CN101463314A - Non-intoxicated liquor and preparation of antialcoholism nutrient fluid therefor - Google Patents
Non-intoxicated liquor and preparation of antialcoholism nutrient fluid therefor Download PDFInfo
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- CN101463314A CN101463314A CNA2008101822421A CN200810182242A CN101463314A CN 101463314 A CN101463314 A CN 101463314A CN A2008101822421 A CNA2008101822421 A CN A2008101822421A CN 200810182242 A CN200810182242 A CN 200810182242A CN 101463314 A CN101463314 A CN 101463314A
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Abstract
The invention relates to a manufacture method for a non-heady liquor and a nutrient fluid neutralizing the effect of alcoholic drinks, which comprises that extracted aescin, alcohol dehydrogenase, acetaldehyde dehydrogenase, daidzein, pueraria flavonoid, taurine, citric acid and the like are combined according to a definite proportion, well stirred, treated for 28 min in an ultrasonic instrument with 120 Hz so as to reinforce the association among molecules, and then stands for hours, is added with soapy clay for defog and stability treatment, and then filtered; finally the nutrient fluid neutralizing the effect of alcoholic drinks is obtained. The nutrient fluid neutralizing the effect of alcoholic drinks is directly added into various liquors according to one in a thousand to ten in a thousand proportion and reserved for 15 days, and then can be drank, can play a good role in anti-intoxication, neutralizing the effect of alcoholic drinks and enlarging capacity for liquor. Or 25m of nutrient liquid is drunk directly before drinking liquor and after intoxication, which also can achieve the purpose of neutralizing the effect alcoholic drinks.
Description
Technical field:
The present invention relates to a kind of Chinese medicinal materials that utilizes, carry out technologies such as biological fermentation, extraction diacolation, the method for making the alcoholic drink with antialcoholism function belongs to the wine product field.
Background technology:
Record and narrate according to patent documentation, possess mostly being of antialcoholism function and adopt the Chinese medicinal materials class, make up and produce, majority is single antialcoholism function, does not have the effect of supporting protecting liver.And all be to be made into tablet or electuary class, must after drunk, just implement to relieve the effect of alcohol.And drink in advance many inconvenient parts are arranged to the people.Chinese patent publication number CN101125170A discloses gastric floating composition for sobering up, though the effect of relieving the effect of alcohol is obvious, must take before drinking.The production method of publication number CN1814209A drunk-sobering tablet, such tablet all are that people take after drunk.No matter can find out from above-mentioned antialcoholism nutrient fluid, be to drink before drinking, and still drinks after drunk, all causes very big inconvenience to people, even caused the drunk fact to the human injury.
The purpose of this invention is to provide a kind of convenient use, do not influence former wine color and physical and chemical index thereof, can be added directly into the biological antialcoholism nutrient fluid of low wine degree in the wine, the effect that can play pre-preventing drunkenness and sober up fast, and can increase drinking amount.How in a few days alcohol in the rapid decomposable body suppresses the absorption of stomach and intestine to alcohol, eliminate drink back headache, dry, the aching and limp phenomenon of human body.
Summary of the invention:
The objective of the invention is to extract diacolation and cooperatively interact with biological fermentation and Chinese medicinal materials, a kind of biological antialcoholism nutrient fluid that can directly add in any wine of making, the flavour of a drug of its preparation own are extremely low, can not change self style and characteristic that is added into wine after adding in the wine.Substantially can not change physical and chemical index and the color and luster that is added into wine.Can not form muddiness and precipitation yet, be fit to various height drinks.
The wine that adds this biological antialcoholism nutrient fluid has many drinks and is difficult for liquor-saturated effect, has the effect of liver protecting simultaneously.Can increase people at ordinary times drinking amount 1-2 doubly.Even excess is drunk, the back dry that also can not occur drinking goes up first-class phenomenon.
Technical solution of the present invention is; a kind of biological antialcoholism nutrient fluid and preparation method thereof is provided; described biological antialcoholism nutrient fluid by raw materials such as Aescin, ethanol dehydrogenase and acetaldehyde dehydrogenase, daidzein, Radix Puerariae total flavones, taurine, citric acid, ethanol, water successively by 7～10: 6～12: 7～14: 5～13: 1～5: 1～3: 8～12: 40～55 weight percents are mixed with, and wherein extracting method is:
1, Aescin: fallow powder, extracting method: the dry mature fruit of natural phant horse-chestnut Aesculuschinensis bge is smashed, pack into diameter be in 1: 2 the percolator at high proportion, edible ethanol with 60% soaks 24h, 60% ethanol with 8 times of sample volumes carries out diacolation then, speed with per minute 3ml/100g raw material is carried out, and gets percolate altogether three times.The percolate of collecting adsorbs through the XDA-10 large aperture adsorption resin earlier, and then decolour, take off flavor by activated carbon column and handle, and carry out condensing crystal, to be further purified processing after the crude product crystallization, obtain its functional component compound Aescin, the general content of its effective constituent Aescin is 12%～20%.
2, the extraction of ethanol dehydrogenase and acetaldehyde dehydrogenase: the extraction of this material is with Flower of Rice Bean, dark plum, hawthorn, Mung Bean flower, dried orange peel, the cadmium yellow melon, red ginseng, Radix Glycyrrhizae, bright pears, matrimony vine, the green apple skin, bright pomegranate, honey raisin tree be raw material successively by 1～3: 2～8: 1～4: 2～5: 1～2: 6～12: 1～3: 2～3: 4～10: 3～6: 2～3: 4～8: 3～6 weight percent compatibilities, mix and pulverize 10～25min, break into pulpous state, the water that adds 1～1.5 times, with 12～22% sucrose, 8/10000ths yeast, 30 ℃ of fermentations of temperature control 12 days, collect fermented liq, centrifugal treating, adding sulfuric acid amine then thereon in the clear liquid makes its concentration reach at 20～30% o'clock, secondary centrifuging was handled 5～12 minutes, collection gained precipitation, adsorb through DEAE-Tuyopearl post layer again, wash-out, underpressure distillation then prepares through gel-filtration again.
3, Radix Puerariae total flavones: extracting method: get the root of kudzu vine and break into meal, measure 70% alcohol reflux 2 times with 4 times, each 1 hour, merge ethanol extract, filter, reclaim ethanol, the aqueous solution is with the ratio of the per 100 gram medicinal materials/100 gram resins macroporous adsorptive resins by the AB-8 type handled well, earlier with the water elution of 4 times of amounts of resin volume, discard water elution liquid, continue and wash, discard elutriant, then with 70% ethanol elution with 10% ethanol, collect elutriant, reclaim ethanol, aqueous solution vacuum concentration, drying promptly get Radix Puerariae total flavones.
The Aescin that adopts among the present invention is the main active ingredient of seven tree section Europe horse-chestnuts, and it has the effect of anti-inflammatory, Ivy extract, enhancing intravenous tension, inhibition stomach emptying, gastric acid inhibitory secretion, removing active oxygen and synergistic antitumor.Empirical tests, the Aescin duodenal administration all has the obvious suppression effect to the gastric acid secretion increase that 2 kinds of agonists cause, and the prompting Aescine can participate in the adjusting of hydrochloric acid in gastric juice by neural and two kinds of approach of internal secretion.Aescine can make gastric mucosal cell quantity and glycoprotein content increase, and can partly suppress the provide protection of Aescine to stomach mucous membrane and give INDOMETHACIN, and the prompting Aescine participates in gastric mucosal protection and suppresses gastric emptying by improving the prostaglandin(PG) level.The principle that Aescin relieves the effect of alcohol is effective constituent Aescin Ia, Ib, IIa and IIb; its structure contains 2 '-O-xylopyranosyl and 2 '-the O-glucopyranosyl; experimental results show that 2 '-the O-xylopyranosyl has the active effect of the ethanol of inhibition; 2 '-the O-glucopyranosyl then has and reduces the active effect of ethanol; and the both is contained deacetylate group; acyl group is very important to the alcoholic acid restraining effect, has the sugar of pressing down activity simultaneously.Can effectively suppress to hold back in the stomach absorption of alcohol, can effectively prevent the inflammation of gastric mucosa simultaneously, ooze out.
Highly active ethanol dehydrogenase and acetaldehyde dehydrogenase be decomposing alcohol rapidly, reduces concentration of ethanol in serum, and serum paraoxonase lipase, slurry lipid peroxide level are reduced, and promotes that acetaldehyde is decomposed into acetate and water rapidly.The main absorption approach of wine is a digestive tube, absorbed alcohol major part enters liver from portal vein, wherein 90%～98% at liver metabolism, only 2%～10% alcohol is got rid of through urine, sweat gland and respiratory tract, the metabolism main path (80%) of alcohol in liver is for to be decomposed into acetaldehyde by ethanol dehydrogenase, change acetyl-CoA by acetaldehyde dehydrogenase into as coenzyme again, further change carbonic acid gas and water into through tricarboxylic acid cycle, or by other compound of Citric Acid circulation changing into.Because the individual difference of human body, the amount of contained ethanol dehydrogenase and acetaldehyde dehydrogenase is also inconsistent.The difference of capacity for liquor has also just showed.
Antialcoholism nutrient fluid with present method preparation has not only kept outside the pharmaceutical use, also because by biological extraction modes such as fermentations, is rich in multiple amino acids, higher oligose, trace element, multiple physiologically active ingredient, VITAMIN etc.It can reach anti-intoxication purpose, has the effect of well relieving the effect of alcohol with liver protecting simultaneously.Can drink separately, also can directly join in the various Wines, can't change the physical and chemical index that original fragrance and taste and drinks detect according to certain ratio.
Embodiment:
Embodiment one:
6 parts of 7 parts of ethanol dehydrogenases of Aescin and acetaldehyde dehydrogenases
8 parts of 8 parts of Radix Puerariae total flavoness of daidzein
2 parts of 1 part of citric acids of taurine
41 parts in 8 parts of water of ethanol
With above-mentioned raw materials according to the weight percent proportioning, earlier 2 parts of citric acids are dissolved in 41 parts of water, add ethanol, stir, slowly add surplus materials, stir, in the ultrasonic instrument of 120Hz, handle 28min then, strengthen the association between the molecule, left standstill then seven days, add millesimal bentonite and carry out turbidity removal and stability processing, filter, promptly get antialcoholism nutrient fluid.This nutritive medium is capable of direct drinking, drinks 25ml after wine is preceding or drunk and can reach the purpose of relieving the effect of alcohol.
Embodiment two:
10 parts of 9 parts of ethanol dehydrogenases of Aescin and acetaldehyde dehydrogenases
12 parts of 12 parts of Radix Puerariae total flavoness of daidzein
2 parts of 1 part of citric acids of taurine
45 parts in 12 parts of water of ethanol
Making method is with embodiment one.
Using method for drunk serious people, can directly be taken this product, generally takes 25ml and can reach the purpose of relieving the effect of alcohol fully in 30min.For drinks manufacturing enterprise, can directly add in the wine according to the ratio of thousandth to ten, store more than 15 days and can dispatch from the factory.
Antialcoholism nutrient fluid with method for preparing reaches the desired result that relieves the effect of alcohol fully through testing, being proved to be, and this antialcoholism nutrient fluid relieves the effect of alcohol and the preventing drunkenness experiment:
Get this antialcoholism nutrient fluid, add 5/1000ths in common 48%VOL liquor, be mixed with and be difficult for liquor-saturated wine, standby.
Get 40 male and female half and half, the kunming mice of weight between 18～21g is experimental subjects, be divided into 4 groups at random, every group 10, be set at experimental group and control group respectively, be divided into big-and-middle small dose group in the experimental group, control group is irritated stomach every day and is given common wine 0.3ml, all the other groups give respectively different amounts be difficult for drunk.Carried out continuously 30, and on the 2nd, 5,10,15,20 mouse is carried out righting reflex experiment respectively, and observe the number of elements of righting reflex loss occurring for mouse in 1 hour after drinking, righting reflex loss can think that animal is drunk, 5 observed results of accumulative total are added up its drunk rate.
Experimental result shows that each experimental group is compared with control group, and drunk rate obviously reduces, and shows that it has the drunk effect of good preventing.
The drunk prevention experiment of table 1 mouse
The present invention can summarize with other the specific form without prejudice to spirit of the present invention or principal character.Therefore no matter from which point, above-mentioned embodiment of the present invention all can only be thought can not limit the present invention to explanation of the present invention, claims have been pointed out scope of the present invention, and scope of the present invention is not pointed out in above-mentioned explanation, therefore, in implication suitable and the change then in the scope, all should think to be included in the scope of claims with claims of the present invention.
Claims (5)
1, a kind of making method that is difficult for liquor-saturated wine and antialcoholism nutrient fluid thereof; it is characterized in that it be by Aescin, ethanol dehydrogenase and acetaldehyde dehydrogenase, daidzein, Radix Puerariae total flavones and taurine, citric acid etc. according to the combination of certain ratio, and the antialcoholism nutrient fluid of making through technology such as clarification, association.
2, as the said a kind of making method that is difficult for liquor-saturated wine and antialcoholism nutrient fluid thereof of claim 1, the extraction that it is characterized in that ethanol dehydrogenase and acetaldehyde dehydrogenase is the mode that adopts biological fermentation, passes through centrifugal treating then, and modes such as column chromatography are extracted.
3, as the said a kind of making method that is difficult for liquor-saturated wine and antialcoholism nutrient fluid thereof of claim 1, it is characterized in that having added in this nutritive medium sulfur-containing amino acid (taurine) and citric acid.
4, as the said a kind of making method that is difficult for liquor-saturated wine and antialcoholism nutrient fluid thereof of claim 1, it is characterized in that this antialcoholism nutrient fluid by raw materials such as Aescin, ethanol dehydrogenase and acetaldehyde dehydrogenase, daidzein, Radix Puerariae total flavones, taurine, citric acid, ethanol, water successively by 7～10: 6～12: 7～14: 5～13: 1～5: 1～3: 8～12: 40～55 weight percents are mixed with.
5, as the said a kind of making method that is difficult for liquor-saturated wine and antialcoholism nutrient fluid thereof of claim 1, it is characterized in that this antialcoholism nutrient fluid passes through ultrasonication, strengthen the association between the molecule, and by the bentonite clarifying treatment, can directly add in the wine, and not change the color of wine and index etc.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2008101822421A CN101463314B (en) | 2008-11-21 | 2008-11-21 | Non-intoxicated liquor and preparation of antialcoholism nutrient fluid therefor |
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| CN2008101822421A CN101463314B (en) | 2008-11-21 | 2008-11-21 | Non-intoxicated liquor and preparation of antialcoholism nutrient fluid therefor |
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| CN101463314A true CN101463314A (en) | 2009-06-24 |
| CN101463314B CN101463314B (en) | 2013-01-30 |
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101796989A (en) * | 2010-03-16 | 2010-08-11 | 唐桂德 | Liver-protecting sober-up tea and preparation thereof |
| CN105838559A (en) * | 2016-05-11 | 2016-08-10 | 合肥九研医药科技开发有限公司 | Mixed wine and preparation method thereof |
| CN105838554A (en) * | 2016-06-12 | 2016-08-10 | 云南金七制药有限公司 | Radix notoginseng, radix astragali and lycii fructus wine and preparation method thereof |
| CN109329941A (en) * | 2018-12-19 | 2019-02-15 | 九仙尊霍山石斛股份有限公司 | A kind of Dendrobidium huoshanness relieves the effect of alcohol particle and preparation method thereof |
| CN111494554A (en) * | 2019-01-31 | 2020-08-07 | 姜辉 | Dendrobium wine and preparation method of dendrobium anti-alcohol liquid |
-
2008
- 2008-11-21 CN CN2008101822421A patent/CN101463314B/en active Active
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101796989A (en) * | 2010-03-16 | 2010-08-11 | 唐桂德 | Liver-protecting sober-up tea and preparation thereof |
| CN101796989B (en) * | 2010-03-16 | 2013-02-20 | 唐桂德 | Liver-protecting sober-up tea and preparation thereof |
| CN105838559A (en) * | 2016-05-11 | 2016-08-10 | 合肥九研医药科技开发有限公司 | Mixed wine and preparation method thereof |
| CN105838554A (en) * | 2016-06-12 | 2016-08-10 | 云南金七制药有限公司 | Radix notoginseng, radix astragali and lycii fructus wine and preparation method thereof |
| CN109329941A (en) * | 2018-12-19 | 2019-02-15 | 九仙尊霍山石斛股份有限公司 | A kind of Dendrobidium huoshanness relieves the effect of alcohol particle and preparation method thereof |
| CN111494554A (en) * | 2019-01-31 | 2020-08-07 | 姜辉 | Dendrobium wine and preparation method of dendrobium anti-alcohol liquid |
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| Publication number | Publication date |
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| CN101463314B (en) | 2013-01-30 |
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