CN101683149A - Preparation of composition of reduced glutathione hormone, vitamin C and selenium compound - Google Patents
Preparation of composition of reduced glutathione hormone, vitamin C and selenium compound Download PDFInfo
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- CN101683149A CN101683149A CN200810139485A CN200810139485A CN101683149A CN 101683149 A CN101683149 A CN 101683149A CN 200810139485 A CN200810139485 A CN 200810139485A CN 200810139485 A CN200810139485 A CN 200810139485A CN 101683149 A CN101683149 A CN 101683149A
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Abstract
The objective of the present invention is to provide a new nutritious health products, and the nutritious health products is formed by mixing pharmaceutical-grade, food-grade reduced glutathione hormone, vitamin C and selenium compound, or formed by mixing pharmaceutical-grade, food-grade reduced glutathione hormone, vitamin C, which can be prepared into forms of buccal tablets, enteric-coated tablets or capsules. The nutritious health product has an efficacy of anti-oxidant, and capable of improving human body immunity, accelerating excretion of free radical and delaying aging, and has a function of preventing carcinogenesis and cardiovascular disease, which can be used as medicine and health product.
Description
Technical field
The present invention relates to the preparation method of the healthy product of a kind of novel nourishing.
Background technology
Glutathione, i.e. γ-L-glutamy-L-cysteinyl-glycine (γ-L-glutamyl-L-cysteinyl-glycine is called for short GSH).It is the active kyrine that forms through the peptide bond condensation by glutamic acid, cysteine and glycine.The glutathione molecular weight is 307.33, and fusing point is 189～193 ℃, and crystal clear elongated column, isoelectric point are 5.93.Glutathione has special physiological properties, has important function to keeping the cell biological function.It can be by the combined with radical in sulfydryl and the body, thereby the acid that can change into easy metabolism quickens the drainage of free radical, has liver-protective function, promote the metabolism of noxious material, simultaneously also help to alleviate the toxic and side effect of chemotherapy, radiotherapy, and the curative effect of chemotherapy, radiotherapy is not had obvious influence; Whole body or local hypoxemia patient for anaemia, poisoning or tissue inflammation cause also can alleviate tissue damage, promote to repair.Therefore be called as the longevity factor and the anti-ageing factor.
Because the glutathione molecule has a special γ-peptide bond; determined its many important physiological function in the human organism; as tricarboxylic acid cycle and glycometabolism in vigor, metabolism and the cytoprotection of the transportation of synthetic, the oxygen of protein and ribonucleic acid and nutriment, endogenous enzymes, the participation body; have anti-oxidant, antifatigue, anti-ageing, remove and cross polyradical in the body, detoxify, protect effects such as liver, prevention diabetes and cancer, be the representative of body defense function peptide.The glutathione disappearance can cause the accumulation of excessive free radicals, thereby causes macromolecules degradation, fatty peroxidating, and toxin produces, and finally causes cell death.Because the importance of glutathione, it is produced and is supplied to tissue continuously by human body.Glutathione can be synthesized by most cells, and human body produces 8～10 gram reduced glutathiones every day, is wherein produced by liver more than 80%, and all the other are generations such as skeletal muscle, red blood cell.
Can not synthesize the capacity glutathione in some disease patient body, as AIDS patient, hepatopath etc.The outside administering mode of glutathione has hypodermic injection, intravenous injection, lung to suck and form such as oral.Glutathione can be absorbed by mucous membrane, particularly the mucous membrane of hypoglossis mucous membrane and duodenum and ileum.Studies show that oral mucosa adopts passive types of transportation fast Absorption glutathione, makes it to enter blood.Mucous membrane of small intestine can adopt passive transportation or active transport form to absorb glutathione.
Vitamin C participates in multiple reaction in vivo, as participating in oxidation-reduction process, plays an important role in biological oxidation and reduction and cellular respiration.From organizing level, ascorbic main effect is synthetic relevant with cytoplasm, comprises collagen, the matrix of tooth and bone, and the binding element between capillary endothelial cell.Therefore, when the caused scurvy of hypovitaminosis C, with the synthetic defective of collagen, show as The wound refused to heal, tooth forms obstacle and the capillary breakage causes a large amount of hemostasis points, and hemostasis point merges and forms ecchymosis.Vitamin C also is a kind of important antioxidants in the body.Because reversibly hydrogenation or dehydrogenation of vitamin C is so play an important role in the many in vivo redox reactions of vitamin C.For example, the active group of many enzymes is that (SH), vitamin C can keep that sulfydryl is in reducing condition and the activity that keeps enzyme to sulfydryl; Vitamin C can make oxidized form of glutathione change reduced glutathione (GSH) into, the hydrogen-peroxide reduction that organism metabolism is produced; Vitamin C also can protect vitamin A, E and some B family vitamin to avoid oxidation.Therefore, during the utilization glutathione,, can improve its effect with vitamin C and usefulness.
Selenium is the essential constituent of HRBC's glutathione peroxidase; Selenium has the effect of the lipid hydroperoxide of elimination as the essential component of multiple antioxidase; Selenium exist with all immunocytes in, Selenium Supplement can obviously improve immunity of organisms and reach the effect of diseases prevention; Because selenides and heavy metal have very strong affinity, so the toxicity of energy antagonism heavy metal.Selenium also has the growth of promotion, the protection organs of vision and antineoplastic action.People such as the Taylor doctor of georgia ,u.s.a university discover that the concentration of selenium in AIDS patient's body is lower.The utilization of AIDS virus and human body competition selenium, selenium plays regulating action in the growth course of AIDS virus.Selenium intake every day that CFN of U.S. scientist research committee is recommended is the 50-200 microgram, World Health Organization's suggestion meals selenium supply scope is 50～250 micrograms, if human body is lower than normal level for a long time for the intake of selenium, the probability of suffering from cancer will strengthen.
Summary of the invention
The object of the present invention is to provide a kind of new nutritious health products, this nutritious health product is formed by pharmaceutical grade, food-grade reduced glutathione, vitamin C and selenium compound mixing, or mix by pharmaceutical grade, food-grade reduced glutathione and vitamin C and to form, can be prepared as buccal tablet, enteric coatel tablets or capsule form.This nutritious health product can play the effect of antioxidant, has the raising body immunity, quickens the drainage of free radical, promotes the metabolism of noxious material, delays senility, and has the effect of prevention canceration and angiocardiopathy preventing, can be used as medicine, health products use.Chinese patent CN1519020A discloses the composite reagent thing of reduced glutathione and selenium compound, points out that " the selenium element can promote the biochemical reaction of reduced glutathione, gives full play to the effect of reduced glutathione, has good medicine synergy." because glutathione is oxidized easily, and vitamin C can make oxidized form of glutathione change reduced glutathione (GSH) into, thus play protective effect to reduced glutathione.The present invention mixes vitamin C simultaneously with glutathione and selenium compound, perhaps vitamin C is mixed with glutathione, can until the absorbed overall process of glutathione glutathione be played a protective role from the beginning of preparation composition, makes it to keep its reduction
The type state.Have research to think that glutathione may be poisonous under the situation of hypovitaminosis C, the present invention provides vitamin C when glutathione is provided, can make human body avoid occurring the situation of hypovitaminosis C, thereby eliminates the possible toxicity of glutathione.Glutathione to the half lethal dose (LD50) of mouse when oral and the lumbar injection at 4～5 gram/kilograms, be that low toxicity or reality are nontoxic.
The invention has the advantages that the reduced form state that uses overall process as far as possible to keep glutathione from producing to, is human body replenishing vitamins C simultaneously, makes human body have no lack of vitamin C, thereby eliminates the potential side effect of glutathione.The technology simple operations is controlled, three-waste free pollution.Three's mass ratio can be adjusted according to the human body needs.Can make forms such as buccal tablet, enteric coatel tablets, capsule as required.
The specific embodiment:
Describe the present invention below in conjunction with example.
Example 1: accurately take by weighing glutathione, vitamin C and selenium compound, the ratio that makes glutathione, vitamin C and selenium element is 1: 0.5: 1 * 10
-4With mixer they are fully mixed; make suitable softwood with auxiliary material then; make 30 orders～60 purpose particles with granulator, about 60 ℃, carry out drying, adopt high speed tablet press to carry out compressing tablet; throw the dust that removes on the tablet with polishing machine; carry out bubble-cap with automatic aluminium-plastic bubble plate packing machine, adorn box then, penetrate sterilization with cobalt 60 width of cloth.
Example 2: accurately take by weighing glutathione, vitamin C and selenium compound, the ratio that makes glutathione, vitamin C and selenium element is 1: 0.3: 5 * 10
-3, fully mix, make suitable softwood with auxiliary material then, make 30 orders～60 purpose particles with granulator, about 60 ℃, carry out drying, adopt high speed tablet press to carry out compressing tablet, promptly can be made into enteric coatel tablets with enteric coating powder dressing again.
Example 3: accurately take by weighing glutathione, vitamin C and selenium compound, making the ratio of glutathione, living plain C and selenium element is 1: 0.5: 1 * 10
-3, with mixer they are fully mixed, capsule technology is made the capsule of required specification routinely.
Example 4: accurately take by weighing glutathione and vitamin C; making glutathione and ascorbic ratio is 1: 0.5; with mixer they are fully mixed, make suitable softwood with auxiliary material then, make 30 orders～60 purpose particles with granulator; about 60 ℃, carry out drying; adopt high speed tablet press to carry out compressing tablet, throw the dust that removes on the tablet, carry out bubble-cap with automatic aluminium-plastic bubble plate packing machine with polishing machine; adorn box then, penetrate sterilization with cobalt 60 width of cloth.
Example 5: accurately take by weighing glutathione and vitamin C; making glutathione and ascorbic ratio is 1: 0.3; with mixer they are fully mixed; make suitable softwood with auxiliary material then; make 30 orders～60 purpose particles with granulator; about 60 ℃, carry out drying, adopt high speed tablet press to carry out compressing tablet, promptly can be made into enteric coatel tablets with enteric coating powder dressing again.
Example 6: accurately take by weighing glutathione and vitamin C, making glutathione and ascorbic ratio is 1: 1, with mixer they is fully mixed, and capsule technology is made the capsule of required specification routinely.
Should be appreciated that shown in the invention is not restricted to here and the specific embodiment of describing.Be not intended to describe in detail those those of ordinary skills at this and reading all conspicuous variation and the changes that to accomplish on the basis of specification of the present invention.But, should be understood that all these variations and change in the scope of the present invention all be included in appended claims and limited.
Claims (6)
1. a reduced glutathione, vitamin C and selenium compound preparation of compositions, it is characterized in that: accurately take by weighing glutathione, vitamin C and selenium compound, the ratio that makes glutathione, vitamin C and selenium element is 1: 0.5: 1 * 10
1, make suitable softwood with auxiliary material then, make 30 orders ~ 60 purpose particles with granulator, about 60 ℃, carry out drying, adopt high speed tablet press to carry out compressing tablet, adorn box then, penetrate sterilization with cobalt 60 width of cloth.
2. a reduced glutathione, vitamin C and selenium compound preparation of compositions, it is characterized in that: accurately take by weighing glutathione, vitamin C and selenium compound, the ratio that makes glutathione, vitamin C and selenium element is 1: 0.3: 5 * 10
-3
3. a reduced glutathione, vitamin C and selenium compound preparation of compositions is characterized in that: accurately take by weighing glutathione, vitamin C and selenium compound, the ratio of make glutathione, giving birth to plain C and selenium element is 1: 0.5: 1 * 10
-3
4. a reduced glutathione, vitamin C and selenium compound preparation of compositions, it is characterized in that: accurately take by weighing glutathione and vitamin C, making glutathione and ascorbic ratio is 1: 0.5.
5. a reduced glutathione, vitamin C and selenium compound preparation of compositions, it is characterized in that: accurately take by weighing glutathione and vitamin C, making glutathione and ascorbic ratio is 1: 0.3.
6. a reduced glutathione, vitamin C and selenium compound preparation of compositions, it is characterized in that: accurately take by weighing glutathione and vitamin C, making glutathione and ascorbic ratio is 1: 1.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200810139485A CN101683149A (en) | 2008-09-26 | 2008-09-26 | Preparation of composition of reduced glutathione hormone, vitamin C and selenium compound |
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| Application Number | Priority Date | Filing Date | Title |
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| CN200810139485A CN101683149A (en) | 2008-09-26 | 2008-09-26 | Preparation of composition of reduced glutathione hormone, vitamin C and selenium compound |
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| CN101683149A true CN101683149A (en) | 2010-03-31 |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652932A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method of Cordyceps militaris polypeptide tablet |
| ITPD20130052A1 (en) * | 2013-03-01 | 2014-09-02 | Enologica Vason S P A | VINIFICATION PROCEDURE AND PRODUCT FOR ENOLOGICAL USE ACT TO BE USED IN THE ABOVE WINE-MAKING PROCEDURE |
| CN108323762A (en) * | 2018-02-02 | 2018-07-27 | 昆明朗盛生物科技有限公司 | A kind of selenium-rich composition and preparation, preparation method and application |
| CN112754021A (en) * | 2021-01-28 | 2021-05-07 | 乐文堂(青岛)大健康产业集团有限公司 | Selenium-containing bovine bone marrow peptide composite sheet for plants and preparation method thereof |
| CN115702910A (en) * | 2021-08-10 | 2023-02-17 | 武汉远大弘元股份有限公司 | Composition of glutathione precursor, preparation method and application |
| WO2024104313A1 (en) * | 2022-11-18 | 2024-05-23 | Govita Tech Limited | Composition for antiviral or oxidation pretreatment, preparation method and usage method thereof |
-
2008
- 2008-09-26 CN CN200810139485A patent/CN101683149A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652932A (en) * | 2012-09-07 | 2014-03-26 | 江苏学府生物工程有限公司 | Production method of Cordyceps militaris polypeptide tablet |
| ITPD20130052A1 (en) * | 2013-03-01 | 2014-09-02 | Enologica Vason S P A | VINIFICATION PROCEDURE AND PRODUCT FOR ENOLOGICAL USE ACT TO BE USED IN THE ABOVE WINE-MAKING PROCEDURE |
| WO2014132123A3 (en) * | 2013-03-01 | 2014-12-04 | Enologica Vason S.P.A. | Vinification process and use of an enological product in said vinification process |
| CN108323762A (en) * | 2018-02-02 | 2018-07-27 | 昆明朗盛生物科技有限公司 | A kind of selenium-rich composition and preparation, preparation method and application |
| CN108323762B (en) * | 2018-02-02 | 2021-05-28 | 昆明朗盛生物科技有限公司 | Selenium-rich composition and preparation, preparation method and application thereof |
| CN112754021A (en) * | 2021-01-28 | 2021-05-07 | 乐文堂(青岛)大健康产业集团有限公司 | Selenium-containing bovine bone marrow peptide composite sheet for plants and preparation method thereof |
| CN115702910A (en) * | 2021-08-10 | 2023-02-17 | 武汉远大弘元股份有限公司 | Composition of glutathione precursor, preparation method and application |
| CN115702910B (en) * | 2021-08-10 | 2024-05-28 | 武汉远大弘元股份有限公司 | Composition, preparation method and application of glutathione precursor |
| WO2024104313A1 (en) * | 2022-11-18 | 2024-05-23 | Govita Tech Limited | Composition for antiviral or oxidation pretreatment, preparation method and usage method thereof |
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Open date: 20100331 |