CN101711836B - Preparation used for treating gastritis and gastric ulcer and protecting gastric mucous membranes - Google Patents
Preparation used for treating gastritis and gastric ulcer and protecting gastric mucous membranes Download PDFInfo
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- CN101711836B CN101711836B CN 200910260975 CN200910260975A CN101711836B CN 101711836 B CN101711836 B CN 101711836B CN 200910260975 CN200910260975 CN 200910260975 CN 200910260975 A CN200910260975 A CN 200910260975A CN 101711836 B CN101711836 B CN 101711836B
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Abstract
The invention relates to a preparation used for treating gastritis and gastric ulcer and protecting gastric mucous membranes, which adopts astragalus root, white atractylodes rhizome, dandelion, evodia rutaecarpa, dahurian angelica root and hyacinth bletilla as raw materials. The preparation is characterized by being prepared from the following raw materials proportioned by weight: 520-580g of astragalus root, 290-350g of white atractylodes rhizome, 250-310g of dandelion, 220-280g of evodia rutaecarpa, 170-230g of dahurian angelica root and 40-80g of hyacinth bletilla. Fine powder is obtained by the processes of extraction, concentration, pulverization, mixing and the like, and different medicament forms, such as capsules, tablets, granules and the like, are prepared by combining medicinal auxiliary materials. The invention has the advantages that various medicines are matched by the astragalus root and the white atractylodes rhizome which have the functions of strengthening the spleen and supplementing qi, the dandelion and the evodia rutaecarpa which have the functions of suppressing gastric acid secretion and resisting ulcers, the dahurian angelica root which has the functions of restoring and healing tissues of the ulcers and the hyacinth bletilla which has the function of protecting the cells of the stomach and the bowel, the gastric acid secretion is suppressed, gastric glands are activated to secrete a great deal of stomach mucus, the tissues with the ulcers are restored and healed, and the health-care functions of protecting the gastric mucous membranes and improving the functions of the stomach and the bowel are exerted together. The invention is suitable for the symptoms of bellyache, abdominal distention, diarrhea, indigestion, anorexia, eructation and the like caused by the gastritis and the gastric ulcer.
Description
Technical field
The present invention relates to a kind of Chinese medicine formula, is a kind of compound Chinese medicinal preparation for the treatment of gastritis and gastric ulcer, protection gastric mucosa.
Background technology
At present, the sickness rate of gastrointestinal disease is more and more higher, and the middle-aged and elderly people more than 50 years old is more common, and the male is higher than the women, and in progressively rejuvenation.Operating pressure is large, diet is irregular and be addicted to drink and all can cause the damage of gastric mucosa.Nervous busy operating pressure can make spirit, the overdraw of physical over loading, cause gastrointestinal dysfunction, gastric mucus reduces, and gastric mucosa is impaired, flatulence, gastric acid, gastric ulcer, dyspeptic symptom appear at short notice, if not as good as early treatment can cause gastric perforation, the serious consequence such as cancerate.Tool authoritative institution investigation shows, China's gastrointestinal disease sickness rate increases than having significantly before 4 years, and its middle school student account for 13%, and the working clan accounts for 56%, and the old man accounts for 31%.Therefore, develop the compound Chinese medicinal preparation that is fit to gastrointestinal disease patient use and seem very important.
Summary of the invention
The invention provides a kind of preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa, not only therapeutic effect is good, and cheap, taking convenience.
The technical solution adopted in the present invention is: it adopts the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Taraxaci, Fructus Evodiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material, it is characterized in that it is the preparation of being made by the raw material of following weight proportioning: take Radix Astragali 520-580g, Rhizoma Atractylodis Macrocephalae 290-350g, Herba Taraxaci 250-310g, Fructus Evodiae 220-280g, Radix Angelicae Dahuricae 170-230g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40-80g as raw material, through extract, the techniques such as concentrated, pulverizing, mixing obtain fine powder, make different dosage forms in conjunction with pharmaceutic adjuvant, such as capsule, tablet, granule etc.
It is 1.5～2.1g that preparation suggestion day of the present invention takes effective dose, divide three times, and one after each meal, warm water delivery service gets final product.
The invention has the beneficial effects as follows: by the Radix Astragali, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI; Herba Taraxaci, Fructus Evodiae gastric acid secretion inhibiting, antiulcer; Radix Angelicae Dahuricae healing chronic ulcer tissue; Pseudobulbus Bletillae (Rhizoma Bletillae) protection gastrointestinal cell; all medicines cooperate, and gastric acid secretion inhibiting activates gastric gland and secretes a large amount of gastric mucus; healing chronic ulcer tissue, common performance are protected gastric mucosa, are improved the health-care effect of gastrointestinal function.Be applicable to because of symptoms such as stomachache that gastritis and gastric ulcer cause, abdominal distention, diarrhoea, dyspepsia, anorexia, heating installation.
Compound basis:
Radix Astragali sweet in the mouth, warm in nature.Return lung, spleen channel.The tool benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, the effect of promoting pus discharge and tissue regeneration strengthening.Main chemical compositions has astragaloside, astragalus polysaccharides, γ-aminobutyric acid, trace element-selenium, manganese, ferrum, calcium etc.Experimental result shows take the Radix Astragali as main Compound Huangqi Decoction, gastric mucosa is had significant protective effect, can prevent or alleviate indometacin to the damage of gastric mucosa of rat.The Radix Astragali essenc oral formulations is at 1.25～5g.kg
-1Dosage range in, continuous use 7 days, but the reduction gastric mucosa of animal damage index of dose dependent has obvious gastric mucosal protective effect.Clinical observation shows that Radix Glycyrrhizae Preparata tragacanth charcoal soup is improved stomach attacking and defending factor dysequilibrium situation, and the protection gastric mucosal barrier promotes the effect of ulcer healing.The Radix Astragali, the Radix Angelicae Sinensis injection injection tsusanli acupoint can suppress the damage of experimental atrophic gastritis gastric mucosal barrier; In the Weiweikang mixture for the treatment of chronic atrophic gastritis compatibility Radix Astragali holder skin ulcer granulation promoting, to help gastric mucosal regeneration, the restoration of old ways of atrophy.In addition, Radix Astragali single uses, or uses with the other medicines compatibility, as treating the diseases such as Deficiency and coldness of spleen and stomach, chronic enteritis, gastritis, diarrhoea with medicine compatibilities such as Radix Paeoniae, Radix Glycyrrhizae, Ramulus Cinnamomi, Rhizoma Alpiniae Officinarum, maltoses.
Rhizoma Atractylodis Macrocephalae bitter but sweet flavor, warm in nature.Return spleen, stomach warp.Have spleen reinforcing, stomach reinforcing, dampness and in effect.Its chemical constituent mainly contains volatile oil, atractylol, and atractylone, selinene etc. also contain the compositions such as vitamin A.Has the function that strengthens gastric mucosal cell propagation and repair and adjust gastrointestinal motility.Rhizoma Atractylodis Macrocephalae acetone extract has inhibitory action to pylorus ligation rat gastric secretion, can reduce gastric acidity, reduces gastric acid and pepsic output, and pepsin activity is had inhibitory action; The per os gastric infusion, 50mg/kg has preventive and therapeutic effect to rat pipe film injury due to hydrochloric acid-ethanol.There are some researches show that the Rhizoma Atractylodis Macrocephalae has very strong preventive effect to stress ulcer, its mechanism is to relax the general underactivity that causes under the stress state, and its active component is atractylone, has similar ACTH effect.Add the flavor SHENLING BAISHU SAN by strengthening the active of antioxidant and suppressing lipid peroxidation and oxidative damage, reach the protective effect to rat pipe film injury due to the indomethacin.
The Herba Taraxaci bitter but sweet flavor, cold in nature.Return liver, stomach warp.Mainly contain taraxasterol, choline, inulin pectin, vitamin C, vitamin D, riboflavin and carotene etc.Heat-clearing and toxic substances removing is arranged, the effect of diuresis eliminating stagnation.Experiment shows that Herba Taraxaci has significant gastric acid secretion inhibitory action; The Herba Taraxaci decoct has protective effect to rat pipe film injury; Herba Taraxaci has the effect that promotes ulcer surface healing and pain relieving for tea-drinking to gastric ulcer.Secondly Herba Taraxaci is improved and improves the effect of mouse cell immunity and non-specific immunity, the immune level of immune function depression animal is restored and protects.
The Fructus Evodiae acrid in the mouth is bitter, and is warm in nature, returns liver, stomach warp.Contain rutaecarpin, rutaecarpine, Hydroxyevodiamine, Limettin, Neosynephrine, evodene etc.Warming middle-JIAO, pain relieving arranged, regulate the flow of vital energy, the effect of dampness.Modern pharmacological research shows that Fructus Evodiae is gastric acid secretion inhibiting significantly, and the gastric juice amount is descended, and reduces gastric acidity, and antiulcer forms, and the two-ways regulation gastrointestinal function is movable, preventing or arresting vomiting antidiarrheal, protection gastric mucosa.The Fructus Evodiae water decoction has anti-hydrochloric acid gastric ulcer and indometacin adds the effect of ethanol gastric ulcer, and water logging irritability and ligation pylorus gastric ulcer are had the tendency that suppresses formation.
Radix Angelicae Dahuricae acrid in the mouth, temperature.Return lung, spleen, stomach warp.Contain isoimperatorin, imperatorin, bergapton, phellopterin, oxypeucedanin etc.Have and dispel the wind, dampness, detumescence, the effect of pain relieving.The clinical observation Radix Angelicae Dahuricae has reducing swelling and alleviating pain, and the merit of blood stasis dispersing and fresh blood promoting is treated peptic ulcer with the Radix Angelicae Dahuricae, and the decapacitation regulating QI to relieve pain can also granulation promoting be put on flesh, and blood stasis dispelling is respond well.Have the scholar to think that the Radix Angelicae Dahuricae has detumescence and pain relieving, granulation promoting with hold back the dual regulation therapeutical effect of infections; Elimination swelling is arranged, healing ulcer, softening spot, the function of regulating neural body of gland.
Pseudobulbus Bletillae (Rhizoma Bletillae) bitter in the mouth, sweet, cool in nature.Attach to the lung and stomach meridians.Mainly contain Rhizoma Bletillae gel (for phlegmatic temperament) and volatilization wet goods composition.Tonifying the lung is arranged, hemostasis, detumescence, granulation promoting, the effect of sore.Pharmacological evaluation shows that Pseudobulbus Bletillae (Rhizoma Bletillae) has cytoprotection to gastric mucosa, various chronic ulcer tissues is had repair and restructuration, and the facilitate tissue structure recovery is normal, significantly the effect of accelerating wound healing.Pseudobulbus Bletillae (Rhizoma Bletillae) is installed with significant therapeutic effect to Stomach duodenum ulcer is acute.
In sum; the Radix Astragali, Rhizoma Atractylodis Macrocephalae invigorating the spleen and benefiting QI in this prescription; Herba Taraxaci, Fructus Evodiae energy gastric acid secretion inhibiting, antiulcer; but Radix Angelicae Dahuricae healing chronic ulcer tissue; Pseudobulbus Bletillae (Rhizoma Bletillae) has cytoprotection; all medicines cooperate, and the effect of gastric mucosa is protected in common performance, and show the health-care effect that has the protection gastric mucosa, improves gastrointestinal function through Long-term clinical experiment and Function detection.
Effect of the present invention:
One, protection and reparation gastric mucosa activate a large amount of gastric mucus of gastric gland secretion, thereby isolation gastric acid and irritable food protection gastric mucosa are without prejudice.The mucosa regeneration factor can activate gastric mucosal regeneration, promotes the impaired face of gastric mucosa to heal as early as possible.Two, upgrade aging gastric mucosa, the gastric mucosa wound of original impaired healing is come off, integral body is grown new gastric mucosa again, thereby reduces the symptoms such as gastric acid, stomachache, flatulence.Three, promote the ulcer surface healing, the contained active factors of this product has good prevention and therapeutical effect to Stomach duodenum ulcer, fast the repairing ulcer tissue.Four, improve gastrointestinal function.
The specific embodiment
Following examples are used for explanation the present invention, but are not used for limiting the scope of the invention.
The invention will be further described below in conjunction with embodiment:
Embodiment 1: a kind of preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa; adopting the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Taraxaci, Fructus Evodiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material; make 1000 of capsules by the following weight proportioning: take Radix Astragali 520-580g, Rhizoma Atractylodis Macrocephalae 290-350g, Herba Taraxaci 250-310g, Fructus Evodiae 220-280g, Radix Angelicae Dahuricae 170-230g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40-80g as raw material through extract, the techniques such as concentrated, pulverizing, mixing obtain fine powder; encapsulated every 0.3g; every day 3 times; each 2; one after each meal; warm water delivery service, 30 days is a course for the treatment of.
Embodiment 2: a kind of preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa; adopting the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Taraxaci, Fructus Evodiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material; make 1000 of capsules by the following weight proportioning: take Radix Astragali 530-570g, Rhizoma Atractylodis Macrocephalae 300-340g, Herba Taraxaci 260-300g, Fructus Evodiae 230-270g, Radix Angelicae Dahuricae 180-220g, Pseudobulbus Bletillae (Rhizoma Bletillae) 45-75g as raw material through extract, the techniques such as concentrated, pulverizing, mixing obtain fine powder; encapsulated every 0.3g; every day 3 times; each 2; one after each meal; warm water delivery service, 30 days is a course for the treatment of.
Embodiment 3: a kind of preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa; adopting the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Taraxaci, Fructus Evodiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material; make 1000 of capsules by the following weight proportioning: take Radix Astragali 540-560g, Rhizoma Atractylodis Macrocephalae 310-330g, Herba Taraxaci 270-290g, Fructus Evodiae 240-260g, Radix Angelicae Dahuricae 190-210g, Pseudobulbus Bletillae (Rhizoma Bletillae) 50-70g as raw material through extract, the techniques such as concentrated, pulverizing, mixing obtain fine powder; encapsulated every 0.3g; every day 3 times; each 2; one after each meal; warm water delivery service, 30 days is a course for the treatment of.
Human feeding trial
Use the capsule of the present invention of preparation among the embodiment 3, the effect of this product is tested.
Tested crowd's standard: meet the chronic superficial gastritis diagnostic criteria and screen the volunteer who is diagnosed as superficial gastritis through gastroscope, the age is between 18～65 years old.
The chronic superficial gastritis diagnostic criteria: course of disease delay, dyspepsia is in various degree arranged, the clinical symptoms such as upper abdominal pain, heartburn, belch, acid regurgitation, abdominal distention can have the epigastrium mild tenderness.
Adopt two kinds of control design between self and group, try voluntarily the trencherman by above-mentioned Standard Selection 100 routine chronic superficial gastritiss, be divided at random test-meal group and matched group according to the symptom weight, every group of 50 examples, the test-meal group is taken capsule of the present invention, matched group eats placebo, and placebo outward appearance, color and luster, weight, instructions of taking are identical with the present invention.Consider to affect as far as possible the principal element of observed result, such as age, sex, the course of disease etc., carry out the harmony check, to guarantee having comparability between the examination group.The experimenter takes 3 everyone every day, each 2, uses warm water delivery service.The duration of test normal diet does not change original dietary habit, and the medicine of all treatment chronic gastropathies of stopping using, and viewing duration is 30 days.
Gastroscopy: check 30 examples (each 15 example of test-meal group and matched group).
Symptom and somatic feature score are observed: by the clinical symptoms weight scores accumulated such as stomachache, belch, acid regurgitation, abdominal distention, inappetence, few food (serious symptom 3 minutes, moderate 2 minutes, slight 1 minute); Check tenderness degree under the xiphoid-process, according to pain degree integration (slight 1 minute, moderate 2 minutes, severe 3 minutes).
The grouping situation sees Table 1.The front two groups of blood of test-meal, urine, just routine and hepatic and renal function, Chest X-rays, electrocardiogram, B ultrasonic etc. check all in normal range, and two groups of subject age, sex, the equal no significant difference of sings and symptoms integration (P＞0.05) have comparability.
Data relatively as table 1 test-meal was last
The sings and symptoms integration improves situation
Table 2 clinical symptoms integral contrast
*With comparison before the test-meal, compare P＜0.01 between P＜0.01 ## group
By as seen from Table 2, to take rear 1 month, two groups of clinical symptoms integrations all are improved, and symptom integral is improved very obviously (P＜0.01) before and after the test-meal of test-meal group, and significantly better than matched group, two group differences are (P＜0.01) very significantly.
Table 3 somatic feature score relatively
*With comparison before the test-meal, compare P＜0.01 between P＜0.01 ## group
By as seen from Table 3, to take rear 1 month, two groups of somatic feature scores all are improved, and somatic feature score improves very obviously (P＜0.01) before and after the test-meal of test-meal group, and significantly better than matched group, two group differences are (P＜0.01) very significantly.
The gastroscopy situation
After the test-meal, test-meal group gastroscope review result shows that each position color and luster is take red and white as main, and patient's gastric antrum section lamellar is oozed out obvious improvement or disappearance, without adding reconstructed image; Matched group gastric antrum section lamellar is oozed out (the only 2 people are improved) nothings of not improving more and is added reconstructed image.
The result
Test-meal group and matched group duration of test normal diet do not change original dietary habit.After 30 days, self relatively reach comparison between test-meal group and matched group group after the test-meal before and after the test-meal of test-meal group, clinical symptoms, somatic feature score all obviously reduce (P＜0.01), and the gastroscope review result has clear improvement; Experimenter's blood before and after the test-meal group test, urine, just the clinical indices such as routine and liver, renal function are all in normal range, the no abnormality seens such as spirit, sleep.So this invention can be treated gastritis and gastric ulcer, protection gastric mucosa.
Claims (3)
1. preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa; it adopts the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Herba Taraxaci, Fructus Evodiae, the Radix Angelicae Dahuricae, Pseudobulbus Bletillae (Rhizoma Bletillae) is raw material of Chinese medicine; it is characterized in that it is the preparation of being made by the raw material of Chinese medicine of following weight proportioning: take Radix Astragali 520-580g, Rhizoma Atractylodis Macrocephalae 290-350g, Herba Taraxaci 250-310g, Fructus Evodiae 220-280g, Radix Angelicae Dahuricae 170-230g, Pseudobulbus Bletillae (Rhizoma Bletillae) 40-80g as raw material of Chinese medicine; through extract, concentrated, pulverizing, hybrid technique obtain fine powder, makes different dosage forms.
2. root a tree name a kind of preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa claimed in claim 1; it is characterized in that it is the preparation of being made by the raw material of Chinese medicine of following weight proportioning: take Radix Astragali 530-570g, Rhizoma Atractylodis Macrocephalae 300-340g, Herba Taraxaci 260-300g, Fructus Evodiae 230-270g, Radix Angelicae Dahuricae 180-220g, Pseudobulbus Bletillae (Rhizoma Bletillae) 45-75g as raw material of Chinese medicine; through extract, concentrated, pulverizing, hybrid technique obtain fine powder, makes different dosage forms.
3. root a tree name a kind of preparation that is used for the treatment of gastritis and gastric ulcer, protection gastric mucosa claimed in claim 1; it is characterized in that it is the preparation of being made by the raw material of Chinese medicine of following weight proportioning: take Radix Astragali 540-560g, Rhizoma Atractylodis Macrocephalae 310-330g, Herba Taraxaci 270-290g, Fructus Evodiae 240-260g, Radix Angelicae Dahuricae 190-210g, Pseudobulbus Bletillae (Rhizoma Bletillae) 50-70g as raw material of Chinese medicine; through extract, concentrated, pulverizing, hybrid technique obtain fine powder, makes different dosage forms.
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| CN102228551B (en) * | 2011-06-30 | 2012-09-26 | 王智森 | Chinese medicinal composition for preventing and treating injury of gastric mucosa and preparation method thereof |
| CN104826065A (en) * | 2015-05-14 | 2015-08-12 | 许建财 | Medicine for treating gastric ulcer |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101244203A (en) * | 2008-02-03 | 2008-08-20 | 李爱英 | Chinese medicine for treating acute and chronic gastritis, enteritis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101244203A (en) * | 2008-02-03 | 2008-08-20 | 李爱英 | Chinese medicine for treating acute and chronic gastritis, enteritis |
Non-Patent Citations (4)
| Title |
|---|
| 任金星等.中医药治疗消化性溃疡的研究近况.《光明中医》.2008,(第11期),1850-1852. * |
| 何善明等.中医药抗消化性溃疡复发的研究进展.《四川中医》.2008,(第07期),43-45. * |
| 李诚.幽门螺杆菌相关胃病的中医药治疗进展.《中国中西医结合消化杂志》.2005,(第01期),60-62. * |
| 贺俭.中医药治疗消化性溃疡研究近况.《中医药信息》.1998,(第04期),14-16. * |
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