGFGCMD-UHFFFAOYSA-N Fulvic acid Natural products O1C2=CC(O)=C(O)C(C(O)=O)=C2C(=O)C2=C1CC(C)(O)OC2 FCYKAQOGGFGCMD-UHFFFAOYSA-N 0.000 title claims abstract description 33
- 229940095100 fulvic acid Drugs 0.000 title claims abstract description 33
- 239000002509 fulvic acid Substances 0.000 title claims abstract description 33
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 9
- 235000000346 sugar Nutrition 0.000 claims abstract description 8
- 239000007788 liquid Substances 0.000 claims abstract description 5
- 230000036541 health Effects 0.000 claims description 19
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 10
- 229930006000 Sucrose Natural products 0.000 claims description 10
- 239000003814 drug Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 7
- 239000000284 extract Substances 0.000 claims description 3
- 239000000126 substance Substances 0.000 claims description 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 2
- 238000011953 bioanalysis Methods 0.000 claims description 2
- 235000021551 crystal sugar Nutrition 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 235000013402 health food Nutrition 0.000 claims description 2
- 239000005720 sucrose Substances 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 20
- 239000008280 blood Substances 0.000 abstract description 4
- 210000004369 blood Anatomy 0.000 abstract description 4
- 230000002349 favourable effect Effects 0.000 abstract 1
- 230000004060 metabolic process Effects 0.000 abstract 1
- 229930014626 natural product Natural products 0.000 abstract 1
- 239000000047 product Substances 0.000 description 18
- 241000699670 Mus sp. Species 0.000 description 15
- 230000000694 effects Effects 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- 229960004756 ethanol Drugs 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 229940079593 drug Drugs 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 4
- 239000004021 humic acid Substances 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 238000012449 Kunming mouse Methods 0.000 description 3
- 239000002253 acid Substances 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 239000003153 chemical reaction reagent Substances 0.000 description 3
- 229960000935 dehydrated alcohol Drugs 0.000 description 3
- 239000007789 gas Substances 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000028527 righting reflex Effects 0.000 description 3
- 239000006228 supernatant Substances 0.000 description 3
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- 206010003084 Areflexia Diseases 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000003077 lignite Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- QJZYHAIUNVAGQP-UHFFFAOYSA-N 3-nitrobicyclo[2.2.1]hept-5-ene-2,3-dicarboxylic acid Chemical compound C1C2C=CC1C(C(=O)O)C2(C(O)=O)[N+]([O-])=O QJZYHAIUNVAGQP-UHFFFAOYSA-N 0.000 description 1
- 208000005584 Alcoholic Intoxication Diseases 0.000 description 1
- 208000006820 Arthralgia Diseases 0.000 description 1
- 206010009900 Colitis ulcerative Diseases 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 206010021531 Impetigo Diseases 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- 208000024770 Thyroid neoplasm Diseases 0.000 description 1
- 201000006704 Ulcerative Colitis Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 231100000570 acute poisoning Toxicity 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 239000012159 carrier gas Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 231100000739 chronic poisoning Toxicity 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000003054 hormonal effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007721 medicinal effect Effects 0.000 description 1
- 238000006386 neutralization reaction Methods 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000012109 statistical procedure Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 208000013076 thyroid tumor Diseases 0.000 description 1
- 238000009834 vaporization Methods 0.000 description 1
- 230000008016 vaporization Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention provides a fulvic acid health-care product with the sober-up and anti-drunk function. The health-care product is oral liquid which is characterized by comprising the following components by weight percent: 1-10 percent of fulvic acid, 5-30 percent of sugar and the balance of water. The invention obviously fastens metabolism of alcohol in human blood, increases the tolerance for human body to alcohol, shortens the drunk time and has favorable sober-up and anti-drunk function. The fulvic acid health-care product is a safe and reliable natural product and can satisfy the needs of people.
Description
Technical field
The present invention relates to a kind of health product, particularly a kind of fulvic acid health-care product with sober-up and anti-drunk function.
Background technology
Humic acids (HA) is the natural organic substance of element of the first species's complexity, is divided three classes according to the difference of its molecular weight: fulvic acid, ulmic acid and humic acid.The degree of oxidation height of fulvic acid, many, the soluble in water utilizations that are absorbed by the body of active function groups are the best a kind of humic acidss of medical effect.Before several thousand, Li Shizhen (1518-1593 A.D.) is the existing medicinal record of similar humic acids in Compendium of Material Medica, mainly in order to diseases such as treatment nosebleed, women's QI and blood pain and all sores, incised wound are hemorrhage.In recent years, there are many reports also to affirm the significant curative effect of fulvic acid, thereby affirmed the pharmaceutical value of fulvic acid diseases such as treatment thyroid tumor, ulcerative colitis, optimum arthralgia, impetigo.
Beverage for dispelling alcoholic intoxication is a lot of both at home and abroad, but mostly is simple excited type, produces class matter hormone effect thereby enter body. and " neutralization " acetaldehyde plays the effect of sobering up to the inhibitory action of human central nervous system, only is " taking stopgap measures ".For example, doctor trained in Western medicine is relieved the effect of alcohol and is mainly adopted the method for diuresis and anti symptom treatment, for acute poisoning certain curative effect is arranged, and the organs and tissues pathological change that causes for chronic poisoning then produces little effect.And its functional component of " sobering up " mostly is the chemosynthesis material, and the relevant expert not thinks should advocate use.Therefore, the health product of seeking a kind of natural sober-up and anti-drunk that has no side effect, can effect a permanent cure are imperative.
Summary of the invention
The objective of the invention is to overcome the deficiency of prior art, a kind of fulvic acid health-care product with sober-up and anti-drunk function is provided.
Health product of the present invention are a kind of oral liquids, it is characterized in that, said health product composition is counted with quality %: fulvic acid 1～10, sugar 5～30, water surplus.
The preferential health product composition of recommending of the present invention is counted with quality %: fulvic acid 5, sugar 5, water surplus.
Said fulvic acid can be the fulvic acid that extracts with chemical method, also can be the fulvic acid that adopts bioanalysis to extract; Said sugar is any in white sugar, sucrose, glucose, the crystal sugar.
The purposes of health product of the present invention is characterized in that, said health product can be used as a kind of medicine or health food with sober-up and anti-drunk function.
The present invention compares with the existing medicine of sobering up, and has the following advantages or good effect:
1, the present invention can obviously accelerate alcoholic acid accretion rate in the blood of human body, increases human body to the ethanol tolerance, shortens the drunk time of people, has a good application prospect aspect sobering up.
2, the present invention has sour-sweet mouthfeel, is fit to drink.
3, the invention belongs to all-natural product, safe and reliable.
4, preparation method of the present invention is simple, and cost consumption is low, has economic advantage.
The specific embodiment
The invention will be further described with embodiment below.
At first use the prior art for preparing fulvic acid, its preparation technology's flow process is:
Brown coal → pulverize → sieve → get fine breeze → hydrogen peroxide upper strata liquid → centrifugal → sucking filtration → get solution → drying → purification → fulvic acid of degrading → get.
Prepare health product of the present invention then, it is as follows that it prepares concrete technological process:
Fulvic acid → add water stirs → fully dissolve → adds in proportion sugar → mix → abundant dissolving → sterilization → bottling → fulvic acid health-care product.
The composition of prepared health product sees Table 1.
Table 1 health product composition of the present invention (in quality %)
By above-mentioned implementing process flow process and embodiment, can make bottled oral liquid health product with sober-up and anti-drunk function.
The zoopery of health product sober-up and anti-drunk function of the present invention
1 materials and methods
1.1 main material and reagent
1.1.1 main material
Kunming mice, male and female have concurrently, purchase the animal center in unming Medical College, feed a week.Selecting body weight is that 18～22 gram mices experimentize.
Fulvic acid: to seek the pasture brown coal is raw material, extracts the purification preparation through this lab assistant.
White sugar: the supermarket is bought.
1.1.2 main agents
Hai Wangjin cup: sea, Shenzhen Wang Jiankang development in science and technology company limited; Dehydrated alcohol (analytical pure): Tianjin causes chemical reagent company limited far away; N-butyl alcohol (analytical pure): Tianjin causes chemical reagent company limited far away; Trichloroacetic acid (analytical pure): Chemical Reagent Co., Ltd., Sinopharm Group.
1.2 key instrument and equipment
Balance: the two outstanding test instrunment in Changshu factory; Centrifuge: U.S. BECKMAN company; AgilentTechnologies 6890N gas chromatograph: Anjelen Sci. ﹠ Tech. Inc; Liquid-transfering gun: Dragon Medical(Shanghai) Co., Ltd.; Syringe: Jintan City second syringe factory; Beaker.
2 test methods
2.1 sober-up and anti-drunk experiment
Get 60 kunming mices, male and female have concurrently, and body weight is the 18-22 gram.Water 12h is can't help in fasting, be divided into 6 groups at random after weighing next day, be blank group, model group, extra large Wang Jin cup matched group, low concentration group (1% fulvic acid+5% white sugar), middle concentration group (3% fulvic acid+5% white sugar), high concentration group (5% fulvic acid+5% white sugar), every group 10 (male and female have concurrently).The administration of every group of mice elder generation, the grouping medication is as shown in table 2.
The medication of table 2 sober-up and anti-drunk experiment
Give 50% ethanol (by the dehydrated alcohol configuration) behind the administration 30min again, dosage is that 0.15ml/10g record mice righting reflex loss to righting reflex recovers the required time, and the number of elements of every group of drunk mice.
2.2 determining concentration of alcohol experiment in the mice plasma
Get 90 kunming mices, male and female have concurrently, and body weight is the 18-22 gram.Water 12h is can't help in fasting, is divided into 5 groups after weighing next day at random, promptly blank group, model group, extra large Wang Jin cup matched group, low concentration group (1% fulvic acid+5% white sugar), high concentration group (5% fulvic acid+5% white sugar), every group 18 (male and female have concurrently).The administration of every group of mice elder generation, the grouping medication is as shown in table 3.
The medication of determining concentration of alcohol experiment in table 3 mice plasma
Give 50% ethanol (by the dehydrated alcohol configuration) behind the administration 30min again, dosage is 0.15mL/10g.After ethanol is irritated stomach, get 6 mices respectively at 30,60, during 90min from each group, pluck eyeball, get blood 0.5mL, the centrifugal 10min of 2000r/min gets supernatant.Add 20 μ L n-butyl alcohol in supernatant, fully after the vibration, add 0.1mL 1mol/L trichloroacetic acid, after the vibration, the centrifugal 10min of 3000r/min gets supernatant with 1 μ L microsyringe, does gas Chromatographic Determination.Condition: Agilent Technologies 6890N gas chromatograph, chromatographic column FFAP, 110 ℃ of column temperatures, carrier gas N
2, flow velocity 13.4ml/min, 160 ℃ of temperature of vaporization chamber, 190 ℃ of sensing chamber's temperature, flame ionization ditector.
2.3 statistical procedures data
Adopt the student-t inspection statistics in the spss statistical software to analyze determining concentration of alcohol result of experiment in sober-up and anti-drunk experiment and the mice plasma, represent, P＜0.05 expression significant difference, P＜0.01 expression difference highly significant with X ± S.
3. result and analysis
3.1 sober-up and anti-drunk experimental result
Table 4 mice righting reflex loss is to recovering required time (min, n=10, x ± s)
Annotate: compare △ P＜0.05 with model group; Compare * P＜0.05 with extra large Wang Jin cup matched group.
3.2 ethanol content measurement result in the mice plasma
Determining concentration of alcohol result of experiment in table 5 mice plasma (μ g/ml, n=6, x ± s)
Annotate: compare with model group: △ P＜0.05, △ △ P＜0.01; Compare * P＜0.05 with extra large Wang Jin cup matched group.
4. conclusion
Prove by above experimentation: fulvic acid health-care product can obviously be accelerated alcoholic acid accretion rate in the mice plasma, shortens the time of mice drunk, reduces the number of elements of drunk mice, has the function of sober-up and anti-drunk.
Claims (4)
1. fulvic acid health-care product with sober-up and anti-drunk function, said health product are a kind of oral liquids, it is characterized in that, said health product composition is counted with quality %: fulvic acid 1～10, sugar 5～30, water surplus.
2. according to the health product of claim 1, it is characterized in that said health product composition is counted with quality %: fulvic acid 5, sugar 5, water surplus.
3. according to the health product of claim 1 or 2, it is characterized in that: said fulvic acid is the fulvic acid that extracts with chemical method, or the fulvic acid that adopts bioanalysis to extract; Said sugar is any in white sugar, sucrose, glucose, the crystal sugar.
4. the purposes of the health product of claim 1～3 is characterized in that, said health product can be used as a kind of medicine or health food with sober-up and anti-drunk function.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910218269A CN101721425A (en) | 2009-12-02 | 2009-12-02 | Fulvic acid health-care product with sober-up and anti-drunk function |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200910218269A CN101721425A (en) | 2009-12-02 | 2009-12-02 | Fulvic acid health-care product with sober-up and anti-drunk function |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN101721425A true CN101721425A (en) | 2010-06-09 |
Family
ID=42443377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200910218269A Pending CN101721425A (en) | 2009-12-02 | 2009-12-02 | Fulvic acid health-care product with sober-up and anti-drunk function |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN101721425A (en) |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404642A (en) * | 2013-08-20 | 2013-11-27 | 昆明理工大学 | Solid instant tea containing fulvic acid and preparation method for solid instant tea |
| CN103564587A (en) * | 2013-11-05 | 2014-02-12 | 云南韵雅生物科技有限公司 | Natural fulvic acid compound health-care beverage as well as preparation method thereof |
| CN106922898A (en) * | 2015-12-31 | 2017-07-07 | 营口富里泥炭科技有限公司 | A kind of fulvic acid alcohol decomposing tea made from kudzuvine flower |
| CN107455632A (en) * | 2017-06-15 | 2017-12-12 | 昆明理工大学 | A kind of young coal degradation solution flavor beverage |
| WO2023057908A1 (en) * | 2021-10-04 | 2023-04-13 | Next Level Health Sciences Inc. | Compositions and methods for treating acute alcohol intake |
-
2009
- 2009-12-02 CN CN200910218269A patent/CN101721425A/en active Pending
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404642A (en) * | 2013-08-20 | 2013-11-27 | 昆明理工大学 | Solid instant tea containing fulvic acid and preparation method for solid instant tea |
| CN103404642B (en) * | 2013-08-20 | 2015-11-04 | 昆明理工大学 | A kind of instant solid tea containing fulvic acid and preparation method thereof |
| CN103564587A (en) * | 2013-11-05 | 2014-02-12 | 云南韵雅生物科技有限公司 | Natural fulvic acid compound health-care beverage as well as preparation method thereof |
| CN106922898A (en) * | 2015-12-31 | 2017-07-07 | 营口富里泥炭科技有限公司 | A kind of fulvic acid alcohol decomposing tea made from kudzuvine flower |
| CN107455632A (en) * | 2017-06-15 | 2017-12-12 | 昆明理工大学 | A kind of young coal degradation solution flavor beverage |
| WO2023057908A1 (en) * | 2021-10-04 | 2023-04-13 | Next Level Health Sciences Inc. | Compositions and methods for treating acute alcohol intake |
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Open date: 20100609 |