CN101715455A - 抗菌的1,4,5-取代的氨基糖苷类似物 - Google Patents

抗菌的1,4,5-取代的氨基糖苷类似物 Download PDF

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Publication number
CN101715455A
CN101715455A CN200880018276A CN200880018276A CN101715455A CN 101715455 A CN101715455 A CN 101715455A CN 200880018276 A CN200880018276 A CN 200880018276A CN 200880018276 A CN200880018276 A CN 200880018276A CN 101715455 A CN101715455 A CN 101715455A
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CN
China
Prior art keywords
compound
amino
mmol
groups
added
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Pending
Application number
CN200880018276A
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English (en)
Chinese (zh)
Inventor
马丁·里恩塞尔
亚当·亚伦·罗德伯鲁姆
詹姆士·阿根
海因兹·摩泽尔
斯蒂芬·哈尼斯恩
坎达萨米·帕查姆图
埃伦·克莱格拉夫
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Achaogen Inc
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Achaogen Inc
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Application filed by Achaogen Inc filed Critical Achaogen Inc
Publication of CN101715455A publication Critical patent/CN101715455A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/228—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings
    • C07H15/232—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to adjacent ring-carbon atoms of the cyclohexane rings with at least three saccharide radicals in the molecule, e.g. lividomycin, neomycin, paromomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN200880018276A 2007-04-10 2008-04-10 抗菌的1,4,5-取代的氨基糖苷类似物 Pending CN101715455A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91090907P 2007-04-10 2007-04-10
US60/910,909 2007-04-10
PCT/US2008/059904 WO2008124821A1 (en) 2007-04-10 2008-04-10 Antibacterial 1,4,5-substituted aminoglycoside analogs

Publications (1)

Publication Number Publication Date
CN101715455A true CN101715455A (zh) 2010-05-26

Family

ID=39473373

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880018276A Pending CN101715455A (zh) 2007-04-10 2008-04-10 抗菌的1,4,5-取代的氨基糖苷类似物

Country Status (6)

Country Link
US (1) US20080300199A1 (cg-RX-API-DMAC10.html)
EP (1) EP2148884A1 (cg-RX-API-DMAC10.html)
JP (1) JP2010527913A (cg-RX-API-DMAC10.html)
CN (1) CN101715455A (cg-RX-API-DMAC10.html)
CA (1) CA2684957A1 (cg-RX-API-DMAC10.html)
WO (1) WO2008124821A1 (cg-RX-API-DMAC10.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103282370A (zh) * 2010-11-17 2013-09-04 尔察祯有限公司 抗菌氨基糖苷类类似物
CN105384673A (zh) * 2015-11-09 2016-03-09 南京富润凯德生物医药有限公司 3-氟代-氮杂环丁烷衍生物的合成方法

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CA2585253C (en) * 2004-11-05 2011-05-24 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
WO2007028012A2 (en) * 2005-09-01 2007-03-08 Isis Pharmaceuticals, Inc. Antibacterial 6'-n-modified 4,5-substituted aminoglycoside analogs
JP5256043B2 (ja) 2005-12-02 2013-08-07 アイシス ファーマシューティカルズ， インコーポレーテッド 複数の置換基を有する抗菌４，５−置換アミノグリコシドアナログ
PL2217610T3 (pl) 2007-11-21 2017-04-28 Achaogen, Inc. Przeciwbakteryjne analogi aminoglikozydów
EP2279291B1 (en) * 2008-04-09 2019-07-03 Cornell University Coferons and methods of making and using them
WO2010030690A1 (en) 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) * 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132757A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132759A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132768A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132760A1 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132765A2 (en) 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2011043817A1 (en) * 2009-10-07 2011-04-14 Cornell University Coferons and methods of making and using them
WO2011044498A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2011044538A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs
MX2012004036A (es) 2009-10-09 2012-06-27 Achaogen Inc Analogos de aminoglicosidos antibacterianos.
WO2011044503A1 (en) * 2009-10-09 2011-04-14 Achaogen, Inc. Antibacterial aminoglycoside analogs

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US3896106A (en) * 1972-06-26 1975-07-22 Bristol Myers Co Antibiotic derivatives
US3808198A (en) * 1972-09-07 1974-04-30 Bristol Myers Co Lividomycin b derivatives
US3860574A (en) * 1972-12-06 1975-01-14 Bristol Myers Co Derivatives of neomycin b and neomycin c
FR2209546B1 (cg-RX-API-DMAC10.html) * 1972-12-06 1977-09-02 Bristol Myers Co
JPS553358B2 (cg-RX-API-DMAC10.html) * 1973-03-13 1980-01-24
US4170642A (en) * 1973-10-01 1979-10-09 Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai Derivatives of kanamycin A
FR2274628A1 (fr) * 1974-04-11 1976-01-09 Farmaceutici Italia Derives de la paromomycine et procede pour les preparer
JPS5850235B2 (ja) * 1974-12-11 1983-11-09 明治製菓株式会社 ３′，４′−α−エポキシ−リボスタマイシン又は−カナマイシンＢの製造法
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US4424343A (en) * 1977-04-28 1984-01-03 Bristol Myers Company Preparation of 1-N- ω-amino-α-hydroxyalkanoyl!kanamycin polysilylates and products
ZA803031B (en) 1979-06-07 1981-05-27 Erba Farmitalia Paromomycin derivatives
US4247687A (en) * 1979-06-12 1981-01-27 Farmitalia Carlo Erba S.P.A. Aminoglycoside antibiotic derivatives and process for their preparation
DE3206725A1 (de) * 1981-05-13 1982-12-02 Merck Patent Gmbh, 6100 Darmstadt Schwer loesliche salze von aminoglykosidantibiotika
DE3431534A1 (de) * 1984-08-28 1986-03-13 Merck Patent Gmbh, 6100 Darmstadt Flavanonderivate
IT1225484B (it) * 1987-11-27 1990-11-14 Pierrel Spa Procedimento di sintesi dell'amikacina
US5470836A (en) * 1988-04-29 1995-11-28 Farmitalia Carlo Erba S.R.L. Paromomycin or its derivatives or salts thereof in combination with sodium stirogluconate for parenteral treatment of human parasitic diseases
US5534408A (en) * 1993-09-24 1996-07-09 University Of Massachusetts Medical Center 2-deoxystreptamine aminoglycoside inhibition of HIV RRE/Rev binding
WO1994009792A1 (en) * 1992-10-23 1994-05-11 University Of Massachusetts Medical Center Small molecule inhibition of rna/ligand binding
WO1997009053A1 (en) * 1995-09-08 1997-03-13 Scriptgen Pharmaceuticals, Inc. 2-deoxystreptamine as a molecular scaffold for preparing functionally and spatially diverse molecules and pharmaceutical compositions thereof
US6541456B1 (en) * 1999-12-01 2003-04-01 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
US7160992B2 (en) * 2003-04-28 2007-01-09 Yeda Research And Development Co., Ltd. Amino-modified polysaccharides and methods of generating and using same
US7635685B2 (en) * 2003-07-03 2009-12-22 Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes and for inhibition of anthrax lethal factor
US20050004052A1 (en) * 2003-07-03 2005-01-06 Technion Research & Development Foundation Ltd. Bifunctional antibiotics for targeting rRNA and resistance-causing enzymes
CA2585253C (en) * 2004-11-05 2011-05-24 Isis Pharmaceuticals, Inc. Antimicrobial 2-deoxystreptamine compounds
WO2007028012A2 (en) * 2005-09-01 2007-03-08 Isis Pharmaceuticals, Inc. Antibacterial 6'-n-modified 4,5-substituted aminoglycoside analogs
JP5256043B2 (ja) * 2005-12-02 2013-08-07 アイシス ファーマシューティカルズ， インコーポレーテッド 複数の置換基を有する抗菌４，５−置換アミノグリコシドアナログ
PL2217610T3 (pl) * 2007-11-21 2017-04-28 Achaogen, Inc. Przeciwbakteryjne analogi aminoglikozydów
WO2010030690A1 (en) * 2008-09-10 2010-03-18 Isis Pharmaceuticals, Inc. Antibacterial 4,6-substituted 6', 6" and 1 modified aminoglycoside analogs
WO2010030704A2 (en) * 2008-09-10 2010-03-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042850A1 (en) * 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010042851A1 (en) * 2008-10-09 2010-04-15 Achaogen, Inc. Antibacterial aminoglycoside analogs
AR076584A1 (es) * 2009-05-14 2011-06-22 Achaogen Inc Metodo para tratar infeccion bacteriana. regimenes de dosificacion de aminoglicosidos. un aminoglucosido
WO2010132777A2 (en) * 2009-05-14 2010-11-18 Achaogen, Inc. Treatment of urinary tract infections with antibacterial aminoglycoside compounds
CN102481307B (zh) * 2009-05-14 2016-08-24 尔察祯有限公司 使用抗菌氨基糖苷化合物治疗肺炎克雷伯杆菌感染
WO2010132759A1 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of dibekacin
WO2010132760A1 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of tobramycin
WO2010132768A1 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial derivatives of sisomicin
WO2010132757A2 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010132765A2 (en) * 2009-05-15 2010-11-18 Achaogen, Inc. Antibacterial aminoglycoside analogs
WO2010147836A1 (en) * 2009-06-17 2010-12-23 Achaogen, Inc. Combination therapies using antibacterial aminoglycoside compounds
JP2013542992A (ja) * 2010-11-17 2013-11-28 アカオジェン インコーポレイテッド 抗菌性アミノグリコシド類似体

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103282370A (zh) * 2010-11-17 2013-09-04 尔察祯有限公司 抗菌氨基糖苷类类似物
CN105384673A (zh) * 2015-11-09 2016-03-09 南京富润凯德生物医药有限公司 3-氟代-氮杂环丁烷衍生物的合成方法
CN105384673B (zh) * 2015-11-09 2017-11-14 南京富润凯德生物医药有限公司 3‑氟代‑氮杂环丁烷衍生物的合成方法

Also Published As

Publication number Publication date
EP2148884A1 (en) 2010-02-03
JP2010527913A (ja) 2010-08-19
CA2684957A1 (en) 2008-10-16
US20080300199A1 (en) 2008-12-04
WO2008124821A1 (en) 2008-10-16

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
C53 Correction of patent of invention or patent application
CB03 Change of inventor or designer information

Inventor after: Linsell Martin

Inventor after: Goldblum Adam Aaron

Inventor after: Aggen James

Inventor after: Moser Heinz

Inventor after: Hanessian Stephen

Inventor after: Pachamuthu Kandasamy

Inventor after: Klegraf Ellen

Inventor after: Dozzo Paola

Inventor after: Hildebrandt Darin James

Inventor before: Linsell Martin

Inventor before: Goldblum Adam Aaron

Inventor before: Aggen James

Inventor before: Moser Heinz

Inventor before: Hanessian Stephen

Inventor before: Pachamuthu Kandasamy

Inventor before: Klegraf Ellen

COR Change of bibliographic data

Free format text: CORRECT: INVENTOR; FROM: LINSELL MARTIN GOLDBLUM ADAM AARON AGGEN JAMES MOSER HEINZ HANESSIAN STEPHEN PACHAMUTHU KANDASAMY KLEGRAF ELLEN TO: LINSELL MARTIN GOLDBLUM ADAM AARON AGGEN JAMES MOSER HEINZ HANESSIAN STEPHEN PACHAMUTHU KANDASAMY KLEGRAF ELLEN DOZZO PAOLA HILDEBRANDT DARIN JAMES

C02 Deemed withdrawal of patent application after publication (patent law 2001)
WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20100526