CN101700028A - Bactericidal composition containing azoxystrobin and thiocarbamate and application thereof - Google Patents
Bactericidal composition containing azoxystrobin and thiocarbamate and application thereof Download PDFInfo
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- CN101700028A CN101700028A CN200910310651A CN200910310651A CN101700028A CN 101700028 A CN101700028 A CN 101700028A CN 200910310651 A CN200910310651 A CN 200910310651A CN 200910310651 A CN200910310651 A CN 200910310651A CN 101700028 A CN101700028 A CN 101700028A
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- fluoxastrobin
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Abstract
The invention belongs to the technical field of agricultural fungicides, in particular to a bactericidal composition containing azoxystrobin and a thiocarbamate fungicide and an application thereof. The azoxystrobin and the thiocarbamate fungicide are adopted for complexing, the thiocarbamate fungicide is any one of mancozeb, zineb, maneb or thiram, and the two can represent excellent synergy within a certain mix proportion range by complexing; compared with a single medicament, the bactericidal composition can significantly improve the bactericidal effect, expand the bactericidal spectrum, effectively avoid the possible problems of drug resistance, reduced efficacy and the like due to the use of the single medicament of the azoxystrobi and prolong the life cycle and the service life of the single medicament.
Description
Technical field
The invention belongs to technical field of agricultural fungicide, be specifically related to composite bactericidal composition of Fluoxastrobin and Carbamates bactericidal agent and application.
Background technology
Fluoxastrobin (Azoxystrobin) is a kind of new and effective methoxy acrylic bactericide, has protection, treats, roots out, infiltration, systemic activity, destroys the synthetic and loss of life power of the energy of germ by the respiration that suppresses germ.Fluoxastrobin has the bactericidal activity of wide spectrum, tens of kinds of diseases such as nearly all Mycophytes (Ascomycetes, Basidiomycetes, Oomycete and Fungi Imperfecti) disease such as powdery mildew, rust, scab, net blotch, downy mildew, rice blast all there is good active, be applicable to various crop such as cereal, vegetables, paddy rice, fruit tree and economic crops, and have good crop safety and very outstanding Environmental compatibility.But because the action site of this bactericide is very single, germ can produce adaptive variation to medicament, the preventive effect of medicament is reduced even invalid and cause the drug-fast generation of germ, in follow-up use, need to strengthen dosage, increase spray medicine number of times, make residue of pesticide improve, influence environment etc., thereby cause a series of vicious circle.The resistance of Fluoxastrobin is found as yet in the field at present, but is had the relevant report that produces resistance in Europe with veriety.
Carbamates bactericidal agent comprises mancozeb (Mancozeb), the complex salt of chemical name ethylidene dithiocarbamate manganese and zinc; Zineb (Zineb), the chemical name zinc ethylene bisdithiocarbamate; Maneb (Maneb), the chemical name ethylidene dithiocarbamate manganese; Tmtd (Thiram), the chemical name tetramethyl thiuram disulfide; The bactericide of this class belongs to the wider protective fungicide of fungicidal spectrum, have good protection activity, but the result of treatment of this series bactericidal agent is not obvious; produce little effect; the peasant considers from the angle of economy and effect, uses seldom separately, thereby make its use be subjected to certain restriction.
Summary of the invention
Purpose of the present invention is exactly to provide bactericidal composition and the application that contains Fluoxastrobin at the defective of above-mentioned existence.Adopt Fluoxastrobin and Carbamates bactericidal agent to carry out composite, described Carbamates bactericidal agent is any one of mancozeb, zineb, maneb or tmtd, by composite, both show good synergistic effect in certain ratio range, compare with single agent, obviously improved bactericidal effect, also enlarged fungicidal spectrum, problems such as the resistance generation that can also effectively avoid using the agent of Fluoxastrobin list to bring, drug effect reduction prolong the life cycle and the service life of single agent.
The bactericidal composition that contains Fluoxastrobin and thiocarbamate of the present invention, its active ingredient is made up of Fluoxastrobin and Carbamates bactericidal agent, Fluoxastrobin and Carbamates bactericidal agent are Fluoxastrobin based on the part by weight pass of active ingredient: Carbamates bactericidal agent=100: 1～1: 100.
As preferably, described Fluoxastrobin and Carbamates bactericidal agent close based on the part by weight of active ingredient and are Fluoxastrobin: Carbamates bactericidal agent=10: 1～1: 20.
Wherein, Carbamates bactericidal agent is any one of mancozeb, zineb, maneb or tmtd.
The weight percentage of described active ingredient is 0.5%～80%.
Bactericidal composition of the present invention adds auxiliary agent and excipient, according to the production technology that those skilled in the art all know, can make different formulations, comprises aqueous emulsion, suspending agent, wetting powder and water dispersible granules.
Said composition can be used for preventing and treating the plant disease that is caused by disease fungus, can be various plants, be used to prevent and treat the disease that causes by disease fungus on cereal, wheat, paddy rice, grape, apple, cucumber, capsicum, eggplant, tomato, potato, peanut, Kidney bean, tobacco, flowers and the lawn.The place of using of composition of the present invention is farmland, orchard or warehouse etc.
Said composition can be used for preventing and treating downy mildew, eqpidemic disease, powdery mildew, rice blast, scab, leaf spot, spot defoliation, brown spot.
Beneficial effect of the present invention is: adopt Fluoxastrobin and Carbamates bactericidal agent to carry out composite, both show good synergistic effect in certain ratio range, compare with single agent, obviously improved bactericidal effect, thereby reduce the medicament usage amount, when reducing peasant's drug cost, reduced influence degree to environment, reduced residue of pesticide; Enlarged fungicidal spectrum on the other hand, the medicament characteristic has also obtained mutual supplement with each other's advantages, a kind of medicament can be prevented and treated multiple diseases simultaneously, a kind of means of prevention easily and effectively is provided, further reduce the cost of medication, reduce spray medicine number of times, save work, downy mildew, eqpidemic disease, powdery mildew, rice blast, scab, leaf spot, spot defoliation, brown spot etc. are all had good control efficiency; The 3rd, two kinds of active substance structures in the composition differ bigger, there is not cross resistance, be mixed and use the resistance that can effectively delay single agent to take place and development, the pesticide resistance that overcomes and delay pathogen there is better action, thereby problems such as the resistance generation that can effectively avoid using the agent of Fluoxastrobin list to bring, drug effect reduction, prolong the life cycle and the service life of single agent, better with the performance of the drug effect of single agent also alleviated the pressure and the manpower and materials of the development of new products.
Measure the indoor virulence of single, the mixture of Fluoxastrobin and thiocarbamate in indoor employing plate blade method to bacterium of downy mildew of cucumber.Test method: cucumber leaves is placed the culture dish processing of preserving moisture, dosage by design sprays medicament respectively, inoculate bacterium of downy mildew of cucumber after 24 hours, and the cultivation of in incubator, preserving moisture, 7d " Invest, Then Investigate " preventive effect, calculate control efficiency with disease index, carry out statistical analysis with the DPS data processing software, calculate the EC50 of each medicament, adopt the abundant method calculating co-toxicity coefficient of Sun Yun (CTC) to estimate and use effect with, the CTC value has synergistic effect greater than 120 o'clock mixtures, less than 80 o'clock be antagonism, have summation action in the time of between 80～120.
The EC50*100 of the EC50/B agent of toxicity index TI (B)=standard agent A
The EC50*100 of the EC50/AB of actual toxicity index ATI (AB)=A
Theoretical toxicity index TTI (AB)=percentage+TI (B) * B the percentage in mixture of TI (A) * A in mixture
Co-toxicity coefficient CTC=ATI (AB)/TTI (AB) * 100
Test data is as follows:
Table 1 Fluoxastrobin and mancozeb list mixture are to the Toxicity Determination of bacterium of downy mildew of cucumber
By table 1 as seen, Fluoxastrobin and mancozeb carry out composite, bacterium of downy mildew of cucumber had good indoor virulence, the CTC value of all proportionings is all above 120, show that these two bactericide have good synergistic effects under this proportioning, and when mixed ratio was between 10: 1～1: 20, synergy was particularly remarkable.
When Fluoxastrobin carries out combine experiment with zineb, maneb and tmtd with aforementioned proportion respectively, show the rule identical with mancozeb, promptly the synergistic effect to bacterium of downy mildew of cucumber is comparatively obvious under 10: 1～1: 20 ratio.
Embodiment
Below in conjunction with specific embodiment technical scheme of the present invention is described in detail, but the present invention is not limited thereto.
Embodiment 1: the bacteriostatic activity of Fluoxastrobin and the composite Phytophthora infestans of mancozeb is measured
Contain the inhibition effect that toxic medium method is measured Fluoxastrobin and the composite Phytophthora infestans of mancozeb in indoor employing, and with the control efficiency of Fluoxastrobin, the agent of mancozeb list in contrast.
Test method: in the PDA medium, add quantitative pharmacy respectively, cooling back inoculation phytophthora infestans, 24 ℃ unglazed according to testing result after cultivating 4 days under the condition, test result sees Table 2.
The bacteriostatic activity measurement result table of comparisons of table 2 Phytophthora infestans
As can be seen from Table 2, Fluoxastrobin and mancozeb are composite, and Phytophthora infestans has good indoor bacteriostatic activity, and are higher than the bacteriostatic activity of single agent.
Embodiment 2:70% Fluoxastrobin Zineb wettable powder, the test of pesticide effectiveness of control alternaria leaf spot of apple
Its prescription consists of, and comprises following component by weight:
Fluoxastrobin 5%
Zineb 65%
Neopelex 2%
White carbon 10%
Wooden calcium 4%
Draw back powder 3%
K12 3％
The precipitated calcium carbonate surplus
Above-mentioned former medicine, various auxiliary agent and filler etc. are fully mixed by formula rate, after ultrafine crusher is pulverized, promptly obtain 70% Fluoxastrobin Zineb wettable powder.
Test method: when apple tree begins to show scab, spray Fluoxastrobin, the agent of zineb list and above-mentioned composite mixture respectively, compare with clear water, spray medicine altogether 3 times, twice medication interval time is 7d, 15d investigation result after the 3rd dispenser, and result of the test sees Table 3.
The test of pesticide effectiveness of table 3 control alternaria leaf spot of apple is the table of comparisons as a result
As can be seen from Table 3, the complex preparation of Fluoxastrobin and zineb can effectively be prevented and treated alternaria leaf spot of apple, and is better than the control efficiency of single agent.
Embodiment 3:40% Fluoxastrobin tmtd suspending agent is prevented and treated the test of pesticide effectiveness of leaf spot of peanut
Its prescription consists of, and comprises following component by weight:
Fluoxastrobin 4%
Tmtd 36%
Methyl naphthalene sulfonate formaldehyde condensate 5.5%
White carbon 5%
Aluminium-magnesium silicate 2%
Ethylene glycol 10%
Tributyl phosphate 0.1%
Diatomite 5%
Water surplus
Above-mentioned former medicine, various auxiliary agent and filler etc. are pressed formula rate add in the sand milling still, carry out porphyrize, make 40% Fluoxastrobin tmtd suspending agent.
, compare the control efficiency of leaf spot of peanut at field test Fluoxastrobin, tmtd and above-mentioned composite mixture with clear water.Spray medicine when the peanut field begins to show scab, dispenser 3 times, twice medication interval time is 7d, 15d investigation result after the 3rd dispenser, result of the test sees Table 4.
The test of pesticide effectiveness that table 4 is prevented and treated leaf spot of peanut is the table of comparisons as a result
As can be seen from Table 4, the complex preparation of Fluoxastrobin and tmtd can effectively be prevented and treated leaf spot of peanut, and is better than the control efficiency of single agent.
Embodiment 4:25% Fluoxastrobin maneb water-dispersible granules is prevented and treated the test of pesticide effectiveness of downy mildew of garpe
Its prescription consists of, and comprises following component by weight:
Fluoxastrobin 5%
Maneb 20%
Methanonaphthalene sodium sulfonate 4%
Neopelex 7%
Polyvinylpyrrolidone 2.5%
The attapulgite surplus
Active component, powder carrier, wetting agent and binding agent etc. mixed pulverize, after adding water and mediating, granulation in the comminutor of packing into, drying, screening make 25% Fluoxastrobin maneb water-dispersible granules again.
Adopt greenhouse cuttage grape seedling, measure Fluoxastrobin, the agent of maneb list and above-mentioned composite mixture, compare with clear water to the control efficiency of downy mildew of garpe.When treating that grape seedling grows to 3～4 leaves, select 2 leaves of growth uniformity, adopt manual sprayer to carry out the blade face reagent spray and handle, contrast spray equivalent clear water.Inoculate pathogen after 24 hours, cultivate 7d " Invest, Then Investigate " result under the condition of preserving moisture, result of the test sees Table 5.
The test of pesticide effectiveness that table 5 is prevented and treated downy mildew of garpe is the table of comparisons as a result
As can be seen from Table 5, the complex preparation of Fluoxastrobin and maneb can effectively be prevented and treated downy mildew of garpe, and is better than the control efficiency of single agent.
By the above embodiments as can be known, Fluoxastrobin and Carbamates bactericidal agent complex composition, in certain ratio range, has good synergistic effects, disease there is good control efficiency, can reduces the usage amount of medicine, reduce residue of pesticide, the more important thing is, can alleviate the pesticide resistance problem of germ.
Claims (8)
1. the bactericidal composition that contains Fluoxastrobin and thiocarbamate, its active ingredient is made up of Fluoxastrobin and Carbamates bactericidal agent, Fluoxastrobin and Carbamates bactericidal agent are Fluoxastrobin based on the part by weight pass of active ingredient: Carbamates bactericidal agent=100: 1～1: 100.
2. bactericidal composition according to claim 1 is characterized in that, described Fluoxastrobin and Carbamates bactericidal agent are Fluoxastrobin based on the part by weight pass of active ingredient: Carbamates bactericidal agent=10: 1～1: 20.
3. bactericidal composition according to claim 1 and 2 is characterized in that, described Carbamates bactericidal agent is any one of mancozeb, zineb, maneb or tmtd.
4. bactericidal composition according to claim 1 and 2 is characterized in that, the weight percentage of described active ingredient is 0.5%～80%.
5. bactericidal composition according to claim 1 and 2 is characterized in that, described bactericidal composition formulation comprises aqueous emulsion, suspending agent, wetting powder and water dispersible granules.
6. bactericidal composition according to claim 1 is characterized in that, said composition is used to prevent and treat the plant disease that is caused by disease fungus.
7. bactericidal composition according to claim 6, it is characterized in that said composition is used to prevent and treat the disease that is caused by disease fungus on cereal, wheat, paddy rice, grape, apple, cucumber, capsicum, eggplant, tomato, potato, peanut, Kidney bean, tobacco, flowers and the lawn.
8. according to claim 6 or 7 described bactericidal compositions, it is characterized in that said composition is used to prevent and treat downy mildew, eqpidemic disease, powdery mildew, rice blast, scab, leaf spot, spot defoliation, brown spot.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN200910310651A CN101700028A (en) | 2009-11-30 | 2009-11-30 | Bactericidal composition containing azoxystrobin and thiocarbamate and application thereof |
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| CN200910310651A CN101700028A (en) | 2009-11-30 | 2009-11-30 | Bactericidal composition containing azoxystrobin and thiocarbamate and application thereof |
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Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984824A (en) * | 2010-07-15 | 2011-03-16 | 江阴苏利科技有限公司 | Sterilizing composition containing azoxystrobin and zineb and application thereof |
| CN102835407A (en) * | 2012-09-17 | 2012-12-26 | 常华 | Bactericidal composition of azoxystrobin and mancozeb |
| CN103098809A (en) * | 2012-07-09 | 2013-05-15 | 南京农业大学 | Method for treating pesticide-resistant colza sclerotinia rot |
| CN103404540A (en) * | 2013-07-29 | 2013-11-27 | 安徽农业大学 | Hot fogging concentrate containing arasan and azoxystrobin and preparation method of hot fogging concentrate |
| CN107114387A (en) * | 2017-05-26 | 2017-09-01 | 广西力拓农业开发有限公司 | A kind of bactericidal composition for being used to prevent and treat citrus disease |
| CN109561690A (en) * | 2016-08-04 | 2019-04-02 | Upl 有限公司 | The method for treating and preventing corn crop hickie |
| EP3073826B1 (en) * | 2013-11-26 | 2019-10-30 | UPL Limited | A method for controlling soybean rust |
| CN114027310A (en) * | 2021-12-03 | 2022-02-11 | 兰州大学 | Application of thiocarbamic acid compound in preventing and treating agricultural pathogenic fungi |
| US11284623B2 (en) * | 2012-11-22 | 2022-03-29 | Basf Corporation | Pesticidal mixtures |
| WO2023042225A1 (en) * | 2021-09-17 | 2023-03-23 | Coromandel International Limited | Fungicide composition comprising pyridine carboxamide, strobilurin and dithiocarbamate |
-
2009
- 2009-11-30 CN CN200910310651A patent/CN101700028A/en active Pending
Cited By (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984824A (en) * | 2010-07-15 | 2011-03-16 | 江阴苏利科技有限公司 | Sterilizing composition containing azoxystrobin and zineb and application thereof |
| CN103098809A (en) * | 2012-07-09 | 2013-05-15 | 南京农业大学 | Method for treating pesticide-resistant colza sclerotinia rot |
| CN102835407A (en) * | 2012-09-17 | 2012-12-26 | 常华 | Bactericidal composition of azoxystrobin and mancozeb |
| US11284623B2 (en) * | 2012-11-22 | 2022-03-29 | Basf Corporation | Pesticidal mixtures |
| CN103404540A (en) * | 2013-07-29 | 2013-11-27 | 安徽农业大学 | Hot fogging concentrate containing arasan and azoxystrobin and preparation method of hot fogging concentrate |
| CN103404540B (en) * | 2013-07-29 | 2015-07-01 | 安徽农业大学 | Hot fogging concentrate containing arasan and azoxystrobin and preparation method of hot fogging concentrate |
| EP3073826B1 (en) * | 2013-11-26 | 2019-10-30 | UPL Limited | A method for controlling soybean rust |
| EP4014741A1 (en) * | 2013-11-26 | 2022-06-22 | UPL Ltd | A method for controlling rust |
| EP4014738A1 (en) * | 2013-11-26 | 2022-06-22 | UPL Ltd | A method for controlling rust |
| EP4018828A1 (en) * | 2013-11-26 | 2022-06-29 | UPL Ltd | A method for controlling rust |
| CN109561690A (en) * | 2016-08-04 | 2019-04-02 | Upl 有限公司 | The method for treating and preventing corn crop hickie |
| CN107114387A (en) * | 2017-05-26 | 2017-09-01 | 广西力拓农业开发有限公司 | A kind of bactericidal composition for being used to prevent and treat citrus disease |
| WO2023042225A1 (en) * | 2021-09-17 | 2023-03-23 | Coromandel International Limited | Fungicide composition comprising pyridine carboxamide, strobilurin and dithiocarbamate |
| CN114027310A (en) * | 2021-12-03 | 2022-02-11 | 兰州大学 | Application of thiocarbamic acid compound in preventing and treating agricultural pathogenic fungi |
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Application publication date: 20100505 |