CN101695370B - Health-care product for reducing blood sugar in assistant mode and preparation method thereof - Google Patents
Health-care product for reducing blood sugar in assistant mode and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a health-care product for reducing blood sugar in an assistant mode and a preparation method thereof. A raw material formula of the health-care product for reducing blood sugar contains the following components in parts by weight: 5-25 parts of ginseng extract, 10-35 parts of bee glue powder, 3-30 parts of kudzu-vine root powder, 3-30 parts of chitosan oligosaccharide and 0.005-0.05 part of chromium picolinate. The preparation method comprises the following steps of firstly, weighing and mixing the ginseng extract, the kudzu-vine root powder, the chromium picolinate and the chitosan oligosaccharide according to a proportion, and after the components are uniformly mixed, adding ethanol as a wetting agent to prepare a soft material; then respectively adopting a pelletizer to pelletize and dry and a granulate machine to granulate, and after granulating, adding and mixing the bee glue powder with obtained granules; after the granules and the bee flue powder are uniformly mixed, preparing the mixture into capsules, and polishing and screening the prepared capsules by a conventional method; and finally, packaging the capsules to obtain the finished product. The product of the invention has stable quality, convenient taking, safety and effectiveness, can be taken for a long time and is an ideal health-care product for diabetic patients. The product can effectively achieve the effects of reducing the blood sugar as well as preventing and improving complications of diabetes.
Description
One, technical field:
The present invention relates to a kind of health products, particularly relate to a kind of health products of auxiliary hyperglycemic.
Two, background technology:
Diabetes are diseases of a kind of serious harm human health, modern medicine think diabetes be a kind of because hypoinsulinism or insulin resistance caused be the general of outstanding behaviours, chronic incretion metabolism disease with the hyperglycaemia.Clinical manifestation is that blood sugar raises, the glucose in urine positive and sugar tolerance reduce, and classical symptom is many drinks, diuresis, eat, become thin more, dizzy and weak.The unfavorable diabetic of glycemic control late period is normal and make up one's mind, many organs and system damage or pathologies such as brain, kidney, eye, nerve skin, cause that organ dysfunction is incomplete or depleted, cause patient's deformity or dead.Therefore, diabetes are the diseases that need lifelong treatment.
Diabetes are one of modal chronic diseases, Along with people's growth in the living standard, aging population and obese patient's increase; The incidence of disease of diabetes is ascendant trend year by year; Be difficult to cure, needs of patients is taken medicine for a long time, and diabetic complication often causes serious consequence.
According to WHO standard, diabetes mainly are divided into I type and II type two big classes, have the diabetic more than 95% to belong to I type and II type in the world approximately, and wherein the type ii diabetes patient accounts for 90% of diabetic's sum.
The diabetic adopts the conventional method treatment of injection regular insulin regularly usually.Wherein type ii diabetes is a Non-Insulin Dependent Diabetes Mellitus, adopts the oral medicine treatment usually.Oral hypoglycemic commonly used comprises sulfonylurea (comprising glibenclamide, Glipizide, Glimepiride, Gliclazide etc.), biguanides (melbine, insoral etc.), insulin sensitivity enhancing medicine (Rosiglitazone, than lattice row ketone etc.), also has acarbose, Repaglinide etc.Though it is effective that above preparation is controlled blood sugar to the type ii diabetes patient, act on understablely, and oral certain indication and bad reaction arranged often.
Diabetes belong to the category of " diabete " in traditional Chinese medicine." the five internal organs fragile ", " number food delicious food savoury " and " internal damage by the excessive seven emotions " be diabete main diseases because of.Diabete is by stomach and intestine knot heat and cause: " heat hold in, insufficiency of the spleenly receive it, in Fu Yang steamed, rapid digestion of food and polyorexia, diet were doubly normal, myogenic meat not, good drinking cold water, frequent urination ".Diabete has card genus deficiency of both qi and yin, the interior pattern of fever of the deficiency of vital energy and deficiency of both qi and yin to hold stasis of blood person under the arm, controls suitable beneficial gas, yin-nourishing, kidney tonifying, invigorating the spleen, heat-clearing, promoting blood circulation and removing blood stasis.The Chinese patent drug of treatment diabetes at present commonly used has that diabetes pill, diabetes pill, hypoglycemic relax, hypoglycemic first sheet etc.Compare with Western medicine, Chinese medicine has the little advantage of side effect, takes for a long time whether can produce ill-effect to body and also require study.
At present; Auxiliary to carry out hypoglycemic Chinese medicine health-care goods with Chinese medicine many, and for example: 1, the patent No. is 200510008637.6, and denomination of invention discloses a kind of health products that reduce the blood sugar function that have for the patent of invention of " health-caring product capable of reducing blood sugar "; These health products have the effect that improves body immunity and delay senility; It has alleviated patient's misery to a certain extent, but health care in practical application, result of treatment is unsatisfactory, and toxic and side effect is to a certain degree arranged.2, application number is 200610170816.4; Denomination of invention is " blood glucose-lowering health-care product and preparation method "; The disclosed health-caring product capable of reducing blood sugar of this patent of invention has promoting blood circulation, nourishing the liver tonifying liver, Yang strengthening and life essence tonifying, Shujin channels and collaterals, the intelligence development of calming the nerves, nourshing kidney temperature kidney, eliminates fatigue, makes the people reduce blood sugar, the effect of tonifying liver profit liver.
In order to prevent and to prevent and treat diabetes this influences the chronic disease of people life, people are constantly groping and are studying, but still do not obtain so far make us satisfied effect.
Three, summary of the invention:
The technical problem that the present invention will solve provides health products of a kind of auxiliary hyperglycemic and preparation method thereof, constant product quality of the present invention, minimum, the taking convenience, safe and effective of toxic and side effect, and the diabetic can take for a long time.
The technical scheme that the present invention adopts is:
The present invention provides a kind of health products of auxiliary hyperglycemic; Represent with weight portion, contain 5～25 parts of ginseng extracts in the said health-caring product capable of reducing blood sugar composition of raw materials, 10～35 parts in propolis powder; 3～30 parts of kudzu-vine root powder, 0.005～0.05 part of 3～30 parts of chitosan oligosaccharides and chromium picolinate.
According to the health products of above-mentioned auxiliary hyperglycemic, contain 10～20 parts of ginseng extracts in the said health-caring product capable of reducing blood sugar composition of raw materials, 15～25 parts in propolis powder, 15～25 parts of kudzu-vine root powder, 0.01～0.03 part of 15～25 parts of chitosan oligosaccharides and chromium picolinate.
According to the health products of above-mentioned auxiliary hyperglycemic, the fineness of said propolis powder is 70～90 orders, and the fineness of kudzu-vine root powder is 80～100 orders.
According to the health products of above-mentioned auxiliary hyperglycemic, contain 30～80% general ginsenoside in the said ginseng extract; Said ginseng extract is that the patent No. is 00103346.8 patent of invention product.
A kind of preparation method of auxiliary hyperglycemic health products, said preparation method's detailed step is following:
A, take by weighing various raw materials according to the proportioning ratio of above-mentioned auxiliary hyperglycemic health products; Earlier the ginseng extract that takes by weighing, kudzu-vine root powder, chromium picolinate and four kinds of raw materials of chitosan oligosaccharide are mixed; Mix the back add concentration be 70～95% ethanol as wetting agent, process softwood; Said concentration is that the weight percentage that the addition of 70～95% ethanol accounts for four kinds of raw material total amounts is 20～30%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 16～20 orders, carries out drying then, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 14～18 orders;
C, whole grain back add the raw material propolis powder that takes by weighing and mix, and process capsule after mixing;
D, the capsule of processing is polished, screens according to conventional method, pack at last.
According to the preparation method of above-mentioned auxiliary hyperglycemic health products, drying described in the step b is to adopt heated-air circulation oven to carry out drying, and baking temperature is 40～60 ℃, and be 2～4 hours drying time.
According to the preparation method of above-mentioned auxiliary hyperglycemic health products, processing capsule described in the step c is to adopt the hard capsule filler filled capsules, and every capsules content is 350mg.
A kind of preparation method of auxiliary hyperglycemic health products, said preparation method's detailed step is following:
A, take by weighing various raw materials according to the proportioning ratio of above-mentioned auxiliary hyperglycemic health products; The ginseng extract that takes by weighing, propolis powder, kudzu-vine root powder, chromium picolinate and five kinds of raw materials of chitosan oligosaccharide are mixed; Mix the back add concentration be 70～95% ethanol as wetting agent, process softwood; Said concentration is that the weight percentage that the addition of 70～95% ethanol accounts for five kinds of raw material total amounts is 20～30%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 16～20 orders, carries out drying then, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 14～18 orders;
C, the particles filled capsule of processing that whole grain is good polish, screen according to conventional method, pack at last;
Perhaps the good particle of whole grain is pressed into tablet according to common process, the tablet of processing is packed.
According to the preparation method of above-mentioned auxiliary hyperglycemic health products, drying described in the step b is to adopt heated-air circulation oven to carry out drying, and baking temperature is 40～60 ℃, and be 2～4 hours drying time;
According to the preparation method of above-mentioned auxiliary hyperglycemic health products, processing capsule described in the step c is to adopt the hard capsule filler filled capsules, and every capsules content is 350mg.
The present invention can also take by weighing various raw materials according to the proportioning ratio of above-mentioned auxiliary hyperglycemic health products, with whole raw materials mixed evenly after, cross 60～80 mesh sieves, directly fill after sieving and process capsule with hard capsule filler.
The present invention can carry out proportioning according to the prescription of above-mentioned auxiliary hyperglycemic health products, take by weighing various raw materials, is prepared into powder and pill according to common process.
Positive beneficial effect of the present invention:
1, the various raw materials of the present invention's employing all have effect in reducing blood glucose, wherein contain total saponin(e, polysaccharide polypeptide constituents in the genseng, and these compositions all have the effect that reduces blood sugar.Propolis has anti-inflammation, it is immune, anti-oxidant to regulate, quicken organization healing etc. significantly acts on, and can be used for the supplemental treatment of hyperlipidemia and diabetes, prevents diabetic complication.The root of kudzu vine can obviously improve diabetic's high insulin levels, and the insulin sensitivity sex index is obviously improved, and to the chronic complicating diseases of diabetes effect of having clear improvement.Chitosan oligosaccharide has the obvious functions of blood sugar effect, can strengthen the load sugar tolerance of mouse, improves the function of islet cells; The trend that insulin in the rising blood is arranged; And can promote beneficial bacterium propagation such as Bifidobacterium, the adjustment intestinal flora of patients with diabetes, thus diabetic symptom is eased.Chromium in the chromium picolinate can some enzymes reach the effect that improves diabetes in the body through raising sugar tolerance, enhancing insulin function and reduction blood fat or through acting on.
2, the present invention share with all medicines of ginseng extract, propolis powder, kudzu-vine root powder, chitosan oligosaccharide and chromium picolinate, can effectively reach the effect that reduces blood sugar, prevention and improve diabetic complication.Product of the present invention adopts advanced preparation process; Under the management of product measure of reasonably method of quality control and strictness, process; Steady quality, taking convenience, safe and effective; Can take for a long time, be the desirable health products of diabetic (main performance index of product of the present invention and related detection data see the following form).
The main performance index of product and relevant test data:
| Project | Index |
| Total saponin(e (in the ginsenoside Re), g/100g | 0.5-5.0 |
| General flavone (in rutin), g/100g | 0.3-3.5 |
| Puerarin g/100g | 0.05-2.5 |
| Chromium picolinate g/100g | 0.03-0.07 |
The efficacy effect of the various raw materials that the present invention adopts:
Genseng: be the dry root and rhizome of Araliaceae genseng Panax ginsengC.A.Mey.." book on Chinese herbal medicine cover bamboo fish trap " record, genseng qi-restoratives on the whole, the cold of insufficiency type can be mended, and abnormal heat also can be mended.Researchs such as the Li Ming of Affiliated Hospital No.1, Lanzhou Medical College are thought: genseng not only can be used for treating the Non-Insulin Dependent Diabetes Mellitus people, also can be used as one of ancillary drug of insulin-dependent diabetes mellitus people.Bibliographical information is proved by researchs such as pharmacology teaching and research room of pharmaceutical college of Jilin University, the chemistry Hu Cuihua of Natural Medicine Chemistry research department of institute of Jilin University: the panoxadiol saponins can reduce the blood sugar of type ii diabetes rat; Improve metabolism disorder of blood lipid; Improve liver and peripheral tissues's insulin sensitivity, improve insulin resistance.Jia Wei etc. think, the polysaccharide polypeptide constituents in the genseng has protective effect to pancreas islet and the β cell that damages, and can improve insulin secretion through reparation and the regeneration that promotes the β cell, reach the hypoglycemic purpose.
Propolis: material be combined into such as propolis resinoid palatine gland secretion on its incorporation that to be honeybee gather from plant and beeswax, pollen.Propolis can anti-inflammation, it is immune, anti-oxidant to regulate, the acceleration organization healing.The supplemental treatment that is used for hyperlipidemia and diabetes.Mensuration such as Hu Fuliang and compared propolis alcohol extract (EEP) and water extracts of propolis (WSP) causes the influence of diabetes rat to alloxan; The result shows that EEP and WSP all can reduce the fasting blood-glucose of diabetes rat; Glycosylated hemoglobin and fructosamine level show that propolis has the rising of the fasting blood-glucose of resistance and improves glycometabolic effect diabetes rat.The research of Zhao Wen etc. confirms: propolis not only causes diabetic mice to alloxan and has the effect of regulating glycometabolism, improving sugar tolerance, and the normal mouse fasting blood-glucose is not had influence.Propolis can strengthening immune system, obviously strengthens the activity of macrophage phagocytic ability and NK (NK), increases antibody production, the specificity and the non-specific immune function of adjusting body, enhances human body premunition and vis medicatrix naturae.It is to improve body resistance against diseases that immunologic function strengthens, and improves the overall quality, and prevents the important foundation of diabetes and complication thereof.
The root of kudzu vine: the root of kudzu vine is the dry root of the sweet kudzu Pueraria of legume thomsonii Benth..The effect that the root of kudzu vine has relieving muscles to expel heat, promotes the production of body fluid, can be used for thirsty, quench one's thirst.Puerarin has another name called Pu Lelin, is a kind of isoflavonoid, and its main component is 8-β-D-glucopyranose-4 ', the 7-dihydroxy isoflavone.Puerarin can obviously improve diabetic's high insulin levels, and insulin sensitivity sex index (IsI) obviously improves.Cao Li etc.; Find inducing the DM mouse with streptozotocin (STZ) and induce in the insulin resistance mouse model with hydrocortisone sodium succinate (HCSS); Puerarin does not have obvious influence to the normal mouse fasting blood-glucose, but can obviously reduce blood sugar and the serum insulin level of the DM mouse that STZ induces, and the insulin sensitivity sex index is significantly raise; The plain opposing of mouse islets that HCSS is induced also improves significantly, and all is certain dose dependent trend.A large amount of clinical researches show, Puerarin all has the improvement effect to chronic complicating diseases of diabetes such as diabetic nephropathy, diabetic cardiomyopathy, diabetic cranial vascular disease, diabetic neuropathy, BDR etc.The pharmacological action of Puerarin is wide, and a lot of clinical diseases are all had good therapeutic action.And the Puerarin few side effects, aboundresources, cheap, be a kind of novel pure Chinese medicinal preparation.
Chitosan oligosaccharide: the Tianjin Institute of Medicine Science wishes that researchs such as monarch plum show that chitosan oligosaccharide has obvious hypoglycemic activity, can strengthen the load sugar tolerance of mouse, improves the function of islet cells, and the trend of insulin in the rising blood is arranged.Chitosan oligosaccharide reduces the effect of blood sugar, can act on insulin receptor with it, and insulin receptor sensitiveness is strengthened, thereby control blood sugar raises relevant.Chitosan oligosaccharide is water-soluble greater than 99%, and the human absorptivity 99.88%, and the fauna that it can improve enteric microorganism distributes, and stimulates the growth of beneficial bacterium.Experiment showed, that chitosan oligosaccharide is applied to dairy products, can make 120 times of Bifidobacterium hyperplasia.Little ecological Studies find that normal intestinal flora and diabetes have certain relation.Discovered that a kind of Escherichia coli can produce ILM, the sealing insulin receptor makes real insulin can't bring into play blood sugar reducing function.Take the probiotics of fostering beneficial bacteriums such as Bifidobacterium, make it to bring into play the biological antagonist effect, eliminating can produce the Escherichia coli of ILM, and diabetes can be eased.There is the report chitosan oligosaccharide can promote beneficial bacterium propagation such as Bifidobacterium, the effect of adjustment gut flora arranged, thereby diabetic symptom is eased.And chitosan oligosaccharide is cheap and easy to get, and water-soluble good, non-immunogenicity can be degraded in vivo voluntarily, and safety has no adverse reaction.
Chromium picolinate: the chromium in the chromium picolinate is Cr
3+, Cr and diabetes are in close relations, and Cr is the important composition composition of GTF, and GTF is Cr
3+, niacin and glutathione complex compound, be the cofactor of insulin, biologically active chromium can be through improving sugar tolerance, strengthen insulin function and reduce blood fat or some enzymes reaching the effect that improves diabetes in the body through acting on.
Various materials safety property:
Mention in the third-class chief editor of Miao Ming " conventional Chinese medicine modern study book series-conventional Chinese medicine toxicology ", genseng toxicity is very little, and general ginsenoside irritates clothes 5g/kg for 1 time for mouse, does not find dead.The oral Pueraria Flavonid 20g/kg of mouse serve on three days, toxic reaction do not occur; Oral root of kudzu vine alcohol preserved material 2g/kg every day adds up February, and the parenchymatous organ does not have pathology and changes; Puerarin does not show that to target cell mutagenesis is active with 0.32%, 0.66% dosage, with 50mg/kg, the 150mg/kg no teratogenesis of tire mouse (45) to female rats (50).Luan Jinshui etc. discover the LD of mouse stomach propolis
50＞7500mg/kg; Genotoxic research shows people such as the Li Xingqin of disease prevention and control center, Hebei province to propolis, and under the condition, being tried thing does not all have mutagenesis in vivo and in vitro, and propolis is safe aspect genetoxic.The edible safety of Zhao Yuqin etc. research chitosan oligosaccharide finds, when test dose is equivalent to recommend 312～368 times of clinical dosage, irritates in the stomach mouse 10d and do not observe acute toxic reaction.The mouse toxicological test shows, the LD of mouse continuous oral chitosan oligosaccharide cumulant
50＞14650mg/kg.Jiang has carried out zoopery and human research to taking in chromium picolinate and other chromic securities with just waiting, and the research of aspects such as non-carcinogenic property toxicity, potential carcinogenic and biological accumulation property is shown: it is safe that trivalent chromium makes an addition in the food with optimal dose.The consumption per day of chromium is lower than the limiting the quantity of of 250 μ g/d of State Food and Drug Administration regulation in the chromium picolinate that is adopted among the present invention.
There are not incompatibility and consumption safety between each raw material of this product.So on prescription, can guarantee the edible safety of product.
The toxicity of product auxiliary hyperglycemic health products of the present invention, function and clinical testing data are summed up:
Toxicological test:
Acute toxicity test: mouse, rat limosis are irritated stomach product of the present invention, observe 7 days, and female, male mouse and rat all do not see poisoning symptom, do not have dead.Female, the male mouse of product of the present invention and rat peroral acute toxicity test MTD＞10.0g/kg.BW, the nontoxic level in true border.
Product A mes test of the present invention, mouse marrow cell micro nuclear test and mouse sperm distortion test result are all negative.Point out product safety of the present invention.
During 30 days feeding trials of product of the present invention, the activity of animal, ingest, ordinary circumstance such as defecation do not see obviously unusually, and body weight, food-intake, routine blood test index, the organ weights of animal do not had obvious influence.Each item detects index and does not all observe ANOMALOUS VARIATIONS when female, male rat high dose group are 3.50g/kg.BW (be equivalent to human body recommended amounts 100 times).
Function:
Carry out the function of blood sugar reduction animal experiment according to " health food check and assessment technique standard (version in 2003) ".Select 48 of Male Kunming strain mice for use, process hyperglycemia model, and be divided into basic, normal, high three dose groups and a model control group at random.26 of alternative healthy male mices are divided into high dose group, normal control group at random.
Per os gives mouse product of the present invention after 30 days continuously, and product of the present invention does not all have obvious influence to normal mouse and hyperglycemia model mouse body weight; Fasting blood-glucose to normal mouse does not have influence; Can reduce the fasting blood-glucose of hyperglycemia model mouse, conspicuousness (P＜0.05) arranged with the control group comparing difference; Can reduce area under the blood glucose curve of hyperglycemia model mouse, conspicuousness (P＜0.01) arranged with the control group comparing difference.Prompting product of the present invention under this experimental condition has auxiliary hyperglycemic function.
Human feeding trial is summed up:
Carry out the function of blood sugar reduction human feeding trial according to " health food check and assessment technique standard (version in 2003) "; Selection state of an illness after diet control or OHA treatment is more stable; Need not change types of drugs and dosage, the adult type ii diabetes patient who only takes maintenance dose includes test in.Adopt two kinds of control design between self and group, select 100 examples to meet the examination trencherman of the standard of including in, roughly balancedly be divided into two groups by blood sugar level, sex, age, the course of disease, the kind of taking medicine, every group 50 example is divided into test-meal group and control group at random.Took product of the present invention 30 days, health check-up.
Result of the test shows that the experimenter took given the test agent after one month, can obviously improve type ii diabetes patient clinical symptoms, reduces fasting blood-glucose and reaches 2h blood sugar (P＜0.05) after the meal; Blood, urine, stool and hepatic and renal function each item detect index all in normal range (NR) before and after the test-meal.Prompting: given the test agent has the auxiliary hyperglycemic effect to the healthy no obvious damage of experimenter.
Four, the specific embodiment:
Following examples have been merely and have further specified the present invention, do not limit content of the present invention.
Embodiment one: health products of a kind of auxiliary hyperglycemic and preparation method thereof
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 10 parts of ginseng extracts, 25 parts in propolis powder, 20 parts of kudzu-vine root powder, 15 parts of chitosan oligosaccharides, 0.01 part of chromium picolinate with weight portion.
The fineness of propolis powder is 70～90 orders in the raw material; The fineness of kudzu-vine root powder is 80～100 orders; Said ginseng extract is that the patent No. is the product that 00103346.8 patent of invention is produced, and contains 30～80% general ginsenoside in the ginseng extract.
The preparation method of auxiliary hyperglycemic health products:
A, take by weighing various raw materials according to the composition of raw materials of above-mentioned auxiliary hyperglycemic health products; Four kinds of raw material ginseng extracts, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharides that will take by weighing earlier mix; Mix the back add concentration be 95% ethanol as wetting agent, process softwood; Wherein concentration is that the weight percentage that the addition of 95% ethanol accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 25%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 20 orders, adopts heated-air circulation oven to carry out drying then; Baking temperature is 50 ℃; Be 2 hours drying time, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 14 orders;
C, whole grain back add the raw material propolis powder that takes by weighing and mix, and process capsule after mixing, and every capsules content is 350mg;
D, the capsule of processing is polished, screens according to conventional method, pack at last.
Embodiment two: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 5 parts of ginseng extracts, 10 parts in propolis powder, 3 parts of kudzu-vine root powder, 3 parts of chitosan oligosaccharides, 0.005 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
A, wherein concentration is that the weight percentage that the addition of 95% ethanol accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 20%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 18 orders, adopts heated-air circulation oven to carry out drying then; Baking temperature is 40 ℃; Be 4 hours drying time, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 16 orders.
Embodiment three: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 25 parts of ginseng extracts, 35 parts in propolis powder, 30 parts of kudzu-vine root powder, 30 parts of chitosan oligosaccharides, 0.05 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
A, wherein concentration is that the weight percentage that the addition of 95% ethanol accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 30%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 20 orders, adopts heated-air circulation oven to carry out drying then; Baking temperature is 60 ℃; Be 2 hours drying time, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 18 orders.
Embodiment four: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 20 parts of ginseng extracts, 30 parts in propolis powder, 25 parts of kudzu-vine root powder, 25 parts of chitosan oligosaccharides, 0.03 part of chromium picolinate with weight portion.
Embodiment five: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 15 parts of ginseng extracts, 25 parts in propolis powder, 20 parts of kudzu-vine root powder, 20 parts of chitosan oligosaccharides, 0.02 part of chromium picolinate with weight portion.
Embodiment six: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 8 parts of ginseng extracts, 12 parts in propolis powder, 6 parts of kudzu-vine root powder, 7 parts of chitosan oligosaccharides, 0.006 part of chromium picolinate with weight portion.
Embodiment seven: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 12 parts of ginseng extracts, 15 parts in propolis powder, 8 parts of kudzu-vine root powder, 10 parts of chitosan oligosaccharides, 0.008 part of chromium picolinate with weight portion.
Embodiment eight: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 18 parts of ginseng extracts, 20 parts in propolis powder, 15 parts of kudzu-vine root powder, 18 parts of chitosan oligosaccharides, 0.01 part of chromium picolinate with weight portion.
Embodiment nine: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 10 parts of ginseng extracts, 22 parts in propolis powder, 12 parts of kudzu-vine root powder, 22 parts of chitosan oligosaccharides, 0.02 part of chromium picolinate with weight portion.
Embodiment ten: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 22 parts of ginseng extracts, 18 parts in propolis powder, 26 parts of kudzu-vine root powder, 12 parts of chitosan oligosaccharides, 0.04 part of chromium picolinate with weight portion.
Embodiment 11: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 10 parts of ginseng extracts, 15 parts in propolis powder, 15 parts of kudzu-vine root powder, 15 parts of chitosan oligosaccharides, 0.01 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
Step a: adding concentration of ethanol is 70%, and the weight percentage that its addition accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 30%.
Embodiment 12: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 20 parts of ginseng extracts, 25 parts in propolis powder, 25 parts of kudzu-vine root powder, 25 parts of chitosan oligosaccharides, 0.03 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
Step a: adding concentration of ethanol is 80%, and the weight percentage that its addition accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 25%.
Embodiment 13: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 15 parts of ginseng extracts, 20 parts in propolis powder, 20 parts of kudzu-vine root powder, 20 parts of chitosan oligosaccharides, 0.02 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
Step a: adding concentration of ethanol is 90%, and the weight percentage that its addition accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 22%.
Embodiment 14: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 13 parts of ginseng extracts, 18 parts in propolis powder, 17 parts of kudzu-vine root powder, 18 parts of chitosan oligosaccharides, 0.015 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
Step a: adding concentration of ethanol is 85%, and the weight percentage that its addition accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 26%.
Embodiment 15: basic identical with embodiment one, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 18 parts of ginseng extracts, 23 parts in propolis powder, 22 parts of kudzu-vine root powder, 23 parts of chitosan oligosaccharides, 0.025 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment one difference:
Step a: adding concentration of ethanol is 75%, and the weight percentage that its addition accounts for four kinds of raw material total amounts (four kinds of raw materials are ginseng extract, kudzu-vine root powder, chromium picolinate and chitosan oligosaccharide) is 28%.
Embodiment 16: health products of a kind of auxiliary hyperglycemic and preparation method thereof
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 10 parts of ginseng extracts, 25 parts in propolis powder, 20 parts of kudzu-vine root powder, 15 parts of chitosan oligosaccharides, 0.01 part of chromium picolinate with weight portion.
The fineness of propolis powder is 70～90 orders in the raw material; The fineness of kudzu-vine root powder is 80～100 orders; Said ginseng extract is that the patent No. is the product that 00103346.8 patent of invention is produced, and contains 30～80% general ginsenoside in the ginseng extract.
The preparation method of auxiliary hyperglycemic health products, this preparation method may further comprise the steps:
A, take by weighing various raw materials according to the proportioning ratio of above-mentioned auxiliary hyperglycemic health products; The ginseng extract that takes by weighing, propolis powder, kudzu-vine root powder, chromium picolinate and five kinds of raw materials of chitosan oligosaccharide are mixed; Mix the back add concentration be 95% ethanol as wetting agent, process softwood; Said concentration is that the weight percentage that the addition of 95% ethanol accounts for five kinds of raw material total amounts is 20%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 20 orders, adopts heated-air circulation oven to carry out drying then; Baking temperature is 50 ℃; Be 2 hours drying time, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 14 orders;
C, the particles filled capsule of processing that whole grain is good, every capsules content is 350mg, polishes, screens according to conventional method, packs at last.
Embodiment 17: originally identical with the embodiment palmityl, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 6 parts of ginseng extracts, 10 parts in propolis powder, 5 parts of kudzu-vine root powder, 5 parts of chitosan oligosaccharides, 0.005 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment 16 differences:
Step a: adding concentration of ethanol is 70%, and the weight percentage that its addition accounts for five kinds of raw material total amounts is 30%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 18 orders, adopts heated-air circulation oven to carry out drying then; Baking temperature is 40 ℃; Be 4 hours drying time, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 16 orders.
Embodiment 18: originally identical with the embodiment palmityl, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 6 parts of ginseng extracts, 10 parts in propolis powder, 5 parts of kudzu-vine root powder, 5 parts of chitosan oligosaccharides, 0.005 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment 16 differences:
Step a: adding concentration of ethanol is 85%, and the weight percentage that its addition accounts for five kinds of raw material total amounts is 25%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 20 orders, adopts heated-air circulation oven to carry out drying then; Baking temperature is 60 ℃; Be 2 hours drying time, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 18 orders.
Embodiment 19: originally identical with the embodiment palmityl, difference is:
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 16 parts of ginseng extracts, 24 parts in propolis powder, 18 parts of kudzu-vine root powder, 20 parts of chitosan oligosaccharides, 0.03 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products is with embodiment 16 differences:
Step c: the good particle of whole grain is pressed into tablet according to common process, the tablet of processing is packed is got final product.
Embodiment 20: health products of a kind of auxiliary hyperglycemic and preparation method thereof
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 23 parts of ginseng extracts, 20 parts in propolis powder, 16 parts of kudzu-vine root powder, 18 parts of chitosan oligosaccharides, 0.02 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products: the proportioning ratio according to above-mentioned auxiliary hyperglycemic health products takes by weighing various raw materials, and whole raw materials are evenly mixed, mixes the back and crosses the 60-80 mesh sieve, and the hard capsule filler filled capsules is directly used in the back of sieving.
Embodiment 21: health products of a kind of auxiliary hyperglycemic and preparation method thereof
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 8 parts of ginseng extracts, 15 parts in propolis powder, 8 parts of kudzu-vine root powder, 10 parts of chitosan oligosaccharides, 0.008 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products: be prepared into powder according to common process.
Embodiment 22: health products of a kind of auxiliary hyperglycemic and preparation method thereof
The composition of raw materials of the health products of auxiliary hyperglycemic is: represent 18 parts of ginseng extracts, 22 parts in propolis powder, 25 parts of kudzu-vine root powder, 16 parts of chitosan oligosaccharides, 0.03 part of chromium picolinate with weight portion.
The preparation method of auxiliary hyperglycemic health products: be prepared into pill according to common process.
Claims (10)
1. the health products of an auxiliary hyperglycemic; It is characterized in that: represent that with weight portion the raw material of said auxiliary hyperglycemic health products is 5～25 parts of ginseng extracts, 10～35 parts in propolis powder; 3～30 parts of kudzu-vine root powder, 0.005～0.05 part of 3～30 parts of chitosan oligosaccharides and chromium picolinate.
2. the health products of auxiliary hyperglycemic according to claim 1; It is characterized in that: the raw material of said auxiliary hyperglycemic health products is 10～20 parts of ginseng extracts; 15～25 parts in propolis powder, 15～25 parts of kudzu-vine root powder, 0.01～0.03 part of 15～25 parts of chitosan oligosaccharides and chromium picolinate.
3. the health products of auxiliary hyperglycemic according to claim 1, it is characterized in that: the fineness of said propolis powder is 70～90 orders, the fineness of kudzu-vine root powder is 80～100 orders.
4. the health products of auxiliary hyperglycemic according to claim 1 is characterized in that: contain 30～80% general ginsenoside in the said ginseng extract.
5. the preparation method of auxiliary hyperglycemic health products is characterized in that, said preparation method may further comprise the steps:
A, take by weighing various raw materials according to the proportioning ratio of the said auxiliary hyperglycemic health products of claim 1; Earlier the ginseng extract that takes by weighing, kudzu-vine root powder, chromium picolinate and four kinds of raw materials of chitosan oligosaccharide are mixed; Mix the back add concentration be 70～95% ethanol as wetting agent, process softwood; Said concentration is that the weight percentage that the addition of 70～95% ethanol accounts for four kinds of raw material total amounts is 20～30%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 16～20 orders, carries out drying then, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 14～18 orders;
C, whole grain back add the raw material propolis powder that takes by weighing and mix, and process capsule after mixing;
D, the capsule of processing is polished, screens according to conventional method, pack at last.
6. the preparation method of auxiliary hyperglycemic health products according to claim 5 is characterized in that: drying described in the step b is to adopt heated-air circulation oven to carry out drying, and baking temperature is 40～60 ℃, and be 2～4 hours drying time.
7. the preparation method of auxiliary hyperglycemic health products according to claim 5 is characterized in that: processing capsule described in the step c is to adopt the hard capsule filler filled capsules, and every capsules content is 350mg.
8. the preparation method of auxiliary hyperglycemic health products is characterized in that, said preparation method may further comprise the steps:
A, take by weighing various raw materials according to the proportioning ratio of the said auxiliary hyperglycemic health products of claim 1; The ginseng extract that takes by weighing, propolis powder, kudzu-vine root powder, chromium picolinate and five kinds of raw materials of chitosan oligosaccharide are mixed; Mix the back add concentration be 70～95% ethanol as wetting agent, process softwood; Said concentration is that the weight percentage that the addition of 70～95% ethanol accounts for five kinds of raw material total amounts is 20～30%;
B, the softwood that step a is processed adopt granulator to granulate, and the screen cloth that granulator adopts is 16～20 orders, carries out drying then, and dry back adopts pelletizing machine to carry out whole grain, and the screen cloth that pelletizing machine adopts is 14～18 orders;
C, the particles filled capsule of processing that whole grain is good polish, screen according to conventional method, pack at last;
Perhaps the good particle of whole grain is pressed into tablet according to common process, the tablet of processing is packed.
9. the preparation method of auxiliary hyperglycemic health products according to claim 8 is characterized in that: drying described in the step b is to adopt heated-air circulation oven to carry out drying, and baking temperature is 40～60 ℃, and be 2～4 hours drying time;
10. the preparation method of auxiliary hyperglycemic health products according to claim 8 is characterized in that: processing capsule described in the step c is to adopt the hard capsule filler filled capsules, and every capsules content is 350mg.
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| CN103284038B (en) * | 2012-12-27 | 2014-12-03 | 福建永生活力生物工程有限公司 | Hyperglycemic composition and preparation method thereof |
| WO2014134833A1 (en) * | 2013-03-08 | 2014-09-12 | 武汉华大药业有限公司 | Edible composition, preparation method therefor, and food product comprising the composition |
| CN104001003A (en) * | 2014-04-15 | 2014-08-27 | 吕士敏 | Oral liquid and sublingual spraying agent for treating diabetes |
| CN106360698A (en) * | 2016-09-29 | 2017-02-01 | 广州市汇吉科技企业孵化器有限公司 | Moringa oleifera health care product capable of relieving hypertension, hyperglycemia and hyperlipidemia, and preparation method thereof |
| CN109247577A (en) * | 2018-09-19 | 2019-01-22 | 金泽宇(武汉)生物科技有限公司 | Charantin and the composition of chitosan oligosaccharide and preparation method thereof |
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| CN101450101A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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| CN101450101A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with blood-sugar reduction function and preparation method thereof |
| CN101450095A (en) * | 2007-11-30 | 2009-06-10 | 北京因科瑞斯医药科技有限公司 | Medicine composition with blood-sugar reduction function and preparation method thereof |
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